Strain Name:
C57BL/6J-MtgxR7622Btlr/Mmmh
Stock Number:
045717-MU
Citation ID:
RRID:MMRRC_045717-MU
Other Names:
R7622 (G1)
Major Collection:

Strain Information

Ncor1
Name: nuclear receptor co-repressor 1
Synonyms: N-CoR, Rxrip13, A230020K14Rik, 5730405M06Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20185
HGNC: HGNC:7672
Homologene: 38166
Cbfa2t2
Name: CBFA2/RUNX1 translocation partner 2
Synonyms: MTGR1, C330013D05Rik, Cbfa2t2h
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12396
HGNC: HGNC:1536
Homologene: 3733
Gapdhs
Name: glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
Synonyms: Gapd-s, Gapds
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 14447
Homologene: 101265
Uba2
Name: ubiquitin-like modifier activating enzyme 2
Synonyms: Sumo-1 activating enzyme subunit 2, UBA2, anthracycline-associated resistance, Arx, SAE2, Uble1b
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 50995
Homologene: 4018
Cdc42bpb
Name: CDC42 binding protein kinase beta
Synonyms: DMPK-like
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217866
VEGA: 12
HGNC: HGNC:1738
Homologene: 55945
Pi4ka
Name: phosphatidylinositol 4-kinase alpha
Synonyms: Pik4ca
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224020
HGNC: HGNC:8983
Homologene: 11171
Xpo4
Name: exportin 4
Synonyms: B430309A01Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 57258
Homologene: 10733
Tex2
Name: testis expressed gene 2
Synonyms: Taz4, Def-5, 4930568E07Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 21763
Homologene: 32414
Bltp1
Name: bridge-like lipid transfer protein family member 1
Synonyms: Tweek, FSA, 4932438A13Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229227
Homologene: 52105
Tmprss6
Name: transmembrane serine protease 6
Synonyms: matriptase-2, 1300008A22Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 71753
VEGA: 15
Homologene: 12408
Ubxn2b
Name: UBX domain protein 2B
Synonyms: 6430407D20Rik, 3110003A22Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 68053
Homologene: 23587
Mycbp
Name: MYC binding protein
Synonyms: Amy-1, 5730488M09Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56309
HGNC: HGNC:7554
Homologene: 49312
Dmxl2
Name: Dmx-like 2
Synonyms: E130119P06Rik, 6430411K14Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235380
HGNC: HGNC:2938
Homologene: 41022
Myh14
Name: myosin, heavy polypeptide 14
Synonyms: NMHC II-C, 2400004E04Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71960
Homologene: 23480
Slit2
Name: slit guidance ligand 2
Synonyms: Slil3, Drad-1, E130320P19Rik, E030015M03Rik, b2b1200.1Clo
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20563
Homologene: 3516
Lrrk2
Name: leucine-rich repeat kinase 2
Synonyms: cI-46, LOC381026, 9330188B09Rik, D630001M17Rik, 4921513O20Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 66725
Homologene: 18982
Wdr25
Name: WD repeat domain 25
Synonyms: B930090D16Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 212198
VEGA: 12
Homologene: 56993
Rnf13
Name: ring finger protein 13
Synonyms: Rzf, 2010001H16Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 24017
Homologene: 13493
Arl6ip6
Name: ADP-ribosylation factor-like 6 interacting protein 6
Synonyms: Aip-6, 2610529A11Rik, 2310057C01Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 65103
Homologene: 11302
Dnajc6
Name: DnaJ heat shock protein family (Hsp40) member C6
Synonyms: 2810027M23Rik, auxilin
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 72685
Homologene: 8865
Adgrd1
Name: adhesion G protein-coupled receptor D1
Synonyms: E230012M21Rik, Gpr133
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 243277
Homologene: 34616
Myo16
Name: myosin XVI
Synonyms: C230040D10Rik, Nyap3, BM140241
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244281
