Strain Name:
C57BL/6J-MtgxR7523Btlr/Mmmh
Stock Number:
045595-MU
Citation ID:
RRID:MMRRC_045595-MU
Other Names:
R7523 (G1)
Major Collection:

Strain Information

Ubr5
Name: ubiquitin protein ligase E3 component n-recognin 5
Synonyms: Edd, Edd1, 4432411E13Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 70790
VEGA: 15
Homologene: 9295
Rtel1
Name: regulator of telomere elongation helicase 1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 269400
Homologene: 13168
Slc44a2
Name: solute carrier family 44, member 2
Synonyms: CTL2, 1110028E10Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 68682
VEGA: 9
Homologene: 10711
Gmps
Name: guanine monophosphate synthetase
Synonyms: Gm9479
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229363
HGNC: HGNC:4378
Homologene: 68367
Sf3b3
Name: splicing factor 3b, subunit 3
Synonyms: 1810061H24Rik, SAP130, 5730409A01Rik, D8Ertd633e, RSE1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 101943
Homologene: 6579
Ptprg
Name: protein tyrosine phosphatase receptor type G
Synonyms: RPTPgamma, 5430405N12Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 19270
HGNC: HGNC:9671
Homologene: 2129
Fxr1
Name: FMR1 autosomal homolog 1
Synonyms: Fxr1h, 9530073J07Rik, 1110050J02Rik, Fxr1p
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 14359
HGNC: HGNC:4023
Homologene: 3573
Tle1
Name: transducin-like enhancer of split 1
Synonyms: Grg1, Estm14, Tle4l, C230057C06Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 21885
Homologene: 21058
Ptbp3
Name: polypyrimidine tract binding protein 3
Synonyms: Rod1, 5830471K22Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230257
Homologene: 55872
Nfx1
Name: nuclear transcription factor, X-box binding 1
Synonyms: 1300017N15Rik, TEG-42, 3000003M19Rik, Tex42
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 74164
HGNC: HGNC:7803
Homologene: 1875
Pik3c3
Name: phosphatidylinositol 3-kinase catalytic subunit type 3
Synonyms: 5330434F23Rik, Vps34
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225326
HGNC: HGNC:8974
Homologene: 1986
Mdn1
Name: midasin AAA ATPase 1
Synonyms: D4Abb1e, 4833432B22Rik, LOC213784
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100019
Homologene: 39689
Camkmt
Name: calmodulin-lysine N-methyltransferase
Synonyms: 1700106N22Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 73582
VEGA: 17
Homologene: 11704
Tenm2
Name: teneurin transmembrane protein 2
Synonyms: D3Bwg1534e, Ten-m2, 9330187F13Rik, Odz2, 2610040L17Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 23964
Homologene: 22672
Zfp90
Name: zinc finger protein 90
Synonyms: Zfp83, 6430515L01Rik, KRAB17, Nk10 expressed protein, Zfp64, NK10
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 22751
Homologene: 86800
Cyth1
Name: cytohesin 1
Synonyms: CTH-1, Pscd1, CLM1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19157
HGNC: HGNC:9501
Homologene: 31262
Zbtb20
Name: zinc finger and BTB domain containing 20
Synonyms: 7330412A13Rik, 1300017A20Rik, D16Wsu73e, Zfp288, A930017C21Rik, HOF
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 56490
Homologene: 9226
Nectin2
Name: nectin cell adhesion molecule 2
Synonyms: MPH, Cd112, Pvrl2, nectin-2, Pvs
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 19294
HGNC: HGNC:9707
Homologene: 86092
Exosc10
Name: exosome component 10
Synonyms: Pmscl2, p2, p3, p4, RRP6, PM-Scl, PM/Scl-100
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 50912
HGNC: HGNC:9138
Homologene: 31105
Tubgcp2
Name: tubulin, gamma complex component 2
Synonyms: 1700022B05Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 74237
Homologene: 55980
Vps13a
Name: vacuolar protein sorting 13A
Synonyms: 4930543C13Rik, 4930516E05Rik, D330038K10Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 271564
VEGA: 19
HGNC: HGNC:1908
Homologene: 22068
Prss35
Name: serine protease 35
Synonyms: 6030424L22Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244954
Homologene: 17734
Atp12a
Name: ATPase, H+/K+ transporting, nongastric, alpha polypeptide
Synonyms: Atp1al1, cHKA, ATPase H+K+-transporting, alpha 2, HKalpha2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 192113
VEGA: 14
Homologene: 68197
Ano4
Name: anoctamin 4
Synonyms: A330096O15Rik, Tmem16d
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 320091
Homologene: 66599
Dnah10
Name: dynein, axonemal, heavy chain 10
Synonyms: Dnahc10
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 56087
HGNC: HGNC:2941
Homologene: 25816
Fbn2
Name: fibrillin 2
Synonyms: Fib-2, Sne, sy
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 14119
VEGA: 18
HGNC: HGNC:3604
Homologene: 1515
Lrp1b
Name: low density lipoprotein-related protein 1B
Synonyms: 9630004P12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 94217
HGNC: HGNC:6693
Homologene: 56810
Stard9
Name: StAR related lipid transfer domain containing 9
Synonyms: E230025N21Rik, Kif16a, 4831403C07Rik, N-3 kinesin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 668880
