Strain Name:
C57BL/6J-MtgxR7726Btlr/Mmmh
Stock Number:
045782-MU
Citation ID:
RRID:MMRRC_045782-MU
Other Names:
R7726 (G1)
Major Collection:

Strain Information

Gpr37
Name: G protein-coupled receptor 37
Synonyms: parkin-associated endothelin B-like receptor, Pael-R
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14763
HGNC: HGNC:4494
Homologene: 3875
Stub1
Name: STIP1 homology and U-Box containing protein 1
Synonyms: 2210017D18Rik, CHIP, 0610033N24Rik, 2310040B03Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 56424
VEGA: 17
Homologene: 4281
Eif3h
Name: eukaryotic translation initiation factor 3, subunit H
Synonyms: 1110008A16Rik, Eif3s3, 9430017H16Rik, EIF3-P40, EIF3-gamma
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 68135
VEGA: 15
HGNC: HGNC:3273
Homologene: 2785
Iqgap1
Name: IQ motif containing GTPase activating protein 1
Synonyms: D7Ertd237e, D7Ertd257e
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 29875
HGNC: HGNC:6110
Homologene: 74514
Nup155
Name: nucleoporin 155
Synonyms: D930027M19Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 170762
VEGA: 15
HGNC: HGNC:8063
Homologene: 43155
Manba
Name: mannosidase, beta A, lysosomal
Synonyms: 2410030O07Rik, B930014J03Rik, Bmn
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 110173
HGNC: HGNC:6831
Homologene: 4317
Tbce
Name: tubulin-specific chaperone E
Synonyms: C530005D02Rik, 2610206D02Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 70430
Homologene: 37744
Armc6
Name: armadillo repeat containing 6
Synonyms: 2410153K17Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 76813
Homologene: 14121
Stk4
Name: serine/threonine kinase 4
Synonyms: Kas-2, sterile 20-like kinase 1, Ysk3, Mst1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 58231
Homologene: 55965
Med15
Name: mediator complex subunit 15
Synonyms: Pcqap, A230074L19Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 94112
VEGA: 16
Tasor
Name: transcription activation suppressor
Synonyms: 4933409E02Rik, D14Abb1e, Fam208a, MommeD6
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 218850
VEGA: 14
Homologene: 9062
Fam222b
Name: family with sequence similarity 222, member B
Synonyms: BC017647
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216971
Homologene: 10054
Mastl
Name: microtubule associated serine/threonine kinase-like
Synonyms: THC2, 2700091H24Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 67121
Homologene: 12086
Ubr4
Name: ubiquitin protein ligase E3 component n-recognin 4
Synonyms: A930005E13Rik, 1810009A16Rik, Zubr1, D930005K06Rik, p600, LOC381562
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 69116
Homologene: 10804
Add3
Name: adducin 3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 27360
VEGA: 19
HGNC: HGNC:245
Homologene: 40893
Lyn
Name: LYN proto-oncogene, Src family tyrosine kinase
Synonyms: Hck-2, Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 17096
HGNC: HGNC:6735
Homologene: 55649
Alas1
Name: aminolevulinic acid synthase 1
Synonyms: Alas-1, succinyl-CoA: glycine C-succinyl transferase, ALAS-N, 5-aminolevulinate synthase
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 11655
HGNC: HGNC:396
Homologene: 55478
Chordc1
Name: cysteine and histidine rich domain containing 1
Synonyms: Chp-1, 1110001O09Rik, morgana
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 66917
VEGA: 9
Homologene: 8111
Hnrnpul2
Name: heterogeneous nuclear ribonucleoprotein U-like 2
Synonyms: Hnrpul2, 1110031M08Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 68693
VEGA: 19
Homologene: 28583
Pom121
Name: nuclear pore membrane protein 121
Synonyms: 2610027A18Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 107939
