Strain Name:
C57BL/6J-MtgxR7525Btlr/Mmmh
Stock Number:
045597-MU
Citation ID:
RRID:MMRRC_045597-MU
Other Names:
R7525 (G1)
Major Collection:

Strain Information

Arhgap10
Name: Rho GTPase activating protein 10
Synonyms: A930033B01Rik, PSGAP-m, PSGAP-s
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 78514
Homologene: 12695
Ptch1
Name: patched 1
Synonyms: Ptc, wig, Patched 1, A230106A15Rik, Ptc1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 19206
HGNC: HGNC:9585
Homologene: 223
H2-D1
Name: histocompatibility 2, D region locus 1
Synonyms: H-2D
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 14964
Homologene: 128352
Prkdc
Name: protein kinase, DNA activated, catalytic polypeptide
Synonyms: DNAPDcs, DNA-PK, slip, XRCC7, DNA-PKcs, dxnph, DOXNPH
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 19090
HGNC: HGNC:9413
Homologene: 5037
Eml4
Name: echinoderm microtubule associated protein like 4
Synonyms: 4930443C24Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 78798
VEGA: 17
HGNC: HGNC:1316
Homologene: 56841
Usp38
Name: ubiquitin specific peptidase 38
Synonyms: 4833420O05Rik, 4631402N15Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 74841
Homologene: 12367
Fblim1
Name: filamin binding LIM protein 1
Synonyms: Cal, migfilin(s), Fblp1, 2410043F08Rik, migfilin
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 74202
Homologene: 56774
Ankib1
Name: ankyrin repeat and IBR domain containing 1
Synonyms: 2310061P20Rik, 4631416I11Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 70797
Homologene: 19076
Lrch4
Name: leucine-rich repeats and calponin homology (CH) domain containing 4
Synonyms: LRRN4, 2810008P14Rik, LRN, 2900069C24Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231798
HGNC: HGNC:6691
Homologene: 20532
Dop1a
Name: DOP1 leucine zipper like protein A
Synonyms: Dopey1, B130005I07Rik, D9Ertd809e
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320615
Homologene: 26645
Akap9
Name: A kinase anchor protein 9
Synonyms: G1-448-15, 5730481H23Rik, mei2-5, AKAP450, repro12
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100986
HGNC: HGNC:379
Homologene: 134583
Syne1
Name: spectrin repeat containing, nuclear envelope 1
Synonyms: SYNE-1, A330049M09Rik, enaptin165, nesprin-1, C130039F11Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 64009
VEGA: 10
Homologene: 52329
Pip4k2c
Name: phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
Synonyms: Pip5k2c
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 117150
VEGA: 10
Homologene: 23484
Pikfyve
Name: phosphoinositide kinase, FYVE type zinc finger containing
Synonyms: PipkIII, Pip5k3, 5230400C17Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18711
Homologene: 32115
Ecpas
Name: Ecm29 proteasome adaptor and scaffold
Synonyms: AI314180
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230249
Homologene: 6056
Psap
Name: prosaposin
Synonyms: SGP-1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19156
HGNC: HGNC:9498
Homologene: 37680
Eif2ak1
Name: eukaryotic translation initiation factor 2 alpha kinase 1
Synonyms: Hri
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 15467
Homologene: 8290
Tmub1
Name: transmembrane and ubiquitin-like domain containing 1
Synonyms: Hops, 2010004O20Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 64295
Homologene: 11187
Bsdc1
Name: BSD domain containing 1
Synonyms: 1110063F24Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100383
Homologene: 32386
Hspbp1
Name: HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
Synonyms: 1500019G21Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 66245
Homologene: 40827
Zfp398
Name: zinc finger protein 398
Synonyms: 5730513I23Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 272347
Homologene: 12358
2900026A02Rik
Name: RIKEN cDNA 2900026A02 gene
Synonyms: LOC231620, Gm449
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 243219
Homologene: 129566
Dpy19l4
Name: dpy-19 like 4
Synonyms: Narg3, LOC381510
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 381510
Homologene: 18773
Hectd4
Name: HECT domain E3 ubiquitin protein ligase 4
Synonyms: Gm15800
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269700
Homologene: 28297
Pgap1
Name: post-GPI attachment to proteins 1
Synonyms: D230012E17Rik, oto, PGAP1, 5033403E17Rik, 9030223K07Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241062
Homologene: 41605
Prom2
Name: prominin 2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 192212
Homologene: 44536
Tmem98
Name: transmembrane protein 98
Synonyms: Rwhs, 6530411B15Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 103743
Homologene: 9185
Ttn
Name: titin
