Strain Name:
C57BL/6J-MtgxR7695Btlr/Mmmh
Stock Number:
045758-MU
Citation ID:
RRID:MMRRC_045758-MU
Other Names:
R7695 (G1)
Major Collection:

Strain Information

Myh9
Name: myosin, heavy polypeptide 9, non-muscle
Synonyms: D0Jmb2, E030044M24Rik, NMHC II-A, Myhn-1, Myhn1, myosin IIA, Fltn
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 17886
HGNC: HGNC:7579
Homologene: 129835
Ide
Name: insulin degrading enzyme
Synonyms: 1300012G03Rik, 4833415K22Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 15925
HGNC: HGNC:5381
Homologene: 3645
Pax2
Name: paired box 2
Synonyms: Pax-2, Opdc
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18504
HGNC: HGNC:8616
Homologene: 2968
Ubap2
Name: ubiquitin-associated protein 2
Synonyms: 1190005K07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 68926
Homologene: 73649
Dnmt1
Name: DNA methyltransferase 1
Synonyms: MTase, Dnmt1o, Cxxc9, MommeD2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 13433
VEGA: 9
HGNC: HGNC:2976
Homologene: 124071
Mfap4
Name: microfibrillar-associated protein 4
Synonyms: 1110007F23Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76293
HGNC: HGNC:7035
Homologene: 134529
Zdbf2
Name: zinc finger, DBF-type containing 2
Synonyms: 9330107J05Rik, 4930431J08Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 73884
Homologene: 52868
Prex2
Name: phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
Synonyms: 6230420N16Rik, C030045D06Rik, Depdc2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 109294
Homologene: 23523
Thrap3
Name: thyroid hormone receptor associated protein 3
Synonyms: 9330151F09Rik, Trap150, B230333E16Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230753
Homologene: 31289
Tacc2
Name: transforming, acidic coiled-coil containing protein 2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 57752
Homologene: 5087
Cnot1
Name: CCR4-NOT transcription complex, subunit 1
Synonyms: 6030411K04Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234594
HGNC: HGNC:7877
Homologene: 9453
Rnf216
Name: ring finger protein 216
Synonyms: UIP83, F830018F18Rik, 2810055G22Rik, Ubce7ip1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 108086
Homologene: 19442
Neo1
Name: neogenin
Synonyms: D930014N22Rik, 2610028H22Rik, Igdcc2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 18007
VEGA: 9
HGNC: HGNC:7754
Homologene: 1870
Kdm3b
Name: KDM3B lysine (K)-specific demethylase 3B
Synonyms: 5830462I21Rik, JHDM2B, Jmjd1b
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 277250
VEGA: 18
HGNC: HGNC:1337
Homologene: 41145
Ccnd3
Name: cyclin D3
Synonyms: 9230106B05Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12445
HGNC: HGNC:1585
Homologene: 20419
Hbs1l
Name: Hbs1-like (S. cerevisiae)
Synonyms: eRFS, 2810035F15Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 56422
VEGA: 10
HGNC: HGNC:4834
Homologene: 68525
Exosc1
Name: exosome component 1
Synonyms: 2610104C07Rik, 2610035C18Rik, 2610312F07Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 66583
VEGA: 19
Homologene: 9359
Cd209b
Name: CD209b antigen
Synonyms: SIGNR1, mSIGNR1, 1810030I22Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 69165
Homologene: 84858
Spp1
Name: secreted phosphoprotein 1
Synonyms: 44kDa bone phosphoprotein, bone sialoprotein 1, osteopontin, ETA-1, BNSP, minopontin, Opn, Opnl, Ric, Spp-1, OP, Apl-1, osteopontin-like protein, 2ar
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20750
Homologene: 20156
Pkd2l2
Name: polycystic kidney disease 2-like 2
Synonyms: Polycystin - L2, TRPP5
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 53871
VEGA: 18
HGNC: HGNC:9012
Homologene: 22812
Reg3d
Name: regenerating islet-derived 3 delta
Synonyms: Ingaprp, INGAP
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 30053
