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Strain Name:
C57BL/6J-MtgxR7606Btlr/Mmmh
Stock Number:
045676-MU
Citation ID:
RRID:MMRRC_045676-MU
Other Names:
R7606 (G1)
Major Collection:

Strain Information

Lyst
Name: lysosomal trafficking regulator
Synonyms: D13Sfk13
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17101
VEGA: 13
HGNC: HGNC:1968
Homologene: 61
Plcd3
Name: phospholipase C, delta 3
Synonyms: 2610205J15Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 72469
HGNC: HGNC:9061
Homologene: 14858
Bcat1
Name: branched chain aminotransferase 1, cytosolic
Synonyms: Eca39, BCATc, Bcat-1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12035
HGNC: HGNC:976
Homologene: 20320
Ppp1ca
Name: protein phosphatase 1 catalytic subunit alpha
Synonyms: Ppp1c, dism2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 19045
VEGA: 19
HGNC: HGNC:9281
Homologene: 105262
Kpna2
Name: karyopherin subunit alpha 2
Synonyms: pendulin, m-importin, m-importin-alpha-P1, Rch1, 2410044B12Rik, Importin alpha, importin alpha 1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16647
HGNC: HGNC:6395
Homologene: 1708
Ccz1
Name: CCZ1 vacuolar protein trafficking and biogenesis associated
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231874
Homologene: 56717
Rbm27
Name: RNA binding motif protein 27
Synonyms: Psc1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225432
VEGA: 18
Homologene: 35410
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 15,312,840 bp
  • T to C, chromosome 1 at 172,200,583 bp
  • T to A, chromosome 2 at 14,238,144 bp
  • T to G, chromosome 2 at 52,226,444 bp
  • A to G, chromosome 2 at 89,075,297 bp
  • A to T, chromosome 2 at 112,645,245 bp
  • T to C, chromosome 2 at 116,063,320 bp
  • T to A, chromosome 3 at 60,036,035 bp
  • T to A, chromosome 3 at 89,181,218 bp
  • T to C, chromosome 3 at 116,121,055 bp
  • T to C, chromosome 4 at 59,958,568 bp
  • T to G, chromosome 4 at 115,877,994 bp
  • A to T, chromosome 5 at 124,817,712 bp
  • G to A, chromosome 5 at 144,014,808 bp
  • A to G, chromosome 6 at 54,593,018 bp
  • A to C, chromosome 6 at 112,739,376 bp
  • A to G, chromosome 6 at 127,470,760 bp
  • G to A, chromosome 6 at 142,392,342 bp
  • G to T, chromosome 6 at 145,048,632 bp
  • A to G, chromosome 7 at 81,332,967 bp
  • T to A, chromosome 7 at 85,751,154 bp
  • A to C, chromosome 7 at 113,386,243 bp
  • T to C, chromosome 8 at 4,136,839 bp
  • T to A, chromosome 8 at 11,443,571 bp
  • C to T, chromosome 8 at 12,844,427 bp
  • A to G, chromosome 8 at 25,769,305 bp
  • T to C, chromosome 8 at 94,477,117 bp
  • T to C, chromosome 8 at 111,982,604 bp
  • A to G, chromosome 9 at 51,118,007 bp
  • G to T, chromosome 9 at 63,145,382 bp
  • T to A, chromosome 10 at 77,556,161 bp
  • T to C, chromosome 10 at 78,037,933 bp
  • T to C, chromosome 11 at 70,961,615 bp
  • A to G, chromosome 11 at 102,444,176 bp
  • A to G, chromosome 11 at 103,076,857 bp
  • A to T, chromosome 11 at 106,992,058 bp
  • A to T, chromosome 12 at 108,537,366 bp
  • T to C, chromosome 13 at 13,637,475 bp
  • T to C, chromosome 13 at 51,723,622 bp
  • A to T, chromosome 14 at 50,820,030 bp
  • A to T, chromosome 14 at 52,349,963 bp
  • T to C, chromosome 14 at 55,066,663 bp
  • T to C, chromosome 14 at 61,540,158 bp
  • T to A, chromosome 14 at 73,182,366 bp
  • C to T, chromosome 14 at 75,038,874 bp
  • A to G, chromosome 15 at 57,951,670 bp
  • A to G, chromosome 16 at 22,951,123 bp
  • C to T, chromosome 16 at 44,218,943 bp
  • T to C, chromosome 16 at 58,674,449 bp
  • T to C, chromosome 17 at 33,576,450 bp
  • A to G, chromosome 17 at 56,256,946 bp
  • T to C, chromosome 17 at 78,763,026 bp
  • A to G, chromosome 18 at 36,682,585 bp
  • G to A, chromosome 18 at 37,335,606 bp
  • A to G, chromosome 18 at 42,327,513 bp
  • T to C, chromosome 18 at 64,555,115 bp
  • C to T, chromosome 18 at 69,642,983 bp
  • C to A, chromosome 19 at 4,193,089 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7606 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045676-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.