Synonyms: connectin, shru, D330041I19Rik, 2310057K23Rik, mdm, D830007G01Rik, 2310074I15Rik, 1100001C23Rik, 2310036G12Rik, L56
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Mroh7
Name: maestro heat-like repeat family member 7
Synonyms: Gm1027, LOC381538, Heatr8
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 381538
Homologene: 19633
Trim16
Name: tripartite motif-containing 16
Synonyms: 9130006M08Rik, EBBP
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 94092
Homologene: 4726
Pcsk5
Name: proprotein convertase subtilisin/kexin type 5
Synonyms: PC5/6A, PC6, b2b1549Clo, SPC6, PC5A, b2b585Clo
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18552
VEGA: 19
HGNC: HGNC:8747
Homologene: 21244
Pdzph1
Name: PDZ and pleckstrin homology domains 1
Synonyms: 2610034M16Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 69239
Homologene: 130756
Emilin2
Name: elastin microfibril interfacer 2
Synonyms: basilin, FOAP-10
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 246707
VEGA: 17
Homologene: 36483
Mgam
Name: maltase-glucoamylase
Synonyms: 6030407P20Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232714
HGNC: HGNC:7043
Homologene: 130099
Hrc
Name: histidine rich calcium binding protein
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 15464
HGNC: HGNC:5178
Homologene: 137234
Lrp1b
Name: low density lipoprotein-related protein 1B
Synonyms: 9630004P12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 94217
HGNC: HGNC:6693
Homologene: 56810
Insr
Name: insulin receptor
Synonyms: IR-B, 4932439J01Rik, D630014A15Rik, IR, CD220, IR-A
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 16337
HGNC: HGNC:6091
Homologene: 20090
Ankar
Name: ankyrin and armadillo repeat containing
Synonyms: 4932422E22Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 319695
Homologene: 85163
Fcrl6
Name: Fc receptor-like 6
Synonyms: FcRH6, ENSMUSG00000070504, moFcRH6, mIFGP6
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 677296
Homologene: 88414
Mfsd13a
Name: major facilitator superfamily domain containing 13a
Synonyms: Tmem180, 4930449A08Rik, 4930538D17Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 75146
Homologene: 12592
Or10ak12
Name: olfactory receptor family 10 subfamily AK member 12
Synonyms: Olfr1335, MOR259-5, GA_x6K02T2QD9B-18723799-18724749, Olfr1334-ps1, MOR259-12, GA_x6K02T2QD9B-18726774-18727577
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 435804
Homologene: 138635
Vmn2r63
Name: vomeronasal 2, receptor 63
Synonyms: EG435975
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 435975
Homologene: 104832
Slc39a12
Name: solute carrier family 39 (zinc transporter), member 12
Synonyms: LOC277468
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 277468
Homologene: 17654
Aadacl4fm2
Name: AADACL4 family member 2
Synonyms: Gm13124
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 627085
Homologene: 135767
Arhgef4
Name: Rho guanine nucleotide exchange factor 4
Synonyms: 9330140K16Rik, Asef, C230030N03Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226970
HGNC: HGNC:684
Homologene: 49414
Akt3
Name: thymoma viral proto-oncogene 3
Synonyms: Nmf350, PKB gamma, D930002M15Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 23797
HGNC: HGNC:393
Homologene: 55904
Lrit2
Name: leucine-rich repeat, immunoglobulin-like and transmembrane domains 2
Synonyms: A930010E21Rik, Lrrc22
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 239038
VEGA: 14
Homologene: 18292
Vmn2r74
Name: vomeronasal 2, receptor 74
Synonyms: EG546980
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 546980
Homologene: 115466
Mylk
Name: myosin, light polypeptide kinase
Synonyms: telokin, nmMlck, Mlck, 9530072E15Rik, MLCK108, MLCK210, A930019C19Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 107589
HGNC: HGNC:7590
Homologene: 14202
Plekhh3
Name: pleckstrin homology domain containing, family H (with MyTH4 domain) member 3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217198
Homologene: 11787
Xkr6
Name: X-linked Kx blood group related 6
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219149
Homologene: 18287
Whamm
Name: WAS protein homolog associated with actin, golgi membranes and microtubules
Synonyms: Whdc1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 434204
Homologene: 45851
Slc24a3
Name: solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
Synonyms: NCKX3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 94249
Homologene: 41390
Camk4
Name: calcium/calmodulin-dependent protein kinase IV
Synonyms: D18Bwg0362e, Ca2+/calmodulin-dependent protein kinase type IV/Gr, A430110E23Rik, CaMKIV, CaMKIV/Gr
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 12326
VEGA: 18
HGNC: HGNC:1464
Homologene: 100780
Parp14
Name: poly (ADP-ribose) polymerase family, member 14
