Strain Name:
C57BL/6J-MtgxR7738Btlr/Mmmh
Stock Number:
045794-MU
Citation ID:
RRID:MMRRC_045794-MU
Other Names:
R7738 (G1)
Major Collection:

Strain Information

Ank2
Name: ankyrin 2, brain
Synonyms: Gm4392, Ank-2, ankyrin B, Ankyrin-2, Ankyrin-B
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 109676
HGNC: HGNC:493
Olig2
Name: oligodendrocyte transcription factor 2
Synonyms: Bhlhb1, bHLHe19, Olg-2, RK17
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 50913
HGNC: HGNC:9398
Homologene: 4241
Glrb
Name: glycine receptor, beta subunit
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 14658
HGNC: HGNC:4329
Homologene: 20224
Ncoa3
Name: nuclear receptor coactivator 3
Synonyms: AIB1, TRAM-1, TRAM1, pCIP, bHLHe42, Src3, KAT13B, 2010305B15Rik, RAC3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17979
HGNC: HGNC:7670
Homologene: 4764
Fgfr1
Name: fibroblast growth factor receptor 1
Synonyms: Flt-2, Fgfr-1, Eask, FGFR-I, Fr1, Hspy
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14182
HGNC: HGNC:3688
Homologene: 69065
Arhgap21
Name: Rho GTPase activating protein 21
Synonyms: 5530401C11Rik, ARHGAP10
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71435
Homologene: 10822
Enox1
Name: ecto-NOX disulfide-thiol exchanger 1
Synonyms: D230005D02Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 239188
VEGA: 14
Homologene: 56793
Ttc3
Name: tetratricopeptide repeat domain 3
Synonyms: D16Ium21, D16Ium21e, TPRD, 2610202A04Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 22129
Homologene: 2487
Kat14
Name: lysine acetyltransferase 14
Synonyms: D2Ertd473e, D2Wsu131e, ATAC2, Csrp2bp, 2510008M08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228714
Homologene: 10745
Dsp
Name: desmoplakin
Synonyms: 5730453H04Rik, DP, rul, 2300002E22Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 109620
HGNC: HGNC:3052
Homologene: 37922
Alkal1
Name: ALK and LTK ligand 1
Synonyms: Augbeta, EG620393, Fam150a, Augmentor beta
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 620393
Homologene: 82437
Pacs1
Name: phosphofurin acidic cluster sorting protein 1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 107975
VEGA: 19
Homologene: 9970
Slfn2
Name: schlafen 2
Synonyms: Shlf2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20556
Homologene: 133205
Ostf1
Name: osteoclast stimulating factor 1
Synonyms: SH3P2, Sh3d3, C78236
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 20409
HGNC: HGNC:8510
Homologene: 8227
Sptbn2
Name: spectrin beta, non-erythrocytic 2
Synonyms: Spnb3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 20743
VEGA: 19
Homologene: 48482
Mpdz
Name: multiple PDZ domain crumbs cell polarity complex component
Synonyms: MUPP1, B930003D11Rik, multiple PDZ domain protein
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 17475
HGNC: HGNC:7208
Homologene: 2841
Dcbld1
Name: discoidin, CUB and LCCL domain containing 1
Synonyms: 4631413K11Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 66686
Homologene: 12010
Clstn1
Name: calsyntenin 1
Synonyms: 1810034E21Rik, calsyntenin-1, alcadein alpha, Cst-1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 65945
Homologene: 8814
Cep57l1
Name: centrosomal protein 57-like 1
Synonyms: 4930484D11Rik, 2410017P07Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 103268
Homologene: 12254
Kbtbd2
Name: kelch repeat and BTB (POZ) domain containing 2
Synonyms: Bklhd1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 210973
Homologene: 17122
Csmd1
Name: CUB and Sushi multiple domains 1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 94109
Homologene: 69536
Rfx8
Name: regulatory factor X 8
Synonyms: 4933400N17Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 619289
Homologene: 82436
Nip7
Name: NIP7, nucleolar pre-rRNA processing protein
Synonyms: 1110017C15Rik, 6330509M23Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 66164
Homologene: 56743
Vmn1r28
Name: vomeronasal 1 receptor 28
Synonyms: V1rc25
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 171198
Homologene: 138094
Armc3
Name: armadillo repeat containing 3
Synonyms: 4921513G22Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 70882
Homologene: 31589
Gpld1
Name: glycosylphosphatidylinositol specific phospholipase D1
Synonyms: 6330541J12Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 14756
HGNC: HGNC:4459
Homologene: 1152
Nrxn3
Name: neurexin III
Synonyms: 4933401A11Rik, neurexin III alpha, neurexin III beta, neurexin III alpha, neurexin III beta, 9330112C09Rik, D12Bwg0831e
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 18191
HGNC: HGNC:8010
Homologene: 83225
Proc
Name: protein C
Synonyms: PC, inactivator of coagulation factors Va, VIII
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 19123
VEGA: 18
HGNC: HGNC:9451
Homologene: 37288
Plekhn1
Name: pleckstrin homology domain containing, family N member 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 231002
