Strain Name:
C57BL/6J-MtgxR7388Btlr/Mmmh
Stock Number:
045470-MU
Citation ID:
RRID:MMRRC_045470-MU
Other Names:
R7388 (G1)
Major Collection:

Strain Information

Dntt
Name: deoxynucleotidyltransferase, terminal
Synonyms: Tdt
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 21673
VEGA: 19
HGNC: HGNC:2983
Homologene: 3014
Nrcam
Name: neuronal cell adhesion molecule
Synonyms: C030017F07Rik, C130076O07Rik, Bravo
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 319504
VEGA: 12
HGNC: HGNC:7994
Homologene: 21041
Cers2
Name: ceramide synthase 2
Synonyms: Lass2, Trh3, 0610013I17Rik, CerS2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 76893
Homologene: 39581
Ddx1
Name: DEAD box helicase 1
Synonyms: DEAD (Asp-Glu-Ala-Asp) box polypeptide 1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 104721
VEGA: 12
HGNC: HGNC:2734
Homologene: 3627
Sec16a
Name: SEC16 homolog A, endoplasmic reticulum export factor
Synonyms: C230052J16Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227648
Homologene: 10533
Gnpat
Name: glyceronephosphate O-acyltransferase
Synonyms: D1Ertd819e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14712
HGNC: HGNC:4416
Homologene: 40716
Ep300
Name: E1A binding protein p300
Synonyms: p300, KAT3B
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 328572
HGNC: HGNC:3373
Homologene: 1094
Tmem161b
Name: transmembrane protein 161B
Synonyms: 2810446P07Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 72745
Homologene: 14519
Afg3l2
Name: AFG3-like AAA ATPase 2
Synonyms: par, Emv66, 2310036I02Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 69597
VEGA: 18
HGNC: HGNC:315
Homologene: 4947
Tbc1d10a
Name: TBC1 domain family, member 10a
Synonyms: Tbc1d10, EPI64
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 103724
Homologene: 32762
Rcn1
Name: reticulocalbin 1
Synonyms: Rcn
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19672
HGNC: HGNC:9934
Homologene: 20637
Lamc1
Name: laminin, gamma 1
Synonyms: Lamb2, laminin B2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226519
HGNC: HGNC:6492
Homologene: 1724
Cspp1
Name: centrosome and spindle pole associated protein 1
Synonyms: 4930413O22Rik, 2310020J12Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 211660
Homologene: 23487
Casz1
Name: castor zinc finger 1
Synonyms: 2410019P08Rik, D4Ertd432e, Cst, castor
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 69743
Homologene: 9824
Pcdh20
Name: protocadherin 20
Synonyms: C630015B17Rik, PCDH13
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219257
Homologene: 11277
Nlrp3
Name: NLR family, pyrin domain containing 3
Synonyms: Cias1, Mmig1, NALP3, cryopyrin, Pypaf1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216799
Homologene: 3600
Spink6
Name: serine peptidase inhibitor, Kazal type 6
Synonyms: EG433180
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 433180
VEGA: 18
Flrt3
Name: fibronectin leucine rich transmembrane protein 3
Synonyms: C430047I10Rik, 5530600M07Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71436
HGNC: HGNC:3762
Homologene: 8322
Sugp1
Name: SURP and G patch domain containing 1
Synonyms: Sf4
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 70616
Homologene: 12360
Wdr6
Name: WD repeat domain 6
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 83669
Homologene: 117682
Arhgap44
Name: Rho GTPase activating protein 44
Synonyms: AU040829
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216831
Homologene: 65284
Slc39a6
Name: solute carrier family 39 (metal ion transporter), member 6
Synonyms: Ermelin, Zip6
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 106957
Homologene: 8199
AW554918
Name: expressed sequence AW554918
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225289
Homologene: 52652
Trmt61a
Name: tRNA methyltransferase 61A
Synonyms: 6720458F09Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 328162
VEGA: 12
Homologene: 6229
Rai1
Name: retinoic acid induced 1
Synonyms: Gt1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19377
HGNC: HGNC:9834
Homologene: 7508
Cdkl2
Name: cyclin dependent kinase like 2
Synonyms: KKIAMRE, Kkm, 5330436L21Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 53886
HGNC: HGNC:1782
Homologene: 55793
Slc35d1
Name: solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter), member D1
Synonyms: UGTREL7
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242585
Homologene: 22870
Lrp1
Name: low density lipoprotein receptor-related protein 1
