Strain Name:
C57BL/6J-MtgxR7325Btlr/Mmmh
Stock Number:
045419-MU
Citation ID:
RRID:MMRRC_045419-MU
Other Names:
R7325 (G1)
Major Collection:

Strain Information

Rgs9
Name: regulator of G-protein signaling 9
Synonyms: RGS9-1, Rgs9-2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19739
Homologene: 2845
Slc17a6
Name: solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
Synonyms: VGLUT2, 2900073D12Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 140919
Homologene: 121617
Upp1
Name: uridine phosphorylase 1
Synonyms: Up, UPase, UdRPase
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 22271
Homologene: 2524
Mtmr14
Name: myotubularin related protein 14
Synonyms: 1110061O04Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 97287
Homologene: 11203
Snapc3
Name: small nuclear RNA activating complex, polypeptide 3
Synonyms: 1810020H02Rik, E030018J20Rik, 5031401C21Rik, 4930558A07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 77634
Homologene: 31130
Fbxo15
Name: F-box protein 15
Synonyms: Fbx15, ecat3
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 50764
VEGA: 18
Homologene: 17644
Fip1l1
Name: factor interacting with PAPOLA and CPSF1
Synonyms: Rje, 1300019H17Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 66899
Homologene: 136254
Usp34
Name: ubiquitin specific peptidase 34
Synonyms: A530081C03Rik, Murr2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17847
Homologene: 40978
Tep1
Name: telomerase associated protein 1
Synonyms: Tp1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 21745
VEGA: 14
Homologene: 5157
Cip2a
Name: cell proliferation regulating inhibitor of protein phosphatase 2A
Synonyms: Cip2a, C330027C09Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224171
Homologene: 10842
Exd1
Name: exonuclease 3'-5' domain containing 1
Synonyms: 4932702D22Rik, Exdl1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241624
Homologene: 17627
Gins1
Name: GINS complex subunit 1
Synonyms: 2810418N01Rik, Psf1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 69270
Homologene: 44516
Ap3d1
Name: adaptor-related protein complex 3, delta 1 subunit
Synonyms: Bolvr, mBLVR1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 11776
VEGA: 10
HGNC: HGNC:568
Homologene: 2926
Insig2
Name: insulin induced gene 2
Synonyms: Insig-2, C730043J18Rik, 2900053I11Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 72999
Homologene: 9400
Cd300lb
Name: CD300 molecule like family member B
Synonyms: LOC217304, Clm7, LMIR5, CLM-7
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217304
Homologene: 18374
Cdan1
Name: codanin 1
Synonyms: CDA-I, 1500015A01Rik, codanin-1, CDA1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68968
HGNC: HGNC:1713
Homologene: 16324
Prim1
Name: DNA primase, p49 subunit
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19075
HGNC: HGNC:9369
Homologene: 730
Slc12a4
Name: solute carrier family 12, member 4
Synonyms: KCC1, K-Cl Co-transporter-1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 20498
Homologene: 21056
Trim33
Name: tripartite motif-containing 33
Synonyms: ectodermin, Tif1g, Ecto, 8030451N04Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 94093
Homologene: 9296
Podn
Name: podocan
Synonyms: SLRR5A
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242608
Homologene: 17803
Agtr1a
Name: angiotensin II receptor, type 1a
Synonyms: AT1a, AT1, Agtr1a, Agtr-1a, Agt1ar, 1810074K20Rik, Angtr-1a
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 11607
HGNC: HGNC:336
Homologene: 3556
Csmd1
Name: CUB and Sushi multiple domains 1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 94109
Homologene: 69536
Dennd5b
Name: DENN domain containing 5B
Synonyms: 9330160C06Rik, D030011O10Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 320560
Homologene: 44911
Tespa1
Name: thymocyte expressed, positive selection associated 1
Synonyms: A430001F24Rik, 5830405N20Rik, Itprid3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 67596
VEGA: 10
Homologene: 106645
Celsr1
Name: cadherin, EGF LAG seven-pass G-type receptor 1
Synonyms: crash, Adgrc1, Crsh, Scy
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12614
VEGA: 15
HGNC: HGNC:1850
Homologene: 7665
Adgrb3
Name: adhesion G protein-coupled receptor B3
Synonyms: Bai3, A830096D10Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 210933
HGNC: HGNC:945