VEGA: 4
Homologene: 12949
Zfp518b
Name: zinc finger protein 518B
Synonyms: 6820424L24Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100515
Homologene: 19115
Snx14
Name: sorting nexin 14
Synonyms: YR-14, C330035N22Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244962
Homologene: 17823
Has2
Name: hyaluronan synthase 2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 15117
HGNC: HGNC:4819
Homologene: 3892
Pabpc2
Name: poly(A) binding protein, cytoplasmic 2
Synonyms: Pabp2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 18459
Homologene: 56509
Igtp
Name: interferon gamma induced GTPase
Synonyms: Irgm3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16145
Homologene: 23118
Pla2g6
Name: phospholipase A2, group VI
Synonyms: iPLA2beta, iPLA2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 53357
HGNC: HGNC:9039
Homologene: 2635
Pcdhb3
Name: protocadherin beta 3
Synonyms: PcdhbC
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93874
HGNC: HGNC:8688
Homologene: 115665
Vmn1r177
Name: vomeronasal 1 receptor 177
Synonyms: V1rd12
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 384572
Homologene: 122945
S1pr4
Name: sphingosine-1-phosphate receptor 4
Synonyms: lpC1, S1P4, Edg6
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 13611
VEGA: 10
HGNC: HGNC:3170
Homologene: 2799
Nfatc4
Name: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4
Synonyms: 3110041H08Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 73181
VEGA: 14
HGNC: HGNC:7778
Homologene: 3349
Tmem44
Name: transmembrane protein 44
Synonyms: 9330161C17Rik, 1700007N03Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224090
Homologene: 26702
Pcdh1
Name: protocadherin 1
Synonyms: 2010005A06Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 75599
HGNC: HGNC:8655
Homologene: 12613
Or55b4
Name: olfactory receptor family 55 subfamily B member 4
Synonyms: Olfr544, GA_x6K02T2PBJ9-5206624-5205620, MOR42-3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 257926
Homologene: 133590
Or5ac16
Name: olfactory receptor family 5 subfamily AC member 16
Synonyms: Olfr198, MOR182-8, GA_x54KRFPKG5P-55416332-55415412
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 258036
Homologene: 51800
Fscn3
Name: fascin actin-bundling protein 3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 56223
HGNC: HGNC:3961
Homologene: 10475
Saxo5
Name: stabilizer of axonemal microtubules 5
Synonyms: Tex45, 1700019B03Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 76406
Homologene: 52367
Zfp729b
Name: zinc finger protein 729b
Synonyms: AA987161
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 100416706
Homologene: 133713
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 6,389,504 bp
  • G to T, chromosome 1 at 39,682,931 bp
  • A to T, chromosome 2 at 19,288,950 bp
  • A to G, chromosome 2 at 20,849,479 bp
  • A to G, chromosome 2 at 20,850,358 bp
  • A to G, chromosome 2 at 144,394,242 bp
  • C to T, chromosome 2 at 166,050,067 bp
  • C to T, chromosome 3 at 80,860,184 bp
  • C to T, chromosome 3 at 126,947,622 bp
  • A to G, chromosome 4 at 81,335,749 bp
  • A to C, chromosome 4 at 149,635,354 bp
  • G to A, chromosome 4 at 156,232,234 bp
  • G to A, chromosome 5 at 38,672,187 bp
  • G to A, chromosome 6 at 28,434,446 bp
  • C to A, chromosome 6 at 56,779,737 bp
  • T to C, chromosome 6 at 58,266,054 bp
  • T to C, chromosome 7 at 23,866,134 bp
  • C to A, chromosome 7 at 102,484,611 bp
  • T to C, chromosome 8 at 3,483,525 bp
  • C to A, chromosome 8 at 16,100,990 bp
  • T to A, chromosome 8 at 25,558,185 bp
  • T to C, chromosome 8 at 107,057,365 bp
  • T to C, chromosome 9 at 88,407,474 bp
  • T to A, chromosome 10 at 41,740,846 bp
  • C to T, chromosome 10 at 52,312,826 bp
  • A to C, chromosome 10 at 81,498,507 bp
  • A to G, chromosome 11 at 58,207,080 bp
  • T to A, chromosome 11 at 83,069,973 bp
  • A to C, chromosome 12 at 88,850,304 bp
  • A to T, chromosome 13 at 24,962,322 bp
  • A to G, chromosome 13 at 38,185,175 bp
  • A to T, chromosome 13 at 67,592,075 bp
  • A to G, chromosome 14 at 55,831,957 bp
  • A to C, chromosome 14 at 77,577,780 bp
  • T to C, chromosome 15 at 56,667,712 bp
  • A to T, chromosome 15 at 79,297,433 bp
  • A to T, chromosome 16 at 30,543,410 bp
  • G to A, chromosome 16 at 59,201,955 bp
  • T to C, chromosome 16 at 91,227,160 bp
  • A to T, chromosome 16 at 94,387,382 bp
  • G to A, chromosome 18 at 32,127,479 bp
  • T to A, chromosome 18 at 37,302,959 bp
  • A to G, chromosome 18 at 38,197,476 bp
  • A to T, chromosome 18 at 39,774,266 bp
  • A to G, chromosome 19 at 4,724,125 bp
  • A to T, chromosome 19 at 5,152,350 bp
  • A to T, chromosome 19 at 18,584,701 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7738 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045794-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.