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Strain Name:
C57BL/6J-MtgxR7609Btlr/Mmmh
Stock Number:
045714-MU
Citation ID:
RRID:MMRRC_045714-MU
Other Names:
R7609 (G1)
Major Collection:

Strain Information

Mc1r
Name: melanocortin 1 receptor
Synonyms: e, Mshra, extension recessive yellow, Mcr1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 17199
HGNC: HGNC:6929
Homologene: 1789
Tyr
Name: tyrosinase
Synonyms: skc35, Oca1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22173
Homologene: 30969
Wrn
Name: Werner syndrome RecQ like helicase
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 22427
Homologene: 6659
Rgs11
Name: regulator of G-protein signaling 11
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 50782
HGNC: HGNC:9993
Homologene: 77719
Epha7
Name: Eph receptor A7
Synonyms: MDK1, Ebk, Cek11, Ehk3, Hek11, Mdk1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 13841
HGNC: HGNC:3390
Homologene: 20935
Plekha7
Name: pleckstrin homology domain containing, family A member 7
Synonyms: A430081P20Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233765
Homologene: 52172
Dtx4
Name: deltex 4, E3 ubiquitin ligase
Synonyms: RNF155
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 207521
VEGA: 19
Homologene: 27781
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 30,805,501 bp
  • G to A, chromosome 1 at 36,539,465 bp
  • A to T, chromosome 1 at 37,804,893 bp
  • A to T, chromosome 1 at 56,637,151 bp
  • T to A, chromosome 1 at 180,952,974 bp
  • T to C, chromosome 1 at 181,155,902 bp
  • A to G, chromosome 2 at 59,962,473 bp
  • A to T, chromosome 2 at 76,795,763 bp
  • T to C, chromosome 2 at 87,309,509 bp
  • T to C, chromosome 2 at 146,112,533 bp
  • A to T, chromosome 2 at 164,405,814 bp
  • G to A, chromosome 2 at 167,984,570 bp
  • A to G, chromosome 3 at 29,956,442 bp
  • A to T, chromosome 3 at 92,993,096 bp
  • C to A, chromosome 3 at 97,715,565 bp
  • T to A, chromosome 3 at 100,095,595 bp
  • C to A, chromosome 3 at 116,807,279 bp
  • C to T, chromosome 4 at 28,871,937 bp
  • T to C, chromosome 4 at 76,072,003 bp
  • T to C, chromosome 4 at 107,887,212 bp
  • T to A, chromosome 4 at 126,925,795 bp
  • T to C, chromosome 4 at 133,296,437 bp
  • T to A, chromosome 5 at 6,770,066 bp
  • T to C, chromosome 5 at 75,166,721 bp
  • C to A, chromosome 5 at 86,147,075 bp
  • C to T, chromosome 5 at 89,135,686 bp
  • A to G, chromosome 6 at 58,472,470 bp
  • A to G, chromosome 6 at 115,586,726 bp
  • A to G, chromosome 7 at 4,927,576 bp
  • G to A, chromosome 7 at 43,802,179 bp
  • T to C, chromosome 7 at 87,483,884 bp
  • T to A, chromosome 7 at 108,081,546 bp
  • T to C, chromosome 7 at 116,164,446 bp
  • T to A, chromosome 7 at 141,861,729 bp
  • A to T, chromosome 8 at 3,476,057 bp
  • A to G, chromosome 8 at 33,310,713 bp
  • A to G, chromosome 8 at 117,558,113 bp
  • A to T, chromosome 8 at 123,408,293 bp
  • A to G, chromosome 9 at 27,345,890 bp
  • A to C, chromosome 9 at 38,330,224 bp
  • C to T, chromosome 9 at 39,820,287 bp
  • T to A, chromosome 9 at 44,505,747 bp
  • T to C, chromosome 9 at 55,989,460 bp
  • A to T, chromosome 9 at 95,485,679 bp
  • C to A, chromosome 9 at 107,997,283 bp
  • A to T, chromosome 10 at 29,148,228 bp
  • A to G, chromosome 10 at 75,436,201 bp
  • A to T, chromosome 10 at 81,158,026 bp
  • A to G, chromosome 10 at 121,552,501 bp
  • T to C, chromosome 11 at 48,916,023 bp
  • C to T, chromosome 11 at 59,000,299 bp
  • T to C, chromosome 11 at 60,488,811 bp
  • T to C, chromosome 11 at 78,226,951 bp
  • T to C, chromosome 11 at 115,339,720 bp
  • T to C, chromosome 11 at 116,289,259 bp
  • C to T, chromosome 11 at 120,677,522 bp
  • C to T, chromosome 12 at 40,124,589 bp
  • A to G, chromosome 12 at 55,566,048 bp
  • A to G, chromosome 14 at 32,566,361 bp
  • G to A, chromosome 14 at 51,039,483 bp
  • T to C, chromosome 15 at 8,305,872 bp
  • A to G, chromosome 15 at 27,912,642 bp
  • T to C, chromosome 16 at 56,111,637 bp
  • CACTTAC to CAC, chromosome 16 at 90,772,573 bp
  • T to C, chromosome 17 at 5,417,991 bp
  • G to T, chromosome 17 at 25,373,210 bp
  • T to C, chromosome 17 at 26,207,441 bp
  • G to T, chromosome 18 at 12,531,834 bp
  • T to C, chromosome 18 at 61,198,460 bp
  • A to G, chromosome 19 at 12,492,281 bp
  • G to A, chromosome 19 at 34,252,531 bp
  • A to G, chromosome 19 at 56,594,896 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7609 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045714-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.