Synonyms: CD91, b2b1554Clo, A2mr
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16971
HGNC: HGNC:6692
Homologene: 1744
Dnah6
Name: dynein, axonemal, heavy chain 6
Synonyms: A730004I20Rik, Dnahc6
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330355
HGNC: HGNC:2951
Homologene: 15221
Il12rb1
Name: interleukin 12 receptor, beta 1
Synonyms: IL-12R[b], CD212
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 16161
HGNC: HGNC:5971
Homologene: 4042
Pkhd1
Name: polycystic kidney and hepatic disease 1
Synonyms: tigmin, FPC
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241035
HGNC: HGNC:9016
Homologene: 16336
Ints15
Name: integrator complex subunit 15
Synonyms: E130309D02Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231868
Homologene: 11445
Gm11639
Name: predicted gene 11639
Synonyms: Gm11639, Efcab15
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 105242472
Scn2a
Name: sodium channel, voltage-gated, type II, alpha
Synonyms: Nav1.2, Scn2a1, A230052E19Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 110876
Homologene: 75001
Nlrp1a
Name: NLR family, pyrin domain containing 1A
Synonyms: Nalp1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 195046
Homologene: 133820
Hc
Name: hemolytic complement
Synonyms: C5, C5a, Hfib2, He
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 15139
HGNC: HGNC:1331
Homologene: 20412
Kmt2b
Name: lysine (K)-specific methyltransferase 2B
Synonyms: Wbp7, 2610014H22Rik, Mll2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 75410
Homologene: 22838
Slc6a19
Name: solute carrier family 6 (neurotransmitter transporter), member 19
Synonyms: 4632401C08Rik, B0AT1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 74338
Homologene: 52819
Dao
Name: D-amino acid oxidase
Synonyms: DAO, Dao1, Dao-1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 13142
HGNC: HGNC:2671
Homologene: 37553
Mmrn1
Name: multimerin 1
Synonyms: 4921530G03Rik, Emilin4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 70945
HGNC: HGNC:7178
Homologene: 49134
Dgkq
Name: diacylglycerol kinase, theta
Synonyms: Dgk theta, 110kDa, Dagk4, DAGK7, Dgkd
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 110524
HGNC: HGNC:2856
Homologene: 20352
Vmn2r11
Name: vomeronasal 2, receptor 11
Synonyms: EG384219
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 384219
Homologene: 129606
Map3k21
Name: mitogen-activated protein kinase kinase kinase 21
Synonyms: BC021891
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234878
Homologene: 32778
Noxred1
Name: NADP+ dependent oxidoreductase domain containing 1
Synonyms: 4933437F05Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 71275
VEGA: 12
Homologene: 51388
Rab13
Name: RAB13, member RAS oncogene family
Synonyms: 0610007N03Rik, B230212B15Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 68328
HGNC: HGNC:9762
Homologene: 113882
Ankrd13b
Name: ankyrin repeat domain 13b
Synonyms: B930093C12Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268445
Homologene: 27367
Asz1
Name: ankyrin repeat, SAM and basic leucine zipper domain containing 1
Synonyms: Gasz, ORF3, 4933400N19Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 74068
HGNC: HGNC:1350
Homologene: 11374
Brinp2
Name: bone morphogenic protein/retinoic acid inducible neural-specific 2
Synonyms: 6430517E21Rik, Fam5b
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240843
Homologene: 10905
Apol10a
Name: apolipoprotein L 10A
Synonyms: 9030421J09Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 245282
Homologene: 129975
Agbl5
Name: ATP/GTP binding protein-like 5
Synonyms: 9430057O19Rik, Ccp5
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231093
Homologene: 11053
Tmem14a
Name: transmembrane protein 14A
Synonyms: PTD011, 5730496E24Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 75712
Homologene: 36341
Syne3
Name: spectrin repeat containing, nuclear envelope family member 3
Synonyms: nesprin-3alpha, 4831426I19Rik, nesprin-3beta, nesprin-3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 212073
VEGA: 12
Homologene: 17625
Spire1
Name: spire type actin nucleation factor 1
Synonyms: Spir-1, 6030430B19Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 68166
VEGA: 18
Homologene: 35507
Tubgcp4
Name: tubulin, gamma complex component 4
Synonyms: 4932441P04Rik, D2Ertd435e
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 51885
Homologene: 8690
Or2z2
Name: olfactory receptor family 2 subfamily Z member 2
