Strain Name:
C57BL/6J-MtgxR7353Btlr/Mmmh
Stock Number:
045439-MU
Citation ID:
RRID:MMRRC_045439-MU
Other Names:
R7353 (G1)
Major Collection:

Strain Information

Zmpste24
Name: zinc metallopeptidase, STE24
Synonyms: A530043O15Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230709
Homologene: 4277
Ccr2
Name: C-C motif chemokine receptor 2
Synonyms: CKR2A, Cmkbr2, CC-CKR-2, CKR2B, CKR2, CCR2A, CCR2B
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12772
HGNC: HGNC:1603
Homologene: 537
Ulk2
Name: unc-51 like kinase 2
Synonyms: Unc51.2, A830085I22Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 29869
Homologene: 5891
Bcar3
Name: breast cancer anti-estrogen resistance 3
Synonyms: AND-34
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 29815
HGNC: HGNC:973
Homologene: 31181
Xpnpep3
Name: X-prolyl aminopeptidase 3, mitochondrial
Synonyms: E430012M05Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 321003
Dop1a
Name: DOP1 leucine zipper like protein A
Synonyms: D9Ertd809e, B130005I07Rik, Dopey1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320615
Homologene: 26645
Cenpf
Name: centromere protein F
Synonyms: Lek1, mitosin, 6530404A22Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 108000
HGNC: HGNC:1857
Homologene: 22969
Mcm10
Name: minichromosome maintenance 10 replication initiation factor
Synonyms: 2410041F14Rik, C330019M07Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 70024
Homologene: 41275
Txnrd3
Name: thioredoxin reductase 3
Synonyms: TR2, Tgr
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232223
Homologene: 60033
N4bp2
Name: NEDD4 binding protein 2
Synonyms: LOC333789, LOC386488, B3bp
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 333789
Homologene: 32396
Ccser2
Name: coiled-coil serine rich 2
Synonyms: 2900054P12Rik, 1700012P13Rik, Gcap14
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 72972
Homologene: 10367
Bicc1
Name: BicC family RNA binding protein 1
Synonyms: Bic-C, jcpk
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 83675
Homologene: 12856
Neurl1a
Name: neuralized E3 ubiquitin protein ligase 1A
Synonyms: Rnf67, Nlz, 2410129E16Rik, Neur1, Neu1, Neurl
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18011
VEGA: 19
HGNC: HGNC:7761
Homologene: 32503
Zfp980
Name: zinc finger protein 980
Synonyms: Gm13242
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100041379
Homologene: 133076
Rps17
Name: ribosomal protein S17
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20068
Homologene: 110867
Plekhg1
Name: pleckstrin homology domain containing, family G (with RhoGef domain) member 1
Synonyms: D10Ertd733e
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 213783
Homologene: 18897
Magel2
Name: MAGE family member L2
Synonyms: nM15, ns7, NDNL1, Mage-l2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 27385
HGNC: HGNC:6814
Homologene: 8460
Boc
Name: BOC cell adhesion associated, oncogene regulated
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 117606
Homologene: 32819
Adgrf3
Name: adhesion G protein-coupled receptor F3
Synonyms: LOC381628, Gpr113, PGR23
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 381628
Homologene: 17826
Lctl
Name: lactase-like
Synonyms: KLPH, E130104I05Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235435
Homologene: 70710
Mia3
Name: MIA SH3 domain ER export factor 3
Synonyms: A930039G15Rik, Tango, LOC385255, B230399H06Rik, 9130229H14Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 338366
Homologene: 85165
Ntng1
Name: netrin G1
Synonyms: Lmnt1, A930010C08Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 80883
Homologene: 8949
