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Strain Name:
C57BL/6J-MtgxR7484Btlr/Mmmh
Stock Number:
045558-MU
Citation ID:
RRID:MMRRC_045558-MU
Other Names:
R7484 (G1)
Major Collection:

Strain Information

Grm1
Name: glutamate receptor, metabotropic 1
Synonyms: mGluR1, Grm1, Gprc1a, nmf373, rcw, 4930455H15Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14816
HGNC: HGNC:4593
Homologene: 649
Sort1
Name: sortilin 1
Synonyms: sortilin, neurotensin receptor 3, Ntsr3, Ntr3, 2900053A11Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20661
Homologene: 136097
Cbx5
Name: chromobox 5
Synonyms: heterochromatin protein 1 alpha, HP1a, Hp1a, 2610029O15Rik, HP1, Hp1alpha
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12419
HGNC: HGNC:1555
Homologene: 7257
Mga
Name: MAX gene associated
Synonyms: Mga, Mad5, C130042M01Rik, D030062C11Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 29808
Homologene: 49351
Ddx23
Name: DEAD box helicase 23
Synonyms: 4921506D17Rik, 3110082M05Rik, DEAD (Asp-Glu-Ala-Asp) box polypeptide 23
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 74351
Homologene: 3542
Plcd3
Name: phospholipase C, delta 3
Synonyms: 2610205J15Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 72469
HGNC: HGNC:9061
Homologene: 14858
Dscaml1
Name: DS cell adhesion molecule like 1
Synonyms: 4930435C18Rik, 4921507G06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 114873
VEGA: 9
Homologene: 79549
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 4,345,481 bp
  • T to C, chromosome 1 at 6,274,217 bp
  • A to G, chromosome 1 at 189,656,821 bp
  • C to T, chromosome 2 at 30,404,565 bp
  • T to C, chromosome 2 at 87,607,937 bp
  • G to T, chromosome 2 at 119,946,229 bp
  • G to A, chromosome 2 at 125,771,532 bp
  • A to G, chromosome 2 at 129,272,535 bp
  • A to T, chromosome 3 at 58,626,691 bp
  • G to T, chromosome 3 at 75,898,135 bp
  • A to G, chromosome 3 at 108,338,825 bp
  • T to C, chromosome 3 at 158,040,557 bp
  • A to T, chromosome 4 at 59,062,286 bp
  • A to T, chromosome 4 at 105,013,302 bp
  • A to G, chromosome 4 at 115,432,563 bp
  • A to G, chromosome 4 at 144,777,951 bp
  • T to C, chromosome 5 at 29,346,852 bp
  • A to G, chromosome 5 at 73,639,845 bp
  • T to A, chromosome 5 at 88,598,472 bp
  • T to G, chromosome 5 at 107,429,746 bp
  • G to A, chromosome 5 at 114,218,862 bp
  • G to C, chromosome 5 at 136,697,971 bp
  • G to A, chromosome 6 at 148,173,913 bp
  • A to T, chromosome 7 at 27,912,134 bp
  • T to C, chromosome 7 at 29,792,806 bp
  • G to T, chromosome 7 at 44,190,264 bp
  • A to G, chromosome 8 at 13,777,605 bp
  • C to A, chromosome 8 at 45,036,184 bp
  • T to A, chromosome 9 at 18,646,768 bp
  • A to G, chromosome 9 at 45,749,446 bp
  • T to C, chromosome 9 at 70,573,897 bp
  • A to T, chromosome 9 at 103,067,986 bp
  • T to G, chromosome 10 at 10,746,659 bp
  • T to C, chromosome 10 at 78,042,570 bp
  • G to A, chromosome 10 at 79,780,031 bp
  • T to C, chromosome 11 at 49,872,836 bp
  • T to A, chromosome 11 at 97,672,616 bp
  • A to T, chromosome 11 at 100,495,963 bp
  • T to G, chromosome 11 at 103,071,719 bp
  • A to T, chromosome 11 at 114,928,519 bp
  • T to C, chromosome 11 at 115,352,581 bp
  • T to A, chromosome 11 at 119,346,357 bp
  • C to T, chromosome 12 at 8,006,884 bp
  • T to C, chromosome 12 at 31,447,788 bp
  • T to A, chromosome 12 at 73,585,527 bp
  • A to G, chromosome 12 at 91,562,973 bp
  • C to T, chromosome 13 at 100,611,560 bp
  • A to T, chromosome 13 at 120,308,481 bp
  • T to A, chromosome 14 at 6,535,135 bp
  • A to G, chromosome 14 at 29,992,968 bp
  • A to G, chromosome 14 at 31,160,317 bp
  • A to C, chromosome 14 at 78,982,234 bp
  • G to A, chromosome 15 at 7,922,081 bp
  • C to A, chromosome 15 at 11,345,648 bp
  • A to G, chromosome 15 at 76,646,235 bp
  • A to G, chromosome 15 at 78,338,899 bp
  • T to G, chromosome 15 at 79,084,136 bp
  • T to A, chromosome 15 at 89,573,224 bp
  • T to C, chromosome 15 at 92,254,041 bp
  • T to C, chromosome 15 at 98,648,689 bp
  • A to C, chromosome 15 at 103,205,829 bp
  • A to G, chromosome 16 at 19,487,003 bp
  • G to A, chromosome 17 at 24,879,988 bp
  • G to T, chromosome 17 at 50,917,545 bp
  • C to A, chromosome 19 at 8,071,127 bp
  • T to C, chromosome 19 at 11,472,529 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7484 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045558-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.