Strain Name:
C57BL/6J-MtgxR7504Btlr/Mmmh
Stock Number:
045577-MU
Citation ID:
RRID:MMRRC_045577-MU
Other Names:
R7504 (G1)
Major Collection:

Strain Information

Cdkn1a
Name: cyclin dependent kinase inhibitor 1A
Synonyms: CDKI, P21, SDI1, CAP20, Waf1, p21WAF, p21Cip1, p21WAF1/CIP1, Cdkn1, mda6, CIP1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12575
HGNC: HGNC:1784
Homologene: 333
Camkk2
Name: calcium/calmodulin-dependent protein kinase kinase 2, beta
Synonyms: 6330570N16Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 207565
HGNC: HGNC:1470
Homologene: 32756
Trmt9b
Name: tRNA methyltransferase 9B
Synonyms: 6430573F11Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 319582
Homologene: 35306
Dst
Name: dystonin
Synonyms: A830042E19Rik, nmf339, bullous pemphigoid antigen 1, Bpag1, 2310001O04Rik, Bpag, Macf2, BPAG1, BPAG1-n, athetoid, bullous pemphigoid antigen 1, ah, nmf203
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Fancd2
Name: Fanconi anemia, complementation group D2
Synonyms: 2410150O07Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 211651
HGNC: HGNC:3585
Homologene: 13212
Traip
Name: TRAF-interacting protein
Synonyms: Trip
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22036
Homologene: 31343
Zfp688
Name: zinc finger protein 688
Synonyms: 2810407K09Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 69234
Homologene: 17058
Ephx2
Name: epoxide hydrolase 2, cytoplasmic
Synonyms: Eph2, sEH, sEP
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 13850
VEGA: 14
HGNC: HGNC:3402
Homologene: 37558
Nmt1
Name: N-myristoyltransferase 1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18107
HGNC: HGNC:7857
Homologene: 69027
Tet2
Name: tet methylcytosine dioxygenase 2
Synonyms: Ayu17-449, E130014J05Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 214133
Homologene: 49498
Rnf216
Name: ring finger protein 216
Synonyms: UIP83, 2810055G22Rik, Ubce7ip1, F830018F18Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 108086
Homologene: 19442
Stag1
Name: STAG1 cohesin complex component
Synonyms: Scc3, SA-1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20842
Homologene: 21191
Dek
Name: DEK proto-oncogene
Synonyms: DEK proto-oncogene (DNA binding), 1810019E15Rik, D13H6S231E
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 110052
HGNC: HGNC:2768
Homologene: 2593
Secisbp2l
Name: SECIS binding protein 2-like
Synonyms: 3110001I20Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 70354
Homologene: 18923
Tenm2
Name: teneurin transmembrane protein 2
Synonyms: D3Bwg1534e, Ten-m2, 9330187F13Rik, Odz2, 2610040L17Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 23964
Homologene: 22672
Ift80
Name: intraflagellar transport 80
Synonyms: 4921524P20Rik, Wdr56
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 68259
Homologene: 12253
Cdc42bpg
Name: CDC42 binding protein kinase gamma
Synonyms: MRCKgamma
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 240505
Homologene: 28384
Nars1
Name: asparaginyl-tRNA synthetase 1
Synonyms: ASNRS, Nars
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 70223
VEGA: 18
HGNC: HGNC:7643
Homologene: 68404
Zfp335
Name: zinc finger protein 335
Synonyms: 1810045J01Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 329559
Homologene: 11129
Gsx2
Name: GS homeobox 2
Synonyms: Gsh2, Gsh-2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14843
Homologene: 15377
Efl1
Name: elongation factor like GTPase 1
Synonyms: 4932434J20Rik, Eftud1, 6030468D11Rik, D7Ertd791e
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101592
Homologene: 11599
Kalrn
Name: kalirin, RhoGEF kinase
Synonyms: LOC224126, E530005C20Rik, 2210407G14Rik, Hapip
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 545156
HGNC: HGNC:4814
Homologene: 57160
Sv2b
Name: synaptic vesicle glycoprotein 2b
Synonyms: A830038F04Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 64176
Homologene: 32236
Insc
Name: INSC spindle orientation adaptor protein
Synonyms: Inscuteable, 3830422K02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233752
Homologene: 78662
Wdr95
Name: WD40 repeat domain 95
Synonyms: 4930434E21Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 381693
Homologene: 124480
Pcdhb11
Name: protocadherin beta 11
Synonyms: PcdhbK, Pcdhb5E
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93882
HGNC: HGNC:8690
Homologene: 62178
Sdk2
Name: sidekick cell adhesion molecule 2
Synonyms: 4632412F08Rik, 5330435L01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237979
Homologene: 10406
Hc
Name: hemolytic complement
Synonyms: C5, C5a, Hfib2, He
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 15139
HGNC: HGNC:1331
Homologene: 20412
Rab11fip1
Name: RAB11 family interacting protein 1 (class I)
Synonyms: 4833414G05Rik, 2010200K21Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 75767
