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Strain Detail Sheet

Strain Name:
C57BL/6J-MtgxR7361Btlr/Mmmh
Stock Number:
045447-MU
Citation ID:
RRID:MMRRC_045447-MU
Other Names:
R7361 (G1)
Major Collection:
Beutler Mutagenetix

Strain Information

Gene Details

Dnajc3
Name: DnaJ heat shock protein family (Hsp40) member C3
Synonyms: p58IPK, mp58, Prkri, Dnajc3, Dnajc3a, Dnajc3b
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 100037258
VEGA: 14
HGNC: HGNC:9439
Homologene: 2486

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Ext1
Name: exostosin glycosyltransferase 1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 14042
HGNC: HGNC:3512
Homologene: 30957

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Notch2
Name: notch 2
Synonyms: Motch B, N2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18129
HGNC: HGNC:7882
Homologene: 7865

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Wsb1
Name: WD repeat and SOCS box-containing 1
Synonyms: 2700038M07Rik, 1110056B13Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 78889
Homologene: 9218

Additional Resources
IMPC
Google
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Nrxn2
Name: neurexin II
Synonyms: neurexin II beta, neurexin II alpha, 6430591O13Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18190
HGNC: HGNC:8009
Homologene: 86984

Additional Resources
IMPC
Google
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PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
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ClinGen
Jmjd1c
Name: jumonji domain containing 1C
Synonyms: TRIP8, 5430433L24Rik, D630035I23Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 108829
Homologene: 3129

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
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ClinGen
Ehmt1
Name: euchromatic histone methyltransferase 1
Synonyms: 9230102N17Rik, KMT1D
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 77683
Homologene: 11698