Arhgef2
Name: Rho/Rac guanine nucleotide exchange factor 2
Synonyms: Lbcl1, LFP40, GEF-H1, Lfc, P40, GEFH1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 16800
HGNC: HGNC:682
Homologene: 3468
Ccdc88a
Name: coiled coil domain containing 88A
Synonyms: A430106J12Rik, C330012F17Rik, GIV, HkRP1, D130005J21Rik, Girdin, C130096N06Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 108686
Homologene: 41180
Nup160
Name: nucleoporin 160
Synonyms: Gtl1-13, 2810011M03Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 59015
Homologene: 32509
Tecpr2
Name: tectonin beta-propeller repeat containing 2
Synonyms: 4930573I19Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 104859
VEGA: 12
Homologene: 8897
Eml5
Name: echinoderm microtubule associated protein like 5
Synonyms: C130068M19Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 319670
VEGA: 12
Homologene: 26807
Tmc2
Name: transmembrane channel-like gene family 2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 192140
Homologene: 25877
Gpr155
Name: G protein-coupled receptor 155
Synonyms: F730029F15Rik, DEPDC3, PGR22, 1110017O10Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68526
Homologene: 16584
Dnajc13
Name: DnaJ heat shock protein family (Hsp40) member C13
Synonyms: Rme8, LOC382100, D030002L11Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235567
Homologene: 13574
Arhgef28
Name: Rho guanine nucleotide exchange factor 28
Synonyms: RIP2, Rho specific exchange factor, D13Bwg1089e, Rgnef, p190RhoGEF, 9230110L08Rik, RhoGEF
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 110596
VEGA: 13
Homologene: 8078
Alox12e
Name: arachidonate lipoxygenase, epidermal
Synonyms: Aloxe, e-LOX1, 8-LOX, Alox12-ps1, Alox12-ps2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11685
Homologene: 105868
Or1n1
Name: olfactory receptor family 1 subfamily N member 1
Synonyms: MOR127-2, Olfr351, GA_x6K02T2NLDC-33554926-33553994
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258944
HGNC: HGNC:8221
Homologene: 10583
Unc13c
Name: unc-13 homolog C
Synonyms: Munc13-3, Unc13h3, D9Ertd414e, 1500037O19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 208898
Homologene: 45443
Vmn2r115
Name: vomeronasal 2, receptor 115
Synonyms: EG638102, V2Rp4
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 638102
Homologene: 86604
Kcnh4
Name: potassium voltage-gated channel, subfamily H (eag-related), member 4
Synonyms: BEC2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380728
HGNC: HGNC:6253
Homologene: 8180
Naip6
Name: NLR family, apoptosis inhibitory protein 6
Synonyms: Naip-rs4, Naip-rs4A, Birc1f
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17952
HGNC: HGNC:7634
Homologene: 113589
Aadacl4
Name: arylacetamide deacetylase like 4
Synonyms: Gm13177
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 435815
Homologene: 82530
Abcc9
Name: ATP-binding cassette, sub-family C member 9
Synonyms: SUR2A, Sur2, SUR2B
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20928
HGNC: HGNC:60
Homologene: 56521
Spn
Name: sialophorin
Synonyms: leukosialin, 3E8 antigen, Cd43, Ly-48, A630014B01Rik, Galgp, Ly48
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20737
Homologene: 36108
Slco2b1
Name: solute carrier organic anion transporter family, member 2b1
Synonyms: OATP-B, Slc21a9
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101488
Homologene: 21419
Vmn2r82
Name: vomeronasal 2, receptor 82
Synonyms: EG624845
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 624845
Homologene: 83483
Fbxo41
Name: F-box protein 41
Synonyms: D6Ertd538e
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330369
