Loading Mouse GIF
Loading...

Strain Name:
C57BL/6J-MtgxR7708Btlr/Mmmh
Stock Number:
045709-MU
Citation ID:
RRID:MMRRC_045709-MU
Other Names:
R7708 (G1)
Major Collection:

Strain Information

Tnf
Name: tumor necrosis factor
Synonyms: TNF-alpha, tumor necrosis factor-alpha, TNF alpha, TNFalpha, DIF, Tnfsf1a, Tnfa
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 21926
Homologene: 496
Scn3a
Name: sodium channel, voltage-gated, type III, alpha
Synonyms: LOC381367, Nav1.3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20269
Homologene: 56005
Mtmr7
Name: myotubularin related protein 7
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 54384
HGNC: HGNC:7454
Homologene: 99732
Phf21a
Name: PHD finger protein 21A
Synonyms: 80kDa, Braf35/HDAC complex (Bhc), PFTF1, Bhc80, D030065N23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 192285
Homologene: 9597
Fkbp5
Name: FK506 binding protein 5
Synonyms: FKBP51, Dit1, D17Ertd592e
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 14229
HGNC: HGNC:3721
Homologene: 3038
Asap1
Name: ArfGAP with SH3 domain, ankyrin repeat and PH domain1
Synonyms: Ddef1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 13196
HGNC: HGNC:2720
Homologene: 7684
Clock
Name: clock circadian regulator
Synonyms: 5330400M04Rik, KAT13D, bHLHe8
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12753
HGNC: HGNC:2082
Homologene: 3603
Gpatch2
Name: G patch domain containing 2
Synonyms: 5830436K05Rik, Gpatc2, 5830433G22Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67769
Homologene: 9976
Arhgef1
Name: Rho guanine nucleotide exchange factor 1
Synonyms: Lsc, Lbcl2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16801
HGNC: HGNC:681
Homologene: 3454
Rreb1
Name: ras responsive element binding protein 1
Synonyms: 1110037N09Rik, B930013M22Rik, sao
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 68750
Homologene: 2218
Gpr89
Name: G protein-coupled receptor 89
Synonyms: SH120, 4933412D19Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 67549
Homologene: 9475
Cxxc1
Name: CXXC finger protein 1
Synonyms: 5830420C16Rik, 2410002I16Rik, PHF18, Cgbp, Cfp1, CXXC finger 1 (PHD domain)
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 74322
VEGA: 18
Homologene: 32221
Rpl7l1
Name: ribosomal protein L7-like 1
Synonyms: 1500016H10Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 66229
VEGA: 17
Homologene: 41632
Orm3
Name: orosomucoid 3
Synonyms: Agp-3, Orm-3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18407
Homologene: 130632
Or8b1c
Name: olfactory receptor family 8 subfamily B member 1C
Synonyms: GA_x6K02T2PVTD-32165709-32166641, MOR167-1, Olfr905
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258800
VEGA: 9
Homologene: 110524
Gm11639
Name: predicted gene 11639
Synonyms: Gm11639, Efcab15
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 105242472
Camk2d
Name: calcium/calmodulin-dependent protein kinase II, delta
Synonyms: CaMK II, 2810011D23Rik, 8030469K03Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 108058
HGNC: HGNC:1462
Homologene: 55561
Bspry
Name: B-box and SPRY domain containing
Synonyms: zetin 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 192120
Homologene: 9781
Or5p80
Name: olfactory receptor family 5 subfamily P member 80
Synonyms: GA_x6K02T2PBJ9-10959726-10960658, MOR204-6, Olfr508
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258769
Homologene: 72039
Atp10b
Name: ATPase, class V, type 10B
Synonyms: 5930426O13Rik, 9030605H24Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 319767
Homologene: 70969
Gm15130
Name: predicted gene 15130
Type: Gene
Species: Mouse
Chromosome: 2
Hivep1
Name: human immunodeficiency virus type I enhancer binding protein 1
Synonyms: Cryabp1, alphaA-CRYBP1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 110521
VEGA: 13
HGNC: HGNC:4920
Homologene: 1596
Pxdn
Name: peroxidasin
Synonyms: 2310075M15Rik, VPO1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 69675
Homologene: 33907
Hoxa2
Name: homeobox A2
Synonyms: Hox-1.11
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 15399
HGNC: HGNC:5103
Homologene: 4901
Tmprss11f
Name: transmembrane protease, serine 11f
Synonyms: 4732406D01Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 243083
Homologene: 65356
Ercc6l2
Name: excision repair cross-complementing rodent repair deficiency, complementation group 6 like 2
Synonyms: 1700019D06Rik, 9330134C04Rik, 0610007P08Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 76251
Homologene: 32564
Krt87
Name: keratin 87
Synonyms: Krt2-25, Krt83
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 406219
VEGA: 15
Homologene: 133804
Vmn1r217
Name: vomeronasal 1 receptor 217
Synonyms: V1rh14
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 171273
Homologene: 110880
Hip1r
Name: huntingtin interacting protein 1 related
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 29816
Homologene: 78348
Adam24
Name: ADAM metallopeptidase domain 24
Synonyms: Dtgn5
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 13526
HGNC: HGNC:203