Homologene: 130712
Ltbp2
Name: latent transforming growth factor beta binding protein 2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 16997
HGNC: HGNC:6715
Homologene: 369
Dazl
Name: deleted in azoospermia-like
Synonyms: Dazla, Tpx2, Daz-like, Tpx-2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 13164
VEGA: 17
Homologene: 86954
Krt78
Name: keratin 78
Synonyms: 2310030B04Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 332131
VEGA: 15
Homologene: 65261
Myo15b
Name: myosin XVB
Synonyms: LOC217328, E330039G21Rik, LOC380737
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217328
Vmn2r114
Name: vomeronasal 2, receptor 114
Synonyms: EG666002
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 666002
Homologene: 86604
Man2a2
Name: mannosidase 2, alpha 2
Synonyms: alpha mannosidase IIx, 4931438M07Rik, 1700052O22Rik, MX
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 140481
HGNC: HGNC:6825
Homologene: 55954
Zfp811
Name: zinc finger protein 811
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240063
Nat3
Name: N-acetyltransferase 3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 17962
Homologene: 69026
Or8j3
Name: olfactory receptor family 8 subfamily J member 3
Synonyms: Olfr1045, MOR185-2, MTPCR11, Olfr28, GA_x6K02T2Q125-47672825-47671878
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 259019
Homologene: 128246
4932414N04Rik
Name: RIKEN cDNA 4932414N04 gene
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 75721
Homologene: 138468
Ciao2b
Name: cytosolic iron-sulfur assembly component 2B
Synonyms: Fam96b, 1110019N10Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 68523
Homologene: 6115
Nexn
Name: nexilin
Synonyms: 1110046H09Rik, nF actin binding protein
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 68810
Homologene: 44892
Or2c1
Name: olfactory receptor family 2 subfamily C member 1
Synonyms: GA_x54KRFPKG5P-348087-349025, Olfr15, MOR256-17, OR3
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 18312
HGNC: HGNC:8242
Homologene: 7459
Ptpn22
Name: protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
Synonyms: 70zpep, Ptpn8
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 19260
HGNC: HGNC:9652
Homologene: 7498
Ppt2
Name: palmitoyl-protein thioesterase 2
Synonyms: 0610007M19Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 54397
HGNC: HGNC:9326
Homologene: 10448
Pdcd4
Name: programmed cell death 4
Synonyms: MA-3, D19Ucla1, TIS
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18569
VEGA: 19
HGNC: HGNC:8763
Homologene: 7879
Tada2b
Name: transcriptional adaptor 2B
Synonyms: LOC231151
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231151
Homologene: 51007
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 2 at 41,511,461 bp
  • T to A, chromosome 2 at 68,662,480 bp
  • A to T, chromosome 2 at 68,739,329 bp
  • T to C, chromosome 2 at 86,198,045 bp
  • T to C, chromosome 2 at 120,699,597 bp
  • G to A, chromosome 2 at 181,322,315 bp
  • T to C, chromosome 3 at 34,039,543 bp
  • T to C, chromosome 3 at 64,011,666 bp
  • A to G, chromosome 3 at 103,912,015 bp
  • T to C, chromosome 3 at 152,247,178 bp
  • A to T, chromosome 4 at 32,667,270 bp
  • A to G, chromosome 4 at 41,016,119 bp
  • A to G, chromosome 4 at 59,546,159 bp
  • A to T, chromosome 4 at 72,145,418 bp
  • A to T, chromosome 4 at 88,690,792 bp
  • A to T, chromosome 4 at 148,563,842 bp
  • T to C, chromosome 5 at 36,476,767 bp
  • A to G, chromosome 5 at 124,747,739 bp
  • A to G, chromosome 7 at 19,730,112 bp
  • G to C, chromosome 7 at 80,368,865 bp
  • A to G, chromosome 7 at 140,006,870 bp
  • T to C, chromosome 8 at 67,547,574 bp
  • G to A, chromosome 8 at 104,641,772 bp
  • A to G, chromosome 8 at 106,423,913 bp
  • A to G, chromosome 8 at 110,813,720 bp
  • A to G, chromosome 9 at 21,345,992 bp
  • T to A, chromosome 9 at 86,755,374 bp
  • C to A, chromosome 10 at 88,971,395 bp
  • A to T, chromosome 11 at 36,078,581 bp
  • A to T, chromosome 11 at 115,890,858 bp
  • TGGGCAA to T, chromosome 11 at 118,183,923 bp
  • T to C, chromosome 12 at 84,791,034 bp
  • T to G, chromosome 14 at 12,237,130 bp
  • T to C, chromosome 14 at 56,365,968 bp
  • T to C, chromosome 15 at 38,004,055 bp
  • T to C, chromosome 15 at 101,946,601 bp
  • T to C, chromosome 16 at 3,839,699 bp
  • T to C, chromosome 16 at 43,610,512 bp
  • A to G, chromosome 17 at 23,310,637 bp
  • A to T, chromosome 17 at 32,797,752 bp
  • A to G, chromosome 17 at 34,626,803 bp
  • G to A, chromosome 17 at 50,287,541 bp
  • A to G, chromosome 17 at 85,391,628 bp
  • C to T, chromosome 18 at 30,293,655 bp
  • T to C, chromosome 18 at 58,066,080 bp
  • G to T, chromosome 19 at 16,703,789 bp
  • G to T, chromosome 19 at 53,910,948 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7523 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045595-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.