Strain Name:
C57BL/6J-MtgxR7596Btlr/Mmmh
Stock Number:
045671-MU
Citation ID:
RRID:MMRRC_045671-MU
Other Names:
R7596 (G1)
Major Collection:

Strain Information

Htr3b
Name: 5-hydroxytryptamine (serotonin) receptor 3B
Synonyms: 5-HT3 receptor subunit B, 5-HT3B
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 57014
VEGA: 9
HGNC: HGNC:5298
Homologene: 38131
Map7
Name: microtubule-associated protein 7
Synonyms: Mtap7, ste, E-MAP-115, mste, mshi
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 17761
VEGA: 10
HGNC: HGNC:6869
Homologene: 20851
Mlst8
Name: MTOR associated protein, LST8 homolog (S. cerevisiae)
Synonyms: mLST8, 0610033N12Rik, Gbl
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 56716
VEGA: 17
Homologene: 6833
Cad
Name: carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
Synonyms: 2410008J01Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 69719
HGNC: HGNC:1424
Homologene: 1412
Slc30a6
Name: solute carrier family 30 (zinc transporter), member 6
Synonyms: ZnT6, ZnT-6
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 210148
VEGA: 17
Homologene: 32380
Kcnk1
Name: potassium channel, subfamily K, member 1
Synonyms: TWIK-1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 16525
HGNC: HGNC:6272
Homologene: 1691
Prpf8
Name: pre-mRNA processing factor 8
Synonyms: Sfprp8l, DBF3/PRP8, Prp8, D11Bwg0410e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 192159
Homologene: 4706
Nup107
Name: nucleoporin 107
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 103468
VEGA: 10
Homologene: 5555
Ubn1
Name: ubinuclein 1
Synonyms: 1110029L11Rik, 2610108L02Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 170644
VEGA: 16
Homologene: 9656
Ubtf
Name: upstream binding transcription factor, RNA polymerase I
Synonyms: UBF1, Tcfubf, A930005G04Rik, UBF
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 21429
Homologene: 7970
Trio
Name: triple functional domain (PTPRF interacting)
Synonyms: Solo, 6720464I07Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223435
VEGA: 15
Homologene: 20847
Smc5
Name: structural maintenance of chromosomes 5
Synonyms: Smc5l1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226026
VEGA: 19
Homologene: 41009
Cecr2
Name: CECR2, histone acetyl-lysine reader
Synonyms: Gtl4, cat eye syndrome chromosome region, candidate 2, 2610101O16Rik, 2810409N01Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330409
HGNC: HGNC:1840
Homologene: 64662
Zbtb16
Name: zinc finger and BTB domain containing 16
Synonyms: Green's luxoid, Zfp145, PLZF
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235320
VEGA: 9
Homologene: 21214
Ceacam19
Name: CEA cell adhesion molecule 19
Synonyms: C130022P09Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 319930
Homologene: 49621
Ube2b
Name: ubiquitin-conjugating enzyme E2B
Synonyms: HR6B, Rad6b, E2-14k
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 22210
Homologene: 101298
Tnks1bp1
Name: tankyrase 1 binding protein 1
Synonyms: TAB182
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228140
Homologene: 14117
Nr4a2
Name: nuclear receptor subfamily 4, group A, member 2
Synonyms: Nurr1, RNR-1, HZF-3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18227
HGNC: HGNC:7981
Homologene: 4509
Dcn
Name: decorin
Synonyms: DC, SLRR1B
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 13179
VEGA: 10
HGNC: HGNC:2705
Homologene: 22430
Smarcc2
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
Synonyms: 5930405J04Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 68094
VEGA: 10
Homologene: 2312
Cpne5
Name: copine V
Synonyms: A830083G22Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240058
HGNC: HGNC:2318
Homologene: 23266
Lig1
Name: ligase I, DNA, ATP-dependent
Synonyms: mLigI, LigI
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16881
HGNC: HGNC:6598
Homologene: 197
Ttn
Name: titin
Synonyms: 2310036G12Rik, 2310057K23Rik, D330041I19Rik, mdm, connectin, D830007G01Rik, 1100001C23Rik, shru, 2310074I15Rik, L56
