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Strain Name:
C57BL/6J-MtgxR7375Btlr/Mmmh
Stock Number:
045458-MU
Citation ID:
RRID:MMRRC_045458-MU
Other Names:
R7375 (G1)
Major Collection:

Strain Information

Utrn
Name: utrophin
Synonyms: G-utrophin, Dmdl, DRP
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 22288
VEGA: 10
Homologene: 21398
Slc17a5
Name: solute carrier family 17 (anion/sugar transporter), member 5
Synonyms: 4631416G20Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235504
Homologene: 56571
Ptprf
Name: protein tyrosine phosphatase receptor type F
Synonyms: LAR, RPTP-LAR
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 19268
HGNC: HGNC:9670
Homologene: 20623
Abl2
Name: ABL proto-oncogene 2, non-receptor tyrosine kinase
Synonyms: Arg, Abll
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 11352
HGNC: HGNC:77
Homologene: 5278
Pik3c2a
Name: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha
Synonyms: PI3KC2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18704
HGNC: HGNC:8971
Homologene: 20581
Psme4
Name: proteasome (prosome, macropain) activator subunit 4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 103554
Homologene: 113742
Rfx5
Name: regulatory factor X, 5 (influences HLA class II expression)
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 53970
HGNC: HGNC:9986
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 21,469,486 bp
  • A to T, chromosome 1 at 44,060,534 bp
  • A to G, chromosome 1 at 46,303,634 bp
  • T to C, chromosome 1 at 97,081,421 bp
  • A to G, chromosome 1 at 98,421,447 bp
  • A to G, chromosome 1 at 123,367,795 bp
  • G to T, chromosome 1 at 132,507,563 bp
  • C to G, chromosome 1 at 146,902,010 bp
  • A to G, chromosome 1 at 156,622,614 bp
  • A to G, chromosome 2 at 76,776,339 bp
  • C to T, chromosome 2 at 89,493,692 bp
  • T to C, chromosome 2 at 120,665,002 bp
  • A to T, chromosome 3 at 93,149,145 bp
  • C to T, chromosome 3 at 94,958,742 bp
  • A to G, chromosome 3 at 107,748,179 bp
  • C to T, chromosome 4 at 71,757,346 bp
  • G to T, chromosome 4 at 114,609,997 bp
  • A to G, chromosome 4 at 118,212,814 bp
  • A to C, chromosome 4 at 130,065,501 bp
  • G to A, chromosome 4 at 143,438,974 bp
  • A to G, chromosome 5 at 8,918,671 bp
  • A to G, chromosome 5 at 73,012,307 bp
  • A to T, chromosome 5 at 102,976,390 bp
  • G to T, chromosome 5 at 104,071,257 bp
  • G to T, chromosome 5 at 141,998,843 bp
  • T to C, chromosome 5 at 144,208,599 bp
  • T to A, chromosome 6 at 7,998,499 bp
  • T to C, chromosome 6 at 29,713,520 bp
  • A to T, chromosome 6 at 57,651,806 bp
  • T to C, chromosome 6 at 87,751,856 bp
  • A to T, chromosome 6 at 100,750,422 bp
  • A to G, chromosome 6 at 147,092,040 bp
  • T to C, chromosome 7 at 43,721,158 bp
  • T to C, chromosome 7 at 99,223,698 bp
  • C to A, chromosome 7 at 102,081,480 bp
  • T to C, chromosome 7 at 116,376,386 bp
  • T to G, chromosome 7 at 119,951,677 bp
  • T to G, chromosome 8 at 47,863,920 bp
  • G to A, chromosome 8 at 94,583,008 bp
  • A to G, chromosome 9 at 22,290,537 bp
  • C to T, chromosome 9 at 78,587,892 bp
  • G to A, chromosome 10 at 12,641,020 bp
  • G to T, chromosome 10 at 127,539,348 bp
  • T to A, chromosome 11 at 30,772,700 bp
  • A to G, chromosome 11 at 53,652,228 bp
  • G to T, chromosome 11 at 67,210,428 bp
  • C to A, chromosome 11 at 95,120,635 bp
  • G to T, chromosome 11 at 100,081,224 bp
  • T to A, chromosome 12 at 52,516,582 bp
  • T to G, chromosome 13 at 93,091,661 bp
  • T to C, chromosome 13 at 100,219,696 bp
  • G to T, chromosome 13 at 100,219,697 bp
  • T to C, chromosome 13 at 114,869,217 bp
  • T to A, chromosome 15 at 76,177,355 bp
  • T to A, chromosome 16 at 38,335,618 bp
  • T to A, chromosome 16 at 62,924,550 bp
  • T to A, chromosome 17 at 19,611,390 bp
  • T to A, chromosome 17 at 20,355,876 bp
  • T to C, chromosome 17 at 44,080,977 bp
  • A to T, chromosome 19 at 7,783,144 bp
  • A to G, chromosome 19 at 8,404,691 bp
  • T to C, chromosome 19 at 60,858,674 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7375 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045458-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.