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Strain Name:
C57BL/6J-MtgxR7414Btlr/Mmmh
Stock Number:
045494-MU
Citation ID:
RRID:MMRRC_045494-MU
Other Names:
R7414 (G1)
Major Collection:

Strain Information

Sbf2
Name: SET binding factor 2
Synonyms: SBF2, 4833411B01Rik, mMTMH1, B430219L04Rik, Mtmr13
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 319934
HGNC: HGNC:2135
Homologene: 41810
Ubxn2a
Name: UBX domain protein 2A
Synonyms: 6330407P03Rik, Ubxd4
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217379
Homologene: 17076
Adcyap1
Name: adenylate cyclase activating polypeptide 1
Synonyms: PACAP
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 11516
VEGA: 17
HGNC: HGNC:241
Homologene: 869
Uchl5
Name: ubiquitin carboxyl-terminal esterase L5
Synonyms: Uch37, 5830413B11Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 56207
Homologene: 9326
Spop
Name: speckle-type BTB/POZ protein
Synonyms: TEF2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20747
Homologene: 68354
Ttc39b
Name: tetratricopeptide repeat domain 39B
Synonyms: 9130422G05Rik, 1810054D07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 69863
Homologene: 25228
Kazn
Name: kazrin, periplakin interacting protein
Synonyms: 2310007B04Rik, 9030409G11Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 71529
Homologene: 16235
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 8,448,065 bp
  • T to A, chromosome 1 at 54,667,380 bp
  • T to C, chromosome 1 at 60,194,597 bp
  • A to G, chromosome 1 at 127,838,452 bp
  • A to T, chromosome 1 at 129,628,980 bp
  • A to T, chromosome 1 at 143,806,695 bp
  • T to C, chromosome 1 at 179,784,105 bp
  • C to A, chromosome 1 at 195,150,036 bp
  • T to G, chromosome 2 at 26,423,631 bp
  • T to C, chromosome 2 at 32,578,235 bp
  • A to T, chromosome 2 at 35,165,467 bp
  • G to A, chromosome 2 at 76,738,149 bp
  • A to C, chromosome 2 at 76,742,786 bp
  • A to G, chromosome 2 at 79,644,728 bp
  • A to T, chromosome 2 at 122,359,582 bp
  • C to A, chromosome 2 at 128,729,393 bp
  • C to A, chromosome 2 at 167,538,668 bp
  • C to T, chromosome 2 at 181,359,514 bp
  • T to A, chromosome 3 at 58,526,081 bp
  • T to C, chromosome 3 at 84,593,821 bp
  • T to A, chromosome 3 at 122,102,738 bp
  • C to A, chromosome 3 at 130,009,865 bp
  • T to C, chromosome 4 at 65,540,956 bp
  • T to A, chromosome 4 at 80,953,754 bp
  • T to C, chromosome 4 at 83,242,222 bp
  • C to T, chromosome 4 at 102,967,624 bp
  • C to T, chromosome 4 at 118,614,931 bp
  • T to C, chromosome 4 at 120,535,254 bp
  • G to A, chromosome 4 at 142,109,338 bp
  • A to G, chromosome 5 at 30,126,612 bp
  • T to A, chromosome 5 at 34,166,133 bp
  • T to C, chromosome 5 at 76,262,764 bp
  • A to C, chromosome 5 at 76,312,512 bp
  • T to C, chromosome 5 at 86,925,834 bp
  • T to C, chromosome 5 at 125,787,491 bp
  • G to A, chromosome 5 at 139,364,024 bp
  • A to G, chromosome 5 at 143,264,652 bp
  • T to A, chromosome 5 at 150,576,293 bp
  • T to A, chromosome 6 at 42,762,828 bp
  • C to T, chromosome 6 at 118,383,745 bp
  • T to C, chromosome 6 at 118,508,780 bp
  • A to T, chromosome 6 at 121,034,113 bp
  • T to C, chromosome 6 at 129,325,633 bp
  • A to T, chromosome 6 at 146,373,208 bp
  • A to T, chromosome 7 at 3,241,347 bp
  • C to A, chromosome 7 at 3,496,802 bp
  • A to G, chromosome 7 at 11,517,432 bp
  • A to G, chromosome 7 at 16,673,310 bp
  • A to T, chromosome 7 at 98,499,994 bp
  • T to A, chromosome 7 at 101,900,508 bp
  • C to T, chromosome 7 at 110,314,064 bp
  • A to T, chromosome 7 at 122,568,227 bp
  • G to T, chromosome 7 at 134,918,009 bp
  • A to G, chromosome 7 at 138,218,057 bp
  • A to T, chromosome 7 at 143,614,905 bp
  • T to A, chromosome 8 at 13,019,022 bp
  • T to C, chromosome 9 at 21,037,593 bp
  • T to A, chromosome 9 at 32,752,857 bp
  • T to C, chromosome 9 at 38,581,468 bp
  • T to A, chromosome 9 at 39,994,053 bp
  • C to T, chromosome 9 at 56,925,867 bp
  • G to A, chromosome 9 at 107,590,171 bp
  • G to A, chromosome 9 at 123,810,222 bp
  • G to T, chromosome 10 at 6,890,673 bp
  • A to T, chromosome 10 at 23,949,817 bp
  • G to A, chromosome 10 at 40,141,996 bp
  • T to A, chromosome 10 at 71,381,294 bp
  • A to T, chromosome 11 at 8,916,267 bp
  • A to T, chromosome 11 at 53,997,428 bp
  • T to A, chromosome 11 at 60,483,483 bp
  • A to T, chromosome 11 at 83,016,792 bp
  • G to A, chromosome 11 at 95,474,508 bp
  • A to C, chromosome 12 at 4,891,381 bp
  • A to T, chromosome 12 at 31,335,526 bp
  • A to G, chromosome 12 at 104,132,886 bp
  • A to G, chromosome 13 at 23,011,276 bp
  • A to G, chromosome 13 at 34,637,152 bp
  • G to C, chromosome 14 at 31,253,615 bp
  • G to T, chromosome 14 at 55,672,802 bp
  • G to A, chromosome 14 at 55,781,633 bp
  • T to A, chromosome 14 at 73,238,800 bp
  • T to C, chromosome 15 at 35,910,827 bp
  • C to T, chromosome 15 at 71,478,256 bp
  • A to G, chromosome 15 at 94,714,895 bp
  • T to A, chromosome 15 at 97,808,511 bp
  • C to T, chromosome 15 at 98,839,856 bp
  • T to G, chromosome 15 at 101,679,014 bp
  • T to C, chromosome 16 at 32,998,513 bp
  • T to C, chromosome 16 at 45,616,938 bp
  • T to C, chromosome 16 at 49,001,635 bp
  • A to G, chromosome 17 at 3,414,113 bp
  • C to A, chromosome 17 at 36,187,383 bp
  • T to A, chromosome 17 at 46,221,369 bp
  • T to C, chromosome 17 at 71,475,079 bp
  • T to A, chromosome 17 at 93,202,828 bp
  • C to T, chromosome 18 at 58,096,050 bp
  • G to T, chromosome 18 at 77,983,532 bp
  • T to C, chromosome 19 at 7,603,970 bp
  • T to A, chromosome 19 at 25,673,586 bp
  • T to C, chromosome 19 at 41,103,829 bp
  • C to A, chromosome 19 at 46,283,358 bp
  • C to A, chromosome 19 at 46,889,889 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7414 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045494-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.