Strain Name:
C57BL/6J-MtgxR7476Btlr/Mmmh
Stock Number:
045550-MU
Citation ID:
RRID:MMRRC_045550-MU
Other Names:
R7476 (G1)
Major Collection:

Strain Information

Utrn
Name: utrophin
Synonyms: G-utrophin, Dmdl, DRP
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 22288
VEGA: 10
Homologene: 21398
Slc1a3
Name: solute carrier family 1 (glial high affinity glutamate transporter), member 3
Synonyms: MGluT1, Eaat1, B430115D02Rik, GLAST, Gmt1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 20512
Homologene: 20882
Dysf
Name: dysferlin
Synonyms: 2310004N10Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 26903
HGNC: HGNC:3097
Homologene: 20748
Lgals8
Name: lectin, galactose binding, soluble 8
Synonyms: Lgals-8, 1200015E08Rik, D13Ertd524e
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 56048
HGNC: HGNC:6569
Homologene: 31386
Rps6ka2
Name: ribosomal protein S6 kinase, polypeptide 2
Synonyms: Rsk3, 90kDa, Rps6ka-rs1, p90rsk, pp90rsk, D17Wsu134e
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 20112
VEGA: 17
Homologene: 100680
Mcmbp
Name: minichromosome maintenance complex binding protein
Synonyms: 1110007A13Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 210711
Homologene: 11749
Nup93
Name: nucleoporin 93
Synonyms: 2410008G02Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 71805
Homologene: 40971
Nrf1
Name: nuclear respiratory factor 1
Synonyms: D6Ertd415e
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 18181
HGNC: HGNC:7996
Homologene: 3674
Fcho1
Name: FCH domain only 1
Synonyms: 3322402E17Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 74015
Homologene: 22869
Rfx2
Name: regulatory factor X, 2 (influences HLA class II expression)
Synonyms: 5430432H19Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 19725
VEGA: 17
HGNC: HGNC:9983
Homologene: 30980
Sarnp
Name: SAP domain containing ribonucleoprotein
Synonyms: 1110005A23Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 66118
VEGA: 10
Homologene: 41628
Ptprm
Name: protein tyrosine phosphatase receptor type M
Synonyms: RPTPmu
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 19274
VEGA: 17
HGNC: HGNC:9675
Homologene: 37694
Nectin2
Name: nectin cell adhesion molecule 2
Synonyms: nectin-2, MPH, Cd112, Pvs, Pvrl2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 19294
HGNC: HGNC:9707
Homologene: 86092
Fat1
Name: FAT atypical cadherin 1
Synonyms: mFat1, 2310038E12Rik, Fath
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14107
HGNC: HGNC:3595
Homologene: 66302
Arhgap19
Name: Rho GTPase activating protein 19
Synonyms: 4933411B03Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 71085
Homologene: 13159
Spats2
Name: spermatogenesis associated, serine-rich 2
Synonyms: 2700012F11Rik, p59scr, 59kDa, Scr59
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 72572
VEGA: 15
Homologene: 11314
Brip1
Name: BRCA1 interacting protein C-terminal helicase 1
Synonyms: 8030460J03Rik, BACH1, 3110009N10Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237911
Homologene: 32766
Pdgfra
Name: platelet derived growth factor receptor, alpha polypeptide
Synonyms: CD140a, Pdgfr-2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18595
HGNC: HGNC:8803
Homologene: 31361
Csmd1
Name: CUB and Sushi multiple domains 1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 94109
Homologene: 69536
Tbx10
Name: T-box 10
Synonyms: Tbx7, Tbx13
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 109575
VEGA: 19
Homologene: 37399
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Hmcn1
Name: hemicentin 1
Synonyms: LOC240793, EG545370
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 545370
Homologene: 23741
Pclo
Name: piccolo (presynaptic cytomatrix protein)
Synonyms: Acz, Pico
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 26875
Homologene: 69111
Lmod2
Name: leiomodin 2 (cardiac)
Synonyms: C-Lmod
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 93677
HGNC: HGNC:6648
Homologene: 28302
Slco1a6
Name: solute carrier organic anion transporter family, member 1a6
Synonyms: organic anion-transporting polypeptide, Oatp-5, 4930422F19Rik, Slc21a13
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 28254
Homologene: 23416
Cldnd1
Name: claudin domain containing 1
Synonyms: 1110019C08Rik, Cldn25
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224250
HGNC: HGNC:1322
Homologene: 10534
Dgkg
Name: diacylglycerol kinase, gamma
Synonyms: Dagk3, E430001K23Rik, 2900055E17Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 110197
HGNC: HGNC:2853
Homologene: 1029
Xirp2
Name: xin actin-binding repeat containing 2
