Strain Name:
C57BL/6J-MtgxR7688Btlr/Mmmh
Stock Number:
045752-MU
Citation ID:
RRID:MMRRC_045752-MU
Other Names:
R7688 (G1)
Major Collection:

Strain Information

Kcnj5
Name: potassium inwardly-rectifying channel, subfamily J, member 5
Synonyms: GIRK4, Kir3.4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 16521
VEGA: 9
HGNC: HGNC:6266
Homologene: 20248
Epb41l2
Name: erythrocyte membrane protein band 4.1 like 2
Synonyms: D10Ertd398e, Epb4.1l2, NBL2, 4.1G
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 13822
VEGA: 10
HGNC: HGNC:3379
Homologene: 37478
Ube2j2
Name: ubiquitin-conjugating enzyme E2J 2
Synonyms: Ubc6, 2400008G19Rik, 1200007B18Rik, 5730472G04Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 140499
Homologene: 10975
Triobp
Name: TRIO and F-actin binding protein
Synonyms: EST478828, Tara, Mus EST 478828
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 110253
Homologene: 5104
Uaca
Name: uveal autoantigen with coiled-coil domains and ankyrin repeats
Synonyms: 2700059D02Rik, nucling
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 72565
VEGA: 9
Homologene: 74297
Dmxl1
Name: Dmx-like 1
Synonyms: C630007L23Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240283
HGNC: HGNC:2937
Homologene: 21136
Focad
Name: focadhesin
Synonyms: BC057079
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230393
Homologene: 9842
Dennd4c
Name: DENN domain containing 4C
Synonyms: 1700065A05Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329877
Homologene: 23057
Klhl12
Name: kelch-like 12
Synonyms: C3ip1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240756
Homologene: 23317
Mcf2l
Name: mcf.2 transforming sequence-like
Synonyms: C130040G20Rik, Dbs
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 17207
Homologene: 11804
Zfp317
Name: zinc finger protein 317
Synonyms: D230022C05Rik, Zfp75, KRAB9, Zfp67
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244713
Homologene: 36389
Lama1
Name: laminin, alpha 1
Synonyms: Lama
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 16772
VEGA: 17
HGNC: HGNC:6481
Homologene: 21146
Hnrnpul2
Name: heterogeneous nuclear ribonucleoprotein U-like 2
Synonyms: Hnrpul2, 1110031M08Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 68693
VEGA: 19
Homologene: 28583
Lig1
Name: ligase I, DNA, ATP-dependent
Synonyms: mLigI, LigI
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16881
HGNC: HGNC:6598
Homologene: 197
Ets1
Name: E26 avian leukemia oncogene 1, 5' domain
Synonyms: p42Ets-1, Ets-1, Tpl1, p51Ets-1, vs
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 23871
HGNC: HGNC:3488
Homologene: 3837
Klhl6
Name: kelch-like 6
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 239743
Homologene: 15603
Muc4
Name: mucin 4
Synonyms: 4933405I11Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 140474
HGNC: HGNC:7514
Homologene: 124469
Slc5a8
Name: solute carrier family 5 (iodide transporter), member 8
Synonyms: SMCT
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216225
VEGA: 10
Homologene: 64832
Flt1
Name: FMS-like tyrosine kinase 1
Synonyms: vascular endothelial growth factor receptor-1, VEGFR-1, Flt-1, VEGFR1, sFlt1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14254
HGNC: HGNC:3763
Homologene: 134179
Vinac1
Name: vinculin/alpha-catenin family member 1
Synonyms: Gm14025
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 668894
Homologene: 86340
Slc44a5
Name: solute carrier family 44, member 5
Synonyms: LOC242259
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242259
Homologene: 72094
Oog4
Name: oogenesin 4
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242737
Tigd2
Name: tigger transposable element derived 2
Synonyms: 3632410O17Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 68140
Homologene: 129603
Tnxb
Name: tenascin XB
Synonyms: Tnx, TN-MHC
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 81877
Homologene: 49589
Vmn2r72
Name: vomeronasal 2, receptor 72
Synonyms: Vmn2r72-ps, EG244114
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244114
Homologene: 115466
Kif14
Name: kinesin family member 14
Synonyms: D1Ertd367e, N-3 kinesin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 381293
Homologene: 8916
Kctd1
Name: potassium channel tetramerisation domain containing 1
Synonyms: 4933402K10Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 106931
VEGA: 18
Homologene: 65999
Macrod1
Name: mono-ADP ribosylhydrolase 1
Synonyms: D930010J01Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 107227
VEGA: 19
Homologene: 8549
Rab25
Name: RAB25, member RAS oncogene family
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 53868
Homologene: 22995
Oasl2
Name: 2'-5' oligoadenylate synthetase-like 2
Synonyms: M1204, Mmu-OASL
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 23962
Homologene: 128369
Bag6
