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Strain Name:
C57BL/6J-MtgxR7711Btlr/Mmmh
Stock Number:
045769-MU
Citation ID:
RRID:MMRRC_045769-MU
Other Names:
R7711 (G1)
Major Collection:

Strain Information

Kit
Name: KIT proto-oncogene receptor tyrosine kinase
Synonyms: Steel Factor Receptor, c-KIT, Dominant white spotting, belly-spot, Tr-kit, SOW3, SCO5, SCO1, Gsfsow3, Gsfsco5, Gsfsco1, CD117
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 16590
HGNC: HGNC:6342
Homologene: 187
Chd7
Name: chromodomain helicase DNA binding protein 7
Synonyms: GENA 60, GENA 47, Gena 52, Cyn, A730019I05Rik, WBE1, Whi, Todo, Obt, Mt, Lda, Flo, Edy, Dz, Cycn
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 320790
Homologene: 19067
Myh7
Name: myosin, heavy polypeptide 7, cardiac muscle, beta
Synonyms: Myhc-b, Myhcb, beta-MHC, B-MHC, MYH-beta/slow, MyHC-I, betaMHC
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 140781
HGNC: HGNC:7577
Homologene: 68044
Snx17
Name: sorting nexin 17
Synonyms: 5830447M19Rik, D5Ertd260e, b2b1625.1Clo
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 266781
Homologene: 8838
Lrp2
Name: low density lipoprotein receptor-related protein 2
Synonyms: Megalin, Gp330, D230004K18Rik, b2b1625.2Clo
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14725
HGNC: HGNC:6694
Homologene: 20952
Fam169a
Name: family with sequence similarity 169, member A
Synonyms: B230112C05Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 320557
VEGA: 13
Homologene: 52656
Dgkh
Name: diacylglycerol kinase, eta
Synonyms: 5930402B05Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 380921
VEGA: 14
HGNC: HGNC:2854
Homologene: 99373
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 24,530,008 bp
  • G to T, chromosome 1 at 136,471,453 bp
  • A to T, chromosome 1 at 161,992,053 bp
  • A to G, chromosome 1 at 165,139,199 bp
  • A to G, chromosome 1 at 174,837,127 bp
  • G to A, chromosome 2 at 66,303,660 bp
  • T to C, chromosome 2 at 66,700,877 bp
  • T to C, chromosome 2 at 69,479,343 bp
  • A to G, chromosome 2 at 87,357,527 bp
  • T to C, chromosome 2 at 94,008,092 bp
  • T to A, chromosome 2 at 111,500,152 bp
  • A to G, chromosome 2 at 119,131,590 bp
  • T to A, chromosome 2 at 132,005,377 bp
  • A to G, chromosome 2 at 137,067,994 bp
  • T to G, chromosome 2 at 155,620,403 bp
  • G to T, chromosome 3 at 5,396,956 bp
  • A to G, chromosome 3 at 79,405,860 bp
  • A to G, chromosome 3 at 84,925,681 bp
  • T to C, chromosome 3 at 89,141,342 bp
  • T to C, chromosome 3 at 138,959,113 bp
  • A to C, chromosome 3 at 152,186,517 bp
  • T to A, chromosome 4 at 8,805,234 bp
  • T to C, chromosome 4 at 88,827,734 bp
  • C to A, chromosome 4 at 134,065,533 bp
  • T to C, chromosome 4 at 143,949,252 bp
  • T to G, chromosome 4 at 156,119,192 bp
  • G to T, chromosome 5 at 31,170,189 bp
  • T to A, chromosome 5 at 31,195,460 bp
  • T to A, chromosome 5 at 75,637,359 bp
  • A to G, chromosome 6 at 17,990,037 bp
  • A to G, chromosome 6 at 29,177,456 bp
  • A to G, chromosome 6 at 31,492,649 bp
  • A to G, chromosome 6 at 65,441,373 bp
  • G to A, chromosome 6 at 135,116,357 bp
  • T to C, chromosome 7 at 18,718,342 bp
  • G to GACCGCGGCC, chromosome 7 at 97,579,909 bp
  • T to C, chromosome 7 at 103,250,282 bp
  • A to T, chromosome 7 at 126,501,269 bp
  • C to A, chromosome 8 at 36,249,221 bp
  • T to C, chromosome 8 at 79,268,145 bp
  • G to A, chromosome 8 at 86,714,008 bp
  • T to C, chromosome 8 at 111,670,162 bp
  • G to A, chromosome 8 at 120,159,984 bp
  • A to T, chromosome 9 at 20,314,023 bp
  • G to A, chromosome 9 at 31,161,349 bp
  • G to T, chromosome 9 at 31,357,232 bp
  • A to G, chromosome 9 at 44,384,462 bp
  • A to G, chromosome 9 at 44,986,336 bp
  • T to A, chromosome 9 at 106,885,943 bp
  • T to C, chromosome 10 at 60,299,855 bp
  • C to A, chromosome 10 at 75,230,808 bp
  • A to T, chromosome 11 at 83,121,263 bp
  • G to T, chromosome 11 at 103,614,912 bp
  • C to T, chromosome 12 at 4,774,414 bp
  • T to C, chromosome 12 at 95,780,754 bp
  • T to G, chromosome 13 at 50,247,095 bp
  • A to G, chromosome 13 at 60,761,551 bp
  • A to G, chromosome 13 at 67,259,600 bp
  • G to T, chromosome 13 at 97,126,688 bp
  • C to G, chromosome 14 at 54,988,801 bp
  • A to T, chromosome 14 at 57,275,556 bp
  • T to A, chromosome 14 at 64,097,488 bp
  • T to A, chromosome 14 at 70,313,675 bp
  • A to G, chromosome 14 at 78,725,019 bp
  • T to C, chromosome 15 at 33,497,347 bp
  • G to T, chromosome 15 at 83,949,924 bp
  • A to G, chromosome 16 at 45,980,330 bp
  • T to C, chromosome 17 at 3,187,634 bp
  • A to G, chromosome 17 at 5,336,820 bp
  • T to A, chromosome 17 at 36,083,878 bp
  • C to T, chromosome 17 at 37,169,956 bp
  • G to T, chromosome 18 at 23,625,196 bp
  • A to T, chromosome 18 at 65,306,484 bp
  • T to A, chromosome 19 at 17,439,080 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7711 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045769-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.