Strain Name:
C57BL/6J-MtgxR7603Btlr/Mmmh
Stock Number:
045713-MU
Citation ID:
RRID:MMRRC_045713-MU
Other Names:
R7603 (G1)
Major Collection:

Strain Information

Adcy10
Name: adenylate cyclase 10
Synonyms: Sacy, 4930431D04Rik, soluble adenylyl cyclase, sAC
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 271639
Homologene: 10188
Epha7
Name: Eph receptor A7
Synonyms: Hek11, MDK1, Mdk1, Ebk, Cek11, Ehk3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 13841
HGNC: HGNC:3390
Homologene: 20935
Phf21a
Name: PHD finger protein 21A
Synonyms: 80kDa, D030065N23Rik, Braf35/HDAC complex (Bhc), PFTF1, Bhc80
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 192285
Homologene: 9597
Phf20
Name: PHD finger protein 20
Synonyms: 6820402O20Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228829
Homologene: 9507
Parp1
Name: poly (ADP-ribose) polymerase family, member 1
Synonyms: sPARP-1, PARP, 5830444G22Rik, Adprp, parp-1, Adprt1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 11545
HGNC: HGNC:270
Homologene: 1222
Urb1
Name: URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
Synonyms: 4921511H13Rik, 5730405K23Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 207932
Homologene: 45941
Herc1
Name: HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
Synonyms: 2810449H11Rik, D130015N03Rik, tbl
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235439
HGNC: HGNC:4867
Homologene: 31207
Rif1
Name: replication timing regulatory factor 1
Synonyms: 6530403D07Rik, D2Ertd145e, 5730435J01Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 51869
Homologene: 41231
Frs2
Name: fibroblast growth factor receptor substrate 2
Synonyms: C330018A15Rik, Frs2alpha, SNT1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 327826
VEGA: 10
Homologene: 4846
Lmbr1l
Name: limb region 1 like
Synonyms: 1110013E13Rik, D15Ertd735e
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 74775
Homologene: 10011
Vps13b
Name: vacuolar protein sorting 13B
Synonyms: 1810042B05Rik, C330002D13Rik, 2310042E16Rik, Coh1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 666173
VEGA: 15
HGNC: HGNC:2183
Homologene: 49516
Canx
Name: calnexin
Synonyms: 1110069N15Rik, CNX
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12330
HGNC: HGNC:1473
Homologene: 1324
Hspg2
Name: perlecan (heparan sulfate proteoglycan 2)
Synonyms: per, Plc, Pcn, perlecan
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 15530
HGNC: HGNC:5273
Homologene: 68473
Ddah1
Name: dimethylarginine dimethylaminohydrolase 1
Synonyms: 2410006N07Rik, 2510015N06Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 69219
HGNC: HGNC:2715
Homologene: 8120
Ints7
Name: integrator complex subunit 7
Synonyms: 5930412E23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 77065
Homologene: 9136
Mfsd14a
Name: major facilitator superfamily domain containing 14A
Synonyms: Hiat1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 15247
Homologene: 22456
Csmd1
Name: CUB and Sushi multiple domains 1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 94109
Homologene: 69536
Lama2
Name: laminin, alpha 2
Synonyms: merosin, mer
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16773
HGNC: HGNC:6482
Homologene: 37306
Actrt3
Name: actin related protein T3
Synonyms: Arpm1, 1700119I24Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 76652
Homologene: 13038
Nek9
Name: NIMA (never in mitosis gene a)-related expressed kinase 9
Synonyms: C130021H08Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217718
Homologene: 13222
Htra4
Name: HtrA serine peptidase 4
Synonyms: B430206E18Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 330723
Homologene: 17801
Abca6
Name: ATP-binding cassette, sub-family A member 6
Synonyms: 6330565N06Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76184
HGNC: HGNC:36
Homologene: 71264
Tpsg1
Name: tryptase gamma 1
Synonyms: Prss31, TMT
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 26945
Homologene: 74994
Lpin3
Name: lipin 3
Synonyms: 9130206L11Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 64899
Homologene: 84844
Nup210
Name: nucleoporin 210
Synonyms: gp190, gp210, Pom210
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 54563
Homologene: 41286
Usp20
Name: ubiquitin specific peptidase 20
Synonyms: 1700055M05Rik, Vdu2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74270
Homologene: 4861
Glipr1
Name: GLI pathogenesis related 1
Synonyms: 2410114O14Rik, RTVP-1, mRTVP-1, RTVP1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 73690
Homologene: 21357
Snap47
Name: synaptosomal-associated protein, 47
Synonyms: SNAP-47, 1110031B06Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67826
Homologene: 14206
Sanbr
Name: SANT and BTB domain regulator of CSR
Synonyms: 0610010F05Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71675
Homologene: 19038
Fggy
Name: FGGY carbohydrate kinase domain containing
Synonyms: 2310009E04Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 75578