Homologene: 34710
Dnah6
Name: dynein, axonemal, heavy chain 6
Synonyms: A730004I20Rik, Dnahc6
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330355
HGNC: HGNC:2951
Homologene: 15221
Klc2
Name: kinesin light chain 2
Synonyms: 8030455F02Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 16594
Homologene: 22468
Sec61bl
Name: SEC61 translocon subunit beta like
Synonyms: Gm10320
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 101055909
Wdfy4
Name: WD repeat and FYVE domain containing 4
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 545030
Homologene: 83473
Stab2
Name: stabilin 2
Synonyms: STAB-2, FEEL-2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 192188
Homologene: 23022
Ppfia2
Name: protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
Synonyms: E130120L08Rik, Liprin-alpha2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 327814
VEGA: 10
HGNC: HGNC:9246
Homologene: 27953
Zc3h12d
Name: zinc finger CCCH type containing 12D
Synonyms: D730019B10Rik, TFL
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237256
VEGA: 10
Homologene: 18225
Gm19410
Name: predicted gene, 19410
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 100502846
Homologene: 132117
Pitpnm2
Name: phosphatidylinositol transfer protein, membrane-associated 2
Synonyms: RDGBA2, NIR3, Rdgb2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19679
Homologene: 7915
Sprr3
Name: small proline-rich protein 3
Synonyms: SPR3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20766
Homologene: 135951
Vmn2r80
Name: vomeronasal 2, receptor 80
Synonyms: EG624765
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 624765
Homologene: 83483
Pign
Name: phosphatidylinositol glycan anchor biosynthesis, class N
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 27392
HGNC: HGNC:8967
Homologene: 6330
Or1j21
Name: olfactory receptor family 1 subfamily J member 21
Synonyms: ID3, MOR136-6, GA_x6K02T2NLDC-33487752-33488690, Olfr50
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18350
Homologene: 74212
Pate4
Name: prostate and testis expressed 4
Synonyms: 9530004K16Rik, SVS VII, Svs7, Pate-B
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 56872
Homologene: 49624
Wdr90
Name: WD repeat domain 90
Synonyms: 3230401M21Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106618
Homologene: 27066
Or52b4i
Name: olfactory receptor family 52 subfamily B member 4I
Synonyms: GA_x6K02T2PBJ9-5263046-5263989, MOR31-13, Olfr548
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258229
Or8k53
Name: olfactory receptor family 8 subfamily K member 53
Synonyms: GA_x6K02T2Q125-47819205-47818258, MOR186-1, Olfr1055
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 259023
Homologene: 131140
Serpina3m
Name: serine (or cysteine) peptidase inhibitor, clade A, member 3M
Synonyms: contrapsin-like, Spi-2rs1, Spi-2l, Spi2-rs1, MMSPi2.4, Spi2.4, MMCM7, 3e46, antitrypsin, alpha-1 antiproteinase
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20717
HGNC: HGNC:16
Homologene: 111129
Pcdhb7
Name: protocadherin beta 7
Synonyms: Pcdhb4B, PcdhbG
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93878
HGNC: HGNC:8689
Homologene: 87123
Vmn1r86
Name: vomeronasal 1 receptor 86
Synonyms: Gm10301
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100312473
Homologene: 74345
Fam170a
Name: family with sequence similarity 170, member A
Synonyms: LOC225497, Znfd
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225497
VEGA: 18
Homologene: 86702
Krt75
Name: keratin 75
Synonyms: Krt2-6hf, 4732468K03Rik, Krtcap1, K6hf
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 109052
Homologene: 20983
Vmn2r67
Name: vomeronasal 2, receptor 67
Synonyms: EG620672
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 620672
