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Strain Name:
C57BL/6J-MtgxR7602Btlr/Mmmh
Stock Number:
045674-MU
Citation ID:
RRID:MMRRC_045674-MU
Other Names:
R7602 (G1)
Major Collection:

Strain Information

Rcan2
Name: regulator of calcineurin 2
Synonyms: MCIP2, ZAKI-4, Csp2, Dscr1l1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 53901
VEGA: 17
HGNC: HGNC:3041
Homologene: 130985
Casp8
Name: caspase 8
Synonyms: Mch5, MACH, FLICE, Caspase-8
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12370
HGNC: HGNC:1509
Homologene: 7657
Tgfa
Name: transforming growth factor alpha
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 21802
Homologene: 2431
Slc12a8
Name: solute carrier family 12 (potassium/chloride transporters), member 8
Synonyms: E330020C02Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 171286
Homologene: 11628
Uri1
Name: URI1, prefoldin-like chaperone
Synonyms: NNX3, Rmp, C80913
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 19777
Homologene: 2813
Phf12
Name: PHD finger protein 12
Synonyms: PF1, 2410142K10Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268448
Homologene: 10841
Gse1
Name: genetic suppressor element 1, coiled-coil protein
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 382034
Homologene: 40964
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 13,177,126 bp
  • A to T, chromosome 1 at 54,543,186 bp
  • A to C, chromosome 1 at 58,833,739 bp
  • G to A, chromosome 1 at 85,579,092 bp
  • G to T, chromosome 1 at 136,225,397 bp
  • A to G, chromosome 1 at 136,433,821 bp
  • A to T, chromosome 1 at 151,980,515 bp
  • G to A, chromosome 1 at 188,648,409 bp
  • T to C, chromosome 2 at 76,851,644 bp
  • A to T, chromosome 2 at 85,923,802 bp
  • G to T, chromosome 2 at 129,609,152 bp
  • T to C, chromosome 3 at 59,877,276 bp
  • A to G, chromosome 3 at 142,569,061 bp
  • C to A, chromosome 4 at 88,722,409 bp
  • A to T, chromosome 4 at 112,118,271 bp
  • A to T, chromosome 4 at 120,921,621 bp
  • A to T, chromosome 4 at 123,292,892 bp
  • T to C, chromosome 4 at 129,120,226 bp
  • T to C, chromosome 4 at 149,473,351 bp
  • G to T, chromosome 5 at 74,462,610 bp
  • T to C, chromosome 6 at 83,311,848 bp
  • A to G, chromosome 6 at 86,269,962 bp
  • T to C, chromosome 6 at 121,642,007 bp
  • A to T, chromosome 6 at 121,670,936 bp
  • T to C, chromosome 6 at 135,225,243 bp
  • T to A, chromosome 7 at 4,942,746 bp
  • G to A, chromosome 7 at 11,401,381 bp
  • A to G, chromosome 7 at 37,981,628 bp
  • A to G, chromosome 7 at 97,417,307 bp
  • T to C, chromosome 7 at 121,997,330 bp
  • A to G, chromosome 7 at 141,010,459 bp
  • T to C, chromosome 8 at 22,792,754 bp
  • C to T, chromosome 8 at 43,626,666 bp
  • T to C, chromosome 8 at 120,569,304 bp
  • T to G, chromosome 9 at 40,075,159 bp
  • C to T, chromosome 9 at 95,907,383 bp
  • T to C, chromosome 9 at 102,898,516 bp
  • A to T, chromosome 10 at 39,142,266 bp
  • A to G, chromosome 10 at 79,998,012 bp
  • T to G, chromosome 10 at 81,144,176 bp
  • A to G, chromosome 10 at 130,112,310 bp
  • T to C, chromosome 11 at 78,023,283 bp
  • T to C, chromosome 11 at 100,102,960 bp
  • T to C, chromosome 11 at 103,200,178 bp
  • A to G, chromosome 12 at 87,341,689 bp
  • A to T, chromosome 12 at 103,416,260 bp
  • T to A, chromosome 12 at 109,455,625 bp
  • A to G, chromosome 13 at 74,736,965 bp
  • T to A, chromosome 13 at 112,944,559 bp
  • C to T, chromosome 14 at 55,501,508 bp
  • T to A, chromosome 15 at 12,159,677 bp
  • C to G, chromosome 16 at 32,753,930 bp
  • C to A, chromosome 16 at 33,625,124 bp
  • T to C, chromosome 16 at 58,796,980 bp
  • T to C, chromosome 16 at 59,775,568 bp
  • A to G, chromosome 17 at 44,017,798 bp
  • G to T, chromosome 17 at 80,274,861 bp
  • T to C, chromosome 19 at 8,831,309 bp
  • C to T, chromosome 19 at 10,535,373 bp
  • A to T, chromosome 19 at 25,422,161 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7602 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045674-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.