Synonyms: A530024P18Rik, 2310008C07Rik, 2310003D02Rik, mXin beta, myomaxin, Cmya3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241431
Homologene: 19388
Snrk
Name: SNF related kinase
Synonyms: SNRK, 2010012F07Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20623
Homologene: 9797
Stk35
Name: serine/threonine kinase 35
Synonyms: CLP-36 interacting kinase, CLIK1, 1700054C12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 67333
Homologene: 15441
Mrpl4
Name: mitochondrial ribosomal protein L4
Synonyms: 1110017G11Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 66163
VEGA: 9
Homologene: 32286
Tdpoz1
Name: TD and POZ domain containing 1
Synonyms: 2cpoz56, Spopl1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 207213
Homologene: 128308
Or5d40
Name: olfactory receptor family 5 subfamily D member 40
Synonyms: GA_x6K02T2Q125-49669483-49670421, MOR174-13, Olfr1168
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258524
Homologene: 128091
Rtl1
Name: retrotransposon Gaglike 1
Synonyms: Mart1, Mor1, Mar
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 353326
VEGA: 12
Homologene: 120261
Vmn1r63
Name: vomeronasal 1 receptor 63
Synonyms: V1R1, V1rd1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 81017
Homologene: 41799
Ccdc69
Name: coiled-coil domain containing 69
Synonyms: 2210021E03Rik, D11Ertd461e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 52570
Homologene: 77613
Chil5
Name: chitinase-like 5
Synonyms: Bclp1, Bclp2, Chi3l7
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229687
Homologene: 132668
Alox5
Name: arachidonate 5-lipoxygenase
Synonyms: 5LO, 5-LOX, 5LX
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 11689
HGNC: HGNC:435
Homologene: 561
Or4a2
Name: olfactory receptor family 4 subfamily A member 2
Synonyms: GA_x6K02T2Q125-50861284-50860367, MOR231-3, Olfr1239
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258972
Homologene: 74244
5730596B20Rik
Name: RIKEN cDNA 5730596B20 gene
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 77580
VEGA: 6
Adam29
Name: a disintegrin and metallopeptidase domain 29
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244486
HGNC: HGNC:207
Homologene: 8607
Daxx
Name: Fas death domain-associated protein
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 13163
HGNC: HGNC:2681
Homologene: 1033
C1ra
Name: complement component 1, r subcomponent A
Synonyms: mC1rA
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 50909
HGNC: HGNC:1246
Homologene: 1313
Abi3bp
Name: ABI family member 3 binding protein
Synonyms: 5033411B22Rik, D930038M13Rik, eratin, TARSH
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 320712
VEGA: 16
Homologene: 134172
Zfp82
Name: zinc finger protein 82
Synonyms: KRAB16
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330502
Homologene: 51177
Shc3
Name: src homology 2 domain-containing transforming protein C3
Synonyms: ShcC, N-Shc, Rai
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20418
VEGA: 13
Homologene: 7536
Map3k9
Name: mitogen-activated protein kinase kinase kinase 9
Synonyms: Mlk1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 338372
VEGA: 12
HGNC: HGNC:6861
Homologene: 76377
Vmn1r83
Name: vomeronasal 1 receptor 83
Synonyms: V1rg8
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 171243
Homologene: 74330
Or2w1b
Name: olfactory receptor family 2 subfamily W member 1B
Synonyms: GA_x6K02T2QHY8-12126170-12125935, MOR256-31, Olfr1369
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 404504
HGNC: HGNC:8281
Nom1
Name: nucleolar protein with MIF4G domain 1
Synonyms: LOC381627, D5Kng1, Gm1040
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 433864
Homologene: 39776
Or4c11c
Name: olfactory receptor family 4 subfamily C member 11C
Synonyms: GA_x6K02T2Q125-50336588-50337313, GA_x6K02T2Q125-50304328-50305251, MOR230-3, MOR230-1, Olfr1203, Olfr1205
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258898
Homologene: 81567
Pou2af3
Name: POU class 2 homeobox associating factor 3
Synonyms: LOC270157, Gm684, OCA-T2, Colca2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 100502940
VEGA: 9
Homologene: 19023
Ajap1
Name: adherens junction associated protein 1
Synonyms: LOC230959
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230959
Homologene: 10312
Alg6
Name: ALG6 alpha-1,3-glucosyltransferase
Synonyms: E230028F23Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 320438
Homologene: 6920
Pnlip
Name: pancreatic lipase
Synonyms: pancreatic triglyceride lipase, PTL, 1810007A24Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 69060
VEGA: 19
HGNC: HGNC:9155
