Strain Name:
C57BL/6J-MtgxR7591Btlr/Mmmh
Stock Number:
045638-MU
Citation ID:
RRID:MMRRC_045638-MU
Other Names:
R7591 (G1)
Major Collection:

Strain Information

Lamb1
Name: laminin B1
Synonyms: Lamb1-1, C80098, C81607, Lamb-1, D130003D08Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 16777
HGNC: HGNC:6486
Homologene: 1722
Dbh
Name: dopamine beta hydroxylase
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13166
HGNC: HGNC:2689
Homologene: 615
Ppcdc
Name: phosphopantothenoylcysteine decarboxylase
Synonyms: 1810057I13Rik, 8430432M10Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 66812
VEGA: 9
Homologene: 11049
Epop
Name: elongin BC and polycomb repressive complex 2 associated protein
Synonyms: E130012A19Rik, E13
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 103551
Homologene: 82351
Kif11
Name: kinesin family member 11
Synonyms: Knsl1, Eg5, Kifl1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 16551
VEGA: 19
HGNC: HGNC:6388
Homologene: 3322
Dennd2c
Name: DENN domain containing 2C
Synonyms: A930010I20Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 329727
Homologene: 19542
Dnttip2
Name: deoxynucleotidyltransferase, terminal, interacting protein 2
Synonyms: 4930588M11Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99480
Homologene: 124162
Kcnh5
Name: potassium voltage-gated channel, subfamily H (eag-related), member 5
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238271
VEGA: 12
HGNC: HGNC:6254
Homologene: 15858
Enpp5
Name: ectonucleotide pyrophosphatase/phosphodiesterase 5
Synonyms: D17Abb1e
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 83965
Homologene: 23313
St3gal1
Name: ST3 beta-galactoside alpha-2,3-sialyltransferase 1
Synonyms: Siat4a, CMP-N-acetylneuraminate: [beta-galactosidase alpha-2,3] sialytransferase, ST3GalI, Siat4
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 20442
VEGA: 15
Homologene: 7540
Nphp3
Name: nephronophthisis 3 (adolescent)
Synonyms: 3632410F03Rik, pcy, D330020E01Rik, nephrocystin 3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74025
HGNC: HGNC:7907
Homologene: 32697
Smad3
Name: SMAD family member 3
Synonyms: Smad 3, Madh3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 17127
HGNC: HGNC:6769
Homologene: 55937
Pigo
Name: phosphatidylinositol glycan anchor biosynthesis, class O
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56703
Homologene: 31761
Trim69
Name: tripartite motif-containing 69
Synonyms: Rnf36, 4921519C19Rik, Trif
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 70928
Homologene: 18827
Nalcn
Name: sodium leak channel, non-selective
Synonyms: Vgcnl1, A530023G15Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 338370
VEGA: 14
Homologene: 21832
Macc1
Name: metastasis associated in colon cancer 1
Synonyms: 4732474O15Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238455
Homologene: 18813
Rhobtb2
Name: Rho-related BTB domain containing 2
Synonyms: E130206H14Rik, Dbc2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 246710
VEGA: 14
Homologene: 22873
Slc5a4a
Name: solute carrier family 5, member 4a
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 64452
VEGA: 10
Plcl1
Name: phospholipase C-like 1
Synonyms: PLC-L, PRIP-1, C230017K02Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227120
HGNC: HGNC:9063
Homologene: 38155
Rp1l1
Name: retinitis pigmentosa 1 homolog like 1
Synonyms: Dcdc4, Rp1hl1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 271209
VEGA: 14
Homologene: 105870
Spata31h1
Name: SPATA31 subfamily H member 1
Synonyms: 4932415D10Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 102635990
VEGA: 10
Homologene: 82476
Itga1
Name: integrin alpha 1
Synonyms: Vla1, CD49A, E130012M19Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 109700
VEGA: 13
HGNC: HGNC:6134
Homologene: 57137
Fam149a
Name: family with sequence similarity 149, member A
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 212326
Homologene: 27540
Chrm3
Name: cholinergic receptor, muscarinic 3, cardiac
Synonyms: M3R, Chrm-3, muscarinic acetylcholine receptor 3
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 12671
HGNC: HGNC:1952
Homologene: 20191
Pramel27
Name: PRAME like 27
Synonyms: Gm13103
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 194225
Homologene: 129883
Vwa5b2
Name: von Willebrand factor A domain containing 5B2
Synonyms: EG328644
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 328643
Homologene: 28056
Vmn2r16
Name: vomeronasal 2, receptor 16
Synonyms: EG384220
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 384220
