Strain Name:
C57BL/6J-MtgxR7357Btlr/Mmmh
Stock Number:
045443-MU
Citation ID:
RRID:MMRRC_045443-MU
Other Names:
R7357 (G1)
Major Collection:

Strain Information

Ntf3
Name: neurotrophin 3
Synonyms: NT-3, Ntf-3, NT3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 18205
HGNC: HGNC:8023
Homologene: 1896
Sult6b1
Name: sulfotransferase family, cytosolic, 6B, member 1
Synonyms: 2410078J06Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 73671
Homologene: 42242
Trp53bp1
Name: transformation related protein 53 binding protein 1
Synonyms: 53BP1, p53BP1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 27223
Homologene: 4137
Dbi
Name: diazepam binding inhibitor
Synonyms: endozepine, Acbp, EP, diazepam-binding inhibitor
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13167
HGNC: HGNC:2690
Homologene: 39086
Setx
Name: senataxin
Synonyms: A930037J23Rik, Als4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 269254
HGNC: HGNC:445
Homologene: 41003
Ctc1
Name: CTS telomere maintenance complex component 1
Synonyms: 1500010J02Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 68964
Homologene: 11830
Tmem39a
Name: transmembrane protein 39a
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 67846
Homologene: 9985
Focad
Name: focadhesin
Synonyms: BC057079
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230393
Homologene: 9842
9530068E07Rik
Name: RIKEN cDNA 9530068E07 gene
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 213673
Homologene: 10620
Tesmin
Name: testis expressed metallothionein like
Synonyms: Mtl5, tesmin
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 17771
HGNC: HGNC:7446
Homologene: 31275
C2cd3
Name: C2 calcium-dependent domain containing 3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 277939
Homologene: 19524
Leng8
Name: leukocyte receptor cluster (LRC) member 8
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232798
Homologene: 13612
Cd300a
Name: CD300A molecule
Synonyms: Clm8, Pigr4, MAIR-I, MMAC8, B230315M08Rik, LMIR1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217303
Homologene: 48514
Chrdl2
Name: chordin-like 2
Synonyms: Chl2, 1810022C01Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 69121
Homologene: 128795
Pamr1
Name: peptidase domain containing associated with muscle regeneration 1
Synonyms: RAMP, E430002G05Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 210622
Homologene: 9134
Morc1
Name: microrchidia 1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 17450
VEGA: 16
HGNC: HGNC:7198
Homologene: 7843
Ppip5k2
Name: diphosphoinositol pentakisphosphate kinase 2
Synonyms: Cfap160, Hisppd1, Vip2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227399
Homologene: 49409
Nup153
Name: nucleoporin 153
Synonyms: B130015D15Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218210
HGNC: HGNC:8062
Homologene: 68442
Dsg3
Name: desmoglein 3
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13512
VEGA: 18
HGNC: HGNC:3050
Homologene: 55513
Fermt3
Name: fermitin family member 3
Synonyms: C79673, Kindlin-3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 108101
VEGA: 19
Homologene: 12877
Celsr1
Name: cadherin, EGF LAG seven-pass G-type receptor 1
Synonyms: Crsh, Scy, crash, Adgrc1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12614
VEGA: 15
HGNC: HGNC:1850
Homologene: 7665
Or52h1
Name: olfactory receptor family 52 subfamily H member 1
Synonyms: Olfr648, MOR31-12, GA_x6K02T2PBJ9-6914780-6913830
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258746
Homologene: 82999
Pik3c2g
Name: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 18705
HGNC: HGNC:8973
Homologene: 3362
Sis
Name: sucrase isomaltase
Synonyms: sucrase-isomaltase, 2010204N08Rik, Si-s
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 69983
Homologene: 37424
Unc13c
Name: unc-13 homolog C
Synonyms: Unc13h3, D9Ertd414e, 1500037O19Rik, Munc13-3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 208898
Homologene: 45443
Carmil3
Name: capping protein regulator and myosin 1 linker 3
Synonyms: Lrrc16b
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 268747
VEGA: 14
Homologene: 74564
Dock3
Name: dedicator of cyto-kinesis 3
Synonyms: Moca, PBP
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 208869
HGNC: HGNC:2989
Homologene: 21030
Cacna1s
Name: calcium channel, voltage-dependent, L type, alpha 1S subunit
Synonyms: sj, Cav1.1, fmd, muscle dysgenesis, DHPR alpha1s, Cchl1a3, mdg
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12292
