Strain Name:
C57BL/6J-MtgxR7606Btlr/Mmmh
Stock Number:
045676-MU
Citation ID:
RRID:MMRRC_045676-MU
Other Names:
R7606 (G1)
Major Collection:

Strain Information

Lyst
Name: lysosomal trafficking regulator
Synonyms: D13Sfk13
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17101
VEGA: 13
HGNC: HGNC:1968
Homologene: 61
Plcd3
Name: phospholipase C, delta 3
Synonyms: 2610205J15Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 72469
HGNC: HGNC:9061
Homologene: 14858
Bcat1
Name: branched chain aminotransferase 1, cytosolic
Synonyms: BCATc, Bcat-1, Eca39
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12035
HGNC: HGNC:976
Homologene: 20320
Ppp1ca
Name: protein phosphatase 1 catalytic subunit alpha
Synonyms: dism2, Ppp1c
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 19045
VEGA: 19
HGNC: HGNC:9281
Homologene: 105262
Kpna2
Name: karyopherin subunit alpha 2
Synonyms: m-importin-alpha-P1, Rch1, m-importin, Importin alpha, 2410044B12Rik, pendulin, importin alpha 1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16647
HGNC: HGNC:6395
Homologene: 1708
Ccz1
Name: CCZ1 vacuolar protein trafficking and biogenesis associated
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231874
Homologene: 56717
Rbm27
Name: RNA binding motif protein 27
Synonyms: Psc1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225432
VEGA: 18
Homologene: 35410
Itgb2
Name: integrin beta 2
Synonyms: Mac-1 beta, Cd18, 2E6
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16414
HGNC: HGNC:6155
Homologene: 20092
Tcf4
Name: transcription factor 4
Synonyms: ME2, MITF-2B, E2-2, ASP-I2, SEF-2, E2.2, 5730422P05Rik, ITF-2, ITF-2b, MITF-2A, SEF2-1, bHLHb19, TFE
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 21413
Homologene: 2407
Golt1b
Name: golgi transport 1B
Synonyms: 2310061A22Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 66964
Homologene: 41102
Sema4d
Name: sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
Synonyms: Semaj, M-sema G, CD100, semaphorin H, Semacl2, coll-4, Semcl2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20354
Homologene: 21282
Adat1
Name: adenosine deaminase, tRNA-specific 1
Synonyms: mADAT1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 30947
HGNC: HGNC:228
Homologene: 8096
Scamp3
Name: secretory carrier membrane protein 3
Synonyms: Sc3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 24045
Homologene: 4164
Nup88
Name: nucleoporin 88
Synonyms: Prei2, Nup84
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19069
HGNC: HGNC:8067
Homologene: 1901
Mknk1
Name: MAP kinase-interacting serine/threonine kinase 1
Synonyms: 2410048M24Rik, Mnk1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 17346
HGNC: HGNC:7110
Homologene: 37838
Parp11
Name: poly (ADP-ribose) polymerase family, member 11
Synonyms: 5330431N24Rik, HIN1L
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 101187
HGNC: HGNC:1186
Homologene: 10680
Heatr5b
Name: HEAT repeat containing 5B
Synonyms: 2010013B10Rik, A230048G03Rik, D330050P16Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 320473
VEGA: 17
Homologene: 25536
Zfhx2
Name: zinc finger homeobox 2
Synonyms: zfh-5
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 239102
Homologene: 52657
Skor1
Name: SKI family transcriptional corepressor 1
Synonyms: Corl1, Lbxcor1, C230094B15Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 207667
Homologene: 18175
Atp8b1
Name: ATPase, class I, type 8B, member 1
Synonyms: Ic, FIC1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 54670
VEGA: 18
HGNC: HGNC:3706
Homologene: 21151
Usf3
Name: upstream transcription factor family member 3
Synonyms: LOC207806, Gm608, LOC385650, 5530400K22Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 207806
Homologene: 19504
Dnah10
Name: dynein, axonemal, heavy chain 10
Synonyms: Dnahc10
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 56087
HGNC: HGNC:2941
Homologene: 25816
Srgap3
Name: SLIT-ROBO Rho GTPase activating protein 3
Synonyms: D130026O08Rik, Arhgap14
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 259302
Homologene: 56686
Mrc1
Name: mannose receptor, C type 1
