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Strain Name:
C57BL/6J-MtgxR7532Btlr/Mmmh
Stock Number:
045604-MU
Citation ID:
RRID:MMRRC_045604-MU
Other Names:
R7532 (G1)
Major Collection:

Strain Information

Smc2
Name: structural maintenance of chromosomes 2
Synonyms: 5730502P04Rik, CAP-E, Fin16, Smc2l1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 14211
Homologene: 4705
Vcl
Name: vinculin
Synonyms: metavinculin
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 22330
VEGA: 14
Homologene: 7594
Chd9
Name: chromodomain helicase DNA binding protein 9
Synonyms: 1810014J18Rik, AD013, A330063D19Rik, 9030205D12Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 109151
Homologene: 11844
Tsc22d1
Name: TSC22 domain family, member 1
Synonyms: TSC-22, Egr5, Tgfb1i4
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 21807
Homologene: 7573
Hectd1
Name: HECT domain E3 ubiquitin protein ligase 1
Synonyms: A630086P08Rik, opm, b2b327Clo
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 207304
VEGA: 12
Homologene: 9115
Dync1h1
Name: dynein cytoplasmic 1 heavy chain 1
Synonyms: MAP1C, dynein heavy chain, retrograde transport, Dnec1, Loa, 9930018I23Rik, Dnchc1, Swl
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13424
HGNC: HGNC:2961
Homologene: 1053
Ap1g1
Name: adaptor protein complex AP-1, gamma 1 subunit
Synonyms: gamma-adaptin, Adtg, D8Ertd374e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11765
HGNC: HGNC:555
Homologene: 47995
C2cd2l
Name: C2 calcium-dependent domain containing 2-like
Synonyms: 1300006O23Rik, Tmem24
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 71764
VEGA: 9
Homologene: 8876
Erc1
Name: ELKS/RAB6-interacting/CAST family member 1
Synonyms: RAB6IP2B, RAB6IP2A, 5033405M01Rik, B430107L16Rik, 9630025C19Rik, Rab6ip2, Elks1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 111173
Homologene: 14229
Prpf39
Name: pre-mRNA processing factor 39
Synonyms: Srcs1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 328110
Homologene: 32377
Ms4a14
Name: membrane-spanning 4-domains, subfamily A, member 14
Synonyms: LOC383435
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 383435
Homologene: 138453
Ifrd2
Name: interferon-related developmental regulator 2
Synonyms: SKMc15, 1810034A24Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 15983
HGNC: HGNC:5457
Homologene: 21341
Cyth2
Name: cytohesin 2
Synonyms: CLM2, Pscd2, ARNO
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 19158
HGNC: HGNC:9502
Homologene: 32116
Bpnt1
Name: 3'(2'), 5'-bisphosphate nucleotidase 1
Synonyms: BPntase, bisphosphate 3'-nucleotidase 1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 23827
HGNC: HGNC:1096
Homologene: 4437
Selenot
Name: selenoprotein T
Synonyms: SelT, 5730408P04Rik, 2810407C02Rik, Selt
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 69227
Homologene: 32304
Dapk1
Name: death associated protein kinase 1
Synonyms: 2310039H24Rik, D13Ucla1, 2810425C21Rik, DAP-Kinase
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 69635
VEGA: 13
HGNC: HGNC:2674
Homologene: 3626
Plxna2
Name: plexin A2
Synonyms: OCT, Plxn2, 2810428A13Rik, PlexA2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18845
HGNC: HGNC:9100
Homologene: 56427
Enpp1
Name: ectonucleotide pyrophosphatase/phosphodiesterase 1
Synonyms: PC-1, NPP1, Pca-1, Npps, Pca, Ly-41, Pdnp1, twy, CD203c, E-NPP1, 4833416E15Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 18605
HGNC: HGNC:3356
Homologene: 38151
Washc5
Name: WASH complex subunit 5
Synonyms: strumpellin, E430025E21Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223593
VEGA: 15
Homologene: 8898
Dclk3
Name: doublecortin-like kinase 3
Synonyms: Click-I, -II related, Dcamkl3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 245038
Homologene: 70580
Unc13b
Name: unc-13 homolog B
Synonyms: Unc13h2, Munc13-2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 22249
Homologene: 31376
Ccser1
Name: coiled-coil serine rich 1
Synonyms: 6230405M12Rik, C130092O11Rik, Fam190a