HGNC: HGNC:1397
Homologene: 37257
Ppic
Name: peptidylprolyl isomerase C
Synonyms: cyclophilin C, CyP-20c
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 19038
VEGA: 18
HGNC: HGNC:9256
Homologene: 727
Mast3
Name: microtubule associated serine/threonine kinase 3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 546071
Homologene: 66191
Sycp2
Name: synaptonemal complex protein 2
Synonyms: 4930518F03Rik, 3830402K23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 320558
Homologene: 8604
Rabgap1l
Name: RAB GTPase activating protein 1-like
Synonyms: 9630005B12Rik, Hh1, 8430421H08Rik, 5830411O09Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 29809
Homologene: 8143
Vwa8
Name: von Willebrand factor A domain containing 8
Synonyms: 4932416F07Rik, 1300010F03Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219189
VEGA: 14
Homologene: 44881
Psd3
Name: pleckstrin and Sec7 domain containing 3
Synonyms: EFA6D, 4931420C21Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234353
Homologene: 87257
Stil
Name: Scl/Tal1 interrupting locus
Synonyms: Sil
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 20460
Homologene: 2283
Ppp1r9b
Name: protein phosphatase 1, regulatory subunit 9B
Synonyms: neurabin II, Spn, spinophilin, SPL
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217124
HGNC: HGNC:9298
Homologene: 32787
Pde4dip
Name: phosphodiesterase 4D interacting protein (myomegalin)
Synonyms: Usmg4, 9430063L05Rik, D130016K21Rik, 4732458A06Rik, D3Bwg1078e
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 83679
Homologene: 66961
Snx14
Name: sorting nexin 14
Synonyms: YR-14, C330035N22Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244962
Homologene: 17823
Sec14l3
Name: SEC14-like lipid binding 3
Synonyms: 1110069O07Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380683
Homologene: 24848
Serpina5
Name: serine (or cysteine) peptidase inhibitor, clade A, member 5
Synonyms: Pci, alpha-1 antiproteinase, antitrypsin, PAI-3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 268591
HGNC: HGNC:8723
Homologene: 20159
Phgdh
Name: 3-phosphoglycerate dehydrogenase
Synonyms: 3-PGDH, PGDH, A10, PGAD, SERA, PGD, 3PGDH
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 236539
HGNC: HGNC:8923
Homologene: 39318
Aldh1l2
Name: aldehyde dehydrogenase 1 family, member L2
Synonyms: D330038I09Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216188
Homologene: 51942
Usp9y
Name: ubiquitin specific peptidase 9, Y chromosome
Synonyms: Fafl2, Dffry
Type: Gene
Species: Mouse
Chromosome: Y
NCBI: 107868
Homologene: 68408
Pebp4
Name: phosphatidylethanolamine binding protein 4
Synonyms: 1700051A02Rik, 1700081D17Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 73523
VEGA: 14
Homologene: 51650
Fbxw15
Name: F-box and WD-40 domain protein 15
Synonyms: Fbxo12J
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 382105
Homologene: 110776
Vmn2r109
Name: vomeronasal 2, receptor 109
Synonyms: EG627814
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627814
Homologene: 129678
Dpp4
Name: dipeptidylpeptidase 4
Synonyms: Dpp-4, Cd26, THAM
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13482
HGNC: HGNC:3009
Homologene: 3279
Ces2f
Name: carboxylesterase 2F
Synonyms: 2310038E17Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 71903
HGNC: HGNC:1864
Homologene: 135673
Prss48
Name: serine protease 48
Synonyms: Esspl, Gm1019
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 368202
Homologene: 133731
Celf3
Name: CUGBP, Elav-like family member 3
Synonyms: CAGH4, 4930415M08Rik, Tnrc4, BRUNOL1, ERDA4
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 78784
Homologene: 48510
Pcsk1
Name: proprotein convertase subtilisin/kexin type 1
Synonyms: Nec1, PC1, Nec-1, PC3, SPC3, prohormone convertase 1/3, Phpp-1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 18548
HGNC: HGNC:8743
Homologene: 379
Retreg1
Name: reticulophagy regulator 1
Synonyms: Fam134b, 1810015C04Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 66270
VEGA: 15
Homologene: 10368
Usp18
Name: ubiquitin specific peptidase 18
Synonyms: UBP43, 1110058H21Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 24110
Homologene: 8047
Ttc12
Name: tetratricopeptide repeat domain 12
Synonyms: E330017O07Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235330
Homologene: 32375
Zfp248
Name: zinc finger protein 248
Synonyms: E130106N01Rik, 2810037F07Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 72720
