Strain Name:
C57BL/6J-MtgxR7595Btlr/Mmmh
Stock Number:
045640-MU
Citation ID:
RRID:MMRRC_045640-MU
Other Names:
R7595 (G1)
Major Collection:

Strain Information

Rptor
Name: regulatory associated protein of MTOR, complex 1
Synonyms: raptor, 4932417H02Rik, Rap
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 74370
Homologene: 80210
Kdm5b
Name: lysine demethylase 5B
Synonyms: PLU-1, 2010009J12Rik, Plu1, Rb-Bp2, 2210016I17Rik, D1Ertd202e, Jarid1b
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 75605
Homologene: 48448
Eml4
Name: echinoderm microtubule associated protein like 4
Synonyms: 4930443C24Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 78798
VEGA: 17
HGNC: HGNC:1316
Homologene: 56841
Ralgapb
Name: Ral GTPase activating protein, beta subunit (non-catalytic)
Synonyms: B230339M05Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228850
Homologene: 10666
Sorbs1
Name: sorbin and SH3 domain containing 1
Synonyms: c-Cbl-associated protein, CAP, Sh3d5, 2310065E01Rik, 9530001P15Rik, Ponsin
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 20411
VEGA: 19
Homologene: 83252
Golph3l
Name: golgi phosphoprotein 3-like
Synonyms: GPP34R, 2010204I15Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229593
Homologene: 23082
Zwilch
Name: zwilch kinetochore protein
Synonyms: 2310031L18Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 68014
Homologene: 32381
Coch
Name: cochlin
Synonyms: Coch-5B2, D12H14S564E
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 12810
VEGA: 12
HGNC: HGNC:2180
Homologene: 20868
Kif26a
Name: kinesin family member 26A
Synonyms: N-11 kinesin
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 668303
Homologene: 18970
Bcar1
Name: breast cancer anti-estrogen resistance 1
Synonyms: p130Cas, Cas, Crkas
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12927
HGNC: HGNC:971
Homologene: 7674
Anxa6
Name: annexin A6
Synonyms: Camb, Anx6, AnxVI, Annexin VI, Cabm
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11749
HGNC: HGNC:544
Homologene: 55558
Dennd1c
Name: DENN domain containing 1C
Synonyms: 4432409M07Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 70785
VEGA: 17
Homologene: 11773
Primpol
Name: primase and polymerase (DNA-directed)
Synonyms: Ccdc111
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 408022
Homologene: 14065
Pkhd1l1
Name: polycystic kidney and hepatic disease 1-like 1
Synonyms: D86 mRNA, PKHDL1, fibrocystin L
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 192190
Homologene: 16332
Wdfy4
Name: WD repeat and FYVE domain containing 4
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 545030
Homologene: 83473
Fa2h
Name: fatty acid 2-hydroxylase
Synonyms: G630055L08Rik, Faxdc1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 338521
Homologene: 56284
Trank1
Name: tetratricopeptide repeat and ankyrin repeat containing 1
Synonyms: A230061D21Rik, LOC235639, C030048J01Rik, Lba1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320429
Homologene: 45845
Taar6
Name: trace amine-associated receptor 6
Synonyms: LOC215855
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 215855
Homologene: 27874
Ly75
Name: lymphocyte antigen 75
Synonyms: DEC-205, CD205
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17076
Homologene: 31085
Adamts16
Name: ADAM metallopeptidase with thrombospondin type 1 motif 16
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 271127
Homologene: 15146
Ttc21a
Name: tetratricopeptide repeat domain 21A
Synonyms: 4921538N17Rik, Thm2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74052
Homologene: 14728
Dthd1
Name: death domain containing 1
Synonyms: Gm17384
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100322896
Homologene: 123510
Cyp4a12a
Name: cytochrome P450, family 4, subfamily a, polypeptide 12a
Synonyms: Cyp4a12
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 277753
Homologene: 134044
Samd5
Name: sterile alpha motif domain containing 5
Synonyms: E130306M17Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 320825
Homologene: 37106
Spopfm1
Name: speckle-type BTB/POZ protein family member 1
Synonyms: Gm4778
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 212727
Or8g20
Name: olfactory receptor family 8 subfamily G member 20
Synonyms: IB3, MOR171-5, GA_x6K02T2PVTD-33181773-33180838, Olfr44
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 18343
VEGA: 9
HGNC: HGNC:8484
Homologene: 133633
Alox12
Name: arachidonate 12-lipoxygenase
Synonyms: P-12LO, Alox12p, 9930022G08Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11684
HGNC: HGNC:429
Homologene: 560
Klk1b4
Name: kallikrein 1-related pepidase b4
Synonyms: mGk-4, Ngfa, Ngfa
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18048
