Strain Name:
C57BL/6J-MtgxR7542Btlr/Mmmh
Stock Number:
045614-MU
Citation ID:
RRID:MMRRC_045614-MU
Other Names:
R7542 (G1)
Major Collection:

Strain Information

Frem2
Name: Fras1 related extracellular matrix protein 2
Synonyms: my, b2b1562Clo, 6030440P17Rik, ne, 8430406N05Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242022
Homologene: 18454
Manba
Name: mannosidase, beta A, lysosomal
Synonyms: 2410030O07Rik, B930014J03Rik, Bmn
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 110173
HGNC: HGNC:6831
Homologene: 4317
Tmem59l
Name: transmembrane protein 59-like
Synonyms: 5330410G16Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 67937
Homologene: 8104
Odf2l
Name: outer dense fiber of sperm tails 2-like
Synonyms: 9630045K08Rik, 4733401D09Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 52184
Homologene: 12011
Fam53a
Name: family with sequence similarity 53, member A
Synonyms: DNTNP, 5430419M09Rik, 2410018C17Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 74504
Homologene: 18660
Urb2
Name: URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 382038
Homologene: 8859
Med25
Name: mediator complex subunit 25
Synonyms: 2610034E13Rik, 2610529E18Rik, ESTM2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 75613
Homologene: 12614
Mcph1
Name: microcephaly, primary autosomal recessive 1
Synonyms: D030046N04Rik, 5430437K10Rik, BRIT1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244329
HGNC: HGNC:6954
Homologene: 32586
Tep1
Name: telomerase associated protein 1
Synonyms: Tp1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 21745
VEGA: 14
Homologene: 5157
Thbs1
Name: thrombospondin 1
Synonyms: TSP1, tbsp1, Thbs-1, TSP-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 21825
Homologene: 31142
Minar1
Name: membrane integral NOTCH2 associated receptor 1
Synonyms: AF529169, DD1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 209743
Homologene: 17782
Furin
Name: furin, paired basic amino acid cleaving enzyme
Synonyms: PACE, Fur, SPC1, 9130404I01Rik, Pcsk3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18550
HGNC: HGNC:8568
Homologene: 1930
Alms1
Name: ALMS1, centrosome and basal body associated
Synonyms: Alstrom syndrome 1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 236266
HGNC: HGNC:428
Homologene: 49406
Elapor1
Name: endosome-lysosome associated apoptosis and autophagy regulator 1
Synonyms: 5330417C22Rik, Iir, Inceptor
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229722
Homologene: 23249
Gna15
Name: guanine nucleotide binding protein, alpha 15
Synonyms: Galpha15, G[a]15
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14676
HGNC: HGNC:4383
Homologene: 1563
Prim1
Name: DNA primase, p49 subunit
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19075
HGNC: HGNC:9369
Homologene: 730
Rras
Name: related RAS viral (r-ras) oncogene
Synonyms: Rras1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20130
Homologene: 4565
Maea
Name: macrophage erythroblast attacher
Synonyms: Gid9, 1110030D19Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 59003
Homologene: 4298
Ttc13
Name: tetratricopeptide repeat domain 13
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234875
Homologene: 11569
Akap11
Name: A kinase anchor protein 11
Synonyms: 6330501D17Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219181
HGNC: HGNC:369
Homologene: 8279
Kdm2a
Name: lysine (K)-specific demethylase 2A
Synonyms: Gm4560, Fbl7, Fbxl11, 5530401A10Rik, Jhdm1a, lalina, Cxxc8
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 225876
Homologene: 56564
Grm2
Name: glutamate receptor, metabotropic 2
Synonyms: 4930441L02Rik, Gprc1b, mGluR2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 108068
HGNC: HGNC:4594
Homologene: 20229
Rundc3a
Name: RUN domain containing 3A
Synonyms: Rpip8, Rap2ip
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 51799
Homologene: 4871
Alox12e
Name: arachidonate lipoxygenase, epidermal
Synonyms: Aloxe, 8-LOX, e-LOX1, Alox12-ps1, Alox12-ps2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11685
Homologene: 105868
Akap6
Name: A kinase anchor protein 6
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238161
VEGA: 12
HGNC: HGNC:376
Homologene: 3157
Csk
Name: c-src tyrosine kinase
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12988
VEGA: 9
HGNC: HGNC:2444
Homologene: 55818
Reln
Name: reelin
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19699
HGNC: HGNC:9957
Homologene: 3699
Setd1b
Name: SET domain containing 1B
Synonyms: KMT2G
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 208043