Synonyms: Olfr30, MOR281-1, MTPCR07, GA_x6K02T2NKPP-957001-957948
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18329
Homologene: 131139
Dpysl5
Name: dihydropyrimidinase-like 5
Synonyms: Crmp5, CRMP-5, CRAM
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 65254
Homologene: 41347
Otos
Name: otospiralin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 260301
Homologene: 16396
Vmn1r79
Name: vomeronasal 1 receptor 79
Synonyms: Gm9807
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100042437
Homologene: 128342
Gk2
Name: glycerol kinase 2
Synonyms: Gk-rs2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14626
HGNC: HGNC:4291
Homologene: 133273
Cdk5rap1
Name: CDK5 regulatory subunit associated protein 1
Synonyms: 2310066P17Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66971
Homologene: 9502
Cfap276
Name: cilia and flagella associated protein 276
Synonyms: 1700013F07Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 75504
Homologene: 18986
Vpreb1a
Name: V-set pre-B cell surrogate light chain 1A
Synonyms: Vpreb-1, CD179a, Vpreb1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 22362
Homologene: 84741
Cga
Name: glycoprotein hormones, alpha subunit
Synonyms: Tsha, aGSU, alpha-GSU, alphaSU, GPHalpha, alphaGSU
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12640
HGNC: HGNC:1885
Homologene: 587
Prrx2
Name: paired related homeobox 2
Synonyms: Prx2, S8
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20204
Homologene: 7524
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 10,065,347 bp
  • C to T, chromosome 1 at 20,239,304 bp
  • C to T, chromosome 1 at 21,229,511 bp
  • T to A, chromosome 1 at 92,644,519 bp
  • T to C, chromosome 1 at 153,249,076 bp
  • A to T, chromosome 1 at 158,255,009 bp
  • C to T, chromosome 2 at 26,428,364 bp
  • A to G, chromosome 2 at 30,880,890 bp
  • A to T, chromosome 2 at 34,984,847 bp
  • T to A, chromosome 2 at 65,688,654 bp
  • C to T, chromosome 2 at 105,391,991 bp
  • G to A, chromosome 2 at 121,189,966 bp
  • C to T, chromosome 2 at 140,661,752 bp
  • G to A, chromosome 2 at 154,360,675 bp
  • T to C, chromosome 3 at 90,221,020 bp
  • T to G, chromosome 3 at 95,321,345 bp
  • T to C, chromosome 3 at 108,543,499 bp
  • T to A, chromosome 4 at 34,907,076 bp
  • A to G, chromosome 4 at 103,189,785 bp
  • A to G, chromosome 4 at 148,952,393 bp
  • T to C, chromosome 5 at 30,745,461 bp
  • T to A, chromosome 5 at 30,903,239 bp
  • T to A, chromosome 5 at 92,019,459 bp
  • A to G, chromosome 5 at 97,456,898 bp
  • A to T, chromosome 5 at 108,658,246 bp
  • A to T, chromosome 5 at 109,054,876 bp
  • T to G, chromosome 5 at 114,015,212 bp
  • G to A, chromosome 5 at 143,311,845 bp
  • G to T, chromosome 6 at 18,074,901 bp
  • T to A, chromosome 6 at 60,976,252 bp
  • T to A, chromosome 6 at 73,192,317 bp
  • T to A, chromosome 7 at 12,176,741 bp
  • C to T, chromosome 7 at 30,581,960 bp
  • T to C, chromosome 8 at 70,052,619 bp
  • A to G, chromosome 8 at 70,810,627 bp
  • T to G, chromosome 8 at 124,887,814 bp
  • T to C, chromosome 8 at 125,927,597 bp
  • A to T, chromosome 9 at 108,574,772 bp
  • G to A, chromosome 10 at 127,583,897 bp
  • T to C, chromosome 11 at 4,205,858 bp
  • C to T, chromosome 11 at 58,455,655 bp
  • T to A, chromosome 11 at 59,565,066 bp
  • A to C, chromosome 11 at 60,189,375 bp
  • A to T, chromosome 11 at 65,024,268 bp
  • A to G, chromosome 11 at 71,123,197 bp
  • T to C, chromosome 11 at 77,472,757 bp
  • T to C, chromosome 11 at 104,721,045 bp
  • A to T, chromosome 12 at 13,225,455 bp
  • A to T, chromosome 12 at 44,598,489 bp
  • C to A, chromosome 12 at 87,227,025 bp
  • A to G, chromosome 12 at 104,967,908 bp
  • A to G, chromosome 12 at 111,678,887 bp
  • G to A, chromosome 13 at 73,693,084 bp
  • C to A, chromosome 13 at 84,222,418 bp
  • A to G, chromosome 14 at 88,468,667 bp
  • A to G, chromosome 15 at 77,489,025 bp
  • T to C, chromosome 15 at 81,648,366 bp
  • T to C, chromosome 16 at 16,868,652 bp
  • A to T, chromosome 18 at 24,584,049 bp
  • A to G, chromosome 18 at 25,340,113 bp
  • A to T, chromosome 18 at 44,082,319 bp
  • T to C, chromosome 18 at 67,422,953 bp
  • T to C, chromosome 18 at 67,519,880 bp
  • A to G, chromosome 19 at 41,038,979 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7388 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045470-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.