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 20,593,953 bp
  • A to T, chromosome 1 at 82,289,114 bp
  • A to T, chromosome 1 at 84,750,442 bp
  • A to G, chromosome 1 at 105,585,053 bp
  • T to C, chromosome 1 at 135,452,853 bp
  • T to C, chromosome 1 at 150,447,621 bp
  • G to A, chromosome 1 at 155,901,491 bp
  • A to T, chromosome 1 at 163,986,033 bp
  • T to C, chromosome 1 at 174,836,948 bp
  • G to T, chromosome 1 at 194,799,779 bp
  • A to T, chromosome 2 at 11,747,076 bp
  • T to A, chromosome 2 at 24,856,701 bp
  • A to T, chromosome 2 at 30,963,741 bp
  • A to G, chromosome 2 at 88,461,492 bp
  • A to G, chromosome 2 at 90,051,745 bp
  • G to A, chromosome 2 at 104,255,018 bp
  • A to T, chromosome 2 at 135,976,148 bp
  • A to G, chromosome 2 at 143,967,444 bp
  • T to C, chromosome 2 at 166,713,570 bp
  • A to T, chromosome 3 at 19,964,306 bp
  • A to G, chromosome 3 at 82,097,720 bp
  • A to G, chromosome 3 at 98,131,402 bp
  • G to A, chromosome 3 at 101,077,444 bp
  • T to A, chromosome 3 at 146,458,754 bp
  • G to A, chromosome 4 at 11,599,782 bp
  • G to T, chromosome 4 at 14,546,305 bp
  • C to T, chromosome 4 at 48,083,203 bp
  • G to T, chromosome 4 at 101,184,339 bp
  • T to C, chromosome 4 at 141,746,852 bp
  • T to C, chromosome 4 at 143,895,886 bp
  • A to G, chromosome 4 at 152,363,288 bp
  • A to G, chromosome 5 at 8,977,534 bp
  • G to A, chromosome 5 at 14,793,868 bp
  • A to T, chromosome 5 at 25,692,757 bp
  • T to A, chromosome 5 at 37,118,804 bp
  • T to A, chromosome 5 at 104,337,143 bp
  • T to A, chromosome 5 at 143,254,675 bp
  • A to G, chromosome 5 at 150,436,847 bp
  • A to G, chromosome 6 at 32,196,122 bp
  • G to T, chromosome 6 at 67,303,466 bp
  • A to G, chromosome 6 at 83,368,094 bp
  • A to G, chromosome 6 at 112,746,921 bp
  • C to T, chromosome 6 at 132,627,471 bp
  • T to C, chromosome 7 at 44,733,139 bp
  • G to T, chromosome 7 at 103,220,623 bp
  • A to G, chromosome 7 at 104,768,877 bp
  • A to C, chromosome 7 at 118,184,977 bp
  • A to G, chromosome 7 at 118,529,575 bp
  • A to G, chromosome 7 at 141,457,431 bp
  • T to C, chromosome 8 at 93,333,679 bp
  • T to A, chromosome 8 at 104,468,799 bp
  • A to G, chromosome 8 at 125,453,332 bp
  • T to A, chromosome 9 at 19,584,560 bp
  • T to C, chromosome 9 at 50,579,314 bp
  • T to C, chromosome 9 at 50,688,653 bp
  • T to C, chromosome 9 at 57,914,622 bp
  • T to A, chromosome 10 at 53,908,009 bp
  • C to A, chromosome 10 at 67,218,364 bp
  • T to C, chromosome 10 at 93,846,468 bp
  • A to G, chromosome 11 at 23,491,099 bp
  • T to A, chromosome 11 at 69,912,079 bp
  • T to C, chromosome 11 at 72,316,974 bp
  • T to C, chromosome 11 at 73,260,377 bp
  • T to A, chromosome 11 at 73,888,001 bp
  • T to A, chromosome 11 at 74,930,153 bp
  • T to A, chromosome 11 at 79,240,797 bp
  • C to A, chromosome 11 at 98,210,468 bp
  • C to T, chromosome 11 at 99,614,594 bp
  • A to G, chromosome 11 at 118,992,159 bp
  • T to C, chromosome 12 at 21,325,601 bp
  • T to C, chromosome 12 at 25,057,000 bp
  • A to T, chromosome 12 at 80,193,715 bp
  • A to G, chromosome 12 at 87,895,400 bp
  • A to G, chromosome 12 at 111,345,605 bp
  • T to A, chromosome 12 at 118,018,742 bp
  • A to T, chromosome 13 at 54,378,826 bp
  • G to A, chromosome 13 at 111,705,249 bp
  • A to G, chromosome 14 at 27,265,578 bp
  • A to T, chromosome 14 at 54,638,921 bp
  • A to T, chromosome 14 at 55,870,400 bp
  • G to A, chromosome 14 at 66,834,215 bp
  • T to A, chromosome 14 at 103,075,903 bp
  • T to C, chromosome 14 at 118,938,164 bp
  • T to C, chromosome 14 at 123,291,839 bp
  • C to A, chromosome 15 at 4,796,922 bp
  • G to A, chromosome 15 at 53,344,723 bp
  • A to C, chromosome 15 at 103,471,282 bp
  • A to C, chromosome 16 at 20,118,000 bp
  • T to A, chromosome 16 at 32,754,670 bp
  • A to G, chromosome 16 at 37,060,428 bp
  • C to A, chromosome 16 at 90,774,768 bp
  • T to A, chromosome 17 at 21,661,934 bp
  • T to A, chromosome 17 at 46,657,007 bp
  • T to C, chromosome 19 at 4,833,350 bp
  • A to T, chromosome 19 at 6,517,082 bp
  • T to C, chromosome 19 at 8,965,334 bp
  • T to G, chromosome 19 at 10,479,579 bp

Strain Description

Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.

Strain Origin

Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7361 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Health Status Report

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.

Appearance

Coat Color
Black

Breeding

MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain

Reproductive Statistics

Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Availability Level

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Conditions of Distribution

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Fees

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*		 Units Notes
045447-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.