Strain Name:
C57BL/6J-MtgxR7616Btlr/Mmmh
Stock Number:
045716-MU
Citation ID:
RRID:MMRRC_045716-MU
Other Names:
R7616 (G1)
Major Collection:

Strain Information

Etv1
Name: ets variant 1
Synonyms: ER81, Etsrp81
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 14009
HGNC: HGNC:3490
Homologene: 3636
Rictor
Name: RPTOR independent companion of MTOR, complex 2
Synonyms: 6030405M08Rik, 4921505C17Rik, D530039E11Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 78757
VEGA: 15
Homologene: 34317
Ptcd2
Name: pentatricopeptide repeat domain 2
Synonyms: 1190005P08Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 68927
VEGA: 13
Homologene: 11695
Nf1
Name: neurofibromin 1
Synonyms: Nf-1, Mhdadsk9, Dsk9, neurofibromin
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18015
HGNC: HGNC:7765
Homologene: 226
Vangl1
Name: VANGL planar cell polarity 1
Synonyms: KITENIN, mStbm, Lpp2, stbm
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229658
Homologene: 44540
Psmb7
Name: proteasome (prosome, macropain) subunit, beta type 7
Synonyms: MC14
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19177
HGNC: HGNC:9544
Homologene: 2093
Arid1b
Name: AT-rich interaction domain 1B
Synonyms: 9330189K18Rik, B230217J03Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 239985
Homologene: 32344
Trim66
Name: tripartite motif-containing 66
Synonyms: Tif1d, D7H11orf29
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330627
Homologene: 28044
Snap91
Name: synaptosomal-associated protein 91
Synonyms: 91kDa, AP180, F1-20
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20616
Homologene: 8429
Dsp
Name: desmoplakin
Synonyms: 2300002E22Rik, 5730453H04Rik, rul, DP
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 109620
HGNC: HGNC:3052
Homologene: 37922
Eif3d
Name: eukaryotic translation initiation factor 3, subunit D
Synonyms: eIF3p66, mouse translation initiation factor eIF3 p66, 66/67kDa, Eif3s7
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 55944
VEGA: 15
HGNC: HGNC:3278
Homologene: 2782
A630089N07Rik
Name: RIKEN cDNA A630089N07 gene
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 320586
VEGA: 16
Wdr25
Name: WD repeat domain 25
Synonyms: B930090D16Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 212198
VEGA: 12
Homologene: 56993
Tenm3
Name: teneurin transmembrane protein 3
Synonyms: Odz3, 2610100B16Rik, Ten-m3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 23965
Homologene: 22673
Zfand2a
Name: zinc finger, AN1-type domain 2A
Synonyms: Airap
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100494
Homologene: 64373
Itpr3
Name: inositol 1,4,5-triphosphate receptor 3
Synonyms: tf, Itpr-3, Ip3r3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 16440
HGNC: HGNC:6182
Homologene: 1675
Muc4
Name: mucin 4
Synonyms: 4933405I11Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 140474
HGNC: HGNC:7514
Homologene: 124469
Nek10
Name: NIMA (never in mitosis gene a)- related kinase 10
Synonyms: LOC238944
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 674895
Homologene: 130947
Stat4
Name: signal transducer and activator of transcription 4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20849
Homologene: 20679
Kmt2b
Name: lysine (K)-specific methyltransferase 2B
Synonyms: Wbp7, 2610014H22Rik, Mll2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 75410
Homologene: 22838
Slc2a2
Name: solute carrier family 2 (facilitated glucose transporter), member 2
Synonyms: Glut-2, Glut2, liver-type glucose transporter
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20526
Homologene: 68047
Mamdc2
Name: MAM domain containing 2
Synonyms: mamcan, 1200015L10Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 71738
VEGA: 19
Homologene: 17722
Grm5
Name: glutamate receptor, metabotropic 5
Synonyms: Gprc1e, Glu5R, mGluR5, 6430542K11Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 108071
HGNC: HGNC:4597
Homologene: 37354
Adam10
Name: a disintegrin and metallopeptidase domain 10
Synonyms: kuzbanian, kuz, 1700031C13Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 11487
HGNC: HGNC:188
Homologene: 865
Cracr2a
Name: calcium release activated channel regulator 2A
Synonyms: Efcab4b, LOC243645, LOC381812
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 381812
Homologene: 41883
Atp8b5
Name: ATPase, class I, type 8B, member 5
Synonyms: FetA, 4930417M19Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 320571
Homologene: 99882
Mylk
Name: myosin, light polypeptide kinase
Synonyms: telokin, Mlck, MLCK210, nmMlck, A930019C19Rik, 9530072E15Rik, MLCK108
