Strain Name:
C57BL/6J-MtgxR7478Btlr/Mmmh
Stock Number:
045552-MU
Citation ID:
RRID:MMRRC_045552-MU
Other Names:
R7478 (G1)
Major Collection:

Strain Information

Rnf220
Name: ring finger protein 220
Synonyms: 5730503K05Rik, 4931406I20Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 66743
Homologene: 10036
Ahcyl2
Name: S-adenosylhomocysteine hydrolase-like 2
Synonyms: 4631427C17Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 74340
Homologene: 69337
Pcm1
Name: pericentriolar material 1
Synonyms: C030044G17Rik, 9430077F19Rik, 2600002H09Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 18536
HGNC: HGNC:8727
Homologene: 4518
Zfp273
Name: zinc finger protein 273
Synonyms: 6820416H06Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 212569
Homologene: 133729
Arid1a
Name: AT-rich interaction domain 1A
Synonyms: BAF250a, Osa1, Smarcf1, 1110030E03Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 93760
Homologene: 21216
Tle1
Name: transducin-like enhancer of split 1
Synonyms: Grg1, Estm14, C230057C06Rik, Tle4l
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 21885
Homologene: 21058
Eif4enif1
Name: eukaryotic translation initiation factor 4E nuclear import factor 1
Synonyms: A930019J01Rik, D11Ertd166e, 2610509L04Rik, Clast4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 74203
Homologene: 10522
Camsap2
Name: calmodulin regulated spectrin-associated protein family, member 2
Synonyms: Camsap1l1, 1600013L13Rik, 4930541M15Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67886
Homologene: 18927
Tank
Name: TRAF family member-associated Nf-kappa B activator
Synonyms: E430026L09Rik, I-TRAF
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 21353
Homologene: 3081
Nek1
Name: NIMA (never in mitosis gene a)-related expressed kinase 1
Synonyms: kat, kidney, anemia and testis, D8Ertd790e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 18004
HGNC: HGNC:7744
Homologene: 14376
Cd72
Name: CD72 antigen
Synonyms: Lyb-2, Ly-32, Ly-19, Ly-m19
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12517
HGNC: HGNC:1696
Homologene: 1350
Sertm1
Name: serine rich and transmembrane domain containing 1
Synonyms: 6030405A18Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 329641
Homologene: 45594
Rasa3
Name: RAS p21 protein activator 3
Synonyms: R-Ras gap, hlb381, Ras GTPase-activating protein III, GAPIII, GAPIII activator 3, scat
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 19414
Homologene: 7217
Rb1
Name: RB transcriptional corepressor 1
Synonyms: Rb-1, pRb, Rb, retinoblastoma 1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 19645
HGNC: HGNC:9884
Homologene: 272
Nxn
Name: nucleoredoxin
Synonyms: l11Jus13
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18230
Homologene: 69028
Midn
Name: midnolin
Synonyms: 3000003C15Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 59090
Homologene: 32510
Myo19
Name: myosin XIX
Synonyms: 1110055A02Rik, Myohd1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 66196
Homologene: 49819
Eml2
Name: echinoderm microtubule associated protein like 2
Synonyms: 1600029N02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 72205
Homologene: 8125
Qser1
Name: glutamine and serine rich 1
Synonyms: 4732486I23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 99003
Homologene: 11710
Tecpr2
Name: tectonin beta-propeller repeat containing 2
Synonyms: 4930573I19Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 104859
VEGA: 12
Homologene: 8897
Pkd1l1
Name: polycystic kidney disease 1 like 1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 171395
Homologene: 51376
Pkd1l3
Name: polycystic kidney disease 1 like 3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244646
Homologene: 14627
C130074G19Rik
Name: RIKEN cDNA C130074G19 gene
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226777
Homologene: 11669
Ust
Name: uronyl-2-sulfotransferase
Synonyms: UA2OST, D930010O20Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 338362
VEGA: 10
Homologene: 4174
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: OTTMUSG00000005786, LOC380698
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380698
Homologene: 70869
Col19a1
Name: collagen, type XIX, alpha 1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12823
HGNC: HGNC:2196
Homologene: 55608
Naglu
Name: alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB)
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 27419
HGNC: HGNC:7632
Homologene: 222
Ak9
Name: adenylate kinase 9
Synonyms: Akd2, LOC215946, Akd1, Gm7127
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 633979
Homologene: 67934
Atrnl1
Name: attractin like 1
Synonyms: Alp
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226255
VEGA: 19
Homologene: 45809
Celsr3
Name: cadherin, EGF LAG seven-pass G-type receptor 3
Synonyms: Adgrc3, flamingo, Fmi1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 107934
HGNC: HGNC:3230
Homologene: 1077
Vmn2r94
Name: vomeronasal 2, receptor 94
Synonyms: EG665227
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 665227
Homologene: 129751
F13b
Name: coagulation factor XIII, beta subunit
Synonyms: Cf-13b, Cf13b