Homologene: 134654
Tesk1
Name: testis specific protein kinase 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 21754
Homologene: 4577
Nav3
Name: neuron navigator 3
Synonyms: Pomfil1p, steerin 3, unc53H3, 9630020C08Rik, 4732483H20Rik, POMFIL1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 260315
Homologene: 56688
Fat4
Name: FAT atypical cadherin 4
Synonyms: 6030410K14Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 329628
Homologene: 14377
Fsip2
Name: fibrous sheath-interacting protein 2
Synonyms: OTTMUSG00000013335
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241516
Homologene: 110349
Megf10
Name: multiple EGF-like-domains 10
Synonyms: LOC240312, 3000002B06Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 70417
Homologene: 23771
Dll1
Name: delta like canonical Notch ligand 1
Synonyms: Delta1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 13388
HGNC: HGNC:2908
Homologene: 4104
Pde4dip
Name: phosphodiesterase 4D interacting protein (myomegalin)
Synonyms: D130016K21Rik, 9430063L05Rik, Usmg4, 4732458A06Rik, D3Bwg1078e
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 83679
Homologene: 66961
Fbxw10
Name: F-box and WD-40 domain protein 10
Synonyms: SM25H2, SM2SH2, Fbw10
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 213980
Homologene: 32757
Kcnh6
Name: potassium voltage-gated channel, subfamily H (eag-related), member 6
Synonyms: m-erg2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 192775
Homologene: 32740
Zcwpw1
Name: zinc finger, CW type with PWWP domain 1
Synonyms: LOC381678
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 381678
Homologene: 9944
Disp2
Name: dispatched RND transporter family member 2
Synonyms: DispB, B230210L08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 214240
Homologene: 24916
Rab7b
Name: RAB7B, member RAS oncogene family
Synonyms: Rab7b, 5430435G22Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226421
Homologene: 64833
AW551984
Name: expressed sequence AW551984
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244810
HGNC: HGNC:6658
Zfp202
Name: zinc finger protein 202
Synonyms: C130037E22Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 80902
Homologene: 68317
Lrrc9
Name: leucine rich repeat containing 9
Synonyms: 4921529O18Rik, 4930432K16Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 78257
Homologene: 12692
Tgs1
Name: trimethylguanosine synthase 1
Synonyms: Pimt, Ncoa6ip, D4Ertd800e
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 116940
Homologene: 32608
Myod1
Name: myogenic differentiation 1
Synonyms: Myod-1, MyoD, MYF3, bHLHc1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17927
HGNC: HGNC:7611
Homologene: 7857
Trim30c
Name: tripartite motif-containing 30C
Synonyms: Trim30-2, Gm5598
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 434219
Adam24
Name: ADAM metallopeptidase domain 24
Synonyms: Dtgn5
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 13526
HGNC: HGNC:203
Homologene: 137232
Cdk5r1
Name: cyclin dependent kinase 5, regulatory subunit 1
Synonyms: p25, D11Bwg0379e, p35
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12569
HGNC: HGNC:1775
Homologene: 31200
Or4c107
Name: olfactory receptor family 4 subfamily C member 107
Synonyms: MOR233-17, GA_x6K02T2Q125-50437014-50437949, Olfr1212, MOR233-20
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258241
Homologene: 66154
Glb1l3
Name: galactosidase, beta 1 like 3
Synonyms: 4921509F24Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 70893
Homologene: 72240
Trpc4
Name: transient receptor potential cation channel, subfamily C, member 4
Synonyms: Trp4, Trrp4, CCE1, STRPC4
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 22066
Homologene: 22955
Kcnc3
Name: potassium voltage gated channel, Shaw-related subfamily, member 3
Synonyms: KShIIID, Kcr2-3, Kv3.3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16504
HGNC: HGNC:6235
Homologene: 3650
Ccpg1
Name: cell cycle progression 1
Synonyms: 9430028F23Rik, 1700030B06Rik, 1810073J13Rik, D9Ertd392e
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 72278
Homologene: 3487
Clgn
Name: calmegin
Synonyms: calnexin-t, 4930459O04Rik, A2/6, Cln
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12745
HGNC: HGNC:2060
Homologene: 68392
Retreg1
Name: reticulophagy regulator 1
Synonyms: 1810015C04Rik, Fam134b
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 66270
VEGA: 15
Homologene: 10368
Tulp1
Name: TUB like protein 1
Synonyms: Tulp1l
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22157
