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Strain Name:
C57BL/6J-MtgxR7501Btlr/Mmmh
Stock Number:
045574-MU
Citation ID:
RRID:MMRRC_045574-MU
Other Names:
R7501 (G1)
Major Collection:

Strain Information

Ptprz1
Name: protein tyrosine phosphatase receptor type Z, polypeptide 1
Synonyms: DSD-1-PG, phosphacan, PTPzeta, PTPbeta, Rptpbeta, Ptpz, Ptprz, RPTPz
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 19283
HGNC: HGNC:9685
Homologene: 2136
Syt6
Name: synaptotagmin VI
Synonyms: 3110037A08Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 54524
Homologene: 10301
Fancd2
Name: Fanconi anemia, complementation group D2
Synonyms: 2410150O07Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 211651
HGNC: HGNC:3585
Homologene: 13212
Zfp706
Name: zinc finger protein 706
Synonyms: C77232, 3110006P09Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 68036
VEGA: 15
Homologene: 128235
B3galnt1
Name: UDP-GalNAc:betaGlcNAc beta 1,3-galactosaminyltransferase, polypeptide 1
Synonyms: Mbrn 1, Brainiac 1, Globoside blood group, B3galt3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 26879
HGNC: HGNC:918
Homologene: 32457
Comp
Name: cartilage oligomeric matrix protein
Synonyms: thrombospondin-5, TSP5
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12845
HGNC: HGNC:2227
Homologene: 74
Gria4
Name: glutamate receptor, ionotropic, AMPA4 (alpha 4)
Synonyms: Glur-4, Glur4, spkw1, Gluralpha4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 14802
HGNC: HGNC:4574
Homologene: 20227
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 46,356,554 bp
  • T to C, chromosome 1 at 53,913,872 bp
  • T to C, chromosome 1 at 54,649,363 bp
  • A to G, chromosome 1 at 160,700,788 bp
  • C to T, chromosome 1 at 194,643,895 bp
  • T to C, chromosome 2 at 26,441,851 bp
  • T to A, chromosome 2 at 28,450,737 bp
  • T to C, chromosome 2 at 131,194,160 bp
  • T to C, chromosome 2 at 147,029,756 bp
  • A to G, chromosome 3 at 36,088,825 bp
  • T to A, chromosome 3 at 38,958,448 bp
  • T to C, chromosome 3 at 69,575,299 bp
  • T to C, chromosome 3 at 82,035,359 bp
  • G to C, chromosome 3 at 85,636,990 bp
  • A to T, chromosome 3 at 103,587,702 bp
  • T to C, chromosome 4 at 42,791,357 bp
  • CAA to CA, chromosome 4 at 143,437,452 bp
  • T to C, chromosome 4 at 155,996,520 bp
  • A to G, chromosome 5 at 13,557,041 bp
  • A to T, chromosome 5 at 22,227,638 bp
  • G to T, chromosome 5 at 30,945,456 bp
  • C to T, chromosome 5 at 121,518,948 bp
  • C to T, chromosome 6 at 23,001,747 bp
  • T to A, chromosome 6 at 87,082,526 bp
  • T to C, chromosome 6 at 113,548,403 bp
  • T to C, chromosome 6 at 134,486,508 bp
  • C to T, chromosome 6 at 149,185,031 bp
  • T to A, chromosome 7 at 11,881,070 bp
  • A to G, chromosome 7 at 35,478,091 bp
  • A to T, chromosome 7 at 81,473,446 bp
  • G to A, chromosome 7 at 126,450,172 bp
  • G to C, chromosome 7 at 141,637,746 bp
  • A to G, chromosome 8 at 70,379,409 bp
  • A to C, chromosome 8 at 123,922,414 bp
  • A to T, chromosome 9 at 4,502,436 bp
  • A to T, chromosome 9 at 7,175,336 bp
  • A to T, chromosome 9 at 64,131,579 bp
  • A to G, chromosome 9 at 72,361,942 bp
  • G to A, chromosome 9 at 72,616,772 bp
  • G to A, chromosome 9 at 108,082,549 bp
  • G to A, chromosome 10 at 79,491,937 bp
  • T to C, chromosome 11 at 49,685,332 bp
  • A to C, chromosome 11 at 50,379,556 bp
  • G to A, chromosome 11 at 59,328,757 bp
  • G to A, chromosome 11 at 101,566,200 bp
  • G to T, chromosome 12 at 72,449,716 bp
  • A to T, chromosome 12 at 84,830,645 bp
  • T to C, chromosome 12 at 111,710,288 bp
  • A to G, chromosome 13 at 23,585,793 bp
  • A to T, chromosome 13 at 27,316,299 bp
  • A to G, chromosome 13 at 65,194,329 bp
  • A to G, chromosome 13 at 114,875,559 bp
  • T to C, chromosome 15 at 37,001,925 bp
  • A to T, chromosome 15 at 77,105,634 bp
  • G to A, chromosome 16 at 14,706,890 bp
  • A to T, chromosome 16 at 48,754,294 bp
  • A to T, chromosome 16 at 90,230,076 bp
  • T to A, chromosome 17 at 5,990,239 bp
  • C to T, chromosome 17 at 25,125,192 bp
  • A to G, chromosome 18 at 11,054,082 bp
  • A to T, chromosome 18 at 46,505,801 bp
  • T to G, chromosome 18 at 65,725,298 bp
  • T to A, chromosome Y at 941,488 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7501 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045574-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.