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Strain Name:
C57BL/6J-MtgxR7577Btlr/Mmmh
Stock Number:
045662-MU
Citation ID:
RRID:MMRRC_045662-MU
Other Names:
R7577 (G1)
Major Collection:

Strain Information

Ylpm1
Name: YLP motif containing 1
Synonyms: ZAP, Zap3, A930013E17Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 56531
Homologene: 87707
Spred1
Name: sprouty protein with EVH-1 domain 1, related sequence
Synonyms: Spred-1, 5730461F13Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 114715
Homologene: 24919
Fos
Name: FBJ osteosarcoma oncogene
Synonyms: c-fos, D12Rfj1, cFos
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 14281
HGNC: HGNC:3796
Homologene: 3844
Trp53bp1
Name: transformation related protein 53 binding protein 1
Synonyms: 53BP1, p53BP1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 27223
Homologene: 4137
Myh10
Name: myosin, heavy polypeptide 10, non-muscle
Synonyms: nonmuscle myosin heavy chain II-B, NMHC-B, SMemb, nonmuscle myosin heavy chain IIB, 9330167F11Rik, 5730504C04Rik, NMHC II-B, Myhn2, Myosin IIB, Myhn-2, myosin IIB, Fltn, Fltn
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 77579
HGNC: HGNC:7568
Homologene: 55941
Prmt7
Name: protein arginine N-methyltransferase 7
Synonyms: 4933402B05Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 214572
Homologene: 10382
Akap9
Name: A kinase anchor protein 9
Synonyms: AKAP450, 5730481H23Rik, G1-448-15, repro12, mei2-5
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100986
HGNC: HGNC:379
Homologene: 134583
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to G, chromosome 1 at 74,158,915 bp
  • T to G, chromosome 1 at 128,300,732 bp
  • T to C, chromosome 1 at 143,647,304 bp
  • T to A, chromosome 1 at 151,718,312 bp
  • G to A, chromosome 1 at 177,767,697 bp
  • T to C, chromosome 1 at 192,983,577 bp
  • C to T, chromosome 2 at 21,205,102 bp
  • A to G, chromosome 2 at 23,207,825 bp
  • A to G, chromosome 2 at 25,355,591 bp
  • T to A, chromosome 2 at 60,229,704 bp
  • G to A, chromosome 2 at 67,514,965 bp
  • T to C, chromosome 2 at 104,051,198 bp
  • T to A, chromosome 2 at 111,479,132 bp
  • T to A, chromosome 2 at 117,177,325 bp
  • T to G, chromosome 2 at 121,236,638 bp
  • C to T, chromosome 2 at 152,932,441 bp
  • G to T, chromosome 2 at 156,328,376 bp
  • C to A, chromosome 2 at 163,315,902 bp
  • C to T, chromosome 3 at 35,975,794 bp
  • T to G, chromosome 3 at 73,051,115 bp
  • C to A, chromosome 3 at 95,628,645 bp
  • A to G, chromosome 3 at 122,174,014 bp
  • T to C, chromosome 3 at 137,904,797 bp
  • G to T, chromosome 4 at 63,562,444 bp
  • A to G, chromosome 4 at 132,579,752 bp
  • G to T, chromosome 4 at 133,615,209 bp
  • A to G, chromosome 4 at 134,564,503 bp
  • C to G, chromosome 5 at 3,968,745 bp
  • T to C, chromosome 5 at 87,929,962 bp
  • A to G, chromosome 5 at 89,225,867 bp
  • A to T, chromosome 5 at 99,967,254 bp
  • G to A, chromosome 5 at 105,236,149 bp
  • T to C, chromosome 5 at 106,896,043 bp
  • C to T, chromosome 5 at 114,766,489 bp
  • A to G, chromosome 6 at 6,863,423 bp
  • A to G, chromosome 6 at 54,485,524 bp
  • A to G, chromosome 6 at 85,615,320 bp
  • T to A, chromosome 6 at 129,516,077 bp
  • A to G, chromosome 7 at 28,154,423 bp
  • G to A, chromosome 7 at 44,550,792 bp
  • T to C, chromosome 7 at 45,862,379 bp
  • C to A, chromosome 7 at 46,287,855 bp
  • T to C, chromosome 7 at 80,396,986 bp
  • T to C, chromosome 8 at 28,891,421 bp
  • A to G, chromosome 8 at 36,146,942 bp
  • A to G, chromosome 8 at 69,814,435 bp
  • A to T, chromosome 8 at 84,838,479 bp
  • T to A, chromosome 8 at 105,375,399 bp
  • A to G, chromosome 8 at 106,242,203 bp
  • A to T, chromosome 9 at 44,348,961 bp
  • A to T, chromosome 9 at 105,864,688 bp
  • A to T, chromosome 9 at 108,070,619 bp
  • A to T, chromosome 9 at 119,072,254 bp
  • T to A, chromosome 10 at 5,124,820 bp
  • T to C, chromosome 10 at 42,318,611 bp
  • T to C, chromosome 10 at 61,695,886 bp
  • T to C, chromosome 10 at 62,590,670 bp
  • C to T, chromosome 10 at 69,992,572 bp
  • C to T, chromosome 10 at 79,066,491 bp
  • T to A, chromosome 10 at 81,880,189 bp
  • T to A, chromosome 10 at 88,549,325 bp
  • T to C, chromosome 10 at 130,354,755 bp
  • T to A, chromosome 11 at 68,745,980 bp
  • T to A, chromosome 11 at 89,503,971 bp
  • T to A, chromosome 11 at 100,081,221 bp
  • T to C, chromosome 12 at 70,062,706 bp
  • T to A, chromosome 12 at 84,997,220 bp
  • T to C, chromosome 12 at 85,475,097 bp
  • T to C, chromosome 12 at 103,197,307 bp
  • T to C, chromosome 12 at 116,485,866 bp
  • T to G, chromosome 13 at 12,602,365 bp
  • A to G, chromosome 13 at 24,962,405 bp
  • A to G, chromosome 14 at 66,915,979 bp
  • C to T, chromosome 15 at 31,606,040 bp
  • C to T, chromosome 15 at 38,501,421 bp
  • G to T, chromosome 16 at 58,889,266 bp
  • A to G, chromosome 17 at 21,261,619 bp
  • T to A, chromosome 17 at 21,722,261 bp
  • C to A, chromosome 17 at 86,493,293 bp
  • G to T, chromosome 18 at 63,053,010 bp
  • A to G, chromosome 19 at 56,529,533 bp
  • T to C, chromosome 19 at 56,944,767 bp
  • A to C, chromosome 19 at 60,853,886 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7577 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045662-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.