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 107589
HGNC: HGNC:7590
Homologene: 14202
Fam120b
Name: family with sequence similarity 120, member B
Synonyms: CCPG, 4932442K08Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 67544
VEGA: 17
Homologene: 13033
Adgrb1
Name: adhesion G protein-coupled receptor B1
Synonyms: B830018M07Rik, Bai1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 107831
HGNC: HGNC:943
Homologene: 1287
Cbfa2t3
Name: CBFA2/RUNX1 translocation partner 3
Synonyms: MTGR2, ETO-2, Eto2, A630044F12Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12398
HGNC: HGNC:1537
Homologene: 74543
Phf2
Name: PHD finger protein 2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 18676
VEGA: 13
HGNC: HGNC:8920
Homologene: 3934
Sult2a5
Name: sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 5
Synonyms: EG434264, Gm15438
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 434264
Homologene: 37741
Vmn1r72
Name: vomeronasal 1 receptor 72
Synonyms: V1rg1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 252905
Homologene: 74318
Angel1
Name: angel homolog 1
Synonyms: 1110030H02Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 68737
Homologene: 32251
Clip4
Name: CAP-GLY domain containing linker protein family, member 4
Synonyms: 1700074B05Rik, 1700024K14Rik, 5830409B12Rik, 4833417L20Rik, Rsnl2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 78785
VEGA: 17
Homologene: 11662
Mtcl3
Name: MTCL family member 3
Synonyms: Soga3, 6330407J23Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 67412
VEGA: 10
Homologene: 28227
4931414P19Rik
Name: RIKEN cDNA 4931414P19 gene
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 74359
VEGA: 14
Homologene: 11078
Slbp
Name: stem-loop binding protein
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20492
Homologene: 31389
Vmn1r175
Name: vomeronasal 1 receptor 175
Synonyms: Gm6299
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 622222
Homologene: 128341
Ffar2
Name: free fatty acid receptor 2
Synonyms: Gpr43
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233079
HGNC: HGNC:4501
Homologene: 133911
4930563M21Rik
Name: RIKEN cDNA 4930563M21 gene
Synonyms: Rfpl3s
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 75258
VEGA: 9
Homologene: 138467
Or10ag55-ps1
Name: olfactory receptor family 10 subfamily AG member 55, pseudogene 1
Synonyms: GA_x6K02T2Q125-48769330-48770299, MOR264-27_p, MOR264-10P, Olfr1117-ps1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258110
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 52,013,878 bp
  • T to C, chromosome 2 at 38,633,964 bp
  • T to C, chromosome 2 at 87,285,273 bp
  • A to G, chromosome 3 at 28,727,111 bp
  • A to T, chromosome 3 at 102,184,065 bp
  • T to A, chromosome 4 at 43,370,823 bp
  • A to T, chromosome 5 at 33,643,866 bp
  • A to T, chromosome 5 at 139,478,566 bp
  • A to G, chromosome 6 at 84,101,963 bp
  • C to T, chromosome 6 at 127,608,697 bp
  • A to G, chromosome 7 at 11,670,345 bp
  • G to A, chromosome 7 at 13,670,682 bp
  • T to A, chromosome 7 at 23,808,606 bp
  • G to T, chromosome 7 at 30,582,208 bp
  • A to G, chromosome 7 at 30,819,932 bp
  • A to T, chromosome 7 at 88,116,201 bp
  • T to A, chromosome 7 at 109,483,749 bp
  • A to T, chromosome 8 at 48,341,049 bp
  • T to G, chromosome 8 at 122,633,337 bp
  • A to G, chromosome 9 at 55,989,454 bp
  • A to G, chromosome 9 at 70,722,711 bp
  • T to A, chromosome 9 at 86,839,621 bp
  • T to C, chromosome 10 at 29,146,578 bp
  • T to A, chromosome 11 at 79,384,266 bp
  • T to A, chromosome 12 at 38,865,606 bp
  • A to G, chromosome 12 at 86,717,736 bp
  • G to A, chromosome 12 at 108,992,893 bp
  • G to T, chromosome 13 at 38,191,482 bp
  • T to A, chromosome 13 at 48,807,607 bp
  • G to A, chromosome 13 at 99,344,699 bp
  • G to A, chromosome 14 at 14,937,759 bp
  • T to C, chromosome 14 at 54,585,666 bp
  • C to T, chromosome 15 at 6,772,154 bp
  • A to G, chromosome 15 at 74,548,569 bp
  • A to T, chromosome 15 at 77,961,686 bp
  • T to A, chromosome 16 at 32,752,361 bp
  • T to C, chromosome 16 at 34,879,557 bp
  • T to A, chromosome 16 at 98,066,210 bp
  • C to G, chromosome 17 at 4,995,386 bp
  • T to G, chromosome 17 at 15,402,836 bp
  • C to A, chromosome 17 at 27,088,977 bp
  • T to C, chromosome 17 at 71,834,273 bp
  • T to A, chromosome 19 at 23,350,804 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7616 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045716-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.