Loading Mouse GIF
Loading...

Strain Name:
C57BL/6J-MtgxR7732Btlr/Mmmh
Stock Number:
045788-MU
Citation ID:
RRID:MMRRC_045788-MU
Other Names:
R7732 (G1)
Major Collection:

Strain Information

Slc1a3
Name: solute carrier family 1 (glial high affinity glutamate transporter), member 3
Synonyms: MGluT1, Eaat1, B430115D02Rik, GLAST, Gmt1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 20512
Homologene: 20882
Slit1
Name: slit guidance ligand 1
Synonyms: Slil1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 20562
Homologene: 2302
Fgd4
Name: FYVE, RhoGEF and PH domain containing 4
Synonyms: Frabin-gamma, Frabin-beta, Frabin-alpha, Frabin, 9330209B17Rik, ZFYVE6
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224014
Homologene: 26727
Dock1
Name: dedicator of cytokinesis 1
Synonyms: D630004B07Rik, 9130006G06Rik, Dock180, b2b3190Clo
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330662
HGNC: HGNC:2987
Homologene: 55575
Hsp90aa1
Name: heat shock protein 90, alpha (cytosolic), class A member 1
Synonyms: hsp4, Hsp90, Hsp86-1, Hsp89, Hspca
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 15519
Homologene: 68464
Sgsm1
Name: small G protein signaling modulator 1
Synonyms: 2410098H20Rik, D5Bwg1524e, Rutbc2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 52850
Homologene: 64485
Taok3
Name: TAO kinase 3
Synonyms: A430105I05Rik, 2900006A08Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 330177
Homologene: 83279
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 12,842,789 bp
  • T to A, chromosome 1 at 60,533,288 bp
  • A to C, chromosome 1 at 119,692,802 bp
  • A to T, chromosome 1 at 171,386,678 bp
  • A to G, chromosome 1 at 175,789,929 bp
  • A to G, chromosome 1 at 185,372,939 bp
  • G to A, chromosome 2 at 76,826,449 bp
  • A to T, chromosome 2 at 84,770,104 bp
  • T to C, chromosome 2 at 167,042,669 bp
  • T to C, chromosome 3 at 127,684,392 bp
  • T to C, chromosome 3 at 152,448,842 bp
  • A to T, chromosome 4 at 46,345,287 bp
  • A to G, chromosome 4 at 124,915,299 bp
  • C to T, chromosome 4 at 155,385,618 bp
  • A to G, chromosome 5 at 108,318,975 bp
  • T to A, chromosome 5 at 113,266,330 bp
  • A to G, chromosome 5 at 117,193,748 bp
  • T to C, chromosome 5 at 121,336,629 bp
  • T to C, chromosome 6 at 18,023,336 bp
  • A to G, chromosome 6 at 49,372,629 bp
  • A to T, chromosome 6 at 52,243,435 bp
  • T to A, chromosome 6 at 92,411,224 bp
  • C to A, chromosome 6 at 94,626,377 bp
  • T to C, chromosome 6 at 124,809,693 bp
  • T to A, chromosome 7 at 24,261,527 bp
  • A to G, chromosome 7 at 26,771,344 bp
  • G to A, chromosome 7 at 30,870,057 bp
  • A to G, chromosome 7 at 42,266,673 bp
  • C to T, chromosome 7 at 45,585,193 bp
  • A to G, chromosome 7 at 79,412,652 bp
  • A to G, chromosome 7 at 81,571,424 bp
  • G to A, chromosome 7 at 88,297,159 bp
  • T to G, chromosome 7 at 134,744,970 bp
  • G to T, chromosome 8 at 22,797,089 bp
  • A to C, chromosome 8 at 72,380,976 bp
  • A to G, chromosome 8 at 105,773,091 bp
  • G to A, chromosome 8 at 110,029,882 bp
  • G to T, chromosome 8 at 125,250,975 bp
  • C to A, chromosome 9 at 21,927,407 bp
  • A to G, chromosome 9 at 38,976,264 bp
  • A to T, chromosome 9 at 67,940,516 bp
  • A to C, chromosome 9 at 79,780,544 bp
  • G to A, chromosome 10 at 80,253,784 bp
  • G to A, chromosome 10 at 107,806,664 bp
  • A to G, chromosome 10 at 114,788,064 bp
  • A to G, chromosome 10 at 128,521,825 bp
  • T to A, chromosome 11 at 14,599,843 bp
  • T to A, chromosome 11 at 16,953,601 bp
  • T to C, chromosome 11 at 103,340,043 bp
  • A to G, chromosome 12 at 16,673,863 bp
  • A to G, chromosome 12 at 84,927,889 bp
  • A to G, chromosome 12 at 110,693,418 bp
  • G to A, chromosome 13 at 32,968,607 bp
  • A to G, chromosome 13 at 33,669,099 bp
  • C to T, chromosome 14 at 50,930,633 bp
  • T to A, chromosome 14 at 63,496,058 bp
  • T to C, chromosome 15 at 8,650,988 bp
  • A to T, chromosome 15 at 36,025,981 bp
  • C to T, chromosome 15 at 76,648,186 bp
  • A to T, chromosome 15 at 91,191,248 bp
  • A to G, chromosome 16 at 16,484,595 bp
  • A to G, chromosome 16 at 39,008,798 bp
  • T to C, chromosome 16 at 79,003,420 bp
  • A to G, chromosome 17 at 6,314,945 bp
  • A to G, chromosome 17 at 14,967,685 bp
  • G to T, chromosome 17 at 24,704,162 bp
  • C to A, chromosome 17 at 32,221,412 bp
  • A to T, chromosome 17 at 34,694,280 bp
  • C to A, chromosome 18 at 34,636,702 bp
  • G to T, chromosome 18 at 42,101,688 bp
  • C to T, chromosome 18 at 71,446,435 bp
  • T to A, chromosome 19 at 4,135,995 bp
  • C to T, chromosome 19 at 11,301,683 bp
  • T to A, chromosome 19 at 41,604,408 bp
  • T to C, chromosome Y at 2,720,436 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7732 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045788-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.