Strain Name:
C57BL/6J-MtgxR7499Btlr/Mmmh
Stock Number:
045572-MU
Citation ID:
RRID:MMRRC_045572-MU
Other Names:
R7499 (G1)
Major Collection:

Strain Information

Dlx5
Name: distal-less homeobox 5
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 13395
HGNC: HGNC:2918
Homologene: 3825
Slco1a5
Name: solute carrier organic anion transporter family, member 1a5
Synonyms: Oatp3, Slc21a7
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 108096
Homologene: 56603
Cep170
Name: centrosomal protein 170
Synonyms: 4933426L22Rik, A330004A13Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 545389
Homologene: 22844
Emsy
Name: EMSY, BRCA2-interacting transcriptional repressor
Synonyms: 2210018M11Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233545
Homologene: 32465
Tep1
Name: telomerase associated protein 1
Synonyms: Tp1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 21745
VEGA: 14
Homologene: 5157
Clpb
Name: ClpB caseinolytic peptidase B
Synonyms: Skd3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20480
Homologene: 32067
Asb6
Name: ankyrin repeat and SOCS box-containing 6
Synonyms: 2510004M11Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 72323
Homologene: 9895
Frem1
Name: Fras1 related extracellular matrix protein 1
Synonyms: heb, eyem02Jus, eyes2, QBRICK, crf11
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329872
Homologene: 27049
Ripor2
Name: RHO family interacting cell polarization regulator 2
Synonyms: Fam65b, 6330500D04Rik, 1700108N18Rik, E430013J17Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 193385
Homologene: 9284
Fgfr3
Name: fibroblast growth factor receptor 3
Synonyms: HBGFR, sam3, Fgfr-3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14184
HGNC: HGNC:3690
Homologene: 55437
Nop2
Name: NOP2 nucleolar protein
Synonyms: 120kDa, Nol1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 110109
HGNC: HGNC:7867
Homologene: 135865
Hmg20a
Name: high mobility group 20A
Synonyms: 5730490E10Rik, Hmgxb1, 1200004E06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 66867
VEGA: 9
HGNC: HGNC:5001
Homologene: 32399
Tvp23b
Name: trans-golgi network vesicle protein 23B
Synonyms: 1810036I24Rik, Fam18b
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67510
Homologene: 128511
Tsc22d4
Name: Tsc22 domain family, member 4
Synonyms: 0610009M14Rik, Spacdr, 1700023B23Rik, Tsc22d4, Thg-1pit
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 78829
Homologene: 11390
Slc7a5
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 5
Synonyms: TA1, D0H16S474E, LAT1, Gm42049
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 20539
Homologene: 55759
Il16
Name: interleukin 16
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16170
HGNC: HGNC:5980
Homologene: 18157
Dnah1
Name: dynein, axonemal, heavy chain 1
Synonyms: E030034C22Rik, Dnahc1, G1-415-19, MDHC7, ferf1, B230373P09Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 110084
VEGA: 14
HGNC: HGNC:2940
Homologene: 67131
Tnik
Name: TRAF2 and NCK interacting kinase
Synonyms: 4831440I19Rik, C530008O15Rik, 1500031A17Rik, C630040K21Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 665113
Homologene: 77943
Dnah5
Name: dynein, axonemal, heavy chain 5
Synonyms: Dnahc5, Mdnah5, b2b1134Clo, b2b1154Clo, b2b1537Clo, b2b1565Clo, b2b3491Clo
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 110082
HGNC: HGNC:2950
Homologene: 1048
Zfp831
Name: zinc finger protein 831
Synonyms: ENSMUSG00000050600, OTTMUSG00000017459
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 100043757
Homologene: 19013
Gm7361
Name: predicted gene 7361
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 664837
Homologene: 69402
Dnah3
Name: dynein, axonemal, heavy chain 3
Synonyms: Dnahc3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 381917
HGNC: HGNC:2949
Homologene: 19674
Armc3
Name: armadillo repeat containing 3
Synonyms: 4921513G22Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 70882
Homologene: 31589
Zan
Name: zonadhesin
Synonyms: Zan
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22635
Homologene: 124417