Homologene: 1289
Afap1l1
Name: actin filament associated protein 1-like 1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 106877
Homologene: 18728
Scgb2b26
Name: secretoglobin, family 2B, member 26
Synonyms: Scgb2b4, Abpg, C2d, Abpbg4, Abpbg26
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 110187
Homologene: 83171
Fyttd1
Name: forty-two-three domain containing 1
Synonyms: 3830421F13Rik, 4933423A17Rik, 2010005M05Rik, 3830411L18Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 69823
Homologene: 12334
Astn2
Name: astrotactin 2
Synonyms: Astnl, 1d8
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56079
Homologene: 77850
Slco1a8
Name: solute carrier organic anion transporter family, member 1a8
Synonyms: Gm6614
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 625716
Homologene: 87075
Arhgef11
Name: Rho guanine nucleotide exchange factor 11
Synonyms: Prg, PDZ-RhoGEF
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 213498
Homologene: 11409
Taok2
Name: TAO kinase 2
Synonyms: TAO1, PSK1, 1110033K02Rik, MAP3K17, TAO2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 381921
Homologene: 74531
Maz
Name: MYC-associated zinc finger protein (purine-binding transcription factor)
Synonyms: SAF-2, PUR1, Pur-1, SAF-1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17188
HGNC: HGNC:6914
Homologene: 106451
Vmn2r93
Name: vomeronasal 2, receptor 93
Synonyms: EG627132
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627132
Homologene: 129750
Shank2
Name: SH3 and multiple ankyrin repeat domains 2
Synonyms: ProSAP1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 210274
Homologene: 105965
Or1e34
Name: olfactory receptor family 1 subfamily E member 34
Synonyms: MOR135-8, GA_x6K02T2P1NL-4043306-4042374, Olfr394
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 259009
Homologene: 133669
Baat
Name: bile acid-Coenzyme A: amino acid N-acyltransferase
Synonyms: taurine N-acyltransferase, BAT
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12012
HGNC: HGNC:932
Homologene: 1286
Flg2
Name: filaggrin family member 2
Synonyms: EG229574
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229574
Homologene: 134146
Bphl
Name: biphenyl hydrolase like
Synonyms: 2010012D11Rik, 5730533B08Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 68021
VEGA: 13
HGNC: HGNC:1094
Homologene: 55812
Ybx2
Name: Y box protein 2
Synonyms: MSY2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 53422
Homologene: 22942
Pcdhb7
Name: protocadherin beta 7
Synonyms: Pcdhb4B, PcdhbG
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93878
HGNC: HGNC:8689
Homologene: 87123
Cadps2
Name: Ca2+-dependent activator protein for secretion 2
Synonyms: cpd2, A230044C21Rik, Caps2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 320405
Homologene: 23060
Zfp536
Name: zinc finger protein 536
Synonyms: 9630010P11Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243937
Homologene: 8813
Ism1
Name: isthmin 1, angiogenesis inhibitor
Synonyms: 5430433G21Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 319909
Homologene: 19061
Jmy
Name: junction-mediating and regulatory protein
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 57748
VEGA: 13
Homologene: 10955
Slc9a9
Name: solute carrier family 9 (sodium/hydrogen exchanger), member 9
Synonyms: 5730527A11Rik, Nhe9
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 331004
Homologene: 69753
Vmn1r47
Name: vomeronasal 1 receptor 47
Synonyms: V1ra4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 113846
Homologene: 137651
Slco2a1
Name: solute carrier organic anion transporter family, member 2a1
Synonyms: mPgt, Slc21a2, 2310021C19Rik, Pgt
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 24059
Homologene: 38077
Or5b113
Name: olfactory receptor family 5 subfamily B member 113
Synonyms: MOR202-15, Olfr1467, GA_x6K02T2RE5P-3695694-3696620
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258686
Homologene: 133888
Gpsm2
Name: G-protein signalling modulator 2 (AGS3-like, C. elegans)
Synonyms: Pins, 6230410J09Rik, LGN
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 76123
Homologene: 56584
Or8k22
Name: olfactory receptor family 8 subfamily K member 22
Synonyms: MOR188-2, GA_x6K02T2Q125-47811880-47810942, Olfr1054
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 259021
Homologene: 133882
Hace1