Homologene: 137232
Or6k6
Name: olfactory receptor family 6 subfamily K member 6
Synonyms: GA_x6K02T2P20D-21053942-21054499, GA_x6K02T2LER7-6-623, GA_x6K02T02K39-452-3, MOR105-4, Olfr425, Olfr244, Olfr231
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 404222
Homologene: 17363
Ptprr
Name: protein tyrosine phosphatase receptor type R
Synonyms: PTPBR7, PTP-SL, RPTPRR
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19279
HGNC: HGNC:9680
Homologene: 2135
Inf2
Name: inverted formin, FH2 and WH2 domain containing
Synonyms: EG629699, 2610204M08Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 70435
VEGA: 12
Homologene: 82406
Trappc13
Name: trafficking protein particle complex 13
Synonyms: 2610524F24Rik, 2410002O22Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 66975
Homologene: 11792
Or4f52
Name: olfactory receptor family 4 subfamily F member 52
Synonyms: GA_x6K02T2Q125-72283260-72282322, MOR245-18, Olfr1275
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 257980
Homologene: 79419
Zfp827
Name: zinc finger protein 827
Synonyms: 2810449M09Rik, D630040G17Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 622675
Homologene: 45622
Vmn2r69
Name: vomeronasal 2, receptor 69
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330581
Homologene: 115466
Nuak2
Name: NUAK family, SNF1-like kinase, 2
Synonyms: 1200013B22Rik, Snark
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74137
Homologene: 12539
Or52e19
Name: olfactory receptor family 52 subfamily E member 19
Synonyms: GA_x6K02T2PBJ9-6019769-6019943, ENSMUSG00000073953, Olfr596-ps1, Gm15117, Olfr596
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100041187
Homologene: 121535
Slc10a6
Name: solute carrier family 10 (sodium/bile acid cotransporter family), member 6
Synonyms: 8430417G17Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 75750
Homologene: 12620
Or8s16
Name: olfactory receptor family 8 subfamily S member 16
Synonyms: GA_x6K02T2NBG7-5440777-5441736, GA_x6K02T2N22H-3824-2865, MOR160-3, Olfr285, Olfr257
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 257943
Homologene: 66175
Polh
Name: polymerase (DNA directed), eta (RAD 30 related)
Synonyms: RAD30A
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 80905
VEGA: 17
HGNC: HGNC:9181
Homologene: 38189
Trbj1-7
Name: T cell receptor beta joining 1-7
Synonyms: Gm16650
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 100125254
Aadacl2fm3
Name: AADACL2 family member 3
Synonyms: Gm8298
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 666803
Homologene: 86204
Gpr135
Name: G protein-coupled receptor 135
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238252
VEGA: 12
Homologene: 11211
Pcdhga2
Name: protocadherin gamma subfamily A, 2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93710
HGNC: HGNC:8700
Homologene: 69262
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 132,325,032 bp
  • A to G, chromosome 1 at 174,117,734 bp
  • A to G, chromosome 1 at 187,232,766 bp
  • C to T, chromosome 2 at 65,483,168 bp
  • T to C, chromosome 2 at 92,327,166 bp
  • T to A, chromosome 2 at 111,144,617 bp
  • T to C, chromosome 2 at 111,231,518 bp
  • A to G, chromosome 3 at 59,865,335 bp
  • G to A, chromosome 3 at 96,880,625 bp
  • A to T, chromosome 3 at 126,597,440 bp
  • G to T, chromosome 4 at 62,496,100 bp
  • A to T, chromosome 4 at 63,357,813 bp
  • T to A, chromosome 5 at 76,266,409 bp
  • C to T, chromosome 5 at 86,524,169 bp
  • C to T, chromosome 5 at 103,629,262 bp
  • T to A, chromosome 5 at 123,997,469 bp
  • T to G, chromosome 6 at 41,535,683 bp
  • A to G, chromosome 6 at 52,164,562 bp
  • G to A, chromosome 7 at 24,916,881 bp
  • T to A, chromosome 7 at 85,412,547 bp
  • T to C, chromosome 7 at 103,310,561 bp
  • C to T, chromosome 7 at 108,630,841 bp
  • A to G, chromosome 8 at 40,590,511 bp
  • A to G, chromosome 8 at 40,680,519 bp
  • T to C, chromosome 8 at 79,175,962 bp
  • A to T, chromosome 9 at 38,473,385 bp
  • A to T, chromosome 9 at 39,593,755 bp
  • A to G, chromosome 10 at 116,162,597 bp
  • C to A, chromosome 11 at 43,202,143 bp
  • G to C, chromosome 11 at 104,964,571 bp
  • C to T, chromosome 12 at 30,006,602 bp
  • T to G, chromosome 12 at 72,069,959 bp
  • T to C, chromosome 12 at 112,607,557 bp
  • T to C, chromosome 13 at 23,114,099 bp
  • A to G, chromosome 13 at 37,929,570 bp
  • T to A, chromosome 13 at 42,164,277 bp
  • T to A, chromosome 13 at 63,841,514 bp
  • C to T, chromosome 13 at 104,147,337 bp
  • T to C, chromosome 15 at 64,152,872 bp
  • A to T, chromosome 15 at 98,313,148 bp
  • T to C, chromosome 15 at 101,487,932 bp
  • A to G, chromosome 17 at 28,438,097 bp
  • A to C, chromosome 17 at 35,200,158 bp
  • G to T, chromosome 17 at 46,172,700 bp
  • A to G, chromosome 17 at 46,779,345 bp
  • T to A, chromosome 18 at 37,671,443 bp
  • G to T, chromosome 18 at 74,216,243 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7708 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045709-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.