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232035
Homologene: 28086
Kng2
Name: kininogen 2
Synonyms: Kininogen-II
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 385643
HGNC: HGNC:6383
Homologene: 88343
Brinp3
Name: bone morphogenetic protein/retinoic acid inducible neural specific 3
Synonyms: B830045N13Rik, Fam5c
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 215378
Homologene: 17786
Rnf135
Name: ring finger protein 135
Synonyms: U 2-3-0, MGC13061, 0610037N03Rik, 2410006N06Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71956
Homologene: 12427
Cdh7
Name: cadherin 7, type 2
Synonyms: CDH7L1, 9330156F07Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241201
HGNC: HGNC:1766
Homologene: 68391
Vmn1r69
Name: vomeronasal 1 receptor 69
Synonyms: V1re9
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 252904
Homologene: 120153
Myh3
Name: myosin, heavy polypeptide 3, skeletal muscle, embryonic
Synonyms: MyHC-emb, Myhs-e, Myhse
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17883
HGNC: HGNC:7573
Homologene: 20553
Impg2
Name: interphotoreceptor matrix proteoglycan 2
Synonyms: PG10.2, IPM200, Spacrcan
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224224
Homologene: 9439
Sp7
Name: Sp7 transcription factor 7
Synonyms: Osx, 6430578P22Rik, osterix
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 170574
VEGA: 15
Homologene: 15607
Lipo3
Name: lipase, member O3
Synonyms: Lipo1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 381236
Homologene: 103863
Mucl2
Name: mucin-like 2
Synonyms: Spt-1, Spt1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 20770
Homologene: 137219
Ano2
Name: anoctamin 2
Synonyms: Tmem16b
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243634
HGNC: HGNC:1183
Homologene: 23221
Gtpbp3
Name: GTP binding protein 3
Synonyms: Gtpbp3, 2410009F13Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 70359
Homologene: 6600
Gm5239
Name: predicted pseudogene 5239
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 383341
VEGA: 18
Klhl9
Name: kelch-like 9
Synonyms: C530050O22Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242521
Homologene: 23125
Mgst1
Name: microsomal glutathione S-transferase 1
Synonyms: 1500002K10Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 56615
HGNC: HGNC:7061
Homologene: 10544
Stom
Name: stomatin
Synonyms: stomatin, protein 7.2b, Epb7.2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13830
HGNC: HGNC:3383
Homologene: 81681
Or6n2
Name: olfactory receptor family 6 subfamily N member 2
Synonyms: GA_x6K02T2P20D-21108443-21107490, MOR105-5P, Olfr430
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 258713
Homologene: 17362
Vmn2r8
Name: vomeronasal 2, receptor 8
Synonyms: EG627479
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 627479
Homologene: 129606
Vmn1r90
Name: vomeronasal 1 receptor 90
Synonyms: B430211C08Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 627280
Homologene: 122945
Itgb6
Name: integrin beta 6
Synonyms: 4831415H04Rik, 2210409C20Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16420
HGNC: HGNC:6161
Homologene: 685
Spata1
Name: spermatogenesis associated 1
Synonyms: SP-2, 4921536I21Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 70951
Homologene: 23356
Rragd
Name: Ras-related GTP binding D
Synonyms: 5730543C08Rik, D4Ertd174e, C030003H22Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 52187
Homologene: 49667
Kcnd3
Name: potassium voltage-gated channel, Shal-related family, member 3
Synonyms: potassium channel Kv4.3M, potassium channel Kv4.3L, Kv4.3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 56543
HGNC: HGNC:6239
Homologene: 21036
Vmn2r69
Name: vomeronasal 2, receptor 69
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330581
Homologene: 115466
Irx1
Name: Iroquois homeobox 1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 16371
Homologene: 19065
Nelfcd
Name: negative elongation factor complex member C/D, Th1l
Synonyms: 2410003I03Rik, trihydrophobin 1, Th1l
