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Strain Name:
C57BL/6J-MtgxR7659Btlr/Mmmh
Stock Number:
045734-MU
Citation ID:
RRID:MMRRC_045734-MU
Other Names:
R7659 (G1)
Major Collection:

Strain Information

Nae1
Name: NEDD8 activating enzyme E1 subunit 1
Synonyms: Appbp1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234664
HGNC: HGNC:621
Homologene: 68370
Rasgrp2
Name: RAS, guanyl releasing protein 2
Synonyms: CalDAG-GEFI, Caldaggef1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 19395
HGNC: HGNC:9879
Homologene: 4250
Rad54l2
Name: RAD54 like 2 (S. cerevisiae)
Synonyms: Arip4, G630026H09Rik, Srisnf2l
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 81000
Homologene: 56698
Arid5b
Name: AT-rich interaction domain 5B
Synonyms: 5430435G07Rik, Desrt, Mrf2beta, Mrf2alpha, Mrf2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 71371
VEGA: 10
Homologene: 45872
Got1
Name: glutamic-oxaloacetic transaminase 1, soluble
Synonyms: cAspAT, cytosolic aspartate aminotransferase, Got-1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 14718
HGNC: HGNC:4432
Homologene: 1571
Paip1
Name: polyadenylate binding protein-interacting protein 1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218693
Homologene: 4709
Prmt7
Name: protein arginine N-methyltransferase 7
Synonyms: 4933402B05Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 214572
Homologene: 10382
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 72,690,135 bp
  • T to A, chromosome 1 at 90,781,745 bp
  • T to A, chromosome 1 at 93,046,820 bp
  • A to G, chromosome 2 at 25,375,966 bp
  • T to A, chromosome 2 at 36,568,625 bp
  • T to A, chromosome 2 at 87,192,365 bp
  • T to C, chromosome 2 at 88,423,926 bp
  • T to A, chromosome 2 at 109,996,766 bp
  • T to G, chromosome 2 at 149,830,619 bp
  • A to G, chromosome 2 at 172,427,027 bp
  • G to A, chromosome 3 at 20,022,814 bp
  • T to C, chromosome 3 at 62,603,835 bp
  • T to C, chromosome 4 at 48,051,269 bp
  • T to C, chromosome 4 at 76,128,916 bp
  • C to A, chromosome 4 at 117,213,741 bp
  • T to A, chromosome 4 at 122,836,333 bp
  • T to C, chromosome 4 at 124,795,426 bp
  • T to C, chromosome 5 at 77,309,390 bp
  • T to C, chromosome 5 at 97,074,719 bp
  • G to A, chromosome 5 at 108,338,619 bp
  • T to C, chromosome 5 at 121,568,960 bp
  • G to T, chromosome 5 at 137,987,513 bp
  • T to C, chromosome 5 at 143,889,462 bp
  • A to G, chromosome 6 at 38,071,972 bp
  • T to A, chromosome 6 at 49,423,406 bp
  • G to A, chromosome 6 at 83,116,825 bp
  • C to A, chromosome 6 at 121,861,220 bp
  • A to G, chromosome 7 at 12,193,050 bp
  • T to C, chromosome 7 at 42,662,424 bp
  • A to G, chromosome 7 at 43,351,770 bp
  • T to C, chromosome 7 at 104,190,187 bp
  • A to T, chromosome 7 at 104,472,347 bp
  • T to A, chromosome 7 at 121,134,044 bp
  • A to G, chromosome 7 at 135,697,426 bp
  • T to C, chromosome 7 at 141,637,060 bp
  • A to G, chromosome 8 at 104,516,164 bp
  • G to T, chromosome 8 at 106,237,286 bp
  • C to T, chromosome 9 at 19,375,558 bp
  • T to C, chromosome 9 at 38,329,716 bp
  • T to A, chromosome 9 at 44,136,770 bp
  • T to C, chromosome 9 at 44,413,493 bp
  • A to C, chromosome 9 at 44,453,511 bp
  • G to A, chromosome 9 at 99,470,857 bp
  • A to G, chromosome 9 at 99,576,610 bp
  • T to C, chromosome 9 at 106,713,578 bp
  • C to T, chromosome 10 at 68,098,587 bp
  • T to C, chromosome 10 at 80,395,185 bp
  • C to A, chromosome 10 at 80,893,009 bp
  • T to A, chromosome 10 at 107,777,120 bp
  • T to G, chromosome 10 at 109,766,990 bp
  • T to C, chromosome 10 at 128,026,589 bp
  • A to G, chromosome 11 at 65,989,780 bp
  • C to G, chromosome 11 at 98,809,873 bp
  • A to T, chromosome 11 at 115,979,731 bp
  • A to C, chromosome 13 at 24,979,981 bp
  • C to T, chromosome 13 at 119,450,770 bp
  • A to C, chromosome 14 at 32,198,978 bp
  • T to C, chromosome 14 at 50,299,241 bp
  • A to T, chromosome 14 at 55,636,335 bp
  • T to A, chromosome 14 at 60,772,304 bp
  • T to C, chromosome 17 at 18,573,487 bp
  • A to T, chromosome 17 at 37,805,163 bp
  • A to G, chromosome 18 at 36,948,166 bp
  • A to T, chromosome 18 at 84,016,075 bp
  • G to T, chromosome 19 at 6,401,827 bp
  • A to G, chromosome 19 at 18,636,135 bp
  • A to G, chromosome 19 at 43,504,639 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7659 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045734-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.