Homologene: 2491
Dnah7c
Name: dynein, axonemal, heavy chain 7C
Synonyms: Dnahc7c
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 100101919
Homologene: 41287
Pxdc1
Name: PX domain containing 1
Synonyms: 1300014I06Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 66895
Homologene: 12051
Cgref1
Name: cell growth regulator with EF hand domain 1
Synonyms: CGR11, 1110004G24Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 68567
Homologene: 4790
Vmn2r43
Name: vomeronasal 2, receptor 43
Synonyms: EC2-V2R
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 381838
Homologene: 113703
Pcdha3
Name: protocadherin alpha 3
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 192163
HGNC: HGNC:8669
Homologene: 129613
Pcdha2
Name: protocadherin alpha 2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 353234
HGNC: HGNC:8668
Homologene: 135719
Defb2
Name: defensin beta 2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 13215
Scgb2b18
Name: secretoglobin, family 2B, member 18
Synonyms: Abpbg18, Gm4692
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100043856
Homologene: 83171
Dchs2
Name: dachsous cadherin related 2
Synonyms: LOC229459
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 100534287
Iqcn
Name: IQ motif containing N
Synonyms: Gm16486
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 637079
Homologene: 141171
Gm8011
Name: predicted gene 8011
Type: Gene
Species: Mouse
Chromosome: 14
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 46,784,498 bp
  • C to T, chromosome 1 at 131,711,641 bp
  • A to T, chromosome 2 at 82,984,852 bp
  • A to T, chromosome 2 at 88,958,775 bp
  • C to T, chromosome 2 at 118,121,174 bp
  • A to G, chromosome 2 at 118,791,118 bp
  • A to G, chromosome 3 at 38,981,355 bp
  • A to T, chromosome 3 at 38,981,621 bp
  • A to T, chromosome 3 at 53,652,579 bp
  • A to G, chromosome 3 at 54,315,654 bp
  • A to G, chromosome 3 at 83,269,284 bp
  • A to G, chromosome 3 at 97,766,655 bp
  • A to T, chromosome 3 at 108,458,227 bp
  • T to C, chromosome 3 at 135,566,593 bp
  • A to C, chromosome 3 at 145,153,436 bp
  • A to G, chromosome 4 at 3,595,439 bp
  • G to T, chromosome 4 at 43,445,941 bp
  • C to A, chromosome 5 at 21,955,181 bp
  • A to T, chromosome 5 at 30,933,593 bp
  • T to C, chromosome 5 at 33,371,663 bp
  • A to G, chromosome 5 at 33,607,471 bp
  • A to T, chromosome 5 at 123,148,447 bp
  • T to C, chromosome 5 at 137,819,523 bp
  • A to T, chromosome 6 at 85,629,362 bp
  • T to C, chromosome 7 at 8,255,489 bp
  • A to T, chromosome 7 at 33,173,322 bp
  • A to G, chromosome 7 at 44,595,714 bp
  • A to T, chromosome 7 at 44,891,791 bp
  • G to A, chromosome 7 at 45,020,342 bp
  • A to T, chromosome 7 at 46,376,673 bp
  • A to G, chromosome 7 at 80,393,459 bp
  • A to T, chromosome 7 at 104,382,218 bp
  • C to T, chromosome 8 at 18,631,689 bp
  • T to C, chromosome 8 at 21,843,344 bp
  • A to T, chromosome 8 at 40,680,809 bp
  • T to C, chromosome 8 at 70,485,164 bp
  • A to G, chromosome 8 at 70,708,766 bp
  • A to T, chromosome 8 at 83,395,545 bp
  • A to G, chromosome 8 at 124,028,588 bp
  • A to T, chromosome 8 at 124,675,103 bp
  • C to A, chromosome 9 at 26,818,195 bp
  • T to A, chromosome 9 at 39,594,631 bp
  • T to C, chromosome 9 at 40,211,147 bp
  • C to A, chromosome 9 at 57,629,000 bp
  • T to A, chromosome 9 at 73,012,459 bp
  • T to A, chromosome 9 at 89,601,911 bp
  • A to T, chromosome 9 at 106,651,169 bp
  • A to G, chromosome 10 at 81,514,302 bp
  • A to T, chromosome 10 at 109,823,533 bp
  • T to C, chromosome 10 at 128,018,034 bp
  • T to C, chromosome 11 at 62,850,596 bp
  • T to C, chromosome 11 at 70,321,756 bp
  • T to C, chromosome 11 at 80,478,364 bp
  • T to A, chromosome 11 at 102,400,045 bp
  • A to G, chromosome 11 at 106,014,561 bp
  • A to G, chromosome 12 at 53,069,234 bp
  • T to C, chromosome 12 at 72,506,320 bp
  • A to G, chromosome 13 at 34,638,163 bp
  • A to T, chromosome 14 at 42,466,784 bp
  • G to A, chromosome 14 at 50,862,491 bp
  • A to T, chromosome 14 at 78,510,292 bp
  • T to A, chromosome 15 at 25,941,210 bp
  • C to T, chromosome 17 at 15,370,347 bp
  • T to C, chromosome 17 at 28,363,755 bp
  • G to A, chromosome 18 at 36,940,089 bp
  • G to A, chromosome 18 at 36,947,731 bp
  • C to A, chromosome 18 at 57,189,570 bp
  • G to A, chromosome 19 at 4,333,830 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7542 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045614-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.