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Strain Name:
C57BL/6J-MtgxR7623Btlr/Mmmh
Stock Number:
045718-MU
Citation ID:
RRID:MMRRC_045718-MU
Other Names:
R7623 (G1)
Major Collection:

Strain Information

Dst
Name: dystonin
Synonyms: bullous pemphigoid antigen 1, BPAG1-n, BPAG1, Bpag1, Bpag, ah, bullous pemphigoid antigen 1, athetoid, Macf2, 2310001O04Rik, nmf203, A830042E19Rik, nmf339
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Mybl2
Name: myeloblastosis oncogene-like 2
Synonyms: Bmyb, B-Myb
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17865
HGNC: HGNC:7548
Homologene: 1847
Ccnb2
Name: cyclin B2
Synonyms: CycB2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12442
VEGA: 9
HGNC: HGNC:1580
Homologene: 74359
Zfr
Name: zinc finger RNA binding protein
Synonyms: C920030H05Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 22763
Homologene: 8009
Dph6
Name: diphthamine biosynthesis 6
Synonyms: 5730421E18Rik, Diphthine ammonia ligase, Atpbd4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66632
Homologene: 80244
Cnot1
Name: CCR4-NOT transcription complex, subunit 1
Synonyms: 6030411K04Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234594
HGNC: HGNC:7877
Homologene: 9453
Lamb2
Name: laminin, beta 2
Synonyms: Lamb-2, Lams, npht
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 16779
HGNC: HGNC:6487
Homologene: 1723
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 23,848,295 bp
  • T to A, chromosome 1 at 25,547,548 bp
  • T to A, chromosome 1 at 34,170,436 bp
  • A to G, chromosome 2 at 32,566,334 bp
  • A to G, chromosome 2 at 58,017,210 bp
  • T to C, chromosome 2 at 111,537,936 bp
  • C to A, chromosome 2 at 114,654,898 bp
  • A to G, chromosome 2 at 118,694,587 bp
  • A to G, chromosome 2 at 163,072,832 bp
  • A to G, chromosome 2 at 177,508,612 bp
  • T to C, chromosome 3 at 97,050,755 bp
  • A to T, chromosome 3 at 103,915,010 bp
  • G to A, chromosome 3 at 107,297,981 bp
  • A to G, chromosome 3 at 122,774,601 bp
  • T to A, chromosome 4 at 4,058,801 bp
  • A to G, chromosome 4 at 46,396,504 bp
  • A to G, chromosome 4 at 135,933,094 bp
  • C to T, chromosome 5 at 86,524,160 bp
  • T to A, chromosome 5 at 110,105,084 bp
  • A to G, chromosome 5 at 110,127,520 bp
  • T to G, chromosome 6 at 52,158,258 bp
  • T to C, chromosome 6 at 88,084,568 bp
  • T to C, chromosome 6 at 120,521,251 bp
  • T to A, chromosome 6 at 126,015,573 bp
  • C to A, chromosome 7 at 16,885,915 bp
  • T to A, chromosome 7 at 16,996,612 bp
  • T to C, chromosome 7 at 24,276,369 bp
  • T to A, chromosome 7 at 29,825,705 bp
  • T to A, chromosome 7 at 131,277,566 bp
  • T to C, chromosome 7 at 139,618,350 bp
  • A to T, chromosome 8 at 95,727,648 bp
  • A to T, chromosome 8 at 117,029,645 bp
  • G to T, chromosome 8 at 123,522,979 bp
  • T to A, chromosome 9 at 15,988,324 bp
  • A to T, chromosome 9 at 19,808,929 bp
  • T to A, chromosome 9 at 44,139,658 bp
  • A to G, chromosome 9 at 70,418,888 bp
  • C to T, chromosome 9 at 108,489,224 bp
  • T to C, chromosome 9 at 109,654,583 bp
  • A to C, chromosome 10 at 116,369,309 bp
  • T to C, chromosome 11 at 11,116,415 bp
  • G to T, chromosome 11 at 70,010,743 bp
  • T to C, chromosome 11 at 110,107,558 bp
  • A to G, chromosome 12 at 65,148,852 bp
  • G to A, chromosome 12 at 108,992,893 bp
  • A to G, chromosome 12 at 111,445,638 bp
  • T to A, chromosome 13 at 21,787,592 bp
  • A to T, chromosome 13 at 22,827,235 bp
  • A to G, chromosome 13 at 81,422,225 bp
  • C to A, chromosome 14 at 31,140,621 bp
  • A to G, chromosome 14 at 52,795,386 bp
  • A to T, chromosome 14 at 54,638,090 bp
  • G to A, chromosome 14 at 55,673,034 bp
  • A to C, chromosome 14 at 70,240,945 bp
  • C to T, chromosome 15 at 12,160,528 bp
  • A to T, chromosome 15 at 36,040,710 bp
  • A to G, chromosome 15 at 47,949,938 bp
  • G to A, chromosome 15 at 78,405,703 bp
  • T to A, chromosome 16 at 19,061,801 bp
  • C to T, chromosome 16 at 20,344,696 bp
  • G to T, chromosome 16 at 21,694,342 bp
  • A to G, chromosome 16 at 35,329,524 bp
  • C to T, chromosome 16 at 38,828,091 bp
  • A to G, chromosome 16 at 45,732,736 bp
  • G to A, chromosome 16 at 87,719,291 bp
  • T to A, chromosome 17 at 29,629,006 bp
  • T to C, chromosome 17 at 53,515,879 bp
  • A to T, chromosome 17 at 80,479,894 bp
  • T to C, chromosome 18 at 66,859,509 bp
  • A to G, chromosome 19 at 4,726,168 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7623 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045718-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.