Strain Name:
C57BL/6J-MtgxR7587Btlr/Mmmh
Stock Number:
045712-MU
Citation ID:
RRID:MMRRC_045712-MU
Other Names:
R7587 (G1)
Major Collection:

Strain Information

Atrn
Name: attractin
Synonyms: Mgca
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11990
HGNC: HGNC:885
Homologene: 22542
Capzb
Name: capping actin protein of muscle Z-line subunit beta
Synonyms: CPB1, 1700120C01Rik, CPbeta1, CPbeta2, Cappb1, CPB2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12345
HGNC: HGNC:1491
Homologene: 3620
Rtel1
Name: regulator of telomere elongation helicase 1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 269400
Homologene: 13168
Lpp
Name: LIM domain containing preferred translocation partner in lipoma
Synonyms: 9430020K16Rik, B130055L10Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 210126
VEGA: 16
HGNC: HGNC:6679
Homologene: 4075
Pepd
Name: peptidase D
Synonyms: peptidase D, Pep-4, Pep4, dal
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18624
HGNC: HGNC:8840
Homologene: 239
Tbce
Name: tubulin-specific chaperone E
Synonyms: C530005D02Rik, 2610206D02Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 70430
Homologene: 37744
Kcnj8
Name: potassium inwardly-rectifying channel, subfamily J, member 8
Synonyms: slmbr, gnite, sltr, Kir6.1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16523
HGNC: HGNC:6269
Homologene: 3654
Stk24
Name: serine/threonine kinase 24
Synonyms: 1810013H02Rik, STE20
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 223255
VEGA: 14
Homologene: 20793
Snrnp200
Name: small nuclear ribonucleoprotein 200 (U5)
Synonyms: U5-200KD, A330064G03Rik, HELIC2, Ascc3l1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 320632
Homologene: 5859
Pop1
Name: processing of precursor 1, ribonuclease P/MRP family, (S. cerevisiae)
Synonyms: 4932434G09Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 67724
Homologene: 41000
Rffl
Name: ring finger and FYVE like domain containing protein
Synonyms: rififylin, Carp-2, 4930516L10Rik, fring, Carp2, 1700051E09Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67338
Homologene: 12116
Nedd1
Name: neural precursor cell expressed, developmentally down-regulated gene 1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 17997
VEGA: 10
HGNC: HGNC:7723
Homologene: 7439
Tram1
Name: translocating chain-associating membrane protein 1
Synonyms: TRAMP, 1810049E02Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 72265
Homologene: 8621
Ncbp3
Name: nuclear cap binding subunit 3
Synonyms: 1200014J11Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 66874
Homologene: 10231
Tasor2
Name: transcription activation suppressor family member 2
Synonyms: Fam208b, BC016423
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 105203
VEGA: 13
Homologene: 26435
Kdm3b
Name: KDM3B lysine (K)-specific demethylase 3B
Synonyms: JHDM2B, 5830462I21Rik, Jmjd1b
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 277250
VEGA: 18
HGNC: HGNC:1337
Homologene: 41145
Lipc
Name: lipase, hepatic
Synonyms: Hpl, HL
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 15450
VEGA: 9
HGNC: HGNC:6619
Homologene: 199
Robo3
Name: roundabout guidance receptor 3
Synonyms: Rig1, Rig-1, Robo3b, Rbig1, Robo3a
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 19649
Homologene: 32119
Unc5b
Name: unc-5 netrin receptor B
Synonyms: Unc5h2, 6330415E02Rik, D10Bwg0792e
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 107449
VEGA: 10
Homologene: 32538
Gucy2c
Name: guanylate cyclase 2c
Synonyms: GC-C
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14917
HGNC: HGNC:4688
Homologene: 3641
D6Wsu163e
Name: DNA segment, Chr 6, Wayne State University 163, expressed
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 28040
HGNC: HGNC:1184
Homologene: 10685
Pms1
Name: PMS1 homolog 1, mismatch repair system component
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227099
HGNC: HGNC:9121
Homologene: 449
Nsun6
Name: NOL1/NOP2/Sun domain family member 6
Synonyms: 4933403D21Rik, NOPD1, 4933414E04Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74455
Homologene: 12564
Atl2
Name: atlastin GTPase 2
Synonyms: Aip-2, 2010110I21Rik, Arl6ip2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 56298
VEGA: 17
Homologene: 56949
Gpr107
Name: G protein-coupled receptor 107
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 277463
Homologene: 81077
Vps13a
Name: vacuolar protein sorting 13A