Homologene: 19837
Rsph10b
Name: radial spoke head 10 homolog B (Chlamydomonas)
Synonyms: 4930526H21Rik, Rsph10b2
Type: Gene
Species: Mouse
Chromosome: 5
Homologene: 18321
Csn1s2a
Name: casein alpha s2-like A
Synonyms: Csn1s2a, Csng
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12993
Homologene: 7284
Kcna5
Name: potassium voltage-gated channel, shaker-related subfamily, member 5
Synonyms: Kv1.5
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16493
HGNC: HGNC:6224
Homologene: 1683
Or52s1
Name: olfactory receptor family 52 subfamily S member 1
Synonyms: GA_x6K02T2PBJ9-5927412-5928362, Olfr593, MOR24-2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258378
Homologene: 27147
Oas2
Name: 2'-5' oligoadenylate synthetase 2
Synonyms: Oasl11, 2'-5' oligoadenylate synthetase-like 11
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 246728
HGNC: HGNC:8087
Homologene: 49478
Cttnbp2
Name: cortactin binding protein 2
Synonyms: Cortbp2, ORF4, 9130022E09Rik, 4732477G22Rik, 3010022N24Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 30785
Homologene: 14125
Nrdc
Name: nardilysin convertase
Synonyms: NRD-C, Nrd1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230598
HGNC: HGNC:7995
Homologene: 68260
Vill
Name: villin-like
Synonyms: Villp
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22351
Homologene: 22650
Or1j4
Name: olfactory receptor family 1 subfamily J member 4
Synonyms: Olfr350, MOR136-13, GA_x6K02T2NLDC-33544602-33545540
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258620
HGNC: HGNC:8211
Homologene: 64897
Emilin3
Name: elastin microfibril interfacer 3
Synonyms: EMILIN-T, Emilin5, 1110013O17Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 280635
Homologene: 18817
Slc2a13
Name: solute carrier family 2 (facilitated glucose transporter), member 13
Synonyms: A630029G22Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239606
Homologene: 43139
Prkag2
Name: protein kinase, AMP-activated, gamma 2 non-catalytic subunit
Synonyms: 2410051C13Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 108099
HGNC: HGNC:9386
Homologene: 136125
Lmtk3
Name: lemur tyrosine kinase 3
Synonyms: Aatyk3, AATYK3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 381983
Homologene: 79449
Or1j1
Name: olfactory receptor family 1 subfamily J member 1
Synonyms: Y71, Olfr3, GA_x6K02T2NLDC-33507606-33506665, MOR136-14
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18328
HGNC: HGNC:8208
Homologene: 66579
Gpr156
Name: G protein-coupled receptor 156
Synonyms: Gababl
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 239845
VEGA: 16
Homologene: 17683
Sult2a8
Name: sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 8
Synonyms: 2810007J24Rik, mL-STL
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 76971
Or10a3n
Name: olfactory receptor family 10 subfamily A member 3N
Synonyms: MOR268-6, Olfr519, GA_x6K02T2PBJ9-11224559-11223615
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 277935
Homologene: 17186
Tbx2
Name: T-box 2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 21385
Homologene: 38123
Lad1
Name: ladinin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16763
HGNC: HGNC:6472
Homologene: 4059
Pnrc1
Name: proline-rich nuclear receptor coactivator 1
Synonyms: Prol2, B4-2, 5730463C12Rik, PRR2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 108767
Homologene: 4960
Znrf4
Name: zinc and ring finger 4
Synonyms: spzn
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 20834
VEGA: 17
Homologene: 7959
Speer1f
Name: spermatogenesis associated glutamate (E)-rich protein 1F
Synonyms: Gm8897
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 667961
