Loading Mouse GIF
Loading...

Strain Name:
C57BL/6J-MtgxR7530Btlr/Mmmh
Stock Number:
045602-MU
Citation ID:
RRID:MMRRC_045602-MU
Other Names:
R7530 (G1)
Major Collection:

Strain Information

Chat
Name: choline O-acetyltransferase
Synonyms: B230380D24Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 12647
VEGA: 14
HGNC: HGNC:1912
Homologene: 40693
Ptprf
Name: protein tyrosine phosphatase receptor type F
Synonyms: LAR, RPTP-LAR
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 19268
HGNC: HGNC:9670
Homologene: 20623
Ssu72
Name: Ssu72 RNA polymerase II CTD phosphatase homolog (yeast)
Synonyms: 2610101M12Rik, 1190002E22Rik, 1500011L16Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 68991
Homologene: 6754
Kansl2
Name: KAT8 regulatory NSL complex subunit 2
Synonyms: 2310037I24Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 69612
VEGA: 15
Homologene: 32367
Utp20
Name: UTP20 small subunit processome component
Synonyms: mDRIM, DRIM, 3830408P06Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70683
VEGA: 10
Homologene: 38373
Nudt5
Name: nudix hydrolase 5
Synonyms: nudix (nucleoside diphosphate linked moiety X)-type motif 5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 53893
HGNC: HGNC:8052
Homologene: 5388
Atp5mc2
Name: ATP synthase membrane subunit c locus 2
Synonyms: 1810041M08Rik, Atp5g2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 67942
HGNC: HGNC:842
Homologene: 57052
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 125,584,538 bp
  • C to T, chromosome 1 at 179,708,480 bp
  • T to C, chromosome 2 at 5,864,368 bp
  • T to C, chromosome 2 at 32,572,301 bp
  • T to A, chromosome 2 at 86,386,171 bp
  • T to A, chromosome 2 at 93,661,653 bp
  • A to G, chromosome 2 at 104,994,570 bp
  • T to C, chromosome 2 at 152,324,292 bp
  • C to T, chromosome 2 at 156,003,920 bp
  • T to C, chromosome 3 at 79,650,461 bp
  • T to A, chromosome 3 at 83,058,682 bp
  • A to G, chromosome 4 at 58,815,317 bp
  • T to C, chromosome 4 at 118,212,748 bp
  • A to G, chromosome 4 at 155,731,329 bp
  • A to C, chromosome 5 at 67,745,628 bp
  • T to C, chromosome 5 at 100,674,142 bp
  • T to C, chromosome 6 at 24,450,623 bp
  • G to T, chromosome 6 at 40,709,218 bp
  • G to A, chromosome 6 at 67,954,397 bp
  • G to A, chromosome 7 at 19,702,904 bp
  • A to G, chromosome 7 at 27,507,972 bp
  • G to A, chromosome 7 at 28,361,928 bp
  • A to C, chromosome 7 at 56,331,972 bp
  • A to G, chromosome 7 at 58,773,976 bp
  • G to T, chromosome 7 at 141,813,799 bp
  • A to T, chromosome 9 at 106,068,390 bp
  • A to G, chromosome 9 at 108,111,956 bp
  • G to T, chromosome 9 at 113,989,173 bp
  • T to A, chromosome 10 at 24,905,953 bp
  • C to T, chromosome 10 at 43,999,073 bp
  • G to A, chromosome 10 at 88,753,006 bp
  • A to T, chromosome 10 at 117,817,452 bp
  • A to C, chromosome 10 at 129,133,980 bp
  • A to G, chromosome 11 at 73,388,363 bp
  • C to T, chromosome 11 at 87,611,876 bp
  • A to G, chromosome 11 at 106,265,761 bp
  • T to A, chromosome 12 at 16,717,206 bp
  • T to A, chromosome 13 at 61,163,117 bp
  • T to C, chromosome 13 at 73,846,959 bp
  • A to T, chromosome 14 at 32,408,958 bp
  • C to A, chromosome 15 at 76,185,644 bp
  • T to C, chromosome 15 at 78,386,316 bp
  • T to C, chromosome 15 at 98,529,015 bp
  • A to T, chromosome 15 at 102,667,748 bp
  • A to G, chromosome 16 at 30,582,601 bp
  • A to T, chromosome 16 at 90,761,634 bp
  • A to G, chromosome 16 at 91,404,313 bp
  • A to G, chromosome 18 at 74,731,731 bp
  • T to G, chromosome 19 at 6,322,275 bp
  • G to T, chromosome 19 at 6,322,276 bp
  • A to T, chromosome 19 at 28,948,721 bp
  • A to T, chromosome 19 at 38,215,905 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7530 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045602-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.