Strain Name:
C57BL/6J-MtgxR7659Btlr/Mmmh
Stock Number:
045734-MU
Citation ID:
RRID:MMRRC_045734-MU
Other Names:
R7659 (G1)
Major Collection:

Strain Information

Nae1
Name: NEDD8 activating enzyme E1 subunit 1
Synonyms: Appbp1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234664
HGNC: HGNC:621
Homologene: 68370
Rasgrp2
Name: RAS, guanyl releasing protein 2
Synonyms: Caldaggef1, CalDAG-GEFI
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 19395
HGNC: HGNC:9879
Homologene: 4250
Rad54l2
Name: RAD54 like 2 (S. cerevisiae)
Synonyms: Srisnf2l, G630026H09Rik, Arip4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 81000
Homologene: 56698
Arid5b
Name: AT-rich interaction domain 5B
Synonyms: Mrf2alpha, Desrt, 5430435G07Rik, Mrf2, Mrf2beta
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 71371
VEGA: 10
Homologene: 45872
Got1
Name: glutamic-oxaloacetic transaminase 1, soluble
Synonyms: cytosolic aspartate aminotransferase, Got-1, cAspAT
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 14718
HGNC: HGNC:4432
Homologene: 1571
Paip1
Name: polyadenylate binding protein-interacting protein 1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218693
Homologene: 4709
Prmt7
Name: protein arginine N-methyltransferase 7
Synonyms: 4933402B05Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 214572
Homologene: 10382
Lgr4
Name: leucine-rich repeat-containing G protein-coupled receptor 4
Synonyms: Gpr48, A330106J01Rik, A930009A08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 107515
Homologene: 10226
Mki67
Name: antigen identified by monoclonal antibody Ki 67
Synonyms: D630048A14Rik, Ki-67, Ki67
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17345
HGNC: HGNC:7107
Homologene: 1814
Casc3
Name: exon junction complex subunit
Synonyms: Btz, Mln51
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 192160
Homologene: 7208
Eif2ak1
Name: eukaryotic translation initiation factor 2 alpha kinase 1
Synonyms: Hri
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 15467
Homologene: 8290
C1qtnf9
Name: C1q and tumor necrosis factor related protein 9
Synonyms: 9130217G22Rik, CTRP9
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 239126
Homologene: 18679
Prim1
Name: DNA primase, p49 subunit
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19075
HGNC: HGNC:9369
Homologene: 730
Inpp5b
Name: inositol polyphosphate-5-phosphatase B
Synonyms: 75kDa
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16330
HGNC: HGNC:6077
Homologene: 69021
Ppt1
Name: palmitoyl-protein thioesterase 1
Synonyms: D4Ertd184e, CLN1, 9530043G02Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 19063
HGNC: HGNC:9325
Homologene: 7488
Timm23
Name: translocase of inner mitochondrial membrane 23
Synonyms: Tim23
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 53600
Homologene: 9651
Dbr1
Name: debranching RNA lariats 1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 83703
Homologene: 9428
Zfp975
Name: zinc finger protein 975
Synonyms: Gm5595
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 434179
Homologene: 134004
Siglecf
Name: sialic acid binding Ig-like lectin F
Synonyms: Siglec5, mSiglec-F
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233186
Homologene: 50482
Nr4a3
Name: nuclear receptor subfamily 4, group A, member 3
Synonyms: Nor1, TEC, MINOR, NOR-1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18124
HGNC: HGNC:7982
Homologene: 5074
Atp6v0a4
Name: ATPase, H+ transporting, lysosomal V0 subunit A4
Synonyms: V-ATPase alpha 4, Atp6n1b
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 140494
HGNC: HGNC:866
Homologene: 39904
Hps3
Name: HPS3, biogenesis of lysosomal organelles complex 2 subunit 1
Synonyms: Hermansky-Pudlak syndrome 3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12807
Homologene: 13019
Ptprd
Name: protein tyrosine phosphatase receptor type D
Synonyms: B230219D21Rik, 1110002J03Rik, 3000002J10Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 19266
HGNC: HGNC:9668
Pigg
Name: phosphatidylinositol glycan anchor biosynthesis, class G
Synonyms: Gpi7
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 433931
Homologene: 39421
Cenatac
Name: centrosomal AT-AC splicing factor
Synonyms: D630044F24Rik, Ccdc84
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 382073
VEGA: 9
Homologene: 13886
Muc6
Name: mucin 6, gastric
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 353328
HGNC: HGNC:7517
Homologene: 18768
Nav3
Name: neuron navigator 3
Synonyms: POMFIL1, steerin 3, unc53H3, Pomfil1p, 9630020C08Rik, 4732483H20Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 260315
Homologene: 56688
Stk31
Name: serine threonine kinase 31