Homologene: 137262
H2bl1
Name: H2B.L histone variant 1
Synonyms: SubH2Bv, 1700024P04Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 69382
Homologene: 105972
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Pcnx4
Name: pecanex homolog 4
Synonyms: 1810048J11Rik, Pcnxl4
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 67708
VEGA: 12
Homologene: 23366
Celsr2
Name: cadherin, EGF LAG seven-pass G-type receptor 2
Synonyms: mfmi1, flamingo, EGFL2, Adgrc2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 53883
HGNC: HGNC:3231
Homologene: 1078
Dpysl4
Name: dihydropyrimidinase-like 4
Synonyms: unc-33-like phosphoprotein 4, Ulip4, CRMP-3, Drp-4, DPY4, Crmp3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 26757
HGNC: HGNC:3016
Homologene: 4691
Scn2a
Name: sodium channel, voltage-gated, type II, alpha
Synonyms: Nav1.2, A230052E19Rik, Scn2a1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 110876
Homologene: 75001
Ppp2r2c
Name: protein phosphatase 2, regulatory subunit B, gamma
Synonyms: IMYPNO1, PR52, 6330548O06Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269643
HGNC: HGNC:9306
Homologene: 36386
Map6
Name: microtubule-associated protein 6
Synonyms: F-STOP, STOP, 2810411E12Rik, Mtap6
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17760
HGNC: HGNC:6868
Homologene: 7850
Csmd3
Name: CUB and Sushi multiple domains 3
Synonyms: 4930500N14Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239420
Homologene: 65982
Sh3pxd2a
Name: SH3 and PX domains 2A
Synonyms: Fish, Sh3md1, Tks5, 2310014D11Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 14218
VEGA: 19
Homologene: 7317
Ccdc39
Name: coiled-coil domain containing 39
Synonyms: 4921507O14Rik, D3Ertd789e, b2b1735Clo, b2b1304Clo, b2b2025.1Clo, prh
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 51938
Homologene: 12149
Igsf10
Name: immunoglobulin superfamily, member 10
Synonyms: 6530405F15Rik, CMF608, Adlican2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242050
Homologene: 18712
Kcna5
Name: potassium voltage-gated channel, shaker-related subfamily, member 5
Synonyms: Kv1.5
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16493
HGNC: HGNC:6224
Homologene: 1683
Adgrb1
Name: adhesion G protein-coupled receptor B1
Synonyms: B830018M07Rik, Bai1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 107831
HGNC: HGNC:943
Homologene: 1287
Gabbr2
Name: gamma-aminobutyric acid type B receptor subunit 2
Synonyms: Gababr2, LOC242425, Gpr51, GB2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242425
HGNC: HGNC:4507
Homologene: 55902
Or4k48
Name: olfactory receptor family 4 subfamily K member 48
Synonyms: GA_x6K02T2Q125-72697413-72696475, MOR248-6, Olfr1298
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258888
Homologene: 121521
Mast1
Name: microtubule associated serine/threonine kinase 1
Synonyms: 9430008B02Rik, SAST170, SAST
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 56527
Homologene: 10543
Or1e17
Name: olfactory receptor family 1 subfamily E member 17
Synonyms: MTPCR50, MOR135-27, GA_x6K02T2P1NL-4097159-4098136, Olfr23
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18321
Homologene: 115483
Upf3a
Name: UPF3 regulator of nonsense transcripts homolog A (yeast)
Synonyms: 4930546M19Rik, RENT3A, UPF3, 2600001C03Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 67031
Homologene: 23395
Gpc5
Name: glypican 5
Synonyms: A230034F01Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 103978
HGNC: HGNC:4453
Homologene: 3285
Zfp946
Name: zinc finger protein 946
Synonyms: 1300003B13Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 74149
Elp5
Name: elongator acetyltransferase complex subunit 5
Synonyms: Clone 13u, Rai12
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 54351
Homologene: 10291
Lrrc71