Synonyms: CoaSt6, 1600029O10Rik, collaborator of Stat6
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 547253
Homologene: 19697
Cyp2d9
Name: cytochrome P450, family 2, subfamily d, polypeptide 9
Synonyms: Cyp2d, testosterone 16alpha-hydroxylase, P450-2D
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 13105
VEGA: 15
Homologene: 86099
Or8g55
Name: olfactory receptor family 8 subfamily G member 55
Synonyms: GA_x6K02T2PVTD-33572803-33573747, MOR171-17, Olfr972
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258603
VEGA: 9
Homologene: 121532
Or8d1
Name: olfactory receptor family 8 subfamily D member 1
Synonyms: GA_x6K02T2PVTD-32550930-32551856, Olfr26, MOR171-9, MTPCR09
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 18324
VEGA: 9
HGNC: HGNC:8481
Homologene: 79676
Dhrs13
Name: dehydrogenase/reductase 13
Synonyms: dehydrogenase/reductase (SDR family) member 13, 2610209N15Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 70451
Homologene: 64807
Taar8c
Name: trace amine-associated receptor 8C
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 494546
Homologene: 77586
Gzme
Name: granzyme E
Synonyms: Ctla6, CCP3, Ctla-6, MCSP-2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 14942
VEGA: 14
Homologene: 133275
Or51aa2
Name: olfactory receptor family 51 subfamily AA member 2
Synonyms: EG545985, Olfr612, MOR15-3, GA_x6K02T2PBJ9-6251685-6250741
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 545985
Homologene: 79675
Pcdhga1
Name: protocadherin gamma subfamily A, 1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93709
HGNC: HGNC:8696
Homologene: 56824
Slc6a16
Name: solute carrier family 6, member 16
Synonyms: LOC381884
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 381884
Homologene: 49366
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 34,809,704 bp
  • T to A, chromosome 1 at 54,530,922 bp
  • C to T, chromosome 1 at 65,244,426 bp
  • T to C, chromosome 1 at 72,688,641 bp
  • T to A, chromosome 1 at 172,597,672 bp
  • T to A, chromosome 1 at 177,020,107 bp
  • T to A, chromosome 2 at 14,494,461 bp
  • A to T, chromosome 2 at 40,657,416 bp
  • T to A, chromosome 2 at 76,731,229 bp
  • T to C, chromosome 2 at 127,532,781 bp
  • A to C, chromosome 2 at 145,613,530 bp
  • G to A, chromosome 4 at 11,317,160 bp
  • A to G, chromosome 4 at 58,847,038 bp
  • A to T, chromosome 4 at 106,709,702 bp
  • A to T, chromosome 4 at 118,809,494 bp
  • A to T, chromosome 4 at 129,461,684 bp
  • A to T, chromosome 4 at 141,590,080 bp
  • A to G, chromosome 4 at 144,565,010 bp
  • T to G, chromosome 5 at 3,755,734 bp
  • C to G, chromosome 5 at 3,968,745 bp
  • T to A, chromosome 5 at 24,446,013 bp
  • T to C, chromosome 5 at 113,183,355 bp
  • C to A, chromosome 5 at 121,343,665 bp
  • T to A, chromosome 5 at 137,639,465 bp
  • T to C, chromosome 5 at 143,886,898 bp
  • T to G, chromosome 6 at 40,766,020 bp
  • A to G, chromosome 6 at 47,865,818 bp
  • A to G, chromosome 7 at 4,663,436 bp
  • A to T, chromosome 7 at 42,926,982 bp
  • T to C, chromosome 7 at 45,259,113 bp
  • A to G, chromosome 7 at 45,336,379 bp
  • G to T, chromosome 7 at 81,593,850 bp
  • A to G, chromosome 7 at 85,961,302 bp
  • A to T, chromosome 7 at 103,539,131 bp
  • A to T, chromosome 8 at 3,192,642 bp
  • A to G, chromosome 8 at 77,420,070 bp
  • A to G, chromosome 8 at 81,014,246 bp
  • A to T, chromosome 9 at 38,855,238 bp
  • T to A, chromosome 9 at 39,874,139 bp
  • C to T, chromosome 9 at 86,506,290 bp
  • T to G, chromosome 10 at 5,185,559 bp
  • T to C, chromosome 10 at 24,101,866 bp
  • T to C, chromosome 10 at 60,299,474 bp
  • A to G, chromosome 10 at 127,208,904 bp
  • T to G, chromosome 11 at 62,820,754 bp
  • C to A, chromosome 11 at 78,032,434 bp
  • A to G, chromosome 11 at 80,817,518 bp
  • A to G, chromosome 11 at 101,166,619 bp
  • C to T, chromosome 13 at 63,511,714 bp
  • A to G, chromosome 14 at 37,072,493 bp
  • A to C, chromosome 14 at 56,119,333 bp
  • G to T, chromosome 14 at 63,819,161 bp
  • T to A, chromosome 15 at 82,454,092 bp
  • A to T, chromosome 16 at 15,672,327 bp
  • G to A, chromosome 16 at 34,988,987 bp
  • A to T, chromosome 16 at 35,857,491 bp
  • A to G, chromosome 17 at 35,265,933 bp
  • A to G, chromosome 17 at 58,967,341 bp
  • T to C, chromosome 17 at 71,274,979 bp
  • T to A, chromosome 17 at 83,445,950 bp
  • T to C, chromosome 18 at 33,185,032 bp
  • T to C, chromosome 18 at 37,662,228 bp
  • T to C, chromosome 19 at 17,642,590 bp
  • T to C, chromosome 19 at 46,369,277 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7525 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045597-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.