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 57314
Homologene: 9496
Nlrp6
Name: NLR family, pyrin domain containing 6
Synonyms: Nalp6
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101613
Homologene: 15881
Rad9a
Name: RAD9 checkpoint clamp component A
Synonyms: Rad9
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 19367
VEGA: 19
HGNC: HGNC:9827
Homologene: 32118
Cst13
Name: cystatin 13
Synonyms: cystatin T, Cymg1, 1700006C19Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 69294
Homologene: 41707
Or1j13
Name: olfactory receptor family 1 subfamily J member 13
Synonyms: GA_x6K02T2NLDC-33174915-33173974, MOR136-2, Olfr341
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258952
Homologene: 74160
Ephx3
Name: epoxide hydrolase 3
Synonyms: 2310063B19Rik, Abhd9
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 71932
Homologene: 69386
Esp34
Name: exocrine gland secreted peptide 34
Synonyms: Gm20410
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 100126773
Spmip9
Name: sperm microtubule inner protein 9
Synonyms: 1700011F03Rik, Tex37
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 74221
Homologene: 17643
Gfy
Name: golgi-associated olfactory signaling regulator
Synonyms: Gm581, Goofy
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100039953
Homologene: 85248
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 110,138,159 bp
  • T to A, chromosome 1 at 146,901,401 bp
  • T to C, chromosome 1 at 174,070,098 bp
  • A to T, chromosome 1 at 185,352,326 bp
  • G to A, chromosome 1 at 194,644,819 bp
  • C to A, chromosome 2 at 35,321,577 bp
  • C to T, chromosome 2 at 36,480,126 bp
  • C to T, chromosome 2 at 60,669,213 bp
  • T to G, chromosome 2 at 148,823,207 bp
  • T to C, chromosome 2 at 174,426,396 bp
  • G to T, chromosome 3 at 58,585,232 bp
  • G to A, chromosome 3 at 105,668,210 bp
  • A to T, chromosome 3 at 146,468,191 bp
  • G to T, chromosome 4 at 33,004,166 bp
  • A to G, chromosome 4 at 43,249,565 bp
  • T to C, chromosome 4 at 52,451,013 bp
  • A to T, chromosome 4 at 88,720,853 bp
  • T to A, chromosome 5 at 108,802,240 bp
  • G to T, chromosome 5 at 143,194,897 bp
  • T to A, chromosome 6 at 62,379,931 bp
  • T to C, chromosome 6 at 70,913,637 bp
  • T to A, chromosome 6 at 119,779,631 bp
  • A to T, chromosome 6 at 125,963,704 bp
  • T to C, chromosome 6 at 138,153,506 bp
  • A to T, chromosome 7 at 10,580,354 bp
  • T to G, chromosome 7 at 14,561,264 bp
  • G to A, chromosome 7 at 45,178,037 bp
  • C to T, chromosome 7 at 45,808,024 bp
  • A to T, chromosome 7 at 85,410,414 bp
  • C to A, chromosome 7 at 140,925,184 bp
  • T to C, chromosome 8 at 71,489,463 bp
  • A to G, chromosome 8 at 90,994,565 bp
  • T to C, chromosome 8 at 109,860,164 bp
  • C to T, chromosome 9 at 44,315,384 bp
  • T to G, chromosome 9 at 107,592,522 bp
  • T to G, chromosome 9 at 111,467,528 bp
  • C to T, chromosome 10 at 24,675,987 bp
  • A to G, chromosome 11 at 67,091,095 bp
  • A to G, chromosome 11 at 80,198,906 bp
  • T to A, chromosome 12 at 51,790,450 bp
  • G to T, chromosome 12 at 65,053,371 bp
  • C to A, chromosome 12 at 110,651,577 bp
  • T to C, chromosome 13 at 60,730,886 bp
  • A to G, chromosome 13 at 71,960,195 bp
  • C to A, chromosome 14 at 21,029,324 bp
  • T to C, chromosome 14 at 76,416,046 bp
  • A to T, chromosome 15 at 59,367,411 bp
  • A to G, chromosome 15 at 102,359,149 bp
  • A to C, chromosome 15 at 103,896,052 bp
  • T to C, chromosome 16 at 23,027,044 bp
  • G to A, chromosome 16 at 56,267,180 bp
  • T to C, chromosome 17 at 32,188,789 bp
  • T to G, chromosome 17 at 38,559,620 bp
  • C to T, chromosome 18 at 35,536,742 bp
  • T to C, chromosome 19 at 4,201,523 bp
  • A to G, chromosome 19 at 11,303,959 bp
  • T to C, chromosome 19 at 33,583,064 bp
  • T to A, chromosome 19 at 53,232,158 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7532 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045604-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.