Name: leucine rich repeat containing 71
Synonyms: 4933430H15Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 74485
Homologene: 83646
Lrrc14b
Name: leucine rich repeat containing 14B
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 432779
Homologene: 47758
Sp110
Name: Sp110 nuclear body protein
Synonyms: 52kDa, Ipr1, 5031415C07Rik, 5830484A20Rik, Ifi75
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 109032
HGNC: HGNC:5401
Homologene: 82192
Or51a25
Name: olfactory receptor family 51 subfamily A member 25
Synonyms: GA_x6K02T2PBJ9-5441154-5440198, MOR11-1, Olfr559
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259116
Homologene: 74124
Or4x6
Name: olfactory receptor family 4 subfamily X member 6
Synonyms: GA_x6K02T2Q125-51551618-51550689, MOR228-3, Olfr1269
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258339
Homologene: 133727
Gkn3
Name: gastrokine 3
Synonyms: 1190003M12Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 68888
Homologene: 87422
Gm16506
Name: predicted gene 16506
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 102634304
Homologene: 128452
Gm49359
Name: predicted gene, 49359
Type: Gene
Species: Mouse
Chromosome: 13
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 11,162,273 bp
  • T to A, chromosome 1 at 63,307,370 bp
  • G to A, chromosome 1 at 85,579,092 bp
  • A to G, chromosome 2 at 65,711,907 bp
  • T to A, chromosome 2 at 76,835,961 bp
  • A to G, chromosome 2 at 90,118,863 bp
  • A to G, chromosome 2 at 111,645,625 bp
  • A to G, chromosome 3 at 33,814,519 bp
  • A to T, chromosome 3 at 59,326,191 bp
  • T to A, chromosome 3 at 87,739,462 bp
  • G to A, chromosome 3 at 108,402,753 bp
  • A to G, chromosome 4 at 41,211,740 bp
  • A to G, chromosome 4 at 46,875,687 bp
  • G to A, chromosome 4 at 126,180,098 bp
  • T to C, chromosome 5 at 36,947,182 bp
  • T to C, chromosome 5 at 104,435,143 bp
  • G to T, chromosome 5 at 114,256,587 bp
  • A to C, chromosome 5 at 143,085,904 bp
  • A to T, chromosome 6 at 70,687,311 bp
  • A to T, chromosome 6 at 78,377,136 bp
  • A to G, chromosome 6 at 87,384,440 bp
  • A to T, chromosome 6 at 126,534,211 bp
  • C to T, chromosome 7 at 99,336,292 bp
  • T to C, chromosome 7 at 102,723,659 bp
  • T to A, chromosome 7 at 130,728,903 bp
  • A to G, chromosome 7 at 139,086,123 bp
  • A to G, chromosome 8 at 3,926,005 bp
  • T to G, chromosome 8 at 13,798,279 bp
  • A to G, chromosome 8 at 84,920,928 bp
  • A to T, chromosome 8 at 95,770,632 bp
  • A to G, chromosome 9 at 5,353,641 bp
  • C to A, chromosome 9 at 20,913,985 bp
  • A to T, chromosome 9 at 58,902,929 bp
  • A to T, chromosome 10 at 21,299,217 bp
  • A to T, chromosome 11 at 61,485,719 bp
  • T to C, chromosome 11 at 69,969,501 bp
  • T to A, chromosome 11 at 73,940,894 bp
  • A to T, chromosome 12 at 72,541,576 bp
  • A to G, chromosome 13 at 62,456,744 bp
  • T to A, chromosome 13 at 74,363,178 bp
  • T to C, chromosome 13 at 98,984,258 bp
  • A to G, chromosome 14 at 7,551,798 bp
  • A to G, chromosome 14 at 43,725,006 bp
  • A to T, chromosome 14 at 115,092,594 bp
  • A to T, chromosome 15 at 47,820,381 bp
  • T to C, chromosome 15 at 74,543,638 bp
  • G to A, chromosome 15 at 76,183,855 bp
  • A to G, chromosome 15 at 77,766,736 bp
  • C to A, chromosome 17 at 22,455,021 bp
  • T to A, chromosome 17 at 47,597,496 bp
  • T to A, chromosome 18 at 34,428,245 bp
  • T to C, chromosome 18 at 34,794,559 bp
  • G to A, chromosome 19 at 37,329,036 bp
  • G to A, chromosome 19 at 41,928,080 bp
  • A to G, chromosome 19 at 44,833,199 bp
  • T to A, chromosome 19 at 47,267,831 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7695 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045758-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.