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Muc4
Name: mucin 4
Synonyms: 4933405I11Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 140474
HGNC: HGNC:7514
Homologene: 124469
Slc35f4
Name: solute carrier family 35, member F4
Synonyms: 4930550L21Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 75288
Homologene: 45939
Hc
Name: hemolytic complement
Synonyms: C5, Hfib2, He, C5a
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 15139
HGNC: HGNC:1331
Homologene: 20412
C8a
Name: complement component 8, alpha polypeptide
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230558
HGNC: HGNC:1352
Homologene: 472
Or11g26
Name: olfactory receptor family 11 subfamily G member 26
Synonyms: GA_x6K02T2PMLR-6224293-6225228, MOR106-6, Olfr742
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 258422
Homologene: 74163
Rhpn1
Name: rhophilin, Rho GTPase binding protein 1
Synonyms: Grbp, Rhophilin
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 14787
Homologene: 7346
Rev3l
Name: REV3 like, DNA directed polymerase zeta catalytic subunit
Synonyms: Sez4, Rev
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19714
HGNC: HGNC:9968
Homologene: 48147
Lrrc19
Name: leucine rich repeat containing 19
Synonyms: 9130022A01Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100061
Homologene: 36410
Vsig10
Name: V-set and immunoglobulin domain containing 10
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231668
Homologene: 10414
Gnptab
Name: N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
Synonyms: EG432486
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 432486
Homologene: 32576
Mdga2
Name: MAM domain containing glycosylphosphatidylinositol anchor 2
Synonyms: Mamdc1, Mdga2, Adp, 9330209L04Rik, 6720489L24Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 320772
Homologene: 45659
Pik3cg
Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
Synonyms: PI(3)Kgamma, PI3Kgamma, 5830428L06Rik, p110gamma, PI3Kgamma
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 30955
HGNC: HGNC:8978
Homologene: 68269
Ttc28
Name: tetratricopeptide repeat domain 28
Synonyms: 2310015L07Rik, TPRBK
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 209683
Homologene: 41023
Pcolce
Name: procollagen C-endopeptidase enhancer protein
Synonyms: Astt2, Astt-2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18542
HGNC: HGNC:8738
Homologene: 1946
Lrrc4b
Name: leucine rich repeat containing 4B
Synonyms: NGL-3, Lrig4, Ngl3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 272381
Homologene: 45681
Adam26b
Name: a disintegrin and metallopeptidase domain 26B
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 382007
Homologene: 128363
Lcn2
Name: lipocalin 2
Synonyms: neu-related lipocalin, NGAL, NRL, 24p3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16819
HGNC: HGNC:6526
Homologene: 4064
Ankrd13b
Name: ankyrin repeat domain 13b
Synonyms: B930093C12Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268445
Homologene: 27367
Vmn2r109
Name: vomeronasal 2, receptor 109
Synonyms: EG627814
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627814
Homologene: 129678
Samhd1
Name: SAM domain and HD domain, 1
Synonyms: E330031J07Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 56045
Homologene: 9160
Ms4a13
Name: membrane-spanning 4-domains, subfamily A, member 13
Synonyms: 1700060E18Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 73466
Homologene: 77851
Sp110
Name: Sp110 nuclear body protein
Synonyms: Ipr1, 5031415C07Rik, 52kDa, Ifi75, 5830484A20Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 109032
HGNC: HGNC:5401
Homologene: 82192
Or13a1
Name: olfactory receptor family 13 subfamily A member 1
Synonyms: MOR253-9, GA_x54KRFPKN04-58127726-58128655, Olfr211
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 258914
Homologene: 17434
Or5b3
Name: olfactory receptor family 5 subfamily B member 3
Synonyms: MOR202-11, Olfr1469, GA_x6K02T2RE5P-3743369-3744289
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258690