Homologene: 69325
Pramel6
Name: PRAME like 6
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 347711
Homologene: 77635
Slco4a1
Name: solute carrier organic anion transporter family, member 4a1
Synonyms: OATP-E, Slc21a12
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 108115
Homologene: 9482
Gm9857
Name: predicted gene 9857
Type: Gene
Species: Mouse
Chromosome: 3
Zfp513
Name: zinc finger protein 513
Synonyms: D430028M17Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 101023
Homologene: 16955
Gm8104
Name: predicted gene 8104
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 101056159
Samd11
Name: sterile alpha motif domain containing 11
Synonyms: mr-s
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 231004
VEGA: 4
Homologene: 34983
Or13l2
Name: olfactory receptor family 13 subfamily L member 2
Synonyms: GA_x6K02T2R76Y-3201307-3200360, MOR217-1, Olfr1402
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 258272
VEGA: 3
Homologene: 17165
6430550D23Rik
Name: RIKEN cDNA 6430550D23 gene
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 320095
Homologene: 122133
Hoxa1
Name: homeobox A1
Synonyms: ERA1, early retinoic acid, Hox-1.6
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 15394
HGNC: HGNC:5099
Homologene: 4032
Kif19b
Name: kinesin family member 19B
Synonyms: Gm4869
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 101055939
Homologene: 82478
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 97,759,216 bp
  • A to G, chromosome 1 at 120,119,893 bp
  • T to C, chromosome 1 at 136,071,021 bp
  • T to C, chromosome 1 at 160,342,038 bp
  • A to G, chromosome 2 at 29,130,301 bp
  • A to T, chromosome 2 at 62,387,077 bp
  • G to T, chromosome 2 at 87,510,512 bp
  • G to A, chromosome 2 at 102,586,704 bp
  • A to T, chromosome 2 at 121,211,300 bp
  • A to T, chromosome 2 at 156,003,867 bp
  • G to T, chromosome 2 at 178,403,804 bp
  • A to G, chromosome 2 at 180,472,137 bp
  • A to T, chromosome 3 at 72,925,071 bp
  • A to T, chromosome 3 at 85,997,221 bp
  • G to A, chromosome 3 at 94,480,330 bp
  • G to C, chromosome 3 at 97,410,655 bp
  • T to C, chromosome 3 at 97,715,541 bp
  • G to A, chromosome 3 at 98,339,822 bp
  • A to C, chromosome 3 at 108,940,162 bp
  • A to T, chromosome 4 at 88,229,335 bp
  • T to C, chromosome 4 at 115,014,226 bp
  • A to T, chromosome 4 at 156,255,007 bp
  • G to A, chromosome 5 at 31,199,788 bp
  • A to G, chromosome 5 at 140,495,051 bp
  • A to T, chromosome 6 at 52,156,949 bp
  • A to G, chromosome 6 at 118,429,657 bp
  • T to C, chromosome 6 at 121,253,849 bp
  • T to A, chromosome 6 at 126,101,998 bp
  • T to C, chromosome 6 at 139,633,793 bp
  • T to A, chromosome 7 at 4,144,933 bp
  • G to A, chromosome 7 at 100,029,207 bp
  • A to G, chromosome 7 at 100,430,103 bp
  • A to T, chromosome 7 at 104,179,771 bp
  • T to C, chromosome 8 at 68,121,497 bp
  • A to G, chromosome 8 at 70,784,859 bp
  • G to A, chromosome 8 at 104,949,963 bp
  • A to C, chromosome 9 at 49,438,387 bp
  • TATAA to TATAATAA, chromosome 9 at 73,933,528 bp
  • ATA to ATAGTA, chromosome 9 at 73,933,529 bp
  • A to T, chromosome 9 at 88,404,316 bp
  • A to G, chromosome 9 at 107,005,369 bp
  • A to G, chromosome 9 at 109,558,240 bp
  • T to C, chromosome 10 at 83,514,544 bp
  • T to A, chromosome 11 at 4,070,127 bp
  • A to T, chromosome 11 at 52,406,994 bp
  • T to A, chromosome 11 at 69,034,742 bp
  • T to C, chromosome 11 at 95,004,598 bp
  • A to T, chromosome 11 at 114,893,327 bp
  • A to T, chromosome 12 at 104,103,380 bp
  • G to T, chromosome 13 at 46,717,166 bp
  • A to G, chromosome 13 at 75,125,960 bp
  • T to C, chromosome 14 at 43,101,611 bp
  • G to T, chromosome 14 at 55,491,133 bp
  • G to A, chromosome 14 at 70,048,415 bp
  • G to A, chromosome 14 at 79,038,201 bp
  • A to T, chromosome 15 at 25,971,943 bp
  • A to C, chromosome 15 at 86,030,514 bp
  • T to A, chromosome 16 at 38,586,230 bp
  • T to C, chromosome 16 at 48,622,590 bp
  • A to T, chromosome 17 at 20,541,274 bp
  • A to G, chromosome 17 at 78,894,630 bp
  • T to A, chromosome 18 at 20,539,783 bp
  • T to C, chromosome 18 at 53,411,067 bp
  • T to C, chromosome 19 at 3,397,042 bp
  • T to C, chromosome 19 at 7,002,843 bp
  • A to T, chromosome Y at 1,333,656 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7357 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045443-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.