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Strain Detail Sheet

Strain Name:
C57BL/6J-MtgxR7425Btlr/Mmmh
Stock Number:
045503-MU
Citation ID:
RRID:MMRRC_045503-MU
Other Names:
R7425 (G1)
Major Collection:
Beutler Mutagenetix

Strain Information

Gene Details

Sbf2
Name: SET binding factor 2
Synonyms: SBF2, 4833411B01Rik, mMTMH1, B430219L04Rik, Mtmr13
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 319934
HGNC: HGNC:2135
Homologene: 41810

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Vcan
Name: versican
Synonyms: PG-M, hdf, heart defect, 5430420N07Rik, Cspg2, DPEAAE
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 13003
HGNC: HGNC:2464
Homologene: 3228

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Gene Ontology
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Fryl
Name: FRY like transcription coactivator
Synonyms: 2310004H21Rik, 2510002A14Rik, 9030227G01Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 72313
Homologene: 103956

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ClinGen
Csnk1a1
Name: casein kinase 1, alpha 1
Synonyms: 4632404G05Rik, 2610208K14Rik, 5430427P18Rik, CK1a
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93687
HGNC: HGNC:2451
Homologene: 111694

Additional Resources
IMPC
Google
Entrez
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Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Virma
Name: vir like m6A methyltransferase associated
Synonyms: 1110037F02Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 66185
Homologene: 41043

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
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Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Sdad1
Name: SDA1 domain containing 1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231452
Homologene: 6036

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
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ClinGen
Bltp1
Name: bridge-like lipid transfer protein family member 1
Synonyms: Tweek, FSA, 4932438A13Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229227
Homologene: 52105

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to C, chromosome 1 at 15,709,807 bp
  • T to G, chromosome 1 at 59,867,351 bp
  • A to T, chromosome 1 at 106,392,573 bp
  • A to G, chromosome 1 at 179,537,704 bp
  • T to G, chromosome 2 at 13,010,418 bp
  • A to T, chromosome 2 at 89,002,200 bp
  • A to G, chromosome 2 at 89,844,445 bp
  • G to A, chromosome 2 at 101,899,900 bp
  • T to A, chromosome 3 at 36,948,341 bp
  • A to T, chromosome 3 at 36,983,394 bp
  • A to T, chromosome 3 at 65,948,758 bp
  • A to G, chromosome 3 at 96,684,788 bp
  • A to G, chromosome 3 at 108,402,457 bp
  • A to C, chromosome 3 at 108,876,659 bp
  • A to G, chromosome 3 at 138,065,695 bp
  • T to A, chromosome 4 at 11,546,211 bp
  • T to C, chromosome 4 at 24,596,287 bp
  • T to C, chromosome 4 at 137,405,588 bp
  • T to A, chromosome 4 at 146,657,641 bp
  • T to G, chromosome 5 at 72,609,525 bp
  • T to C, chromosome 5 at 73,104,748 bp
  • T to C, chromosome 5 at 92,300,121 bp
  • T to A, chromosome 5 at 96,834,821 bp
  • A to T, chromosome 6 at 24,603,476 bp
  • A to T, chromosome 6 at 57,390,566 bp
  • A to T, chromosome 6 at 116,556,437 bp
  • A to G, chromosome 6 at 146,574,700 bp
  • T to A, chromosome 7 at 44,770,924 bp
  • A to C, chromosome 7 at 67,733,446 bp
  • A to T, chromosome 7 at 104,975,061 bp
  • C to A, chromosome 7 at 105,591,861 bp
  • G to A, chromosome 7 at 110,375,777 bp
  • T to A, chromosome 7 at 139,992,481 bp
  • A to G, chromosome 8 at 119,485,588 bp
  • G to A, chromosome 9 at 21,976,827 bp
  • A to G, chromosome 9 at 35,554,586 bp
  • T to C, chromosome 10 at 5,425,760 bp
  • T to C, chromosome 10 at 6,956,066 bp
  • T to C, chromosome 10 at 21,994,110 bp
  • G to C, chromosome 10 at 53,301,570 bp
  • T to A, chromosome 10 at 80,721,592 bp
  • A to T, chromosome 10 at 119,216,243 bp
  • T to C, chromosome 10 at 130,478,892 bp
  • G to A, chromosome 11 at 69,314,734 bp
  • T to C, chromosome 11 at 69,665,112 bp
  • T to C, chromosome 11 at 70,978,246 bp
  • G to T, chromosome 11 at 70,978,247 bp
  • G to T, chromosome 12 at 13,469,880 bp
  • C to T, chromosome 12 at 89,513,100 bp
  • A to G, chromosome 12 at 101,591,498 bp
  • A to T, chromosome 12 at 111,260,661 bp
  • T to C, chromosome 13 at 11,705,644 bp
  • C to A, chromosome 13 at 23,788,382 bp
  • G to A, chromosome 13 at 64,758,252 bp
  • A to G, chromosome 13 at 89,689,832 bp
  • G to A, chromosome 15 at 79,308,733 bp
  • C to T, chromosome 16 at 19,699,612 bp
  • G to A, chromosome 16 at 29,297,460 bp
  • T to C, chromosome 16 at 33,005,707 bp
  • T to A, chromosome 16 at 96,629,398 bp
  • A to G, chromosome 17 at 14,196,331 bp
  • T to C, chromosome 17 at 34,921,691 bp
  • T to C, chromosome 17 at 57,204,039 bp
  • T to C, chromosome 17 at 73,318,058 bp
  • T to A, chromosome 18 at 37,708,566 bp
  • C to T, chromosome 18 at 61,585,259 bp
  • T to C, chromosome 19 at 6,255,652 bp
  • A to C, chromosome 19 at 12,422,840 bp
  • T to A, chromosome 19 at 16,723,702 bp

Strain Description

Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.

Strain Origin

Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7425 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Health Status Report

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.

Appearance

Coat Color
Black

Breeding

MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain

Reproductive Statistics

Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Availability Level

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Conditions of Distribution

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Fees

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*		 Units Notes
045503-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.