Strain Name:
C57BL/6J-MtgxR7314Btlr/Mmmh
Stock Number:
045412-MU
Citation ID:
RRID:MMRRC_045412-MU
Other Names:
R7314 (G1)
Major Collection:

Strain Information

Eps8
Name: epidermal growth factor receptor pathway substrate 8
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 13860
HGNC: HGNC:3420
Homologene: 3272
Ppp1r13b
Name: protein phosphatase 1, regulatory subunit 13B
Synonyms: ASPP1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 21981
VEGA: 12
Homologene: 9090
Lgi3
Name: leucine-rich repeat LGI family, member 3
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 213469
VEGA: 14
Homologene: 16406
Ireb2
Name: iron responsive element binding protein 2
Synonyms: D9Ertd85e, Irp2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 64602
VEGA: 9
HGNC: HGNC:6115
Homologene: 11280
Vps13c
Name: vacuolar protein sorting 13C
Synonyms: C230055H22Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320528
VEGA: 9
Homologene: 41188
Hspbap1
Name: Hspb associated protein 1
Synonyms: 3830421G21Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 66667
VEGA: 16
Homologene: 11617
Cstf1
Name: cleavage stimulation factor, 3' pre-RNA, subunit 1
Synonyms: 1700057K18Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 67337
HGNC: HGNC:2483
Homologene: 1012
Phkb
Name: phosphorylase kinase beta
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 102093
HGNC: HGNC:8927
Homologene: 247
Jph4
Name: junctophilin 4
Synonyms: JPHL1, 9330157P13Rik, JP-4
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 319984
Homologene: 13034
Adss2
Name: adenylosuccinate synthase 2
Synonyms: Adss, AS
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 11566
HGNC: HGNC:292
Homologene: 875
Ubr3
Name: ubiquitin protein ligase E3 component n-recognin 3
Synonyms: A130030D10Rik, Zfp650, 4833421P10Rik, 1110059H15Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68795
Homologene: 52092
Lca5
Name: Leber congenital amaurosis 5 (human)
Synonyms: 4930431B11Rik, 5730406O13Rik, ORF64
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 75782
Homologene: 32718
Nrip1
Name: nuclear receptor interacting protein 1
Synonyms: 8430438I05Rik, 6030458L20Rik, RIP140
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 268903
HGNC: HGNC:8001
Homologene: 2606
Zfp369
Name: zinc finger protein 369
Synonyms: B930030B22Rik, NRIF2, D230020H11Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 170936
Homologene: 129707
Map3k7
Name: mitogen-activated protein kinase kinase kinase 7
Synonyms: Tak1, transforming growth factor beta-activated kinase 1, TAK1, transforming growth factor-beta-activated kinase 1, TGF-beta activated kinase 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 26409
HGNC: HGNC:6859
Homologene: 118818
Tmco3
Name: transmembrane and coiled-coil domains 3
Synonyms: B230339H12Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234076
Homologene: 32376
Klhl6
Name: kelch-like 6
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 239743
Homologene: 15603
Dnah14
Name: dynein, axonemal, heavy chain 14
Synonyms: LOC381311, Gm980, A230079K17Rik, Dnahc14
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240960
HGNC: HGNC:2945
Homologene: 90078
Pcdhgb8
Name: protocadherin gamma subfamily B, 8
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93705
Homologene: 81868
Pdzd8
Name: PDZ domain containing 8
Synonyms: Pdzk8, A630041P07Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 107368
VEGA: 19
Homologene: 14879
Aplp1
Name: amyloid beta precursor like protein 1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11803
HGNC: HGNC:597
Homologene: 68447
Dnah9
Name: dynein, axonemal, heavy chain 9
Synonyms: Dnahc9, D11Ertd686e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237806
HGNC: HGNC:2953
Homologene: 20357
Pcdha1
Name: protocadherin alpha 1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 116731
HGNC: HGNC:8663
Homologene: 75093
C4b
Name: complement C4B (Chido blood group)
Synonyms: Ss, C4
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12268
Homologene: 36030
Rpap2
Name: RNA polymerase II associated protein 2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231571
Homologene: 11733
Celsr3
Name: cadherin, EGF LAG seven-pass G-type receptor 3
Synonyms: Adgrc3, flamingo, Fmi1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 107934
HGNC: HGNC:3230
Homologene: 1077
Obox3
Name: oocyte specific homeobox 3
Synonyms: Ohx
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 246791
Homologene: 44937
Tecpr1
Name: tectonin beta-propeller repeat containing 1
Synonyms: 2210010N04Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 70381
Homologene: 9120
Tmprss11f
Name: transmembrane protease, serine 11f
Synonyms: 4732406D01Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 243083
Homologene: 65356
Sntg2
Name: syntrophin, gamma 2
