Strain Name:
C57BL/6J-MtgxR7602Btlr/Mmmh
Stock Number:
045674-MU
Citation ID:
RRID:MMRRC_045674-MU
Other Names:
R7602 (G1)
Major Collection:

Strain Information

Rcan2
Name: regulator of calcineurin 2
Synonyms: MCIP2, Dscr1l1, Csp2, ZAKI-4
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 53901
VEGA: 17
HGNC: HGNC:3041
Homologene: 130985
Casp8
Name: caspase 8
Synonyms: Caspase-8, FLICE, Mch5, MACH
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12370
HGNC: HGNC:1509
Homologene: 7657
Tgfa
Name: transforming growth factor alpha
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 21802
Homologene: 2431
Slc12a8
Name: solute carrier family 12 (potassium/chloride transporters), member 8
Synonyms: E330020C02Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 171286
Homologene: 11628
Uri1
Name: URI1, prefoldin-like chaperone
Synonyms: Rmp, NNX3, C80913
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 19777
Homologene: 2813
Phf12
Name: PHD finger protein 12
Synonyms: PF1, 2410142K10Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268448
Homologene: 10841
Gse1
Name: genetic suppressor element 1, coiled-coil protein
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 382034
Homologene: 40964
Atr
Name: ataxia telangiectasia and Rad3 related
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 245000
HGNC: HGNC:882
Homologene: 96916
Sptlc2
Name: serine palmitoyltransferase, long chain base subunit 2
Synonyms: LCB2, Spt2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20773
Homologene: 21610
Pabpc4
Name: poly(A) binding protein, cytoplasmic 4
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230721
HGNC: HGNC:8557
Homologene: 37855
Zfr
Name: zinc finger RNA binding protein
Synonyms: C920030H05Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 22763
Homologene: 8009
Cast
Name: calpastatin
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 12380
VEGA: 13
HGNC: HGNC:1515
Homologene: 7658
Cpsf7
Name: cleavage and polyadenylation specific factor 7
Synonyms: 5730453I16Rik, C330017N18Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 269061
VEGA: 19
Homologene: 11731
Thrsp
Name: thyroid hormone responsive
Synonyms: Spot 14, S14
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 21835
Homologene: 2441
Nmnat1
Name: nicotinamide nucleotide adenylyltransferase 1
Synonyms: nmnat, 2610529L11Rik, D4Cole1e, 5730441G13Rik, nicotinamide mononucleotide adenylyl transferase
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 66454
Homologene: 39074
Kank1
Name: KN motif and ankyrin repeat domains 1
Synonyms: A930031B09Rik, D330024H06Rik, Ankrd15
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 107351
Homologene: 17706
Epha6
Name: Eph receptor A6
Synonyms: Hek12, m-ehk2, Ehk2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 13840
Homologene: 56396
Ncoa2
Name: nuclear receptor coactivator 2
Synonyms: glucocorticoid receptor-interacting protein 1, TIF2/GRIP-1, Grip1, TIF-2, TIF2, KAT13C, D1Ertd433e, SRC-2, bHLHe75
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17978
HGNC: HGNC:7669
Homologene: 4768
Ddx24
Name: DEAD box helicase 24
Synonyms: 2510027P10Rik, DEAD (Asp-Glu-Ala-Asp) box polypeptide 24, 1700055J08Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 27225
VEGA: 12
Homologene: 10702
Hnrnpul2
Name: heterogeneous nuclear ribonucleoprotein U-like 2
Synonyms: Hnrpul2, 1110031M08Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 68693
VEGA: 19
Homologene: 28583
Tube1
Name: tubulin, epsilon 1
Synonyms: 2310061K05Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 71924
VEGA: 10
Homologene: 17762
Gga2
Name: golgi associated, gamma adaptin ear containing, ARF binding protein 2
Synonyms: 1200007E24Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 74105
Homologene: 22860
Inava
Name: innate immunity activator
Synonyms: 5730559C18Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67313
Homologene: 10103
Dhx29
Name: DExH-box helicase 29
Synonyms: DEAH (Asp-Glu-Ala-His) box polypeptide 29, E130202M19Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218629
VEGA: 13
Homologene: 10387
Scfd2
Name: Sec1 family domain containing 2
Synonyms: E430013M20Rik, STXBP1L1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 212986