Homologene: 70878
Bhlhe40
Name: basic helix-loop-helix family, member e40
Synonyms: cytokine response gene 8, Clast5, Stra13, Bhlhb2, C130042M06Rik, eip1 (E47 interaction protein 1), Stra14, Sharp2, DEC1, CR8
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20893
HGNC: HGNC:1046
Homologene: 2722
Spink5
Name: serine peptidase inhibitor, Kazal type 5
Synonyms: LEKT1, 2310065D10Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 72432
Homologene: 4987
Myh6
Name: myosin, heavy polypeptide 6, cardiac muscle, alpha
Synonyms: A830009F23Rik, alphaMHC, Myhca, alpha myosin, Myhc-a, alpha-MHC, alpha cardiac MHC, cardiomyopathy, hypertrophic 1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 17888
HGNC: HGNC:7576
Homologene: 124414
Arap3
Name: ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
Synonyms: DRAG1, E030006K04Rik, Centd3
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 106952
VEGA: 18
Homologene: 11199
Msh4
Name: mutS homolog 4
Synonyms: mMsh4, 4930485C04Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 55993
HGNC: HGNC:7327
Homologene: 1830
Dhx36
Name: DEAH-box helicase 36
Synonyms: 2810407E23Rik, RHAU, Ddx36
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 72162
Homologene: 6356
Exph5
Name: exophilin 5
Synonyms: B130009M24Rik, Slac2b, slac2-b, AC079869.22gm5
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320051
Homologene: 9007
Cpne8
Name: copine VIII
Synonyms: 1500031E20Rik, 1200003E11Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 66871
Homologene: 12049
Vmn2r3
Name: vomeronasal 2, receptor 3
Synonyms: EG637004
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 637004
Spata31e2
Name: spermatogenesis associated 31 subfamily E member 2
Synonyms: 4931408C20Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 210940
Homologene: 86827
Scap
Name: SREBF chaperone
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235623
Homologene: 8160
Fras1
Name: Fraser extracellular matrix complex subunit 1
Synonyms: bl, E130113P14Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231470
Homologene: 23516
Adam34
Name: a disintegrin and metallopeptidase domain 34
Synonyms: testase 4
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 252866
Homologene: 78104
Slc28a2b
Name: solute carrier family 28 member 2b
Synonyms: Gm14085
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 381417
Kcnh6
Name: potassium voltage-gated channel, subfamily H (eag-related), member 6
Synonyms: m-erg2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 192775
Homologene: 32740
Papss2
Name: 3'-phosphoadenosine 5'-phosphosulfate synthase 2
Synonyms: Sk2, Atpsk2, 1810018P12Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 23972
VEGA: 19
HGNC: HGNC:8604
Homologene: 55840
Sirpb1c
Name: signal-regulatory protein beta 1C
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 100038947
Homologene: 82993
Brf1
Name: BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
Synonyms: TFIIIB90, GTF3B, TAFIII90, TAF3C, 2510002F24Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 72308
VEGA: 12
Homologene: 1161
Pcnx2
Name: pecanex homolog 2
Synonyms: Pcnxl2, E330039K12Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 270109
HGNC: HGNC:8736
Homologene: 8987
Atrnl1
Name: attractin like 1
Synonyms: Alp
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226255
VEGA: 19
Homologene: 45809
Cabs1
Name: calcium binding protein, spermatid specific 1
Synonyms: 4931407G18Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 70977
Homologene: 13225
Ntn4
Name: netrin 4
Synonyms: beta-netrin
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 57764
