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Strain Name:
C57BL/6J-MtgxR7719Btlr/Mmmh
Stock Number:
045776-MU
Citation ID:
RRID:MMRRC_045776-MU
Other Names:
R7719 (G1)
Major Collection:

Strain Information

Myo5a
Name: myosin VA
Synonyms: MVa, MyoVA, Myo5, flail, 9630007J19Rik, Dbv
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 17918
HGNC: HGNC:7602
Homologene: 20100
Vcan
Name: versican
Synonyms: PG-M, hdf, heart defect, 5430420N07Rik, Cspg2, DPEAAE
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 13003
HGNC: HGNC:2464
Homologene: 3228
Clasrp
Name: CLK4-associating serine/arginine rich protein
Synonyms: SWAP2, Srsf16, Sfrs16
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 53609
Homologene: 134306
Prrc2b
Name: proline-rich coiled-coil 2B
Synonyms: 5830434P21Rik, Bat2l
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227723
Homologene: 106649
Col18a1
Name: collagen, type XVIII, alpha 1
Synonyms: endostatin
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 12822
HGNC: HGNC:2195
Homologene: 7673
Ewsr1
Name: Ewing sarcoma breakpoint region 1
Synonyms: Ews
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14030
HGNC: HGNC:3508
Homologene: 134632
Cks1b
Name: CDC28 protein kinase 1b
Synonyms: 2610005D03Rik, 2410005G18Rik, Cks1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 54124
Homologene: 123798
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 17,091,991 bp
  • A to T, chromosome 1 at 20,979,520 bp
  • A to T, chromosome 1 at 34,589,002 bp
  • T to C, chromosome 1 at 64,921,742 bp
  • A to G, chromosome 1 at 75,375,825 bp
  • A to G, chromosome 1 at 85,941,337 bp
  • T to A, chromosome 1 at 150,565,329 bp
  • T to A, chromosome 1 at 155,687,012 bp
  • A to T, chromosome 2 at 30,111,231 bp
  • T to A, chromosome 2 at 32,217,268 bp
  • A to T, chromosome 2 at 90,266,259 bp
  • T to A, chromosome 2 at 153,787,745 bp
  • T to A, chromosome 2 at 158,143,118 bp
  • T to C, chromosome 3 at 89,416,328 bp
  • G to A, chromosome 3 at 101,435,541 bp
  • A to G, chromosome 3 at 132,734,728 bp
  • T to C, chromosome 4 at 45,284,841 bp
  • G to A, chromosome 4 at 58,068,523 bp
  • G to A, chromosome 4 at 96,568,842 bp
  • G to A, chromosome 4 at 115,250,940 bp
  • A to T, chromosome 4 at 116,052,420 bp
  • T to A, chromosome 4 at 119,333,616 bp
  • C to T, chromosome 4 at 148,944,524 bp
  • G to T, chromosome 4 at 156,047,208 bp
  • T to C, chromosome 5 at 109,171,752 bp
  • G to T, chromosome 5 at 113,075,968 bp
  • G to A, chromosome 5 at 129,873,858 bp
  • A to C, chromosome 5 at 145,220,866 bp
  • A to T, chromosome 6 at 127,729,503 bp
  • T to C, chromosome 6 at 149,327,355 bp
  • T to A, chromosome 7 at 8,483,461 bp
  • G to A, chromosome 7 at 19,096,878 bp
  • T to C, chromosome 7 at 19,587,844 bp
  • C to T, chromosome 7 at 26,095,670 bp
  • T to C, chromosome 7 at 45,709,750 bp
  • GGCG to GGCGACGGCCGCG, chromosome 7 at 97,579,906 bp
  • T to C, chromosome 7 at 101,289,867 bp
  • C to T, chromosome 7 at 101,346,113 bp
  • T to C, chromosome 7 at 101,901,029 bp
  • T to A, chromosome 8 at 27,045,946 bp
  • G to T, chromosome 8 at 71,483,140 bp
  • T to C, chromosome 8 at 106,419,093 bp
  • T to A, chromosome 9 at 9,704,898 bp
  • T to A, chromosome 9 at 75,144,084 bp
  • T to A, chromosome 9 at 95,560,776 bp
  • C to T, chromosome 9 at 107,540,184 bp
  • T to C, chromosome 9 at 123,715,330 bp
  • T to C, chromosome 10 at 4,427,496 bp
  • A to T, chromosome 10 at 77,078,012 bp
  • A to G, chromosome 10 at 102,545,600 bp
  • T to C, chromosome 11 at 5,085,900 bp
  • T to A, chromosome 11 at 79,502,233 bp
  • T to C, chromosome 11 at 98,375,676 bp
  • T to C, chromosome 11 at 102,772,477 bp
  • T to C, chromosome 11 at 105,111,848 bp
  • A to G, chromosome 13 at 11,730,343 bp
  • G to T, chromosome 13 at 27,851,797 bp
  • A to G, chromosome 13 at 48,586,290 bp
  • G to A, chromosome 13 at 64,772,777 bp
  • A to T, chromosome 13 at 89,704,619 bp
  • T to C, chromosome 15 at 63,778,964 bp
  • T to C, chromosome 15 at 79,620,712 bp
  • A to T, chromosome 15 at 102,921,858 bp
  • C to T, chromosome 16 at 3,909,603 bp
  • A to G, chromosome 16 at 33,920,116 bp
  • A to G, chromosome 16 at 90,496,666 bp
  • A to G, chromosome 17 at 69,253,414 bp
  • A to C, chromosome 17 at 91,237,044 bp
  • T to C, chromosome 18 at 34,547,535 bp
  • G to T, chromosome 18 at 73,589,990 bp
  • T to A, chromosome 19 at 40,912,768 bp
  • C to T, chromosome 19 at 55,081,670 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7719 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045776-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.