Homologene: 77411
Pgap1
Name: post-GPI attachment to proteins 1
Synonyms: D230012E17Rik, oto, PGAP1, 5033403E17Rik, 9030223K07Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241062
Homologene: 41605
Dlk1
Name: delta like non-canonical Notch ligand 1
Synonyms: ZOG, DlkI, pref-1, SCP1, pG2, Peg9, FA1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13386
HGNC: HGNC:2907
Homologene: 2846
Mthfd2
Name: methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase
Synonyms: NMDMC
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 17768
HGNC: HGNC:7434
Homologene: 21321
Sirpa
Name: signal-regulatory protein alpha
Synonyms: SIRP, SHPS-1, CD172a, Idd13.2, Bit, Ptpns1, P84
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19261
HGNC: HGNC:9662
Homologene: 7246
Ttn
Name: titin
Synonyms: connectin, shru, D330041I19Rik, 2310057K23Rik, mdm, D830007G01Rik, 2310074I15Rik, 1100001C23Rik, 2310036G12Rik, L56
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Dhx57
Name: DExH-box helicase 57
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106794
VEGA: 17
Homologene: 56267
Muc4
Name: mucin 4
Synonyms: 4933405I11Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 140474
HGNC: HGNC:7514
Homologene: 124469
Ush2a
Name: usherin
Synonyms: Ushrn, A930037M10Rik, MUSH2A, LOC269160, A930011D15Rik, LOC381317, Ush2a
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22283
Homologene: 66151
Carmil3
Name: capping protein regulator and myosin 1 linker 3
Synonyms: Lrrc16b
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 268747
VEGA: 14
Homologene: 74564
Or5k1
Name: olfactory receptor family 5 subfamily K member 1
Synonyms: MOR184-3, GA_x54KRFPKG5P-54960233-54959268, Olfr173
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 259002
Homologene: 45084
A2m
Name: alpha-2-macroglobulin
Synonyms: A2mp
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232345
HGNC: HGNC:7
Homologene: 37248
Adam34l
Name: a disintegrin and metallopeptidase domain 34 like
Synonyms: Gm5346
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 384813
Homologene: 78104
Fam234b
Name: family with sequence similarity 234, member B
Synonyms: 8430419L09Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 74525
Homologene: 12572
Ssc5d
Name: scavenger receptor cysteine rich family, 5 domains
Synonyms: A430110N23Rik, s5d-srcrb
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 269855
Homologene: 77555
Gbp3
Name: guanylate binding protein 3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 55932
Homologene: 137329
Or5m13b
Name: olfactory receptor family 5 subfamily M member 13B
Synonyms: MOR196-4, Olfr1026, GA_x6K02T2Q125-47402610-47403533
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258577
Homologene: 73971
Ddx59
Name: DEAD box helicase 59
Synonyms: 4833411G06Rik, DEAD (Asp-Glu-Ala-Asp) box polypeptide 59, 1210002B07Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67997
Homologene: 12222
Or10s1
Name: olfactory receptor family 10 subfamily S member 1
Synonyms: MOR223-4, Olfr982, GA_x6K02T2PVTD-33772307-33773260
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258853
VEGA: 9
Homologene: 17415
Klhl9
Name: kelch-like 9
Synonyms: C530050O22Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242521
Homologene: 23125
Krt36
Name: keratin 36
Synonyms: HRa-1, keratin 5, Krt1-5, Krt1-22
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16673
HGNC: HGNC:6454
Homologene: 88459
Exo5
Name: exonuclease 5
Synonyms: Dem1, 3110037I16Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 73172
Homologene: 41497
Sp110
Name: Sp110 nuclear body protein
Synonyms: Ipr1, 5830484A20Rik, 52kDa, 5031415C07Rik, Ifi75
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 109032
HGNC: HGNC:5401
Homologene: 82192
Or9r3
Name: olfactory receptor family 9 subfamily R member 3
Synonyms: MOR210-4, GA_x6K02T2PULF-11783479-11782532, Olfr823
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258668
Homologene: 45026
Skint4
Name: selection and upkeep of intraepithelial T cells 4
Synonyms: 9530098N22Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 320640
Abca7
Name: ATP-binding cassette, sub-family A member 7
Synonyms: Abc51
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 27403