HGNC: HGNC:8324
Homologene: 133675
Podnl1
Name: podocan-like 1
Synonyms: 5832418A03Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244550
Homologene: 41590
Gm5591
Name: predicted gene 5591
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 434171
Homologene: 80005
Ikbip
Name: IKBKB interacting protein
Synonyms: 1700023M03Rik, 1200009F10Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 67454
Homologene: 12138
Spopfm2
Name: speckle-type BTB/POZ protein family member 2
Synonyms: Gm10696
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 100043188
Homologene: 128308
Bckdk
Name: branched chain ketoacid dehydrogenase kinase
Synonyms: BCKD-kinase
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 12041
Homologene: 37642
Krtap13-20
Name: keratin associated protein 13-20
Synonyms: 2310034C09Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 117172
Homologene: 114409
Tango2
Name: transport and golgi organization 2
Synonyms: T10, D16H22S680E
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 27883
Homologene: 44029
Rpl9-ps6
Name: ribosomal protein L9, pseudogene 6
Synonyms: Gm10117
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 100042823
VEGA: 19
Rnf187
Name: ring finger protein 187
Synonyms: 2410016F01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 108660
Homologene: 23360
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 60,763,328 bp
  • G to A, chromosome 1 at 85,579,092 bp
  • A to G, chromosome 2 at 32,385,709 bp
  • A to G, chromosome 2 at 35,000,847 bp
  • G to C, chromosome 2 at 57,108,231 bp
  • A to G, chromosome 2 at 76,808,579 bp
  • A to G, chromosome 2 at 85,062,713 bp
  • A to T, chromosome 2 at 157,101,834 bp
  • T to A, chromosome 3 at 94,176,430 bp
  • T to G, chromosome 4 at 94,643,355 bp
  • T to C, chromosome 4 at 104,853,867 bp
  • A to G, chromosome 5 at 31,069,048 bp
  • T to C, chromosome 5 at 111,280,124 bp
  • T to C, chromosome 5 at 117,334,783 bp
  • A to G, chromosome 5 at 137,606,825 bp
  • T to A, chromosome 6 at 116,494,197 bp
  • A to G, chromosome 6 at 120,762,206 bp
  • T to C, chromosome 7 at 13,305,998 bp
  • A to G, chromosome 7 at 19,881,887 bp
  • T to G, chromosome 7 at 38,520,184 bp
  • C to T, chromosome 7 at 44,461,886 bp
  • G to T, chromosome 7 at 127,906,400 bp
  • A to C, chromosome 8 at 43,520,200 bp
  • A to G, chromosome 8 at 84,126,395 bp
  • T to C, chromosome 8 at 125,995,611 bp
  • C to A, chromosome 9 at 48,832,404 bp
  • T to C, chromosome 9 at 48,936,061 bp
  • A to G, chromosome 10 at 20,278,181 bp
  • A to G, chromosome 10 at 39,821,538 bp
  • T to G, chromosome 10 at 88,443,370 bp
  • A to T, chromosome 10 at 91,083,029 bp
  • A to T, chromosome 10 at 97,510,009 bp
  • T to C, chromosome 10 at 117,777,160 bp
  • A to G, chromosome 10 at 128,482,793 bp
  • T to C, chromosome 11 at 51,986,743 bp
  • T to C, chromosome 11 at 58,938,415 bp
  • T to C, chromosome 11 at 75,491,504 bp
  • C to A, chromosome 11 at 77,472,314 bp
  • G to A, chromosome 11 at 102,306,707 bp
  • A to G, chromosome 12 at 32,204,741 bp
  • A to T, chromosome 12 at 66,506,123 bp
  • T to A, chromosome 14 at 49,306,209 bp
  • A to T, chromosome 14 at 50,515,545 bp
  • A to T, chromosome 15 at 27,749,826 bp
  • A to G, chromosome 15 at 75,712,313 bp
  • T to A, chromosome 16 at 5,081,558 bp
  • A to G, chromosome 16 at 18,302,710 bp
  • C to G, chromosome 16 at 32,753,930 bp
  • G to A, chromosome 16 at 88,759,336 bp
  • A to T, chromosome 17 at 20,540,680 bp
  • C to T, chromosome 17 at 24,478,110 bp
  • C to T, chromosome 17 at 29,226,217 bp
  • A to G, chromosome 17 at 74,415,669 bp
  • A to T, chromosome 19 at 11,169,965 bp
  • C to T, chromosome 19 at 13,411,147 bp
  • A to C, chromosome 19 at 23,214,169 bp
  • C to T, chromosome 19 at 32,466,383 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7596 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045671-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.