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Strain Name:
C57BL/6J-MtgxR7597Btlr/Mmmh
Stock Number:
045672-MU
Citation ID:
RRID:MMRRC_045672-MU
Other Names:
R7597 (G1)
Major Collection:

Strain Information

Rai14
Name: retinoic acid induced 14
Synonyms: 1700020L11Rik, Ankycorbin, Norpeg, 1700008J19Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 75646
VEGA: 15
Homologene: 9199
Mta3
Name: metastasis associated 3
Synonyms: 1110002J22Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 116871
Homologene: 14282
Col18a1
Name: collagen, type XVIII, alpha 1
Synonyms: endostatin
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 12822
HGNC: HGNC:2195
Homologene: 7673
Lims1
Name: LIM and senescent cell antigen-like domains 1
Synonyms: 2310016J22Rik, 4921524A02Rik, Lims1l, PINCH1, C430041B13Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 110829
HGNC: HGNC:6616
Homologene: 68428
Asap1
Name: ArfGAP with SH3 domain, ankyrin repeat and PH domain1
Synonyms: Ddef1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 13196
HGNC: HGNC:2720
Homologene: 7684
Kmt2a
Name: lysine (K)-specific methyltransferase 2A
Synonyms: trithorax Drosophila, HTRX1, ALL-1, All1, Cxxc7, Mll, Mll1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 214162
HGNC: HGNC:7132
Homologene: 4338
Traf3ip1
Name: TRAF3 interacting protein 1
Synonyms: 3930402D05Rik, MIP-T3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74019
Homologene: 22913
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 88,328,196 bp
  • T to A, chromosome 1 at 91,511,445 bp
  • T to C, chromosome 1 at 153,240,454 bp
  • T to A, chromosome 2 at 10,249,376 bp
  • G to T, chromosome 2 at 27,027,183 bp
  • T to A, chromosome 2 at 67,525,755 bp
  • T to C, chromosome 2 at 69,973,468 bp
  • T to C, chromosome 2 at 74,568,972 bp
  • T to A, chromosome 2 at 112,142,580 bp
  • A to T, chromosome 3 at 107,471,352 bp
  • A to G, chromosome 3 at 108,471,429 bp
  • T to A, chromosome 3 at 151,543,258 bp
  • G to A, chromosome 4 at 15,963,911 bp
  • A to G, chromosome 4 at 33,148,964 bp
  • A to G, chromosome 4 at 154,349,593 bp
  • C to T, chromosome 5 at 14,677,587 bp
  • A to C, chromosome 5 at 14,858,855 bp
  • A to G, chromosome 5 at 23,548,519 bp
  • A to T, chromosome 5 at 115,886,681 bp
  • T to C, chromosome 5 at 129,739,573 bp
  • C to A, chromosome 5 at 146,754,369 bp
  • T to C, chromosome 6 at 28,260,765 bp
  • T to A, chromosome 6 at 80,022,445 bp
  • C to A, chromosome 6 at 89,893,836 bp
  • T to C, chromosome 7 at 3,842,461 bp
  • T to G, chromosome 7 at 13,296,344 bp
  • C to T, chromosome 7 at 44,509,799 bp
  • A to G, chromosome 7 at 45,995,237 bp
  • T to G, chromosome 8 at 43,625,244 bp
  • A to T, chromosome 8 at 60,671,281 bp
  • A to G, chromosome 8 at 105,695,489 bp
  • A to T, chromosome 8 at 121,608,500 bp
  • G to A, chromosome 9 at 38,464,506 bp
  • T to C, chromosome 9 at 44,831,353 bp
  • C to T, chromosome 9 at 52,060,896 bp
  • C to T, chromosome 10 at 39,822,884 bp
  • A to G, chromosome 10 at 58,412,441 bp
  • T to C, chromosome 10 at 77,113,303 bp
  • A to G, chromosome 10 at 127,991,358 bp
  • T to C, chromosome 11 at 115,928,381 bp
  • T to C, chromosome 11 at 121,357,883 bp
  • T to C, chromosome 12 at 69,269,868 bp
  • C to T, chromosome 13 at 67,517,293 bp
  • C to A, chromosome 13 at 97,172,578 bp
  • C to T, chromosome 13 at 100,300,600 bp
  • T to C, chromosome 13 at 114,974,140 bp
  • G to A, chromosome 14 at 54,781,400 bp
  • C to A, chromosome 14 at 70,166,196 bp
  • A to G, chromosome 15 at 10,574,851 bp
  • C to A, chromosome 15 at 56,668,421 bp
  • A to G, chromosome 15 at 64,312,455 bp
  • A to T, chromosome 15 at 82,334,834 bp
  • G to A, chromosome 15 at 82,375,852 bp
  • C to G, chromosome 16 at 32,753,930 bp
  • T to C, chromosome 16 at 78,329,108 bp
  • A to T, chromosome 17 at 34,739,675 bp
  • T to C, chromosome 17 at 36,040,516 bp
  • T to C, chromosome 17 at 83,775,582 bp
  • G to T, chromosome 18 at 32,123,636 bp
  • A to G, chromosome 18 at 40,530,795 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7597 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045672-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.