Strain Name:
C57BL/6J-MtgxR7639Btlr/Mmmh
Stock Number:
045697-MU
Citation ID:
RRID:MMRRC_045697-MU
Other Names:
R7639 (G1)
Major Collection:

Strain Information

Evl
Name: Ena-vasodilator stimulated phosphoprotein
Synonyms: b2b2600Clo
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 14026
VEGA: 12
Homologene: 56752
Rnf145
Name: ring finger protein 145
Synonyms: 3732413I11Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 74315
Homologene: 14427
Cnot7
Name: CCR4-NOT transcription complex, subunit 7
Synonyms: Caf1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 18983
Homologene: 49011
Ppp1r13b
Name: protein phosphatase 1, regulatory subunit 13B
Synonyms: ASPP1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 21981
VEGA: 12
Homologene: 9090
Traf2
Name: TNF receptor-associated factor 2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22030
Homologene: 22520
Bicd1
Name: BICD cargo adaptor 1
Synonyms: B830009D06Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12121
HGNC: HGNC:1049
Homologene: 37518
Abl1
Name: c-abl oncogene 1, non-receptor tyrosine kinase
Synonyms: c-Abl, E430008G22Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11350
HGNC: HGNC:76
Homologene: 3783
Abcg5
Name: ATP binding cassette subfamily G member 5
Synonyms: trac, Sterolin-1, cmp
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 27409
Homologene: 31909
Nat10
Name: N-acetyltransferase 10
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 98956
Homologene: 6785
Rock1
Name: Rho-associated coiled-coil containing protein kinase 1
Synonyms: Rock-I, 1110055K06Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 19877
VEGA: 18
Homologene: 55899
Dsg4
Name: desmoglein 4
Synonyms: lah, CDHF13
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 16769
Homologene: 65341
Erbb3
Name: erb-b2 receptor tyrosine kinase 3
Synonyms: Erbb3r, Erbb-3, HER3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 13867
HGNC: HGNC:3431
Homologene: 20457
Dync2h1
Name: dynein cytoplasmic 2 heavy chain 1
Synonyms: b2b414Clo, D330044F14Rik, 4432416O06Rik, DHC1b, D030010H02Rik, Dnchc2, m407Asp, DHC2, m152Asp
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 110350
HGNC: HGNC:2962
Homologene: 14468
Nav1
Name: neuron navigator 1
Synonyms: unc53H1, steerin-1, 9930003A20Rik, POMFIL3, C230080M11Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 215690
Homologene: 10719
Mettl8
Name: methyltransferase 8, methylcytidine
Synonyms: TIP
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228019
Homologene: 11706
Brip1
Name: BRCA1 interacting protein C-terminal helicase 1
Synonyms: 3110009N10Rik, BACH1, 8030460J03Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237911
Homologene: 32766
Fbxo46
Name: F-box protein 46
Synonyms: 20D7-FC4, 4932704E22Rik, Fbxo34l
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243867
Homologene: 18467
Trpa1
Name: transient receptor potential cation channel, subfamily A, member 1
Synonyms: ANKTM1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 277328
HGNC: HGNC:497
Homologene: 7189
Atp8b1
Name: ATPase, class I, type 8B, member 1
Synonyms: Ic, FIC1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 54670
VEGA: 18
HGNC: HGNC:3706
Homologene: 21151
Gkap1
Name: G kinase anchoring protein 1
Synonyms: Gkap42, D13Ertd340e, 42kDa, 4933400B15Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 56278
VEGA: 13
Homologene: 10515
Nlrc4
Name: NLR family, CARD domain containing 4
Synonyms: 9530011P19Rik, Ipaf, Card12
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 268973
VEGA: 17
Homologene: 10924
Syne2
Name: spectrin repeat containing, nuclear envelope 2
Synonyms: syne-2, 6820443O06Rik, D12Ertd777e, nesprin-2, Cpfl8, Nesp2g, diminished cone electroretinogram, dice
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 319565
Homologene: 56700
Celsr1
Name: cadherin, EGF LAG seven-pass G-type receptor 1
Synonyms: crash, Crsh, Adgrc1, Scy
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12614
VEGA: 15
HGNC: HGNC:1850
Homologene: 7665
Muc4
Name: mucin 4
Synonyms: 4933405I11Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 140474
HGNC: HGNC:7514
Homologene: 124469
Oat
Name: ornithine aminotransferase
Synonyms: rhg
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18242
HGNC: HGNC:8091
Homologene: 231
Unc13c
Name: unc-13 homolog C
Synonyms: 1500037O19Rik, D9Ertd414e, Munc13-3, Unc13h3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 208898
Homologene: 45443
Hfm1
Name: HFM1, ATP-dependent DNA helicase homolog
Synonyms: LOC381663, A330009G12Rik, Sec63d1, Mer3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 330149
Homologene: 87103
Rims1
Name: regulating synaptic membrane exocytosis 1