HGNC: HGNC:37
Homologene: 22783
Zbtb7a
Name: zinc finger and BTB domain containing 7a
Synonyms: FBI-1, Pokemon, 9030619K07Rik, 9130006G12Rik, Zbtb7, Lrf, Leukemia/lymphoma Related Factor
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16969
Homologene: 7820
Ap3m2
Name: adaptor-related protein complex 3, mu 2 subunit
Synonyms: 5830445E16Rik, AP-3B
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 64933
HGNC: HGNC:570
Homologene: 4950
Ryk
Name: receptor-like tyrosine kinase
Synonyms: ERK-3, Vik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20187
Homologene: 68287
Ifitm3
Name: interferon induced transmembrane protein 3
Synonyms: mil-1, fragilis, IP15, Fgls, 1110004C05Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 66141
HGNC: HGNC:5414
Homologene: 136199
1700025G04Rik
Name: RIKEN cDNA 1700025G04 gene
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 69399
Homologene: 12776
Efcab15
Name: EF-hand calcium binding domain 15
Synonyms: 1700023F06Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69441
Homologene: 132455
Hpca
Name: hippocalcin
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 15444
HGNC: HGNC:5144
Homologene: 55634
Aadacl2fm3
Name: AADACL2 family member 3
Synonyms: Gm8298
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 666803
Homologene: 86204
Zscan4f
Name: zinc finger and SCAN domain containing 4F
Synonyms: C330039H09Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 665902
Homologene: 85986
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 13,177,126 bp
  • A to T, chromosome 1 at 54,543,186 bp
  • A to C, chromosome 1 at 58,833,739 bp
  • G to A, chromosome 1 at 85,579,092 bp
  • G to T, chromosome 1 at 136,225,397 bp
  • A to G, chromosome 1 at 136,433,821 bp
  • A to T, chromosome 1 at 151,980,515 bp
  • G to A, chromosome 1 at 188,648,409 bp
  • T to C, chromosome 2 at 76,851,644 bp
  • A to T, chromosome 2 at 85,923,802 bp
  • G to T, chromosome 2 at 129,609,152 bp
  • T to C, chromosome 3 at 59,877,276 bp
  • A to G, chromosome 3 at 142,569,061 bp
  • C to A, chromosome 4 at 88,722,409 bp
  • A to T, chromosome 4 at 112,118,271 bp
  • A to T, chromosome 4 at 120,921,621 bp
  • A to T, chromosome 4 at 123,292,892 bp
  • T to C, chromosome 4 at 129,120,226 bp
  • T to C, chromosome 4 at 149,473,351 bp
  • G to T, chromosome 5 at 74,462,610 bp
  • T to C, chromosome 6 at 83,311,848 bp
  • A to G, chromosome 6 at 86,269,962 bp
  • T to C, chromosome 6 at 121,642,007 bp
  • A to T, chromosome 6 at 121,670,936 bp
  • T to C, chromosome 6 at 135,225,243 bp
  • T to A, chromosome 7 at 4,942,746 bp
  • G to A, chromosome 7 at 11,401,381 bp
  • A to G, chromosome 7 at 37,981,628 bp
  • A to G, chromosome 7 at 97,417,307 bp
  • T to C, chromosome 7 at 121,997,330 bp
  • A to G, chromosome 7 at 141,010,459 bp
  • T to C, chromosome 8 at 22,792,754 bp
  • C to T, chromosome 8 at 43,626,666 bp
  • T to C, chromosome 8 at 120,569,304 bp
  • T to G, chromosome 9 at 40,075,159 bp
  • C to T, chromosome 9 at 95,907,383 bp
  • T to C, chromosome 9 at 102,898,516 bp
  • A to T, chromosome 10 at 39,142,266 bp
  • A to G, chromosome 10 at 79,998,012 bp
  • T to G, chromosome 10 at 81,144,176 bp
  • A to G, chromosome 10 at 130,112,310 bp
  • T to C, chromosome 11 at 78,023,283 bp
  • T to C, chromosome 11 at 100,102,960 bp
  • T to C, chromosome 11 at 103,200,178 bp
  • A to G, chromosome 12 at 87,341,689 bp
  • A to T, chromosome 12 at 103,416,260 bp
  • T to A, chromosome 12 at 109,455,625 bp
  • A to G, chromosome 13 at 74,736,965 bp
  • T to A, chromosome 13 at 112,944,559 bp
  • C to T, chromosome 14 at 55,501,508 bp
  • T to A, chromosome 15 at 12,159,677 bp
  • C to G, chromosome 16 at 32,753,930 bp
  • C to A, chromosome 16 at 33,625,124 bp
  • T to C, chromosome 16 at 58,796,980 bp
  • T to C, chromosome 16 at 59,775,568 bp
  • A to G, chromosome 17 at 44,017,798 bp
  • G to T, chromosome 17 at 80,274,861 bp
  • T to C, chromosome 19 at 8,831,309 bp
  • C to T, chromosome 19 at 10,535,373 bp
  • A to T, chromosome 19 at 25,422,161 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7602 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045674-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.