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Strain Name:
C57BL/6J-MtgxR7532Btlr/Mmmh
Stock Number:
045604-MU
Citation ID:
RRID:MMRRC_045604-MU
Other Names:
R7532 (G1)
Major Collection:

Strain Information

Smc2
Name: structural maintenance of chromosomes 2
Synonyms: 5730502P04Rik, CAP-E, Fin16, Smc2l1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 14211
Homologene: 4705
Vcl
Name: vinculin
Synonyms: metavinculin
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 22330
VEGA: 14
Homologene: 7594
Chd9
Name: chromodomain helicase DNA binding protein 9
Synonyms: 1810014J18Rik, AD013, A330063D19Rik, 9030205D12Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 109151
Homologene: 11844
Tsc22d1
Name: TSC22 domain family, member 1
Synonyms: TSC-22, Egr5, Tgfb1i4
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 21807
Homologene: 7573
Hectd1
Name: HECT domain E3 ubiquitin protein ligase 1
Synonyms: A630086P08Rik, opm, b2b327Clo
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 207304
VEGA: 12
Homologene: 9115
Dync1h1
Name: dynein cytoplasmic 1 heavy chain 1
Synonyms: MAP1C, dynein heavy chain, retrograde transport, Dnec1, Loa, 9930018I23Rik, Dnchc1, Swl
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13424
HGNC: HGNC:2961
Homologene: 1053
Ap1g1
Name: adaptor protein complex AP-1, gamma 1 subunit
Synonyms: gamma-adaptin, Adtg, D8Ertd374e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11765
HGNC: HGNC:555
Homologene: 47995
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 110,138,159 bp
  • T to A, chromosome 1 at 146,901,401 bp
  • T to C, chromosome 1 at 174,070,098 bp
  • A to T, chromosome 1 at 185,352,326 bp
  • G to A, chromosome 1 at 194,644,819 bp
  • C to A, chromosome 2 at 35,321,577 bp
  • C to T, chromosome 2 at 36,480,126 bp
  • C to T, chromosome 2 at 60,669,213 bp
  • T to G, chromosome 2 at 148,823,207 bp
  • T to C, chromosome 2 at 174,426,396 bp
  • G to T, chromosome 3 at 58,585,232 bp
  • G to A, chromosome 3 at 105,668,210 bp
  • A to T, chromosome 3 at 146,468,191 bp
  • G to T, chromosome 4 at 33,004,166 bp
  • A to G, chromosome 4 at 43,249,565 bp
  • T to C, chromosome 4 at 52,451,013 bp
  • A to T, chromosome 4 at 88,720,853 bp
  • T to A, chromosome 5 at 108,802,240 bp
  • G to T, chromosome 5 at 143,194,897 bp
  • T to A, chromosome 6 at 62,379,931 bp
  • T to C, chromosome 6 at 70,913,637 bp
  • T to A, chromosome 6 at 119,779,631 bp
  • A to T, chromosome 6 at 125,963,704 bp
  • T to C, chromosome 6 at 138,153,506 bp
  • A to T, chromosome 7 at 10,580,354 bp
  • T to G, chromosome 7 at 14,561,264 bp
  • G to A, chromosome 7 at 45,178,037 bp
  • C to T, chromosome 7 at 45,808,024 bp
  • A to T, chromosome 7 at 85,410,414 bp
  • C to A, chromosome 7 at 140,925,184 bp
  • T to C, chromosome 8 at 71,489,463 bp
  • A to G, chromosome 8 at 90,994,565 bp
  • T to C, chromosome 8 at 109,860,164 bp
  • C to T, chromosome 9 at 44,315,384 bp
  • T to G, chromosome 9 at 107,592,522 bp
  • T to G, chromosome 9 at 111,467,528 bp
  • C to T, chromosome 10 at 24,675,987 bp
  • A to G, chromosome 11 at 67,091,095 bp
  • A to G, chromosome 11 at 80,198,906 bp
  • T to A, chromosome 12 at 51,790,450 bp
  • G to T, chromosome 12 at 65,053,371 bp
  • C to A, chromosome 12 at 110,651,577 bp
  • T to C, chromosome 13 at 60,730,886 bp
  • A to G, chromosome 13 at 71,960,195 bp
  • C to A, chromosome 14 at 21,029,324 bp
  • T to C, chromosome 14 at 76,416,046 bp
  • A to T, chromosome 15 at 59,367,411 bp
  • A to G, chromosome 15 at 102,359,149 bp
  • A to C, chromosome 15 at 103,896,052 bp
  • T to C, chromosome 16 at 23,027,044 bp
  • G to A, chromosome 16 at 56,267,180 bp
  • T to C, chromosome 17 at 32,188,789 bp
  • T to G, chromosome 17 at 38,559,620 bp
  • C to T, chromosome 18 at 35,536,742 bp
  • T to C, chromosome 19 at 4,201,523 bp
  • A to G, chromosome 19 at 11,303,959 bp
  • T to C, chromosome 19 at 33,583,064 bp
  • T to A, chromosome 19 at 53,232,158 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7532 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045604-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.