Synonyms: RIM1a, RIM1alpha, C030033M19Rik, RIM1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 116837
Homologene: 128399
Ccdc180
Name: coiled-coil domain containing 180
Synonyms: E230008N13Rik, LOC381522
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 381522
Homologene: 117988
Fam234b
Name: family with sequence similarity 234, member B
Synonyms: 8430419L09Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 74525
Homologene: 12572
Defa34
Name: defensin, alpha, 34
Synonyms: Gm15315, ENSMUSG00000063206
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 100041952
Homologene: 113382
Fanca
Name: Fanconi anemia, complementation group A
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14087
HGNC: HGNC:3582
Homologene: 108
Smcp
Name: sperm mitochondria-associated cysteine-rich protein
Synonyms: Mcsp
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 17235
HGNC: HGNC:6962
Oas2
Name: 2'-5' oligoadenylate synthetase 2
Synonyms: Oasl11, 2'-5' oligoadenylate synthetase-like 11
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 246728
HGNC: HGNC:8087
Homologene: 49478
Itga10
Name: integrin, alpha 10
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 213119
HGNC: HGNC:6135
Homologene: 2697
Miip
Name: migration and invasion inhibitory protein
Synonyms: D4Wsu114e
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 28010
Homologene: 15879
Cdc14b
Name: CDC14 cell division cycle 14B
Synonyms: 2810432N10Rik, A530086E13Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218294
VEGA: 13
Homologene: 104197
Tpra1
Name: transmembrane protein, adipocyte asscociated 1
Synonyms: 40kDa, Gpr175, Tpra40
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 24100
Homologene: 40799
Bhmt2
Name: betaine-homocysteine methyltransferase 2
Synonyms: D13Ucla2, C81077
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 64918
HGNC: HGNC:1048
Homologene: 49496
Or7a41
Name: olfactory receptor family 7 subfamily A member 41
Synonyms: GA_x6K02T2QGN0-2777431-2776472, IF12, Olfr57, MOR139-3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 18357
Homologene: 133620
Otop3
Name: otopetrin 3
Synonyms: 2310011E08Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69602
Homologene: 26091
Lipi
Name: lipase, member I
Synonyms: lpd1, D930038D03Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 320355
Homologene: 77864
Zfp729b
Name: zinc finger protein 729b
Synonyms: AA987161
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 100416706
Homologene: 133713
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 14,886,913 bp
  • A to T, chromosome 1 at 22,805,669 bp
  • T to C, chromosome 1 at 135,471,122 bp
  • TAGA to TA, chromosome 2 at 25,537,088 bp
  • T to A, chromosome 2 at 31,779,161 bp
  • A to T, chromosome 2 at 70,982,182 bp
  • G to A, chromosome 2 at 103,743,090 bp
  • G to A, chromosome 3 at 92,584,490 bp
  • G to A, chromosome 3 at 96,649,582 bp
  • A to T, chromosome 4 at 45,928,043 bp
  • A to T, chromosome 4 at 147,862,564 bp
  • A to C, chromosome 5 at 34,133,151 bp
  • T to A, chromosome 5 at 106,889,925 bp
  • A to G, chromosome 5 at 106,898,475 bp
  • C to T, chromosome 5 at 120,745,686 bp
  • A to G, chromosome 6 at 88,910,176 bp
  • A to T, chromosome 6 at 135,225,800 bp
  • A to G, chromosome 6 at 149,513,004 bp
  • T to A, chromosome 7 at 19,136,635 bp
  • A to T, chromosome 7 at 132,566,801 bp
  • A to T, chromosome 8 at 21,665,867 bp
  • A to G, chromosome 8 at 40,507,453 bp
  • A to G, chromosome 8 at 123,291,395 bp
  • C to A, chromosome 9 at 7,141,254 bp
  • T to A, chromosome 9 at 73,933,168 bp
  • A to G, chromosome 10 at 79,035,372 bp
  • A to G, chromosome 10 at 128,569,847 bp
  • T to C, chromosome 11 at 44,531,357 bp
  • A to T, chromosome 11 at 86,152,822 bp
  • T to C, chromosome 11 at 115,344,361 bp
  • A to C, chromosome 12 at 75,934,499 bp
  • A to G, chromosome 12 at 108,686,103 bp
  • G to T, chromosome 12 at 111,833,615 bp
  • T to G, chromosome 13 at 58,263,970 bp
  • A to G, chromosome 13 at 64,205,329 bp
  • C to T, chromosome 13 at 67,591,852 bp
  • C to T, chromosome 13 at 93,663,314 bp
  • C to T, chromosome 15 at 85,929,872 bp
  • C to G, chromosome 16 at 32,753,930 bp
  • T to A, chromosome 16 at 75,560,855 bp
  • C to T, chromosome 17 at 74,447,957 bp
  • T to A, chromosome 17 at 84,670,103 bp
  • A to G, chromosome 18 at 10,140,244 bp
  • G to T, chromosome 18 at 20,449,712 bp
  • A to G, chromosome 18 at 64,564,543 bp
  • C to T, chromosome 19 at 7,457,991 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7639 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045697-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.