Synonyms: MR, CD206
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17533
HGNC: HGNC:7228
Homologene: 37622
Neb
Name: nebulin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17996
HGNC: HGNC:7720
Homologene: 136285
Rubcnl
Name: RUN and cysteine rich domain containing beclin 1 interacting protein like
Synonyms: 5031414D18Rik, LOC380917
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 271221
VEGA: 14
Homologene: 57021
Ryr3
Name: ryanodine receptor 3
Synonyms: calcium release channel isoform 3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20192
Homologene: 68151
Eml1
Name: echinoderm microtubule associated protein like 1
Synonyms: 1110008N23Rik, A930030P13Rik, heco, ELP79
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 68519
HGNC: HGNC:3330
Homologene: 20931
Nlrc5
Name: NLR family, CARD domain containing 5
Synonyms: AI451557
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 434341
Homologene: 88935
Hrg
Name: histidine-rich glycoprotein
Synonyms: D16JH2, D18020
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 94175
HGNC: HGNC:5181
Homologene: 137650
Myo1f
Name: myosin IF
Synonyms: C330006B10Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 17916
HGNC: HGNC:7600
Homologene: 56276
Pde8a
Name: phosphodiesterase 8A
Synonyms: Pde8
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18584
HGNC: HGNC:8793
Homologene: 1957
Vmn2r72
Name: vomeronasal 2, receptor 72
Synonyms: EG244114, Vmn2r72-ps
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244114
Homologene: 115466
Cd209g
Name: CD209g antigen
Synonyms: 2310066I10Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 70192
Homologene: 137382
Col4a2
Name: collagen, type IV, alpha 2
Synonyms: Col4a-2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12827
HGNC: HGNC:2203
Homologene: 1390
Fam171a2
Name: family with sequence similarity 171, member A2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217219
Homologene: 19144
Parp2
Name: poly (ADP-ribose) polymerase family, member 2
Synonyms: Adprt2, Adprtl2, PARP-2, C78626, Aspartl2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 11546
VEGA: 14
HGNC: HGNC:272
Homologene: 4004
Atp11a
Name: ATPase, class VI, type 11A
Synonyms: 4930558F19Rik, LOC100045280, 9130422H11Rik, Ih
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 50770
Homologene: 75050
Tbc1d31
Name: TBC1 domain family, member 31
Synonyms: LOC210544, Wdr67, D330013L20Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 210544
Homologene: 17089
Kcnb2
Name: potassium voltage gated channel, Shab-related subfamily, member 2
Synonyms: 9630047L19Rik, Kv2.2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98741
HGNC: HGNC:6232
Homologene: 31263
Vcam1
Name: vascular cell adhesion molecule 1
Synonyms: CD106, Vcam-1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 22329
Homologene: 838
Rcbtb2
Name: regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
Synonyms: 2610028E02Rik, Rc/btb2, 2810420M18Rik, Chc1l
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 105670
HGNC: HGNC:1914
Homologene: 970
Meis2
Name: Meis homeobox 2
Synonyms: Mrg1, Stra10, A430109D20Rik, Meis2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17536
HGNC: HGNC:7001
Homologene: 7846
Aadac
Name: arylacetamide deacetylase
Synonyms: 5033417E09Rik, Aada
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 67758
HGNC: HGNC:17
Homologene: 37436
Cpox
Name: coproporphyrinogen oxidase
Synonyms: Cpo, M100835, clone 560, cac, nct
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 12892
VEGA: 16
HGNC: HGNC:2321
Homologene: 76
Bag4
Name: BCL2-associated athanogene 4
Synonyms: 2410112I15Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 67384
HGNC: HGNC:940
Homologene: 31270
Or4c114
Name: olfactory receptor family 4 subfamily C member 114
Synonyms: MOR233-6, GA_x6K02T2Q125-50555603-50554668, Olfr1219
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258901
Homologene: 27292
Pcdhb6
Name: protocadherin beta 6
Synonyms: PcdhbF, Pcdhb5B
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93877
HGNC: HGNC:8690
Homologene: 62177