Synonyms: 4930543C13Rik, 4930516E05Rik, D330038K10Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 271564
VEGA: 19
HGNC: HGNC:1908
Homologene: 22068
Dennd2a
Name: DENN domain containing 2A
Synonyms: B930096L08Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 209773
Homologene: 35238
Prss35
Name: serine protease 35
Synonyms: 6030424L22Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244954
Homologene: 17734
Ltbr
Name: lymphotoxin B receptor
Synonyms: TNF receptor-related protein, TNF-R-III, Tnfrsf3, LT-beta receptor, Tnfbr, Ltar, TNFRrp, LT beta-R, TNFCR, LTbetaR, TNFR2-RP
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 17000
HGNC: HGNC:6718
Homologene: 1753
Tnr
Name: tenascin R
Synonyms: J1-tenascin, janusin, restrictin, TN-R
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 21960
Homologene: 124416
Agl
Name: amylo-1,6-glucosidase, 4-alpha-glucanotransferase
Synonyms: 9430004C13Rik, 1110061O17Rik, 9630046L06Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 77559
HGNC: HGNC:321
Homologene: 536
Lrp1b
Name: low density lipoprotein-related protein 1B
Synonyms: 9630004P12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 94217
HGNC: HGNC:6693
Homologene: 56810
Cfap44
Name: cilia and flagella associated protein 44
Synonyms: 6330444M21Rik, Wdr52, D16Ertd642e
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 212517
Homologene: 75085
BC034090
Name: cDNA sequence BC034090
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 207792
Homologene: 19490
Ppp1r9b
Name: protein phosphatase 1, regulatory subunit 9B
Synonyms: spinophilin, neurabin II, Spn, SPL
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217124
HGNC: HGNC:9298
Homologene: 32787
Mroh3
Name: maestro heat-like repeat family member 3
Synonyms: 2310006M14Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 76422
Spef2
Name: sperm flagellar 2
Synonyms: C230086A09Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 320277
Homologene: 23371
Pappa2
Name: pappalysin 2
Synonyms: PAPP-A2, placenta-specific 3, pregnancy-associated plasma protein-E, pregnancy-associated plasma preproprotein-A2, PLAC3, Pappe
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 23850
Homologene: 10661
Asic1
Name: acid-sensing ion channel 1
Synonyms: ASIC1b, ASIC1 beta, ASICalpha, ASIC1a, B530003N02Rik, Accn2, ASIC, BNaC2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 11419
VEGA: 15
HGNC: HGNC:100
Homologene: 121755
D630003M21Rik
Name: RIKEN cDNA D630003M21 gene
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228846
Homologene: 18598
Rfc3
Name: replication factor C (activator 1) 3
Synonyms: 2810416I22Rik, Recc3, 38kDa, 38kDa
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 69263
HGNC: HGNC:9971
Homologene: 2188
Mylk
Name: myosin, light polypeptide kinase
Synonyms: telokin, nmMlck, Mlck, 9530072E15Rik, MLCK108, MLCK210, A930019C19Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 107589
HGNC: HGNC:7590
Homologene: 14202
Dio2
Name: deiodinase, iodothyronine, type II
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13371
VEGA: 12
HGNC: HGNC:2884
Homologene: 621
Or7g32
Name: olfactory receptor family 7 subfamily G member 32
Synonyms: Olfr851, MOR155-1, GA_x6K02T2PVTD-13234278-13235216
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258907
HGNC: HGNC:8466
Homologene: 74178
Gpr108
Name: G protein-coupled receptor 108
Synonyms: 1810015L19Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 78308
VEGA: 17
Homologene: 32495
Cdh20
Name: cadherin 20
Synonyms: Cdh7
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 23836
HGNC: HGNC:1760
Homologene: 8015
Smco1
Name: single-pass membrane protein with coiled-coil domains 1
Synonyms: 2310010M20Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 69576
Homologene: 18842
Nat3
Name: N-acetyltransferase 3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 17962
Homologene: 69026
Nox4
Name: NADPH oxidase 4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 50490
HGNC: HGNC:7891
Homologene: 41065
Nexn
Name: nexilin
Synonyms: 1110046H09Rik, nF actin binding protein
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 68810
Homologene: 44892
Ttll3
Name: tubulin tyrosine ligase-like family, member 3
Synonyms: 4833441J24Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 101100
Homologene: 134361
Asah1
Name: N-acylsphingosine amidohydrolase 1
Synonyms: 2310081N20Rik, acid ceramidase