Homologene: 10934
Palm2
Name: paralemmin 2
Synonyms: 53-H12, pEN70
Type: Gene
Species: Mouse
Chromosome: 4
Klk1b9
Name: kallikrein 1-related peptidase b9
Synonyms: Klk9, mGk-9, Egfbp-3, Egfbp3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13648
Homologene: 68141
Col17a1
Name: collagen, type XVII, alpha 1
Synonyms: BP180, Bpag, BPAg2, Bpag2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 12821
HGNC: HGNC:2194
Homologene: 7276
Wfdc8
Name: WAP four-disulfide core domain 8
Synonyms: LOC277343
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 277343
Homologene: 33799
Sting1
Name: stimulator of interferon response cGAMP interactor 1
Synonyms: Sting, ERIS, MPYS, Tmem173, 2610307O08Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 72512
VEGA: 18
Homologene: 18868
Fbxl6
Name: F-box and leucine-rich repeat protein 6
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 30840
VEGA: 15
Homologene: 8130
Kndc1
Name: kinase non-catalytic C-lobe domain (KIND) containing 1
Synonyms: very-kind, VKIND, 2410012C07Rik, B830014K08Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 76484
Homologene: 45138
Tchhl1
Name: trichohyalin-like 1
Synonyms: S100a17, Thhl1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 71325
Homologene: 84625
Fgf14
Name: fibroblast growth factor 14
Synonyms: Fhf4
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 14169
HGNC: HGNC:3671
Homologene: 3037
Or2y1d
Name: olfactory receptor family 2 subfamily Y member 1D
Synonyms: GA_x6K02T2QP88-6004387-6003452, MOR256-1, Olfr1389
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 259069
Homologene: 86690
Fam184a
Name: family with sequence similarity 184, member A
Synonyms: 4930589M24Rik, 4930438C08Rik, 3110012E06Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 75906
Homologene: 11600
Ccdc162
Name: coiled-coil domain containing 162
Synonyms: 5033413D22Rik, Gm6976, Gm29096
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 75973
Homologene: 136355
Zfp874b
Name: zinc finger protein 874b
Synonyms: 9630025I21Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 408067
Homologene: 135597
Men1
Name: multiple endocrine neoplasia 1
Synonyms: menin
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 17283
HGNC: HGNC:7010
Homologene: 7418
Atp6v1e2
Name: ATPase, H+ transporting, lysosomal V1 subunit E2
Synonyms: Atp6e1, 4930500C14Rik, E1, lysosomal 31kDa
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 74915
VEGA: 17
Homologene: 41770
Prss33
Name: serine protease 33
Synonyms: tryptase-6, mT6, Eos
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 353130
Homologene: 77185
Or6b2b
Name: olfactory receptor family 6 subfamily B member 2B
Synonyms: GA_x6K02T2R7CC-81266841-81267776, MOR103-12, Olfr1415
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 258228
Homologene: 79367
Ero1b
Name: endoplasmic reticulum oxidoreductase 1 beta
Synonyms: 1300013B24Rik, 1700065B09Rik, Ero1lb
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 67475
VEGA: 13
Homologene: 8740
Zscan4d
Name: zinc finger and SCAN domain containing 4D
Synonyms: EG545913
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 545913
Homologene: 85986
Shfl
Name: shiftless antiviral inhibitor of ribosomal frameshifting
Synonyms: A230050P20Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 319278
Homologene: 10165
Cd55b
Name: CD55 molecule, decay accelerating factor for complement B
Synonyms: Daf2, TM-DAF, complement-transmembrane, Daf-TM
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13137
HGNC: HGNC:2665
Homologene: 479
Cx3cl1
Name: C-X3-C motif chemokine ligand 1
Synonyms: D8Bwg0439e, Scyd1, fractalkine, neurotactin, CX3C