Homologene: 68141
Dytn
Name: dystrotelin
Synonyms: LOC241073
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241073
Homologene: 104042
Kcnc3
Name: potassium voltage gated channel, Shaw-related subfamily, member 3
Synonyms: Kv3.3, KShIIID, Kcr2-3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16504
HGNC: HGNC:6235
Homologene: 3650
Tmem132a
Name: transmembrane protein 132A
Synonyms: 6720481D13Rik, Hspa5bp1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 98170
Homologene: 75076
Pcsk4
Name: proprotein convertase subtilisin/kexin type 4
Synonyms: PC4, SPC5
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 18551
HGNC: HGNC:8746
Homologene: 22495
Atp6ap1l
Name: ATPase, H+ transporting, lysosomal accessory protein 1-like
Synonyms: EG435376
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 435376
Homologene: 28130
Zswim9
Name: zinc finger SWIM-type containing 9
Synonyms: 6330408A02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 321008
Homologene: 52386
4930516K23Rik
Name: RIKEN cDNA 4930516K23 gene
Type: Gene
Species: Mouse
Chromosome: 7
Gm5592
Name: predicted gene 5592
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 434172
Homologene: 45597
Cdh22
Name: cadherin 22
Synonyms: PB-cadherin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 104010
Homologene: 23148
Mfsd4b1
Name: major facilitator superfamily domain containing 4B1
Synonyms: AI317395
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 215929
Homologene: 77426
Cideb
Name: cell death-inducing DNA fragmentation factor, alpha subunit-like effector B
Synonyms: DFFA-like B, 1110030C18Rik, CIDE-B
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 12684
HGNC: HGNC:1977
Homologene: 7666
Ggh
Name: gamma-glutamyl hydrolase
Synonyms: gamma-GH
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 14590
HGNC: HGNC:4248
Homologene: 2881
Ikbip
Name: IKBKB interacting protein
Synonyms: 1700023M03Rik, 1200009F10Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 67454
Homologene: 12138
Fv1
Name: Friend virus susceptibility 1
Synonyms: Fv-1, Rv-1, Rv1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 14349
Srgn
Name: serglycin
Synonyms: Sgc, Prg1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19073
HGNC: HGNC:9361
Homologene: 137238
Klf14
Name: Kruppel-like transcription factor 14
Synonyms: BTEB5, 5330411L03Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 619665
Homologene: 76469
Spopfm3
Name: speckle-type BTB/POZ protein family member 3
Synonyms: Gm5286
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 383977
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 63,659,002 bp
  • T to A, chromosome 1 at 134,608,966 bp
  • A to G, chromosome 2 at 60,293,827 bp
  • G to A, chromosome 2 at 158,426,165 bp
  • A to G, chromosome 2 at 165,112,463 bp
  • A to G, chromosome 3 at 94,198,417 bp
  • A to G, chromosome 3 at 94,266,678 bp
  • A to G, chromosome 3 at 95,609,783 bp
  • C to G, chromosome 4 at 20,049,833 bp
  • C to A, chromosome 4 at 115,331,892 bp
  • A to G, chromosome 4 at 147,870,170 bp
  • A to G, chromosome 5 at 62,818,715 bp
  • T to C, chromosome 6 at 30,958,540 bp
  • T to C, chromosome 7 at 13,261,072 bp
  • A to G, chromosome 7 at 41,286,443 bp
  • A to G, chromosome 7 at 44,210,708 bp
  • G to A, chromosome 7 at 44,591,469 bp
  • T to C, chromosome 7 at 104,059,263 bp
  • A to G, chromosome 8 at 46,610,615 bp
  • T to A, chromosome 8 at 111,355,490 bp
  • A to C, chromosome 8 at 111,720,993 bp
  • A to C, chromosome 9 at 39,484,315 bp
  • A to G, chromosome 9 at 64,149,264 bp
  • T to C, chromosome 9 at 111,365,991 bp
  • T to C, chromosome 9 at 119,958,069 bp
  • T to C, chromosome 10 at 9,628,994 bp
  • C to T, chromosome 10 at 23,985,070 bp
  • A to T, chromosome 10 at 40,003,225 bp
  • T to A, chromosome 10 at 62,508,006 bp
  • T to A, chromosome 10 at 80,322,101 bp
  • A to G, chromosome 10 at 91,096,585 bp
  • C to A, chromosome 11 at 54,985,085 bp
  • T to A, chromosome 11 at 70,242,404 bp
  • T to A, chromosome 11 at 119,743,953 bp
  • T to A, chromosome 12 at 51,598,233 bp
  • C to T, chromosome 12 at 112,179,325 bp
  • A to G, chromosome 13 at 70,730,115 bp
  • A to T, chromosome 13 at 90,891,016 bp
  • C to T, chromosome 14 at 32,974,154 bp
  • T to C, chromosome 14 at 55,754,804 bp
  • T to A, chromosome 15 at 44,495,521 bp
  • A to C, chromosome 17 at 57,071,633 bp
  • A to G, chromosome 17 at 83,456,084 bp
  • G to A, chromosome 19 at 10,858,205 bp
  • A to T, chromosome 19 at 40,314,653 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7595 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045640-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.