Slc66a1
Name: solute carrier family 66 member 1
Synonyms: Pqlc2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 212555
Homologene: 56784
Or5p62
Name: olfactory receptor family 5 subfamily P member 62
Synonyms: Olfr486, GA_x6K02T2PBJ9-10501920-10500976, MOR204-19
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258489
Homologene: 110483
Gm5114
Name: predicted gene 5114
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330513
Homologene: 45597
Phkg1
Name: phosphorylase kinase gamma 1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18682
HGNC: HGNC:8930
Homologene: 68508
Bche
Name: butyrylcholinesterase
Synonyms: C730038G20Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12038
HGNC: HGNC:983
Homologene: 20065
Ifi206
Name: interferon activated gene 206
Synonyms: Gm4955, Pyblhin-C
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 102639543
HGNC: HGNC:5395
Homologene: 115929
Phykpl
Name: 5-phosphohydroxy-L-lysine phospholyase
Synonyms: 2900006B13Rik, Agxt2l2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 72947
Homologene: 75268
Tsfm
Name: Ts translation elongation factor, mitochondrial
Synonyms: EF-TS, EF-Tsmt, 2310050B20Rik, 9430024O13Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 66399
Homologene: 4184
Dmc1
Name: DNA meiotic recombinase 1
Synonyms: Mei11, sgdp, Dmc1h, Dmc1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 13404
VEGA: 15
HGNC: HGNC:2927
Homologene: 5135
Atp11a
Name: ATPase, class VI, type 11A
Synonyms: 4930558F19Rik, LOC100045280, 9130422H11Rik, Ih
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 50770
Homologene: 75050
Vgf
Name: VGF nerve growth factor inducible
Synonyms: LOC381677
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 381677
Homologene: 2536
Mettl14
Name: methyltransferase 14, N6-adenosine-methyltransferase subunit
Synonyms: G430022H21Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 210529
Homologene: 10865
Sh2b3
Name: SH2B adaptor protein 3
Synonyms: Lnk
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 16923
Homologene: 36179
Bag6
Name: BCL2-associated athanogene 6
Synonyms: Scythe, 2410045D21Rik, G3, D17H6S52E, Bat3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224727
Homologene: 3409
Ankfn1
Name: ankyrin-repeat and fibronectin type III domain containing 1
Synonyms: mWAKE, LOC382543, nmf9, 4932411E22Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 382543
Homologene: 34996
Rab13
Name: RAB13, member RAS oncogene family
Synonyms: B230212B15Rik, 0610007N03Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 68328
HGNC: HGNC:9762
Homologene: 113882
Maf
Name: MAF bZIP transcription factor
Synonyms: 2810401A20Rik, A230108G15Rik, c-maf
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 17132
HGNC: HGNC:6776
Homologene: 74552
Mpped1
Name: metallophosphoesterase domain containing 1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223726
HGNC: HGNC:1306
Homologene: 15012
Ifnb1
Name: interferon beta 1, fibroblast
Synonyms: IFNB, interferon beta 1, fibroblast, IFN-beta, Ifb
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 15977
HGNC: HGNC:5434
Homologene: 1640
Hmbox1
Name: homeobox containing 1
Synonyms: F830020C16Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219150
Homologene: 11589
Sec61a2
Name: SEC61 translocon subunit alpha 2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 57743
Homologene: 38481
Trdn
Name: triadin
Synonyms: triadin-1, EG432451, triadin 3, triadin 1, 2310045H21Rik, triadin-2, triadin-3, triadin 2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 76757
VEGA: 10
Homologene: 38137
Cela3a
Name: chymotrypsin-like elastase family, member 3A
Synonyms: Gm13011
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242711
Homologene: 129880
Polr3gl
Name: polymerase (RNA) III (DNA directed) polypeptide G like
Synonyms: 2010003I19Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 69870
Homologene: 41712
Cpa5
Name: carboxypeptidase A5
Synonyms: 4930430M09Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 74649
Homologene: 62246
Chfr