Name: HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1
Synonyms: A730034A22Rik, 1700042J16Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 209462
Homologene: 10807
Tpmt
Name: thiopurine methyltransferase
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 22017
Homologene: 313
Anks1b
Name: ankyrin repeat and sterile alpha motif domain containing 1B
Synonyms: AIDA-1b, LOC380650, E530015N03Rik, Gm10937, C030032C09Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 77531
Homologene: 51570
Zfp583
Name: zinc finger protein 583
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 213011
Homologene: 65048
Prrt1
Name: proline-rich transmembrane protein 1
Synonyms: G5b, NG5, SynDIG4
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 260297
Homologene: 134500
Pcp4l1
Name: Purkinje cell protein 4-like 1
Synonyms: 1500036F01Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 66425
Homologene: 136091
Boll
Name: boule homolog, RNA binding protein
Synonyms: 4930597B14Rik, 4930554P13Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 75388
Homologene: 33650
Cfap91
Name: cilia and flagella associated protein 91
Synonyms: Spata26, 4932425I24Rik, Maats1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 320214
Homologene: 33470
Pcdhac2
Name: protocadherin alpha subfamily C, 2
Synonyms: CNRc2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 353237
HGNC: HGNC:8677
Homologene: 49562
Gm5565
Name: predicted gene 5565
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 433961
Homologene: 86127
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 25,532,630 bp
  • T to C, chromosome 1 at 55,304,598 bp
  • A to G, chromosome 1 at 121,306,937 bp
  • G to A, chromosome 1 at 171,174,465 bp
  • A to G, chromosome 2 at 86,333,000 bp
  • A to G, chromosome 2 at 119,520,139 bp
  • T to C, chromosome 2 at 120,724,704 bp
  • T to C, chromosome 2 at 139,757,043 bp
  • T to A, chromosome 2 at 150,916,166 bp
  • T to C, chromosome 3 at 87,713,292 bp
  • T to A, chromosome 3 at 93,203,372 bp
  • T to C, chromosome 3 at 103,321,636 bp
  • T to C, chromosome 3 at 108,702,928 bp
  • C to A, chromosome 4 at 49,490,213 bp
  • C to T, chromosome 4 at 65,542,669 bp
  • T to C, chromosome 4 at 83,435,270 bp
  • C to T, chromosome 4 at 108,017,702 bp
  • A to G, chromosome 5 at 74,536,799 bp
  • G to C, chromosome 5 at 146,158,361 bp
  • T to G, chromosome 6 at 23,409,935 bp
  • T to C, chromosome 6 at 90,022,272 bp
  • T to A, chromosome 6 at 113,269,548 bp
  • T to C, chromosome 6 at 141,989,225 bp
  • T to A, chromosome 6 at 149,020,570 bp
  • C to T, chromosome 7 at 6,316,586 bp
  • C to A, chromosome 7 at 33,944,357 bp
  • T to C, chromosome 7 at 37,479,860 bp
  • G to T, chromosome 7 at 51,645,018 bp
  • A to G, chromosome 7 at 126,871,088 bp
  • A to C, chromosome 7 at 127,025,553 bp
  • C to A, chromosome 7 at 144,411,685 bp
  • G to A, chromosome 8 at 16,058,707 bp
  • C to T, chromosome 8 at 105,955,715 bp
  • C to T, chromosome 9 at 94,712,898 bp
  • T to A, chromosome 9 at 103,085,749 bp
  • C to A, chromosome 10 at 45,589,507 bp
  • A to T, chromosome 10 at 80,723,803 bp
  • A to G, chromosome 10 at 90,941,432 bp
  • A to G, chromosome 10 at 128,022,919 bp
  • A to T, chromosome 10 at 130,362,041 bp
  • T to C, chromosome 11 at 9,134,743 bp
  • T to C, chromosome 11 at 23,419,052 bp
  • A to T, chromosome 11 at 69,940,355 bp
  • C to T, chromosome 11 at 73,888,275 bp
  • A to T, chromosome 11 at 109,276,581 bp
  • T to A, chromosome 11 at 114,925,032 bp
  • A to C, chromosome 13 at 30,381,907 bp
  • A to T, chromosome 13 at 34,050,341 bp
  • G to A, chromosome 13 at 47,041,484 bp
  • A to T, chromosome 13 at 93,472,743 bp
  • T to A, chromosome 14 at 50,866,038 bp
  • T to A, chromosome 15 at 86,033,008 bp
  • T to A, chromosome 16 at 32,884,248 bp
  • T to A, chromosome 16 at 38,321,601 bp
  • T to A, chromosome 16 at 49,005,821 bp
  • A to G, chromosome 17 at 18,303,987 bp
  • T to A, chromosome 17 at 34,632,187 bp
  • T to A, chromosome 18 at 37,145,360 bp
  • T to A, chromosome 18 at 37,343,387 bp
  • T to C, chromosome 18 at 61,736,846 bp
  • C to T, chromosome 18 at 84,959,118 bp
  • A to G, chromosome 19 at 13,364,637 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7325 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045419-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.