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11886
HGNC: HGNC:735
Homologene: 10504
Ppt2
Name: palmitoyl-protein thioesterase 2
Synonyms: 0610007M19Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 54397
HGNC: HGNC:9326
Homologene: 10448
Slc1a7
Name: solute carrier family 1 (glutamate transporter), member 7
Synonyms: A930031E15Rik, EAAT5
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242607
Homologene: 21327
Clpsl2
Name: colipase-like 2
Synonyms: Gm749, LOC328788
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 328788
Homologene: 86835
Or52n2c
Name: olfactory receptor family 52 subfamily N member 2C
Synonyms: Olfr668, MOR34-3, GA_x6K02T2PBJ9-7554614-7553658
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259061
Homologene: 64947
Tada2b
Name: transcriptional adaptor 2B
Synonyms: LOC231151
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231151
Homologene: 51007
Lipi
Name: lipase, member I
Synonyms: lpd1, D930038D03Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 320355
Homologene: 77864
Tlnrd1
Name: talin rod domain containing 1
Synonyms: Mesdc1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 80889
Homologene: 11209
Dchs2
Name: dachsous cadherin related 2
Synonyms: LOC229459
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 100534287
Or1e1b-ps1
Name: olfactory receptor family 1 subfamily E member 1B, pseudogene 1
Synonyms: MOR135-18, GA_x6K02T2P1NL-4111497-4112433, Olfr22-ps1, MTPCR35
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258209
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 13,579,547 bp
  • A to G, chromosome 1 at 53,207,316 bp
  • T to C, chromosome 1 at 104,941,279 bp
  • A to G, chromosome 1 at 136,190,998 bp
  • A to G, chromosome 1 at 155,217,486 bp
  • T to C, chromosome 1 at 158,851,131 bp
  • T to A, chromosome 1 at 159,886,208 bp
  • T to C, chromosome 2 at 15,039,825 bp
  • A to T, chromosome 2 at 31,168,826 bp
  • T to G, chromosome 2 at 40,730,717 bp
  • G to A, chromosome 2 at 127,227,902 bp
  • T to A, chromosome 2 at 130,980,114 bp
  • T to C, chromosome 2 at 158,196,388 bp
  • T to A, chromosome 2 at 158,201,056 bp
  • G to A, chromosome 2 at 181,322,315 bp
  • A to G, chromosome 3 at 83,304,515 bp
  • T to C, chromosome 3 at 116,792,087 bp
  • T to C, chromosome 3 at 152,247,178 bp
  • T to A, chromosome 4 at 108,010,486 bp
  • T to A, chromosome 4 at 139,262,023 bp
  • T to C, chromosome 5 at 36,476,767 bp
  • A to G, chromosome 5 at 95,521,411 bp
  • A to T, chromosome 5 at 151,651,151 bp
  • T to G, chromosome 6 at 39,483,135 bp
  • CAAAGTAA to CAAAGTAAAGTAA, chromosome 6 at 113,399,157 bp
  • T to C, chromosome 6 at 125,312,352 bp
  • A to G, chromosome 6 at 126,955,896 bp
  • A to G, chromosome 6 at 136,704,290 bp
  • T to C, chromosome 6 at 142,566,339 bp
  • T to C, chromosome 7 at 34,969,540 bp
  • A to G, chromosome 7 at 83,882,947 bp
  • A to G, chromosome 7 at 87,317,302 bp
  • C to T, chromosome 7 at 104,925,056 bp
  • A to T, chromosome 8 at 41,374,541 bp
  • T to C, chromosome 8 at 67,547,574 bp
  • T to A, chromosome 9 at 19,497,522 bp
  • T to C, chromosome 9 at 37,429,646 bp
  • A to G, chromosome 9 at 70,818,924 bp
  • T to A, chromosome 9 at 86,755,374 bp
  • C to T, chromosome 10 at 60,783,120 bp
  • G to A, chromosome 10 at 92,698,730 bp
  • T to C, chromosome 11 at 73,066,765 bp
  • C to T, chromosome 11 at 73,955,184 bp
  • T to C, chromosome 11 at 82,810,148 bp
  • T to A, chromosome 11 at 95,001,940 bp
  • A to G, chromosome 12 at 90,729,560 bp
  • T to C, chromosome 13 at 3,568,849 bp
  • C to T, chromosome 13 at 14,019,742 bp
  • C to T, chromosome 14 at 121,302,287 bp
  • T to A, chromosome 15 at 9,713,219 bp
  • A to T, chromosome 15 at 34,502,413 bp
  • A to C, chromosome 15 at 99,695,590 bp
  • A to T, chromosome 16 at 24,762,279 bp
  • A to G, chromosome 16 at 32,273,723 bp
  • A to G, chromosome 16 at 34,922,517 bp
  • A to G, chromosome 16 at 44,404,106 bp
  • C to T, chromosome 16 at 75,550,215 bp
  • G to A, chromosome 17 at 28,549,541 bp
  • A to G, chromosome 17 at 34,626,803 bp
  • C to T, chromosome 17 at 57,236,732 bp
  • A to T, chromosome 17 at 79,865,067 bp
  • A to G, chromosome 18 at 34,797,027 bp
  • G to A, chromosome 19 at 16,703,789 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7587 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045712-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.