Kcne2
Name: potassium voltage-gated channel, Isk-related subfamily, gene 2
Synonyms: 2200002I16Rik, MiRP1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 246133
HGNC: HGNC:6242
Homologene: 71688
3110070M22Rik
Name: RIKEN cDNA 3110070M22 gene
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 67304
VEGA: 13
Tstd1
Name: thiosulfate sulfurtransferase (rhodanese)-like domain containing 1
Synonyms: Gm4848
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226654
Homologene: 7014
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 135,827,775 bp
  • G to T, chromosome 1 at 171,419,955 bp
  • G to T, chromosome 1 at 183,327,392 bp
  • T to A, chromosome 1 at 189,654,138 bp
  • G to A, chromosome 2 at 5,007,109 bp
  • A to G, chromosome 2 at 36,812,903 bp
  • A to T, chromosome 2 at 36,850,069 bp
  • G to A, chromosome 2 at 36,859,668 bp
  • A to T, chromosome 2 at 73,367,491 bp
  • T to C, chromosome 2 at 90,703,952 bp
  • G to A, chromosome 2 at 130,196,577 bp
  • T to A, chromosome 2 at 160,908,821 bp
  • T to A, chromosome 3 at 88,635,686 bp
  • T to C, chromosome 3 at 110,135,447 bp
  • A to G, chromosome 3 at 122,512,692 bp
  • G to A, chromosome 4 at 33,248,300 bp
  • A to G, chromosome 4 at 109,039,749 bp
  • A to G, chromosome 4 at 121,095,581 bp
  • G to A, chromosome 4 at 144,617,920 bp
  • A to G, chromosome 4 at 145,702,144 bp
  • G to A, chromosome 5 at 11,416,436 bp
  • A to T, chromosome 5 at 24,880,686 bp
  • T to A, chromosome 5 at 30,198,497 bp
  • G to A, chromosome 5 at 65,806,371 bp
  • A to T, chromosome 5 at 87,785,302 bp
  • A to T, chromosome 5 at 120,738,522 bp
  • G to A, chromosome 5 at 143,967,220 bp
  • A to T, chromosome 6 at 18,375,944 bp
  • G to T, chromosome 6 at 85,479,976 bp
  • A to G, chromosome 6 at 89,661,585 bp
  • A to G, chromosome 6 at 126,534,845 bp
  • T to A, chromosome 6 at 142,601,005 bp
  • T to C, chromosome 7 at 14,413,715 bp
  • A to T, chromosome 7 at 45,788,000 bp
  • G to T, chromosome 7 at 62,379,331 bp
  • T to A, chromosome 7 at 81,344,345 bp
  • A to T, chromosome 7 at 99,690,557 bp
  • A to C, chromosome 7 at 103,212,309 bp
  • A to G, chromosome 7 at 108,894,222 bp
  • T to C, chromosome 7 at 127,137,006 bp
  • G to A, chromosome 9 at 64,126,967 bp
  • T to C, chromosome 9 at 73,574,073 bp
  • T to A, chromosome 9 at 86,512,859 bp
  • C to A, chromosome 9 at 104,230,031 bp
  • T to C, chromosome 9 at 119,065,493 bp
  • T to C, chromosome 9 at 124,106,756 bp
  • A to T, chromosome 10 at 3,964,327 bp
  • G to T, chromosome 10 at 70,947,900 bp
  • T to A, chromosome 10 at 79,396,618 bp
  • T to A, chromosome 11 at 29,463,368 bp
  • T to C, chromosome 11 at 61,819,348 bp
  • T to C, chromosome 11 at 70,321,435 bp
  • C to A, chromosome 11 at 85,833,489 bp
  • T to A, chromosome 11 at 100,757,199 bp
  • A to G, chromosome 12 at 98,825,424 bp
  • A to T, chromosome 12 at 110,967,844 bp
  • T to A, chromosome 13 at 98,075,202 bp
  • C to T, chromosome 13 at 100,299,751 bp
  • C to A, chromosome 13 at 119,488,178 bp
  • T to C, chromosome 14 at 36,941,143 bp
  • T to C, chromosome 15 at 81,430,887 bp
  • T to C, chromosome 15 at 91,321,604 bp
  • T to A, chromosome 16 at 37,992,161 bp
  • C to T, chromosome 16 at 44,485,737 bp
  • A to T, chromosome 16 at 92,296,822 bp
  • T to C, chromosome 17 at 23,345,913 bp
  • A to G, chromosome 17 at 56,512,169 bp
  • T to C, chromosome 19 at 47,240,660 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7353 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045439-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.