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Strain Name:
C57BL/6J-MtgxR7664Btlr/Mmmh
Stock Number:
045704-MU
Citation ID:
RRID:MMRRC_045704-MU
Other Names:
R7664 (G1)
Major Collection:

Strain Information

Ncor1
Name: nuclear receptor co-repressor 1
Synonyms: N-CoR, Rxrip13, A230020K14Rik, 5730405M06Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20185
HGNC: HGNC:7672
Homologene: 38166
Camkk2
Name: calcium/calmodulin-dependent protein kinase kinase 2, beta
Synonyms: 6330570N16Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 207565
HGNC: HGNC:1470
Homologene: 32756
Crhr1
Name: corticotropin releasing hormone receptor 1
Synonyms: CRFR1, CRF-R1alpha, CRF 1 receptor, CRF1R
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12921
Homologene: 20920
Nrg1
Name: neuregulin 1
Synonyms: HGL, HRG, Hgl, SMDF, GGF, ARIA, heregulin, D230005F13Rik, HRGalpha, 6030402G23Rik, GGFII, NDF
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 211323
HGNC: HGNC:7997
Homologene: 138451
Nudt3
Name: nudix hydrolase 3
Synonyms: diphosphoinositol polyphosphate phosphohydrolase, Dipp, 1110011B09Rik, nudix (nucleoside diphosphate linked moiety X)-type motif 3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 56409
HGNC: HGNC:8050
Homologene: 31400
Lrp2
Name: low density lipoprotein receptor-related protein 2
Synonyms: Megalin, Gp330, D230004K18Rik, b2b1625.2Clo
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14725
HGNC: HGNC:6694
Homologene: 20952
Odf2l
Name: outer dense fiber of sperm tails 2-like
Synonyms: 4733401D09Rik, 9630045K08Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 52184
Homologene: 12011
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 52,709,053 bp
  • A to G, chromosome 1 at 54,987,467 bp
  • A to G, chromosome 1 at 58,119,539 bp
  • A to G, chromosome 1 at 74,192,675 bp
  • G to A, chromosome 1 at 107,379,988 bp
  • T to A, chromosome 1 at 144,541,249 bp
  • T to C, chromosome 1 at 155,241,631 bp
  • T to A, chromosome 2 at 3,570,710 bp
  • T to G, chromosome 2 at 69,506,732 bp
  • T to A, chromosome 2 at 69,670,717 bp
  • T to C, chromosome 2 at 73,319,370 bp
  • A to T, chromosome 2 at 128,849,054 bp
  • A to G, chromosome 2 at 132,843,533 bp
  • A to T, chromosome 2 at 144,258,004 bp
  • T to A, chromosome 2 at 178,470,042 bp
  • T to C, chromosome 3 at 24,058,139 bp
  • T to A, chromosome 3 at 145,148,584 bp
  • C to T, chromosome 4 at 40,724,090 bp
  • T to C, chromosome 4 at 43,010,066 bp
  • A to T, chromosome 4 at 98,496,950 bp
  • A to C, chromosome 5 at 30,907,663 bp
  • A to T, chromosome 5 at 36,614,617 bp
  • A to G, chromosome 5 at 38,230,817 bp
  • A to T, chromosome 5 at 90,760,031 bp
  • T to G, chromosome 5 at 110,656,919 bp
  • T to A, chromosome 5 at 120,961,276 bp
  • A to T, chromosome 5 at 122,756,582 bp
  • A to G, chromosome 6 at 60,976,705 bp
  • T to A, chromosome 6 at 70,074,298 bp
  • C to A, chromosome 6 at 121,861,220 bp
  • A to G, chromosome 6 at 122,966,422 bp
  • T to C, chromosome 6 at 133,851,957 bp
  • A to T, chromosome 7 at 19,443,226 bp
  • A to T, chromosome 7 at 24,778,332 bp
  • A to T, chromosome 7 at 27,910,712 bp
  • A to T, chromosome 7 at 30,022,290 bp
  • T to C, chromosome 7 at 59,987,491 bp
  • T to A, chromosome 7 at 85,155,811 bp
  • T to C, chromosome 7 at 101,830,097 bp
  • A to T, chromosome 7 at 109,708,980 bp
  • A to G, chromosome 7 at 141,067,713 bp
  • A to T, chromosome 8 at 3,386,390 bp
  • G to T, chromosome 8 at 32,009,141 bp
  • A to T, chromosome 9 at 18,409,486 bp
  • A to T, chromosome 9 at 18,607,722 bp
  • A to C, chromosome 9 at 21,586,990 bp
  • A to G, chromosome 9 at 44,513,310 bp
  • A to T, chromosome 9 at 63,141,763 bp
  • A to T, chromosome 9 at 77,138,546 bp
  • A to G, chromosome 9 at 121,814,213 bp
  • G to T, chromosome 10 at 4,353,748 bp
  • T to C, chromosome 10 at 12,941,326 bp
  • A to T, chromosome 10 at 17,902,370 bp
  • C to A, chromosome 11 at 4,044,178 bp
  • T to C, chromosome 11 at 54,466,125 bp
  • T to C, chromosome 11 at 62,398,328 bp
  • T to C, chromosome 11 at 69,787,024 bp
  • C to T, chromosome 11 at 84,245,349 bp
  • T to C, chromosome 11 at 94,102,160 bp
  • G to T, chromosome 11 at 100,750,322 bp
  • A to G, chromosome 11 at 102,460,840 bp
  • T to A, chromosome 11 at 104,169,142 bp
  • A to G, chromosome 12 at 4,103,132 bp
  • T to A, chromosome 13 at 22,293,762 bp
  • C to T, chromosome 13 at 54,214,856 bp
  • T to G, chromosome 13 at 55,659,051 bp
  • A to T, chromosome 13 at 104,220,290 bp
  • A to T, chromosome 14 at 56,438,878 bp
  • T to A, chromosome 14 at 88,469,367 bp
  • A to G, chromosome 14 at 123,846,550 bp
  • G to A, chromosome 16 at 57,317,947 bp
  • C to G, chromosome 16 at 91,495,194 bp
  • T to A, chromosome 17 at 15,555,571 bp
  • T to C, chromosome 17 at 23,820,981 bp
  • A to G, chromosome 17 at 27,623,175 bp
  • A to G, chromosome 17 at 33,136,402 bp
  • T to A, chromosome 17 at 33,918,579 bp
  • A to G, chromosome 17 at 34,029,577 bp
  • T to C, chromosome 17 at 45,545,935 bp
  • T to C, chromosome 18 at 21,554,649 bp
  • T to A, chromosome 18 at 37,309,240 bp
  • C to T, chromosome 18 at 62,014,971 bp
  • T to A, chromosome 18 at 65,307,002 bp
  • A to G, chromosome 19 at 29,812,076 bp
  • T to C, chromosome 19 at 41,321,630 bp
  • C to T, chromosome X at 8,962,804 bp
  • C to T, chromosome X at 8,962,808 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7664 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045704-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.