Homologene: 115466
Or12e1
Name: olfactory receptor family 12 subfamily E member 1
Synonyms: GA_x6K02T2Q125-48676316-48677272, MOR264-6, Olfr1112
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258655
Homologene: 64901
Lrp11
Name: low density lipoprotein receptor-related protein 11
Synonyms: 9830160H19Rik, 1700034J19Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237253
Homologene: 13133
Rwdd2b
Name: RWD domain containing 2B
Synonyms: ORF5
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 53858
HGNC: HGNC:1302
Homologene: 9654
Lrrc52
Name: leucine rich repeat containing 52
Synonyms: 4930413P14Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240899
Homologene: 35430
Prr7
Name: proline rich 7 (synaptic)
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 432763
VEGA: 13
Homologene: 57114
Cfap54
Name: cilia and flagella associated protein 54
Synonyms: LOC380653, Gm872, 4930485B16Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 380654
Homologene: 133438
Ighv2-5
Name: immunoglobulin heavy variable 2-5
Synonyms: Gm16593
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 638605
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 105,648,117 bp
  • A to T, chromosome 1 at 166,495,872 bp
  • G to T, chromosome 1 at 167,466,095 bp
  • G to T, chromosome 1 at 167,466,096 bp
  • A to G, chromosome 2 at 36,793,931 bp
  • A to G, chromosome 2 at 53,217,327 bp
  • A to G, chromosome 2 at 86,347,662 bp
  • A to T, chromosome 2 at 87,192,250 bp
  • A to G, chromosome 2 at 154,500,445 bp
  • C to A, chromosome 3 at 36,948,413 bp
  • A to T, chromosome 3 at 57,820,534 bp
  • G to T, chromosome 3 at 92,457,285 bp
  • C to T, chromosome 4 at 6,214,692 bp
  • A to G, chromosome 4 at 101,640,491 bp
  • C to T, chromosome 4 at 123,905,301 bp
  • T to C, chromosome 4 at 144,158,319 bp
  • A to T, chromosome 5 at 47,985,205 bp
  • A to G, chromosome 5 at 124,122,027 bp
  • G to A, chromosome 5 at 129,139,624 bp
  • G to A, chromosome 6 at 56,126,925 bp
  • G to T, chromosome 6 at 73,124,759 bp
  • T to G, chromosome 7 at 13,102,758 bp
  • G to A, chromosome 7 at 30,739,331 bp
  • A to C, chromosome 7 at 34,165,435 bp
  • A to G, chromosome 7 at 44,632,422 bp
  • A to T, chromosome 7 at 85,136,454 bp
  • A to G, chromosome 7 at 102,542,623 bp
  • T to C, chromosome 7 at 123,466,660 bp
  • A to G, chromosome 8 at 10,376,238 bp
  • A to T, chromosome 8 at 35,810,347 bp
  • A to G, chromosome 9 at 35,608,299 bp
  • C to T, chromosome 9 at 54,472,218 bp
  • G to A, chromosome 10 at 7,590,172 bp
  • A to G, chromosome 10 at 7,867,269 bp
  • T to A, chromosome 10 at 79,194,263 bp
  • A to T, chromosome 10 at 86,873,902 bp
  • A to C, chromosome 10 at 92,956,944 bp
  • G to A, chromosome 10 at 106,830,659 bp
  • G to T, chromosome 11 at 62,317,968 bp
  • C to A, chromosome 11 at 106,546,895 bp
  • A to G, chromosome 12 at 104,389,575 bp
  • G to A, chromosome 12 at 108,992,893 bp
  • T to G, chromosome 12 at 111,294,772 bp
  • G to A, chromosome 12 at 113,685,738 bp
  • A to G, chromosome 13 at 55,472,796 bp
  • T to A, chromosome 13 at 98,489,724 bp
  • A to T, chromosome 14 at 33,078,274 bp
  • A to G, chromosome 14 at 57,597,011 bp
  • A to G, chromosome 15 at 78,446,726 bp
  • A to T, chromosome 15 at 91,812,323 bp
  • A to G, chromosome 15 at 101,570,272 bp
  • C to A, chromosome 16 at 17,293,977 bp
  • T to C, chromosome 16 at 87,434,612 bp
  • G to T, chromosome 17 at 25,854,109 bp
  • A to C, chromosome 18 at 37,342,461 bp
  • A to G, chromosome 18 at 50,282,902 bp
  • T to C, chromosome 19 at 5,111,632 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7622 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045717-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.