Homologene: 49535
Cyp2c23
Name: cytochrome P450, family 2, subfamily c, polypeptide 23
Synonyms: Cyp2c44
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226143
Homologene: 115563
Map1lc3b
Name: microtubule-associated protein 1 light chain 3 beta
Synonyms: Map1lc3, LC3b, 1010001C15Rik, Atg8
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 67443
Homologene: 69359
Pogk
Name: pogo transposable element with KRAB domain
Synonyms: BASS2, 9130401E23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 71592
Homologene: 32346
Sele
Name: selectin, endothelial cell
Synonyms: CD62E, E-selectin, Elam
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20339
Homologene: 389
Fastkd5
Name: FAST kinase domains 5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 380601
Homologene: 36400
Apol7b
Name: apolipoprotein L 7b
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 278679
HGNC: HGNC:619
Homologene: 40940
Tmcc1
Name: transmembrane and coiled coil domains 1
Synonyms: 3632431M01Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330401
Homologene: 8995
Lin7b
Name: lin-7 homolog B, crumbs cell polarity complex component
Synonyms: MALS-2, Veli2, LIN-7B
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22342
Homologene: 22648
Vmn1r202
Name: vomeronasal 1 receptor 202
Synonyms: V1ri7
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 171258
Homologene: 110880
H2-Q7
Name: histocompatibility 2, Q region locus 7
Synonyms: Qa-7, Qa7, Ped, H-2Q7
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 15018
Homologene: 128352
Abhd16a
Name: abhydrolase domain containing 16A
Synonyms: D17H6S82E, Bat5, NG26
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 193742
Homologene: 10904
Phc3
Name: polyhomeotic 3
Synonyms: E030046K01Rik, HPH3, EDR3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 241915
Homologene: 69390
Ndufa12
Name: NADH:ubiquinone oxidoreductase subunit A12
Synonyms: 2410011G03Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 66414
Homologene: 10314
Slc4a1ap
Name: solute carrier family 4 (anion exchanger), member 1, adaptor protein
Synonyms: kanadaptin
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20534
Homologene: 7543
Or52m2
Name: olfactory receptor family 52 subfamily M member 2
Synonyms: MOR25-2, Olfr553, GA_x6K02T2PBJ9-5333671-5332712
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233578
Homologene: 17194
Tcstv3
Name: 2 cell stage variable group member 3
Synonyms: clone L3
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 236219
VEGA: 13
Gnpnat1
Name: glucosamine-phosphate N-acetyltransferase 1
Synonyms: EMeg32
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 54342
VEGA: 14
Homologene: 41323
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 164,049,515 bp
  • C to T, chromosome 1 at 165,564,237 bp
  • A to G, chromosome 1 at 166,401,911 bp
  • T to C, chromosome 1 at 180,600,212 bp
  • A to T, chromosome 1 at 191,596,224 bp
  • T to A, chromosome 2 at 31,011,474 bp
  • C to T, chromosome 2 at 52,076,175 bp
  • A to C, chromosome 2 at 92,357,007 bp
  • A to G, chromosome 2 at 130,615,041 bp
  • C to T, chromosome 2 at 156,302,851 bp
  • G to T, chromosome 2 at 160,903,754 bp
  • C to T, chromosome 3 at 30,598,547 bp
  • T to C, chromosome 3 at 30,907,452 bp
  • C to A, chromosome 3 at 116,633,883 bp
  • T to C, chromosome 3 at 145,759,019 bp
  • C to T, chromosome 4 at 28,871,937 bp
  • G to A, chromosome 4 at 95,769,506 bp
  • T to C, chromosome 4 at 137,548,368 bp
  • T to A, chromosome 4 at 137,557,192 bp
  • T to C, chromosome 5 at 31,546,195 bp
  • A to T, chromosome 6 at 91,076,697 bp
  • A to T, chromosome 6 at 116,043,131 bp
  • T to C, chromosome 7 at 45,368,432 bp
  • A to G, chromosome 7 at 102,614,938 bp
  • A to T, chromosome 8 at 16,288,682 bp
  • T to G, chromosome 8 at 25,025,700 bp
  • A to T, chromosome 8 at 121,593,529 bp
  • T to A, chromosome 9 at 66,451,383 bp
  • T to C, chromosome 10 at 27,266,680 bp
  • C to T, chromosome 10 at 94,220,779 bp
  • A to T, chromosome 10 at 111,988,832 bp
  • T to C, chromosome 10 at 117,074,063 bp
  • T to C, chromosome 11 at 23,566,191 bp
  • A to T, chromosome 11 at 50,311,628 bp
  • T to C, chromosome 11 at 59,428,547 bp
  • T to C, chromosome 11 at 110,180,258 bp
  • A to G, chromosome 12 at 85,303,514 bp
  • A to T, chromosome 13 at 22,501,620 bp
  • T to C, chromosome 13 at 120,317,610 bp
  • C to T, chromosome 14 at 45,384,617 bp
  • T to C, chromosome 15 at 35,576,439 bp
  • T to C, chromosome 15 at 77,423,456 bp
  • G to A, chromosome 15 at 98,908,691 bp
  • CACTTAC to CAC, chromosome 16 at 90,772,573 bp
  • G to T, chromosome 17 at 25,373,210 bp
  • T to A, chromosome 17 at 35,101,960 bp
  • T to C, chromosome 17 at 35,439,963 bp
  • C to T, chromosome 19 at 44,014,930 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7603 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045713-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.