Name: checkpoint with forkhead and ring finger domains
Synonyms: RNF116, 5730484M20Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231600
Homologene: 10078
Serpinb5
Name: serine (or cysteine) peptidase inhibitor, clade B, member 5
Synonyms: ovalbumin, Spi7, Maspin, 1110036M19Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20724
HGNC: HGNC:8949
Homologene: 20580
Coro2a
Name: coronin, actin binding protein 2A
Synonyms: coronin 4, 9030208C03Rik, IR10
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 107684
HGNC: HGNC:2255
Homologene: 2546
Serpine3
Name: serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3
Synonyms: E130113E03Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 319433
VEGA: 14
Homologene: 53117
G6pc1
Name: glucose-6-phosphatase catalytic subunit 1
Synonyms: G6pc, G6Pase, G6pt, Glc-6-Pase, Glc-6-Pase-alpha
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14377
HGNC: HGNC:4056
Homologene: 20079
4930563M21Rik
Name: RIKEN cDNA 4930563M21 gene
Synonyms: Rfpl3s
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 75258
VEGA: 9
Homologene: 138467
Abat
Name: 4-aminobutyrate aminotransferase
Synonyms: GABA-T, 9630038C02Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 268860
HGNC: HGNC:23
Homologene: 542
Ctsd
Name: cathepsin D
Synonyms: CatD, CD
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13033
HGNC: HGNC:2529
Homologene: 55616
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 106,872,389 bp
  • T to A, chromosome 1 at 173,482,041 bp
  • A to T, chromosome 1 at 176,774,462 bp
  • T to C, chromosome 2 at 5,877,914 bp
  • C to T, chromosome 2 at 19,285,979 bp
  • T to C, chromosome 2 at 30,824,460 bp
  • T to C, chromosome 2 at 174,644,023 bp
  • T to C, chromosome 3 at 28,630,594 bp
  • G to A, chromosome 3 at 73,701,898 bp
  • A to G, chromosome 3 at 90,225,533 bp
  • A to T, chromosome 3 at 96,579,821 bp
  • A to G, chromosome 3 at 123,374,854 bp
  • T to C, chromosome 4 at 46,539,188 bp
  • T to C, chromosome 4 at 83,005,770 bp
  • T to C, chromosome 4 at 88,522,674 bp
  • T to A, chromosome 4 at 137,405,639 bp
  • T to A, chromosome 4 at 139,306,512 bp
  • C to A, chromosome 5 at 26,261,190 bp
  • GGACCTCTCCGTG to GG, chromosome 5 at 33,735,422 bp
  • T to C, chromosome 5 at 110,151,683 bp
  • T to C, chromosome 5 at 121,818,473 bp
  • G to A, chromosome 5 at 129,873,268 bp
  • C to A, chromosome 5 at 137,032,245 bp
  • G to A, chromosome 5 at 137,464,356 bp
  • G to A, chromosome 5 at 137,747,723 bp
  • G to A, chromosome 6 at 6,878,340 bp
  • A to C, chromosome 6 at 6,878,341 bp
  • A to G, chromosome 6 at 30,630,857 bp
  • C to A, chromosome 6 at 125,144,208 bp
  • T to C, chromosome 6 at 142,262,531 bp
  • A to G, chromosome 7 at 39,409,065 bp
  • T to C, chromosome 7 at 83,674,494 bp
  • A to G, chromosome 7 at 98,630,331 bp
  • T to C, chromosome 7 at 101,722,728 bp
  • A to G, chromosome 7 at 108,171,800 bp
  • A to G, chromosome 7 at 120,060,912 bp
  • A to T, chromosome 7 at 142,383,412 bp
  • T to C, chromosome 8 at 12,832,575 bp
  • T to C, chromosome 8 at 115,693,181 bp
  • A to G, chromosome 8 at 121,883,722 bp
  • T to A, chromosome 9 at 55,999,902 bp
  • A to G, chromosome 9 at 56,488,943 bp
  • A to T, chromosome 10 at 33,196,101 bp
  • T to C, chromosome 10 at 127,022,548 bp
  • T to A, chromosome 11 at 51,591,458 bp
  • T to C, chromosome 11 at 62,879,463 bp
  • G to A, chromosome 11 at 89,391,750 bp
  • C to A, chromosome 11 at 101,376,694 bp
  • A to G, chromosome 13 at 24,693,772 bp
  • G to A, chromosome 14 at 31,315,122 bp
  • G to A, chromosome 14 at 50,853,590 bp
  • G to A, chromosome 14 at 62,665,027 bp
  • A to G, chromosome 14 at 64,896,677 bp
  • A to T, chromosome 15 at 28,302,450 bp
  • G to T, chromosome 15 at 79,602,420 bp
  • G to A, chromosome 15 at 83,800,050 bp
  • T to C, chromosome 16 at 8,603,754 bp
  • G to A, chromosome 17 at 35,144,392 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7499 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045572-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.