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 20312
Homologene: 2251
Crtac1
Name: cartilage acidic protein 1
Synonyms: 2810454P21Rik, Lotus, Crtac1B
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 72832
VEGA: 19
Homologene: 23070
Ntmt2
Name: N-terminal Xaa-Pro-Lys N-methyltransferase 2
Synonyms: Mettl11b, LOC240879
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240879
Homologene: 28168
Pcdhgc3
Name: protocadherin gamma subfamily C, 3
Synonyms: Pcdh2, PC43
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93706
HGNC: HGNC:8716
Homologene: 31099
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 26,684,498 bp
  • A to T, chromosome 1 at 92,491,307 bp
  • A to T, chromosome 1 at 130,411,493 bp
  • A to G, chromosome 1 at 163,703,184 bp
  • T to C, chromosome 2 at 23,140,795 bp
  • A to G, chromosome 2 at 122,486,733 bp
  • T to G, chromosome 2 at 164,110,226 bp
  • C to A, chromosome 2 at 164,599,986 bp
  • T to A, chromosome 3 at 15,848,386 bp
  • G to T, chromosome 3 at 62,488,968 bp
  • G to T, chromosome 3 at 64,275,518 bp
  • A to G, chromosome 3 at 93,471,758 bp
  • C to T, chromosome 3 at 135,518,009 bp
  • C to T, chromosome 3 at 153,866,320 bp
  • C to A, chromosome 4 at 3,756,428 bp
  • C to T, chromosome 4 at 57,709,876 bp
  • C to T, chromosome 4 at 139,458,920 bp
  • A to T, chromosome 5 at 87,980,286 bp
  • A to T, chromosome 5 at 96,712,451 bp
  • C to T, chromosome 5 at 135,378,148 bp
  • G to A, chromosome 6 at 25,669,117 bp
  • T to A, chromosome 6 at 108,662,598 bp
  • G to T, chromosome 7 at 11,165,242 bp
  • A to T, chromosome 7 at 43,978,416 bp
  • T to C, chromosome 7 at 80,757,456 bp
  • C to A, chromosome 7 at 139,939,838 bp
  • T to G, chromosome 8 at 43,651,171 bp
  • C to A, chromosome 8 at 70,222,598 bp
  • T to C, chromosome 8 at 94,780,239 bp
  • C to T, chromosome 8 at 125,850,330 bp
  • A to G, chromosome 9 at 18,302,214 bp
  • T to C, chromosome 9 at 20,873,165 bp
  • G to A, chromosome 9 at 53,373,175 bp
  • T to C, chromosome 9 at 106,246,951 bp
  • G to A, chromosome 9 at 110,378,367 bp
  • T to A, chromosome 10 at 41,553,075 bp
  • C to A, chromosome 10 at 53,633,706 bp
  • A to G, chromosome 10 at 93,733,682 bp
  • T to A, chromosome 11 at 49,430,900 bp
  • A to G, chromosome 11 at 78,153,751 bp
  • T to C, chromosome 11 at 106,017,575 bp
  • T to G, chromosome 12 at 112,964,245 bp
  • A to G, chromosome 13 at 12,605,833 bp
  • A to G, chromosome 13 at 14,029,290 bp
  • T to C, chromosome 13 at 67,473,856 bp
  • C to A, chromosome 14 at 27,447,497 bp
  • G to T, chromosome 14 at 54,965,365 bp
  • T to C, chromosome 14 at 124,136,244 bp
  • C to T, chromosome 15 at 8,122,139 bp
  • G to T, chromosome 15 at 51,786,823 bp
  • C to A, chromosome 15 at 76,535,886 bp
  • A to T, chromosome 15 at 90,501,418 bp
  • T to G, chromosome 16 at 17,655,174 bp
  • A to G, chromosome 17 at 23,834,229 bp
  • A to T, chromosome 17 at 25,831,132 bp
  • G to A, chromosome 17 at 86,944,385 bp
  • C to T, chromosome 18 at 35,735,265 bp
  • T to C, chromosome 18 at 37,806,879 bp
  • C to T, chromosome 18 at 37,989,467 bp
  • T to C, chromosome 18 at 43,963,352 bp
  • G to A, chromosome 19 at 6,337,282 bp
  • G to T, chromosome 19 at 8,831,280 bp
  • A to T, chromosome 19 at 32,634,003 bp
  • G to T, chromosome 19 at 42,302,251 bp
  • C to A, chromosome 19 at 47,655,190 bp
  • C to G, chromosome 19 at 53,239,461 bp
  • A to G, chromosome 19 at 57,702,072 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7726 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045782-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.