Synonyms: C330007K24Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 77485
Homologene: 12677
Gpld1
Name: glycosylphosphatidylinositol specific phospholipase D1
Synonyms: 6330541J12Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 14756
HGNC: HGNC:4459
Homologene: 1152
Col6a3
Name: collagen, type VI, alpha 3
Synonyms: Col6a-3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12835
HGNC: HGNC:2213
Homologene: 37917
Dnah9
Name: dynein, axonemal, heavy chain 9
Synonyms: Dnahc9, D11Ertd686e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237806
HGNC: HGNC:2953
Homologene: 20357
Itgb4
Name: integrin beta 4
Synonyms: CD104
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 192897
HGNC: HGNC:6158
Homologene: 179
Kif1a
Name: kinesin family member 1A
Synonyms: ATSV, Kns1, C630002N23Rik, N-3 kinesin, LOC381283
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16560
HGNC: HGNC:888
Homologene: 99729
Cass4
Name: Cas scaffolding protein family member 4
Synonyms: F730031O20Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 320664
Homologene: 75128
Ankar
Name: ankyrin and armadillo repeat containing
Synonyms: 4932422E22Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 319695
Homologene: 85163
Tshz1
Name: teashirt zinc finger family member 1
Synonyms: Mtsh1, Sdccag33, teashirt1, 5730407I04Rik, NY-CO-33, Tsh1, D18Bwg1409e
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 110796
Homologene: 4227
Otoa
Name: otoancorin
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 246190
Homologene: 71803
Or2b4
Name: olfactory receptor family 2 subfamily B member 4
Synonyms: A3, MOR256-3, GA_x6K02T2PSCP-2264806-2265753, SR1, Olfr124
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 259064
Homologene: 74266
Or1j15
Name: olfactory receptor family 1 subfamily J member 15
Synonyms: MOR136-12, GA_x6K02T2NLDC-33262744-33263673, Olfr344
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258621
Otogl
Name: otogelin-like
Synonyms: Gm6924
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 628870
Homologene: 46008
Mug1
Name: murinoglobulin 1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 17836
HGNC: HGNC:9750
Homologene: 136663
Nmrk1
Name: nicotinamide riboside kinase 1
Synonyms: D630020N23Rik, BC016495
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 225994
Homologene: 6787
Tmprss9
Name: transmembrane protease, serine 9
Synonyms: Serase-1B
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 432478
VEGA: 10
Homologene: 115302
Noa1
Name: nitric oxide associated 1
Synonyms: mAtNOS1, 2610024G14Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 56412
Homologene: 10518
Mcam
Name: melanoma cell adhesion molecule
Synonyms: Muc18, 1-gicerin, s-endo, CD146, s-gicerin
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 84004
HGNC: HGNC:6934
Homologene: 4742
Tm9sf1
Name: transmembrane 9 superfamily member 1
Synonyms: 1200014D02Rik, MP70
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 74140
Homologene: 4671
Bmp2k
Name: BMP2 inducible kinase
Synonyms: BIKE, 4933417M22Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 140780
Homologene: 34134
Or52h2
Name: olfactory receptor family 52 subfamily H member 2
Synonyms: MOR31-7, Olfr649, GA_x6K02T2PBJ9-6924585-6923647
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259057
Homologene: 74119
Vmn1r80
Name: vomeronasal 1 receptor 80
Synonyms: V1rg3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 171238
Vmn2r96
Name: vomeronasal 2, receptor 96
Synonyms: EG433070
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 433070
Armh1
Name: armadillo-like helical domain containing 1
Synonyms: LOC381544, LOC381543, Gm1661, Ncrna00082
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 381544
Homologene: 28727
Or8c9
Name: olfactory receptor family 8 subfamily C member 9
Synonyms: MTPCR18, MOR170-4, GA_x6K02T2PVTD-32017922-32018863, Olfr25
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 18323
VEGA: 9
Upk2
Name: uroplakin 2
Synonyms: uroplakin II, UPII
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22269
VEGA: 9
Homologene: 4920
Or4n4b
Name: olfactory receptor family 4 subfamily N member 4B
Synonyms: MOR241-2, GA_x6K02T2PMLR-5992342-5991416, Olfr733
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 258657
Homologene: 128266
Gpr149
Name: G protein-coupled receptor 149
Synonyms: Ieda, 9630018L10Rik, PGR10, R35
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229357
Homologene: 16359
Aldh2
Name: aldehyde dehydrogenase 2, mitochondrial
Synonyms: Ahd5, Ahd-5
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 11669
HGNC: HGNC:404
Homologene: 55480
Trim30d
Name: tripartite motif-containing 30D
Synonyms: Trim79, TRIM30-3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 209387