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14060
HGNC: HGNC:3534
Homologene: 1512
Ankrd34a
Name: ankyrin repeat domain 34A
Synonyms: Ankrd34
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 545554
Homologene: 82882
Efcc1
Name: EF hand and coiled-coil domain containing 1
Synonyms: Ccdc48, AB041550
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 58229
Homologene: 130011
Hif3a
Name: hypoxia inducible factor 3, alpha subunit
Synonyms: MOP7, bHLHe17, Nepas
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 53417
Homologene: 9646
C1ra
Name: complement component 1, r subcomponent A
Synonyms: mC1rA
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 50909
HGNC: HGNC:1246
Homologene: 1313
Catsperd
Name: cation channel sperm associated auxiliary subunit delta
Synonyms: Gm6095, 4921529N20Rik, 4933402B14Rik, Tmem146
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106757
VEGA: 17
Homologene: 51896
Aldh3b3
Name: aldehyde dehydrogenase 3 family, member B3
Synonyms: 1700055N04Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 73458
HGNC: HGNC:411
Homologene: 133295
Tmed5
Name: transmembrane p24 trafficking protein 5
Synonyms: 3110020O18Rik, 4432412D15Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 73130
Homologene: 4996
Tdrd9
Name: tudor domain containing 9
Synonyms: 4930441E05Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 74691
Homologene: 14311
Stard4
Name: StAR related lipid transfer domain containing 4
Synonyms: 9030213J02Rik, 4632419C16Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 170459
Homologene: 15874
Man2b2
Name: mannosidase 2, alpha B2
Synonyms: 135 kDa alpha-D-mannosidase
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 17160
Homologene: 7411
Slfn5
Name: schlafen 5
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 327978
Homologene: 18839
Zfp764l1
Name: zinc finger protein 764 like 1
Synonyms: E430018J23Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101604
Homologene: 138471
Prl7d1
Name: prolactin family 7, subfamily d, member 1
Synonyms: Plfr, PLF-RP, PRP
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 18814
Homologene: 7894
Cbx2
Name: chromobox 2
Synonyms: M33
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12416
HGNC: HGNC:1552
Homologene: 7256
Tagap
Name: T cell activation Rho GTPase activating protein
Synonyms: Tcd-1, tcs1, TRD, Tcd1, Tcd1a, tcs-1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 72536
Homologene: 44943
Arpc4
Name: actin related protein 2/3 complex, subunit 4
Synonyms: 5330419I20Rik, p20-Arc
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 68089
HGNC: HGNC:707
Homologene: 4177
Tarbp2
Name: TARBP2, RISC loading complex RNA binding subunit
Synonyms: TRBP, Prbp
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 21357
Homologene: 7562
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 24,317,707 bp
  • T to C, chromosome 1 at 136,270,940 bp
  • A to G, chromosome 1 at 139,507,695 bp
  • T to C, chromosome 1 at 184,874,427 bp
  • T to C, chromosome 2 at 61,650,169 bp
  • G to A, chromosome 2 at 104,789,514 bp
  • A to G, chromosome 3 at 54,899,328 bp
  • T to C, chromosome 3 at 96,598,500 bp
  • T to G, chromosome 4 at 43,454,515 bp
  • G to A, chromosome 4 at 72,137,112 bp
  • T to A, chromosome 4 at 88,816,676 bp
  • T to C, chromosome 4 at 117,296,136 bp
  • T to A, chromosome 4 at 133,685,171 bp
  • G to A, chromosome 5 at 36,810,313 bp
  • A to G, chromosome 5 at 108,124,629 bp
  • A to G, chromosome 6 at 29,903,267 bp
  • T to C, chromosome 6 at 87,730,990 bp
  • T to A, chromosome 6 at 113,384,131 bp
  • G to A, chromosome 6 at 124,517,725 bp
  • G to A, chromosome 7 at 17,042,635 bp
  • T to A, chromosome 7 at 19,206,141 bp
  • C to T, chromosome 7 at 127,393,324 bp
  • A to G, chromosome 8 at 13,614,605 bp
  • A to G, chromosome 8 at 41,261,373 bp
  • T to A, chromosome 8 at 61,130,145 bp
  • C to A, chromosome 8 at 109,633,315 bp
  • A to G, chromosome 9 at 108,843,578 bp
  • A to G, chromosome 10 at 8,390,886 bp
  • T to C, chromosome 10 at 41,389,091 bp
  • A to G, chromosome 10 at 80,155,322 bp
  • T to A, chromosome 11 at 3,227,709 bp
  • T to C, chromosome 11 at 8,929,441 bp
  • G to A, chromosome 11 at 59,093,416 bp
  • A to T, chromosome 11 at 76,261,552 bp
  • A to G, chromosome 11 at 82,960,616 bp
  • A to T, chromosome 11 at 84,885,800 bp
  • T to C, chromosome 11 at 101,071,899 bp
  • T to C, chromosome 11 at 119,029,115 bp
  • C to A, chromosome 12 at 110,968,439 bp
  • T to C, chromosome 12 at 111,985,042 bp
  • C to A, chromosome 13 at 27,710,185 bp
  • A to T, chromosome 13 at 67,825,132 bp
  • A to T, chromosome 14 at 73,269,137 bp
  • A to T, chromosome 15 at 102,521,734 bp
  • C to A, chromosome 17 at 7,933,590 bp
  • T to C, chromosome 17 at 18,257,505 bp
  • A to G, chromosome 17 at 56,664,055 bp
  • T to C, chromosome 18 at 33,205,324 bp
  • A to G, chromosome 19 at 3,964,549 bp
  • A to G, chromosome 19 at 57,696,312 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7478 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045552-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.