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Strain Name:
C57BL/6J-MtgxR7467Btlr/Mmmh
Stock Number:
045541-MU
Citation ID:
RRID:MMRRC_045541-MU
Other Names:
R7467 (G1)
Major Collection:

Strain Information

Kmt2c
Name: lysine (K)-specific methyltransferase 2C
Synonyms: E330008K23Rik, HALR, Mll3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231051
Homologene: 46480
Sema7a
Name: sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A
Synonyms: Semaphorin K1, CDw108, Semal, 2900057C09Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20361
VEGA: 9
Homologene: 2678
Dst
Name: dystonin
Synonyms: bullous pemphigoid antigen 1, BPAG1-n, BPAG1, Bpag1, Bpag, ah, bullous pemphigoid antigen 1, athetoid, Macf2, 2310001O04Rik, nmf203, A830042E19Rik, nmf339
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Pds5b
Name: PDS5 cohesin associated factor B
Synonyms: AS3, Aprin
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100710
Homologene: 41001
Manba
Name: mannosidase, beta A, lysosomal
Synonyms: Bmn, 2410030O07Rik, B930014J03Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 110173
HGNC: HGNC:6831
Homologene: 4317
Tmem121
Name: transmembrane protein 121
Synonyms: Hole, 2410008J05Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 69195
Homologene: 11900
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 4,912,330 bp
  • G to A, chromosome 1 at 34,191,155 bp
  • T to A, chromosome 1 at 34,499,392 bp
  • T to A, chromosome 1 at 58,726,438 bp
  • G to T, chromosome 1 at 59,289,779 bp
  • T to A, chromosome 1 at 75,362,961 bp
  • A to G, chromosome 1 at 82,770,826 bp
  • G to A, chromosome 1 at 86,116,633 bp
  • T to A, chromosome 1 at 92,511,848 bp
  • T to C, chromosome 1 at 131,292,667 bp
  • A to T, chromosome 1 at 162,677,363 bp
  • A to T, chromosome 1 at 163,815,833 bp
  • A to C, chromosome 2 at 30,409,982 bp
  • T to G, chromosome 2 at 85,430,827 bp
  • T to C, chromosome 2 at 118,118,200 bp
  • T to A, chromosome 2 at 120,022,188 bp
  • A to G, chromosome 2 at 121,954,472 bp
  • T to A, chromosome 2 at 127,133,875 bp
  • T to A, chromosome 2 at 128,849,151 bp
  • T to A, chromosome 2 at 131,274,047 bp
  • T to A, chromosome 2 at 153,129,930 bp
  • T to A, chromosome 2 at 155,299,089 bp
  • T to A, chromosome 2 at 164,819,875 bp
  • C to T, chromosome 3 at 51,225,201 bp
  • T to A, chromosome 3 at 93,692,958 bp
  • G to T, chromosome 3 at 135,544,801 bp
  • C to A, chromosome 4 at 88,603,265 bp
  • A to T, chromosome 4 at 108,818,392 bp
  • A to G, chromosome 4 at 126,814,310 bp
  • G to A, chromosome 4 at 136,931,088 bp
  • T to C, chromosome 5 at 25,308,532 bp
  • T to C, chromosome 5 at 65,390,967 bp
  • T to C, chromosome 5 at 67,345,644 bp
  • C to A, chromosome 5 at 73,411,968 bp
  • T to A, chromosome 5 at 121,323,961 bp
  • T to C, chromosome 5 at 121,802,267 bp
  • T to A, chromosome 5 at 150,736,327 bp
  • T to C, chromosome 6 at 12,331,585 bp
  • T to C, chromosome 6 at 48,486,303 bp
  • T to C, chromosome 6 at 97,142,833 bp