Homologene: 11853
Scara3
Name: scavenger receptor class A, member 3
Synonyms: C130058N24Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219151
VEGA: 14
Homologene: 9437
Btn1a1
Name: butyrophilin, subfamily 1, member A1
Synonyms: Btn
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 12231
HGNC: HGNC:1135
Homologene: 1312
Tmem132c
Name: transmembrane protein 132C
Synonyms: 4632425D07Rik, 2810482M11Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 208213
Homologene: 76567
Hps1
Name: HPS1, biogenesis of lysosomal organelles complex 3 subunit 1
Synonyms: 6030422N11Rik, Hermansky-Pudlak syndrome 1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 192236
HGNC: HGNC:5163
Homologene: 163
Or7a36
Name: olfactory receptor family 7 subfamily A member 36
Synonyms: GA_x6K02T2QGN0-2828447-2827518, MOR139-1, Olfr1352
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 259074
Homologene: 131141
Usp45
Name: ubiquitin specific petidase 45
Synonyms: 3110003C05Rik, Gcap7, 4930550B20Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 77593
Homologene: 17674
Pbx3
Name: pre B cell leukemia homeobox 3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18516
HGNC: HGNC:8634
Homologene: 21243
Vmn2r81
Name: vomeronasal 2, receptor 81
Synonyms: EC1-VR2, V2rf2, pheromone recepter
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216144
Homologene: 83483
Or8c8
Name: olfactory receptor family 8 subfamily C member 8
Synonyms: K18, GA_x6K02T2PVTD-31941084-31942025, Olfr143, MOR170-6
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258802
Homologene: 133627
Zfp760
Name: zinc finger protein 760
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240034
VEGA: 17
Togaram1
Name: TOG array regulator of axonemal microtubules 1
Synonyms: A430041B07Rik, Fam179b
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 328108
VEGA: 12
Homologene: 15025
Grid1
Name: glutamate receptor, ionotropic, delta 1
Synonyms: GluRdelta1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 14803
HGNC: HGNC:4575
Homologene: 69017
1600012H06Rik
Name: RIKEN cDNA 1600012H06 gene
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 67912
Homologene: 57051
Zfp128
Name: zinc finger protein 128
Synonyms: mZnf8, 9630016P15Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243833
Homologene: 10889
Isg15
Name: ISG15 ubiquitin-like modifier
Synonyms: G1p2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100038882
VEGA: 4
HGNC: HGNC:4053
Homologene: 48326
Or10q12
Name: olfactory receptor family 10 subfamily Q member 12
Synonyms: GA_x6K02T2RE5P-4101369-4102328, Olfr1495, MOR266-9
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258341
Homologene: 73965
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 34,201,017 bp
  • T to C, chromosome 2 at 34,175,924 bp
  • G to A, chromosome 2 at 35,061,319 bp
  • T to C, chromosome 2 at 125,758,171 bp
  • G to A, chromosome 2 at 164,909,418 bp
  • T to C, chromosome 3 at 68,918,005 bp
  • C to A, chromosome 3 at 133,487,339 bp
  • T to G, chromosome 4 at 21,816,892 bp
  • T to C, chromosome 4 at 156,200,045 bp
  • G to A, chromosome 5 at 75,076,399 bp
  • G to T, chromosome 5 at 94,317,047 bp
  • G to A, chromosome 5 at 122,746,308 bp
  • T to C, chromosome 5 at 127,554,632 bp
  • A to G, chromosome 5 at 143,075,759 bp
  • T to C, chromosome 5 at 149,581,846 bp
  • T to A, chromosome 6 at 113,545,038 bp
  • G to A, chromosome 7 at 12,890,478 bp
  • A to T, chromosome 7 at 75,136,383 bp
  • T to A, chromosome 7 at 82,683,049 bp
  • G to T, chromosome 7 at 114,791,298 bp
  • C to A, chromosome 7 at 127,419,311 bp
  • T to C, chromosome 8 at 27,152,953 bp
  • A to C, chromosome 8 at 36,512,155 bp
  • A to T, chromosome 9 at 38,254,243 bp
  • C to T, chromosome 9 at 100,888,328 bp
  • T to C, chromosome 9 at 107,961,544 bp
  • A to G, chromosome 10 at 78,984,660 bp
  • A to T, chromosome 10 at 79,268,332 bp
  • C to T, chromosome 11 at 36,139,743 bp
  • T to G, chromosome 11 at 103,056,459 bp
  • T to A, chromosome 11 at 113,867,967 bp
  • A to G, chromosome 12 at 64,992,617 bp
  • A to T, chromosome 13 at 23,461,716 bp
  • A to G, chromosome 13 at 47,088,035 bp
  • G to T, chromosome 14 at 35,562,513 bp
  • A to G, chromosome 14 at 65,931,331 bp
  • A to G, chromosome 14 at 66,101,617 bp
  • A to G, chromosome 16 at 34,256,233 bp
  • C to G, chromosome 17 at 14,943,653 bp
  • T to C, chromosome 17 at 21,722,674 bp
  • T to C, chromosome 17 at 29,098,514 bp
  • A to T, chromosome 18 at 37,421,799 bp
  • A to C, chromosome 18 at 64,512,022 bp
  • C to A, chromosome 19 at 6,306,784 bp
  • T to A, chromosome 19 at 13,768,732 bp
  • T to C, chromosome 19 at 42,766,720 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7504 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045577-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.