Homologene: 30999
Vmn1r175
Name: vomeronasal 1 receptor 175
Synonyms: Gm6299
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 622222
Homologene: 128341
Hoxd11
Name: homeobox D11
Synonyms: Hox-5.4, Hox-4.6, E230017H14Rik, Hox-5.5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 15431
HGNC: HGNC:5134
Homologene: 7368
Or5g25
Name: olfactory receptor family 5 subfamily G member 25
Synonyms: GA_x6K02T2Q125-47127746-47126790, MOR175-2, Olfr1002
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258566
Homologene: 104131
Dmrta2
Name: doublesex and mab-3 related transcription factor like family A2
Synonyms: Dmrt5
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242620
Homologene: 100682
Lactbl1
Name: lactamase, beta-like 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242707
Homologene: 82492
Or9s27
Name: olfactory receptor family 9 subfamily S member 27
Synonyms: GA_x6K02T2R7CC-81165686-81164721, MOR208-4, Olfr1412
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 258274
Homologene: 115514
Noto
Name: notochord homeobox
Synonyms: tc, Not, Flh, MmNot
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 384452
Homologene: 53496
Malrd1
Name: MAM and LDL receptor class A domain containing 1
Synonyms: Gm13318, Gm13364, Diet1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 102635496
Homologene: 136214
Gm21798
Name: predicted gene, 21798
Type: Gene
Species: Mouse
Chromosome: 15
Ugt2a2
Name: UDP glucuronosyltransferase 2 family, polypeptide A2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 552899
Homologene: 115736
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to C, chromosome 1 at 92,589,264 bp
  • T to C, chromosome 1 at 150,580,267 bp
  • T to C, chromosome 2 at 16,142,304 bp
  • T to C, chromosome 2 at 67,510,634 bp
  • T to C, chromosome 2 at 74,684,115 bp
  • T to G, chromosome 2 at 76,714,145 bp
  • T to C, chromosome 2 at 76,771,186 bp
  • T to A, chromosome 2 at 85,648,168 bp
  • A to T, chromosome 2 at 88,184,966 bp
  • A to G, chromosome 2 at 88,831,588 bp
  • T to C, chromosome 2 at 89,417,499 bp
  • T to C, chromosome 2 at 129,810,725 bp
  • A to G, chromosome 3 at 93,670,775 bp
  • G to A, chromosome 3 at 106,020,007 bp
  • C to A, chromosome 4 at 99,743,876 bp
  • A to G, chromosome 4 at 109,982,025 bp
  • A to G, chromosome 4 at 136,637,639 bp
  • C to T, chromosome 4 at 153,384,855 bp
  • A to T, chromosome 5 at 14,521,331 bp
  • T to C, chromosome 5 at 29,442,536 bp
  • T to A, chromosome 5 at 75,170,603 bp
  • A to T, chromosome 5 at 87,474,494 bp
  • T to A, chromosome 6 at 24,597,921 bp
  • T to A, chromosome 6 at 30,116,272 bp
  • C to T, chromosome 6 at 52,179,034 bp
  • A to T, chromosome 6 at 84,064,896 bp
  • T to C, chromosome 6 at 85,425,499 bp
  • A to T, chromosome 6 at 116,415,433 bp
  • C to T, chromosome 6 at 124,522,699 bp
  • G to T, chromosome 6 at 142,103,001 bp
  • T to A, chromosome 7 at 5,803,001 bp
  • A to G, chromosome 7 at 12,321,615 bp
  • T to C, chromosome 7 at 19,717,621 bp
  • T to C, chromosome 7 at 23,808,422 bp
  • A to G, chromosome 7 at 30,056,172 bp
  • C to A, chromosome 7 at 128,703,582 bp
  • A to G, chromosome 8 at 15,895,731 bp
  • G to T, chromosome 8 at 45,031,274 bp
  • G to T, chromosome 8 at 55,873,195 bp
  • C to A, chromosome 8 at 71,713,546 bp
  • T to C, chromosome 8 at 94,303,632 bp
  • G to T, chromosome 9 at 21,002,771 bp
  • G to A, chromosome 9 at 51,277,600 bp
  • A to G, chromosome 9 at 122,157,222 bp
  • C to A, chromosome 10 at 12,640,951 bp
  • A to G, chromosome 10 at 128,833,354 bp
  • C to T, chromosome 11 at 55,051,198 bp
  • A to G, chromosome 11 at 86,157,808 bp
  • C to T, chromosome 12 at 81,743,808 bp
  • T to A, chromosome 12 at 109,591,105 bp
  • A to T, chromosome 13 at 12,448,481 bp
  • A to C, chromosome 13 at 21,116,021 bp
  • A to T, chromosome 13 at 51,448,006 bp
  • T to A, chromosome 15 at 8,643,084 bp
  • T to C, chromosome 15 at 64,817,706 bp
  • T to A, chromosome 15 at 99,212,141 bp
  • T to A, chromosome 16 at 22,622,304 bp
  • A to T, chromosome 16 at 56,614,746 bp
  • A to G, chromosome 16 at 58,729,544 bp
  • T to C, chromosome 17 at 7,271,633 bp
  • T to G, chromosome 17 at 33,911,281 bp
  • T to C, chromosome 17 at 56,803,527 bp
  • A to T, chromosome 17 at 66,725,791 bp
  • T to C, chromosome 19 at 3,999,034 bp
  • A to T, chromosome 19 at 41,782,363 bp
  • G to A, chromosome 19 at 58,679,634 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7476 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045550-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.