Or10g3b
Name: olfactory receptor family 10 subfamily G member 3B
Synonyms: Olfr1513, MOR223-10, GA_x6K02T2RJGY-644134-645075, MOR223-7P
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 258008
HGNC: HGNC:8171
Homologene: 79404
Slc35a4
Name: solute carrier family 35, member A4
Synonyms: 2610030J16Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 67843
Homologene: 12195
Fem1a
Name: fem 1 homolog a
Synonyms: Eprap
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 14154
VEGA: 17
Homologene: 7713
Mup4
Name: major urinary protein 4
Synonyms: Mup-4
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 17843
Homologene: 74304
Btg4
Name: BTG anti-proliferation factor 4
Synonyms: PC3B
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 56057
VEGA: 9
Homologene: 9734
Spryd7
Name: SPRY domain containing 7
Synonyms: 6330409N04Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 66674
Homologene: 10725
Pea15a
Name: proliferation and apoptosis adaptor protein 15A
Synonyms: Pea15, Pkcs15, Mat1, phosphoprotein enriched in astrocytes 15A, PEA-15
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18611
HGNC: HGNC:8822
Homologene: 7884
Pth
Name: parathyroid hormone
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 19226
HGNC: HGNC:9606
Homologene: 266
Fkbp14
Name: FK506 binding protein 14
Synonyms: FKBP22
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 231997
Homologene: 23059
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 15,312,840 bp
  • T to C, chromosome 1 at 172,200,583 bp
  • T to A, chromosome 2 at 14,238,144 bp
  • T to G, chromosome 2 at 52,226,444 bp
  • A to G, chromosome 2 at 89,075,297 bp
  • A to T, chromosome 2 at 112,645,245 bp
  • T to C, chromosome 2 at 116,063,320 bp
  • T to A, chromosome 3 at 60,036,035 bp
  • T to A, chromosome 3 at 89,181,218 bp
  • T to C, chromosome 3 at 116,121,055 bp
  • T to C, chromosome 4 at 59,958,568 bp
  • T to G, chromosome 4 at 115,877,994 bp
  • A to T, chromosome 5 at 124,817,712 bp
  • G to A, chromosome 5 at 144,014,808 bp
  • A to G, chromosome 6 at 54,593,018 bp
  • A to C, chromosome 6 at 112,739,376 bp
  • A to G, chromosome 6 at 127,470,760 bp
  • G to A, chromosome 6 at 142,392,342 bp
  • G to T, chromosome 6 at 145,048,632 bp
  • A to G, chromosome 7 at 81,332,967 bp
  • T to A, chromosome 7 at 85,751,154 bp
  • A to C, chromosome 7 at 113,386,243 bp
  • T to C, chromosome 8 at 4,136,839 bp
  • T to A, chromosome 8 at 11,443,571 bp
  • C to T, chromosome 8 at 12,844,427 bp
  • A to G, chromosome 8 at 25,769,305 bp
  • T to C, chromosome 8 at 94,477,117 bp
  • T to C, chromosome 8 at 111,982,604 bp
  • A to G, chromosome 9 at 51,118,007 bp
  • G to T, chromosome 9 at 63,145,382 bp
  • T to A, chromosome 10 at 77,556,161 bp
  • T to C, chromosome 10 at 78,037,933 bp
  • T to C, chromosome 11 at 70,961,615 bp
  • A to G, chromosome 11 at 102,444,176 bp
  • A to G, chromosome 11 at 103,076,857 bp
  • A to T, chromosome 11 at 106,992,058 bp
  • A to T, chromosome 12 at 108,537,366 bp
  • T to C, chromosome 13 at 13,637,475 bp
  • T to C, chromosome 13 at 51,723,622 bp
  • A to T, chromosome 14 at 50,820,030 bp
  • A to T, chromosome 14 at 52,349,963 bp
  • T to C, chromosome 14 at 55,066,663 bp
  • T to C, chromosome 14 at 61,540,158 bp
  • T to A, chromosome 14 at 73,182,366 bp
  • C to T, chromosome 14 at 75,038,874 bp
  • A to G, chromosome 15 at 57,951,670 bp
  • A to G, chromosome 16 at 22,951,123 bp
  • C to T, chromosome 16 at 44,218,943 bp
  • T to C, chromosome 16 at 58,674,449 bp
  • T to C, chromosome 17 at 33,576,450 bp
  • A to G, chromosome 17 at 56,256,946 bp
  • T to C, chromosome 17 at 78,763,026 bp
  • A to G, chromosome 18 at 36,682,585 bp
  • G to A, chromosome 18 at 37,335,606 bp
  • A to G, chromosome 18 at 42,327,513 bp
  • T to C, chromosome 18 at 64,555,115 bp
  • C to T, chromosome 18 at 69,642,983 bp
  • C to A, chromosome 19 at 4,193,089 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7606 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045676-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.