Homologene: 114426
Or12e1
Name: olfactory receptor family 12 subfamily E member 1
Synonyms: GA_x6K02T2Q125-48676316-48677272, MOR264-6, Olfr1112
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258655
Homologene: 64901
Or7g29
Name: olfactory receptor family 7 subfamily G member 29
Synonyms: GA_x6K02T2PVTD-13113073-13112135, Olfr847, MOR149-2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258518
Homologene: 17281
Mbd3
Name: methyl-CpG binding domain protein 3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 17192
HGNC: HGNC:6918
Homologene: 2917
Mogs
Name: mannosyl-oligosaccharide glucosidase
Synonyms: 1810017N02Rik, Gcs1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 57377
Homologene: 4593
Sapcd2
Name: suppressor APC domain containing 2
Synonyms: 6030458L21Rik, ang, 2010317E24Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 72080
Homologene: 18664
Azgp1
Name: alpha-2-glycoprotein 1, zinc
Synonyms: Zag
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12007
HGNC: HGNC:910
Homologene: 915
Or4p20
Name: olfactory receptor family 4 subfamily P member 20
Synonyms: GA_x6K02T2Q125-49911636-49910701, Olfr1181, MOR225-9P
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258060
Homologene: 86666
Pcdha3
Name: protocadherin alpha 3
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 192163
HGNC: HGNC:8669
Homologene: 129613
Nme9
Name: NME/NM23 family member 9
Synonyms: Txndc6
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 623534
Homologene: 52255
C530025M09Rik
Name: RIKEN cDNA C530025M09 gene
Type: Gene
Species: Mouse
Chromosome: 2
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 72,690,135 bp
  • T to A, chromosome 1 at 90,781,745 bp
  • T to A, chromosome 1 at 93,046,820 bp
  • A to G, chromosome 2 at 25,375,966 bp
  • T to A, chromosome 2 at 36,568,625 bp
  • T to A, chromosome 2 at 87,192,365 bp
  • T to C, chromosome 2 at 88,423,926 bp
  • T to A, chromosome 2 at 109,996,766 bp
  • T to G, chromosome 2 at 149,830,619 bp
  • A to G, chromosome 2 at 172,427,027 bp
  • G to A, chromosome 3 at 20,022,814 bp
  • T to C, chromosome 3 at 62,603,835 bp
  • T to C, chromosome 4 at 48,051,269 bp
  • T to C, chromosome 4 at 76,128,916 bp
  • C to A, chromosome 4 at 117,213,741 bp
  • T to A, chromosome 4 at 122,836,333 bp
  • T to C, chromosome 4 at 124,795,426 bp
  • T to C, chromosome 5 at 77,309,390 bp
  • T to C, chromosome 5 at 97,074,719 bp
  • G to A, chromosome 5 at 108,338,619 bp
  • T to C, chromosome 5 at 121,568,960 bp
  • G to T, chromosome 5 at 137,987,513 bp
  • T to C, chromosome 5 at 143,889,462 bp
  • A to G, chromosome 6 at 38,071,972 bp
  • T to A, chromosome 6 at 49,423,406 bp
  • G to A, chromosome 6 at 83,116,825 bp
  • C to A, chromosome 6 at 121,861,220 bp
  • A to G, chromosome 7 at 12,193,050 bp
  • T to C, chromosome 7 at 42,662,424 bp
  • A to G, chromosome 7 at 43,351,770 bp
  • T to C, chromosome 7 at 104,190,187 bp
  • A to T, chromosome 7 at 104,472,347 bp
  • T to A, chromosome 7 at 121,134,044 bp
  • A to G, chromosome 7 at 135,697,426 bp
  • T to C, chromosome 7 at 141,637,060 bp
  • A to G, chromosome 8 at 104,516,164 bp
  • G to T, chromosome 8 at 106,237,286 bp
  • C to T, chromosome 9 at 19,375,558 bp
  • T to C, chromosome 9 at 38,329,716 bp
  • T to A, chromosome 9 at 44,136,770 bp
  • T to C, chromosome 9 at 44,413,493 bp
  • A to C, chromosome 9 at 44,453,511 bp
  • G to A, chromosome 9 at 99,470,857 bp
  • A to G, chromosome 9 at 99,576,610 bp
  • T to C, chromosome 9 at 106,713,578 bp
  • C to T, chromosome 10 at 68,098,587 bp
  • T to C, chromosome 10 at 80,395,185 bp
  • C to A, chromosome 10 at 80,893,009 bp
  • T to A, chromosome 10 at 107,777,120 bp
  • T to G, chromosome 10 at 109,766,990 bp
  • T to C, chromosome 10 at 128,026,589 bp
  • A to G, chromosome 11 at 65,989,780 bp
  • C to G, chromosome 11 at 98,809,873 bp
  • A to T, chromosome 11 at 115,979,731 bp
  • A to C, chromosome 13 at 24,979,981 bp
  • C to T, chromosome 13 at 119,450,770 bp
  • A to C, chromosome 14 at 32,198,978 bp
  • T to C, chromosome 14 at 50,299,241 bp
  • A to T, chromosome 14 at 55,636,335 bp
  • T to A, chromosome 14 at 60,772,304 bp
  • T to C, chromosome 17 at 18,573,487 bp
  • A to T, chromosome 17 at 37,805,163 bp
  • A to G, chromosome 18 at 36,948,166 bp
  • A to T, chromosome 18 at 84,016,075 bp
  • G to T, chromosome 19 at 6,401,827 bp
  • A to G, chromosome 19 at 18,636,135 bp
  • A to G, chromosome 19 at 43,504,639 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7659 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045734-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.