Synonyms: 2210008K22Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 268534
Homologene: 41298
4930596D02Rik
Name: RIKEN cDNA 4930596D02 gene
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 239036
Dnase2b
Name: deoxyribonuclease II beta
Synonyms: Dlad, DnaseIIb
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 56629
Homologene: 1052
Or5d37
Name: olfactory receptor family 5 subfamily D member 37
Synonyms: GA_x6K02T2Q125-49585842-49584862, Olfr1164, MOR174-11
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258634
Homologene: 74077
Krt16
Name: keratin 16
Synonyms: Krt1-16, K16
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16666
HGNC: HGNC:6423
Homologene: 21145
Parp8
Name: poly (ADP-ribose) polymerase family, member 8
Synonyms: D13Ertd275e, 2810430O08Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 52552
VEGA: 13
Homologene: 11621
Abcc10
Name: ATP-binding cassette, sub-family C member 10
Synonyms: Mrp7
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224814
HGNC: HGNC:52
Homologene: 58616
Setd4
Name: SET domain containing 4
Synonyms: ORF21
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224440
HGNC: HGNC:1258
Homologene: 41173
Oas1g
Name: 2'-5' oligoadenylate synthetase 1G
Synonyms: Mmu-L, Mmu-L2, L2, Oias1, Oias-1, Oas1a
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 23960
HGNC: HGNC:8086
Homologene: 1903
Or6b13
Name: olfactory receptor family 6 subfamily B member 13
Synonyms: Olfr524, GA_x6K02T2PBJ9-42354580-42353624, MOR103-14P
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258055
Homologene: 79347
Trhr2
Name: thyrotropin releasing hormone receptor 2
Synonyms: TRH-R2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 170732
Homologene: 44052
Lingo3
Name: leucine rich repeat and Ig domain containing 3
Synonyms: LERN2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237403
VEGA: 10
Homologene: 78065
Endod1
Name: endonuclease domain containing 1
Synonyms: 2310067E08Rik, 2210414F18Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 71946
VEGA: 9
Homologene: 12425
1700020L13Rik
Name: RIKEN cDNA 1700020L13 gene
Synonyms: Thap8, 1700020L13Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 108167416
Ghdc
Name: GH3 domain containing
Synonyms: D11Lgp1e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 80860
Homologene: 32760
Smad9
Name: SMAD family member 9
Synonyms: SMAD8B, MADH6, SMAD8A, Madh9
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 55994
HGNC: HGNC:6774
Homologene: 21198
Hmgn2-ps
Name: high mobility group nucleosomal binding domain 2, pseudogene
Synonyms: Gm10282
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 100042405
HGNC: HGNC:4986
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 177,767,751 bp
  • A to T, chromosome 1 at 181,785,254 bp
  • T to A, chromosome 2 at 69,991,600 bp
  • A to G, chromosome 2 at 88,093,114 bp
  • A to G, chromosome 2 at 172,373,034 bp
  • A to G, chromosome 3 at 54,789,323 bp
  • T to C, chromosome 3 at 146,582,396 bp
  • G to T, chromosome 4 at 31,985,769 bp
  • T to C, chromosome 5 at 86,524,053 bp
  • T to C, chromosome 5 at 107,620,379 bp
  • A to T, chromosome 5 at 120,878,463 bp
  • A to G, chromosome 5 at 144,217,332 bp
  • A to G, chromosome 6 at 137,527,092 bp
  • T to A, chromosome 7 at 15,627,154 bp
  • G to A, chromosome 7 at 30,289,895 bp
  • T to C, chromosome 7 at 30,435,989 bp
  • A to T, chromosome 7 at 140,202,413 bp
  • G to A, chromosome 8 at 13,319,605 bp
  • C to T, chromosome 8 at 72,304,995 bp
  • A to G, chromosome 8 at 85,942,392 bp
  • A to G, chromosome 8 at 122,358,750 bp
  • T to C, chromosome 9 at 14,356,999 bp
  • T to C, chromosome 9 at 54,892,510 bp
  • T to A, chromosome 9 at 67,943,340 bp
  • T to C, chromosome 9 at 83,395,510 bp
  • T to C, chromosome 9 at 108,829,144 bp
  • T to C, chromosome 10 at 80,834,873 bp
  • G to A, chromosome 11 at 65,989,851 bp
  • T to C, chromosome 11 at 100,247,869 bp
  • T to C, chromosome 11 at 100,769,102 bp
  • A to G, chromosome 12 at 30,267,108 bp
  • T to C, chromosome 12 at 111,846,356 bp
  • T to C, chromosome 13 at 65,292,104 bp
  • G to T, chromosome 13 at 116,868,460 bp
  • A to G, chromosome 14 at 35,811,649 bp
  • TCCATTCTCGTATACCCCA to TCCA, chromosome 14 at 55,109,739 bp
  • T to C, chromosome 14 at 70,532,112 bp
  • A to G, chromosome 16 at 19,957,005 bp
  • T to A, chromosome 16 at 35,825,171 bp
  • A to G, chromosome 16 at 76,291,190 bp
  • T to C, chromosome 16 at 93,587,823 bp
  • C to T, chromosome 17 at 34,740,356 bp
  • C to A, chromosome 17 at 46,315,404 bp
  • T to C, chromosome 18 at 36,931,500 bp
  • A to G, chromosome 18 at 37,762,999 bp
  • A to T, chromosome 19 at 59,301,351 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7314 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045412-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.