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Strain Name:
C57BL/6J-MtgxR7543Btlr/Mmmh
Stock Number:
045615-MU
Citation ID:
RRID:MMRRC_045615-MU
Other Names:
R7543 (G1)
Major Collection:

Strain Information

Pkd1
Name: polycystin 1, transient receptor potential channel interacting
Synonyms: polycystin-1, PC1, PC-1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 18763
VEGA: 17
HGNC: HGNC:9008
Homologene: 250
Il4i1
Name: interleukin 4 induced 1
Synonyms: Fig1-ps, Fig1, H46, H4, H-46, H-4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 14204
Homologene: 22567
Ddx23
Name: DEAD box helicase 23
Synonyms: 4921506D17Rik, 3110082M05Rik, DEAD (Asp-Glu-Ala-Asp) box polypeptide 23
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 74351
Homologene: 3542
Topors
Name: topoisomerase I binding, arginine/serine-rich
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 106021
Homologene: 4237
Wdfy3
Name: WD repeat and FYVE domain containing 3
Synonyms: Ggtb3, 2610509D04Rik, D5Ertd66e, Bwf1, Bchs, Alfy
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 72145
Homologene: 22855
Ttc27
Name: tetratricopeptide repeat domain 27
Synonyms: 2610511O17Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 74196
VEGA: 17
Homologene: 41191
Aspscr1
Name: ASPSCR1 tether for SLC2A4, UBX domain containing
Synonyms: ASPCR1, RCC17, ASPC, 1190006K01Rik, TUG, ASPL
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 68938
Homologene: 41550
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 64,735,840 bp
  • T to C, chromosome 1 at 71,075,430 bp
  • T to C, chromosome 1 at 133,627,030 bp
  • G to T, chromosome 1 at 161,157,247 bp
  • C to A, chromosome 2 at 25,577,398 bp
  • T to A, chromosome 2 at 37,469,432 bp
  • A to T, chromosome 2 at 155,549,835 bp
  • G to A, chromosome 3 at 30,607,039 bp
  • T to C, chromosome 3 at 54,729,248 bp
  • T to C, chromosome 3 at 73,701,733 bp
  • T to C, chromosome 3 at 142,566,580 bp
  • A to G, chromosome 4 at 40,268,312 bp
  • A to T, chromosome 4 at 41,413,993 bp
  • T to A, chromosome 4 at 137,402,572 bp
  • T to C, chromosome 4 at 143,398,423 bp
  • A to G, chromosome 4 at 152,108,034 bp
  • A to C, chromosome 5 at 101,936,059 bp
  • T to A, chromosome 5 at 125,482,856 bp
  • A to G, chromosome 5 at 149,754,139 bp
  • C to T, chromosome 6 at 5,168,400 bp
  • T to C, chromosome 6 at 5,784,464 bp
  • T to A, chromosome 6 at 34,048,935 bp
  • A to G, chromosome 6 at 86,106,225 bp
  • T to C, chromosome 6 at 89,322,855 bp
  • G to T, chromosome 6 at 124,861,392 bp
  • A to G, chromosome 6 at 143,841,179 bp
  • A to G, chromosome 7 at 24,275,108 bp
  • A to T, chromosome 7 at 28,414,286 bp
  • A to G, chromosome 7 at 44,836,775 bp
  • G to A, chromosome 7 at 44,846,079 bp
  • A to T, chromosome 7 at 81,466,146 bp
  • T to A, chromosome 7 at 107,815,101 bp
  • A to G, chromosome 7 at 118,545,756 bp
  • T to A, chromosome 8 at 111,132,888 bp
  • A to G, chromosome 9 at 18,644,732 bp
  • T to C, chromosome 9 at 106,554,226 bp
  • C to T, chromosome 9 at 108,218,081 bp
  • T to A, chromosome 10 at 58,271,264 bp
  • C to T, chromosome 10 at 69,951,016 bp
  • A to G, chromosome 10 at 80,314,886 bp
  • A to T, chromosome 11 at 61,744,971 bp
  • T to A, chromosome 11 at 99,072,253 bp
  • A to G, chromosome 11 at 120,709,423 bp
  • A to T, chromosome 12 at 55,868,212 bp
  • A to G, chromosome 12 at 75,906,842 bp
  • G to T, chromosome 12 at 110,614,107 bp
  • A to C, chromosome 12 at 112,852,202 bp
  • C to T, chromosome 13 at 11,638,431 bp
  • T to A, chromosome 13 at 67,347,889 bp
  • T to A, chromosome 13 at 74,674,634 bp
  • A to C, chromosome 13 at 120,154,754 bp
  • T to A, chromosome 14 at 54,144,235 bp
  • T to C, chromosome 15 at 3,977,903 bp
  • T to C, chromosome 15 at 8,225,392 bp
  • T to A, chromosome 15 at 34,530,447 bp
  • T to A, chromosome 15 at 44,683,452 bp
  • A to G, chromosome 15 at 98,658,258 bp
  • A to G, chromosome 15 at 102,031,461 bp
  • A to G, chromosome 15 at 103,009,754 bp
  • T to A, chromosome 16 at 43,898,209 bp
  • A to T, chromosome 17 at 15,807,515 bp
  • A to G, chromosome 17 at 24,595,253 bp
  • A to G, chromosome 17 at 32,820,560 bp
  • A to T, chromosome 17 at 34,050,456 bp
  • T to C, chromosome 17 at 36,014,851 bp
  • A to G, chromosome 17 at 57,058,106 bp
  • A to T, chromosome 17 at 74,717,750 bp
  • T to C, chromosome 18 at 61,756,901 bp
  • T to G, chromosome 18 at 74,274,449 bp
  • A to G, chromosome 19 at 11,521,791 bp
  • T to C, chromosome 19 at 42,198,863 bp
  • G to A, chromosome 19 at 55,278,183 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7543 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045615-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.