Homologene: 104825
Spata18
Name: spermatogenesis associated 18
Synonyms: 1700067I02Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 73472
Homologene: 17057
Skint9
Name: selection and upkeep of intraepithelial T cells 9
Synonyms: A030013N09Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329918
Homologene: 136292
Or4p7
Name: olfactory receptor family 4 subfamily P member 7
Synonyms: MOR225-6P, GA_x6K02T2Q125-49870417-49871388, Olfr1178
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258203
Homologene: 73979
Syne3
Name: spectrin repeat containing, nuclear envelope family member 3
Synonyms: nesprin-3alpha, nesprin-3, nesprin-3beta, 4831426I19Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 212073
VEGA: 12
Homologene: 17625
Vmn1r40
Name: vomeronasal 1 receptor 40
Synonyms: V1rb7
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 113855
Homologene: 113975
Zp1
Name: zona pellucida glycoprotein 1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 22786
Homologene: 33483
Or5b112
Name: olfactory receptor family 5 subfamily B member 112
Synonyms: MOR202-12, Olfr1466, GA_x6K02T2RE5P-3672907-3673839
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258689
HGNC: HGNC:8324
Homologene: 133677
Cyp4a14
Name: cytochrome P450, family 4, subfamily a, polypeptide 14
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 13119
Homologene: 134697
Impa2
Name: inositol monophosphatase 2
Synonyms: inositol (myo)-1(or 4)-monophosphatase 2, 2210415D20Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 114663
VEGA: 18
HGNC: HGNC:6051
Homologene: 22799
Cldn11
Name: claudin 11
Synonyms: oligodendrocyte-specific protein, Otm, Osp
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18417
HGNC: HGNC:8514
Homologene: 4093
Scrt1
Name: scratch family zinc finger 1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 170729
VEGA: 15
Homologene: 113534
Or4s2
Name: olfactory receptor family 4 subfamily S member 2
Synonyms: Olfr526-ps1, MOR230-9, GA_x6K02T2PRF0-44595-45531, GA_x6K02T2Q125-50121628-50122030, Olfr1191
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 404399
Eppk1
Name: epiplakin 1
Synonyms: EPPK, EPIPL1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223650
VEGA: 15
Homologene: 20006
Or14p1
Name: olfactory receptor family 14 subfamily P member 1
Synonyms: Olfr465, MOR218-3, GA_x6K02T2PB7A-3043252-3044200
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 258419
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 55,697,449 bp
  • A to G, chromosome 2 at 27,170,510 bp
  • G to A, chromosome 2 at 88,391,876 bp
  • A to C, chromosome 2 at 88,643,467 bp
  • G to A, chromosome 2 at 122,167,973 bp
  • A to T, chromosome 2 at 150,408,172 bp
  • A to T, chromosome 3 at 31,150,287 bp
  • T to A, chromosome 3 at 103,133,345 bp
  • T to A, chromosome 3 at 122,276,468 bp
  • T to C, chromosome 4 at 11,201,393 bp
  • T to C, chromosome 4 at 43,025,093 bp
  • A to T, chromosome 4 at 112,390,950 bp
  • A to G, chromosome 4 at 115,489,960 bp
  • A to T, chromosome 4 at 143,850,911 bp
  • A to T, chromosome 5 at 73,672,416 bp
  • T to A, chromosome 5 at 109,362,357 bp
  • A to T, chromosome 6 at 89,714,773 bp
  • T to A, chromosome 8 at 45,350,435 bp
  • A to T, chromosome 9 at 57,434,979 bp
  • C to T, chromosome 9 at 63,654,717 bp
  • T to C, chromosome 9 at 104,018,278 bp
  • T to C, chromosome 10 at 76,147,667 bp
  • C to A, chromosome 10 at 82,292,212 bp
  • A to T, chromosome 11 at 97,628,332 bp
  • C to A, chromosome 12 at 31,326,648 bp
  • T to C, chromosome 12 at 75,007,767 bp
  • A to G, chromosome 12 at 104,940,604 bp
  • T to C, chromosome 12 at 119,446,658 bp
  • A to T, chromosome 13 at 9,877,313 bp
  • A to G, chromosome 13 at 50,473,867 bp
  • T to C, chromosome 13 at 65,144,648 bp
  • G to A, chromosome 13 at 114,982,779 bp
  • T to C, chromosome 14 at 64,026,109 bp
  • A to G, chromosome 14 at 69,799,741 bp
  • T to C, chromosome 14 at 123,323,885 bp
  • A to G, chromosome 15 at 67,111,346 bp
  • T to C, chromosome 15 at 76,107,597 bp
  • C to A, chromosome 15 at 76,519,494 bp
  • A to G, chromosome 16 at 20,601,567 bp
  • G to A, chromosome 17 at 44,085,264 bp
  • T to C, chromosome 18 at 67,318,410 bp
  • T to C, chromosome 19 at 10,919,471 bp
  • A to G, chromosome 19 at 13,342,255 bp
  • A to G, chromosome 19 at 37,384,263 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7591 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045638-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.