  • A to G, chromosome 7 at 5,060,326 bp
  • A to T, chromosome 7 at 19,371,380 bp
  • A to T, chromosome 7 at 23,606,895 bp
  • A to G, chromosome 7 at 45,145,907 bp
  • G to A, chromosome 7 at 47,464,529 bp
  • T to C, chromosome 7 at 48,804,408 bp
  • G to A, chromosome 7 at 75,730,465 bp
  • A to G, chromosome 7 at 105,566,132 bp
  • T to C, chromosome 7 at 140,419,374 bp
  • T to C, chromosome 7 at 141,433,976 bp
  • C to A, chromosome 8 at 13,878,579 bp
  • T to C, chromosome 8 at 84,073,913 bp
  • A to G, chromosome 8 at 110,811,456 bp
  • A to G, chromosome 8 at 124,028,511 bp
  • A to G, chromosome 9 at 7,447,621 bp
  • C to T, chromosome 9 at 7,450,125 bp
  • T to C, chromosome 9 at 14,705,041 bp
  • T to C, chromosome 9 at 21,481,376 bp
  • T to C, chromosome 9 at 57,961,422 bp
  • T to C, chromosome 9 at 59,557,400 bp
  • A to G, chromosome 9 at 59,949,151 bp
  • A to G, chromosome 9 at 95,769,113 bp
  • T to C, chromosome 9 at 108,573,002 bp
  • A to G, chromosome 9 at 109,069,354 bp
  • A to T, chromosome 9 at 109,732,697 bp
  • T to C, chromosome 10 at 63,322,150 bp
  • C to A, chromosome 10 at 121,855,439 bp
  • T to A, chromosome 10 at 128,277,903 bp
  • T to C, chromosome 11 at 50,815,426 bp
  • T to C, chromosome 11 at 53,654,908 bp
  • A to C, chromosome 11 at 58,566,462 bp
  • T to C, chromosome 11 at 78,154,347 bp
  • G to A, chromosome 11 at 80,586,917 bp
  • A to T, chromosome 11 at 80,820,185 bp
  • C to T, chromosome 11 at 97,335,289 bp
  • T to C, chromosome 11 at 97,865,167 bp
  • C to A, chromosome 11 at 99,793,136 bp
  • A to T, chromosome 11 at 102,912,348 bp
  • C to A, chromosome 11 at 102,916,408 bp
  • A to T, chromosome 12 at 71,985,806 bp
  • A to G, chromosome 12 at 110,552,883 bp
  • C to A, chromosome 12 at 113,189,070 bp
  • T to C, chromosome 13 at 23,846,967 bp
  • A to T, chromosome 13 at 30,925,733 bp
  • T to A, chromosome 13 at 67,672,961 bp
  • T to C, chromosome 13 at 104,025,022 bp
  • A to G, chromosome 14 at 47,087,856 bp
  • A to T, chromosome 14 at 96,123,277 bp
  • T to C, chromosome 15 at 47,629,244 bp
  • C to T, chromosome 15 at 65,857,511 bp
  • C to G, chromosome 15 at 98,805,366 bp
  • T to C, chromosome 16 at 32,238,521 bp
  • T to G, chromosome 16 at 90,719,978 bp
  • C to G, chromosome 17 at 23,644,782 bp
  • A to T, chromosome 17 at 25,736,921 bp
  • A to G, chromosome 17 at 35,844,556 bp
  • G to A, chromosome 17 at 55,791,952 bp
  • A to G, chromosome 17 at 86,099,274 bp
  • T to C, chromosome 18 at 3,123,393 bp
  • T to A, chromosome 18 at 36,022,406 bp
  • T to C, chromosome 18 at 36,947,531 bp
  • T to C, chromosome 18 at 60,831,905 bp
  • T to A, chromosome 19 at 12,283,475 bp
  • T to C, chromosome 19 at 12,428,514 bp
  • T to C, chromosome 19 at 16,873,640 bp
  • T to A, chromosome 19 at 22,978,334 bp
  • A to G, chromosome 19 at 46,082,334 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7467 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045541-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.