Name: BCL2-associated athanogene 6
Synonyms: D17H6S52E, G3, Scythe, 2410045D21Rik, Bat3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224727
Homologene: 3409
F11
Name: coagulation factor XI
Synonyms: FXI, plasma thromboplastin antecedent, Cf11, 1600027G01Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 109821
HGNC: HGNC:3529
Homologene: 86654
Megf11
Name: multiple EGF-like-domains 11
Synonyms: 2410080H04Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 214058
Homologene: 13031
Pdcl2
Name: phosducin-like 2
Synonyms: 1700016K07Rik, 1700010B22Rik, Mgcphlp
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 79455
Homologene: 74832
Slc22a18
Name: solute carrier family 22 (organic cation transporter), member 18
Synonyms: TSSC5, p45-BWR1A, BWSCR1A, Slc22a1l, BWR1A, Orctl2, Impt1, IMPT1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18400
Homologene: 1918
Spata18
Name: spermatogenesis associated 18
Synonyms: 1700067I02Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 73472
Homologene: 17057
Or4b12
Name: olfactory receptor family 4 subfamily B member 12
Synonyms: Olfr1271, GA_x6K02T2Q125-51620802-51619885, MOR227-5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258789
HGNC: HGNC:8290
Fam13a
Name: family with sequence similarity 13, member A
Synonyms: D430015B01Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 58909
Homologene: 135847
Tas2r115
Name: taste receptor, type 2, member 115
Synonyms: T2R15, Tas2r15, mGR15, mt2r49
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 353325
Or14a257
Name: olfactory receptor family 14 subfamily A member 257
Synonyms: MOR219-4, GA_x6K02T2NHDJ-9619796-9620794, Olfr298
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 257905
Or52e8
Name: olfactory receptor family 52 subfamily E member 8
Synonyms: GA_x6K02T2PBJ9-7604826-7603885, Olfr671, MOR32-12
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 257910
Homologene: 133595
Pfkfb3
Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
Synonyms: uPFK-2, E330010H22Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 170768
HGNC: HGNC:8874
Homologene: 88708
Gm5150
Name: predicted gene 5150
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 381484
Homologene: 129516
Leng1
Name: leukocyte receptor cluster (LRC) member 1
Synonyms: 1500001K17Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 69757
Homologene: 11520
Cldn24
Name: claudin 24
Synonyms: Gm10107
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 100039801
Homologene: 136011
Trbj2-3
Name: T cell receptor beta joining 2-3
Synonyms: Gm16974
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 100125257
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 134,489,030 bp
  • T to C, chromosome 1 at 136,494,654 bp
  • A to G, chromosome 2 at 11,492,639 bp
  • A to T, chromosome 2 at 90,265,615 bp
  • G to A, chromosome 2 at 129,039,044 bp
  • A to G, chromosome 3 at 15,963,583 bp
  • A to T, chromosome 3 at 88,544,963 bp
  • T to A, chromosome 3 at 153,973,800 bp
  • T to C, chromosome 4 at 86,795,140 bp
  • T to A, chromosome 4 at 88,178,133 bp
  • CAA to CA, chromosome 4 at 143,437,452 bp
  • T to A, chromosome 4 at 155,956,428 bp
  • A to G, chromosome 5 at 73,651,662 bp
  • T to C, chromosome 5 at 76,317,923 bp
  • A to T, chromosome 5 at 114,897,848 bp
  • C to T, chromosome 5 at 147,676,325 bp
  • T to A, chromosome 6 at 41,543,225 bp
  • C to T, chromosome 6 at 58,935,707 bp
  • T to A, chromosome 6 at 59,210,397 bp
  • T to A, chromosome 6 at 132,737,680 bp
  • G to A, chromosome 7 at 3,662,810 bp
  • T to C, chromosome 7 at 13,289,463 bp
  • T to A, chromosome 7 at 85,754,890 bp
  • A to G, chromosome 7 at 86,488,975 bp
  • C to A, chromosome 7 at 103,250,775 bp
  • C to A, chromosome 7 at 104,975,125 bp
  • G to A, chromosome 7 at 143,479,823 bp
  • T to A, chromosome 8 at 12,948,130 bp
  • A to T, chromosome 8 at 45,250,090 bp
  • G to A, chromosome 8 at 47,822,705 bp
  • T to G, chromosome 9 at 19,647,955 bp
  • A to G, chromosome 9 at 32,322,968 bp
  • T to A, chromosome 9 at 32,696,424 bp
  • A to G, chromosome 9 at 60,874,127 bp
  • A to G, chromosome 9 at 64,691,864 bp
  • T to C, chromosome 10 at 25,479,138 bp
  • A to G, chromosome 10 at 88,921,699 bp
  • T to C, chromosome 15 at 78,961,111 bp
  • C to A, chromosome 16 at 19,947,131 bp
  • A to T, chromosome 16 at 32,751,460 bp
  • T to A, chromosome 17 at 34,671,906 bp
  • T to C, chromosome 17 at 35,146,892 bp
  • A to T, chromosome 17 at 67,761,628 bp
  • T to G, chromosome 18 at 14,974,198 bp
  • T to A, chromosome 18 at 49,955,871 bp
  • C to A, chromosome 19 at 7,196,865 bp
  • T to A, chromosome 19 at 8,820,630 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7688 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045752-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.