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Strain Name:
C57BL/6J-MtgxR7739Btlr/Mmmh
Stock Number:
045795-MU
Citation ID:
RRID:MMRRC_045795-MU
Other Names:
R7739 (G1)
Major Collection:

Strain Information

Pik3r1
Name: phosphoinositide-3-kinase regulatory subunit 1
Synonyms: p85alpha, p50alpha, p55alpha, PI3K
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 18708
HGNC: HGNC:8979
Homologene: 7889
Dspp
Name: dentin sialophosphoprotein
Synonyms: Dmp3, Dpp, Dsp
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 666279
HGNC: HGNC:3054
Macf1
Name: microtubule-actin crosslinking factor 1
Synonyms: Acf7, Aclp7, trabeculin alpha
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11426
Homologene: 136191
Drd5
Name: dopamine receptor D5
Synonyms: DRD1b, Drd-5, Gpcr1, Drd1b, D5R
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 13492
HGNC: HGNC:3026
Homologene: 20216
Pik3c2a
Name: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha
Synonyms: PI3KC2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18704
HGNC: HGNC:8971
Homologene: 20581
Atp2a2
Name: ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
Synonyms: sarco/endoplasmic reticulum Ca2+-ATPase 2, SERCA2, 9530097L16Rik, D5Wsu150e, SERCA2B, Serca2a
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 11938
HGNC: HGNC:812
Homologene: 80167
Cabin1
Name: calcineurin binding protein 1
Synonyms: Ppp3in, Cain, A330070M20Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 104248
VEGA: 10
Homologene: 49307
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 28,777,608 bp
  • G to A, chromosome 1 at 44,056,418 bp
  • G to T, chromosome 1 at 54,405,039 bp
  • T to A, chromosome 1 at 131,872,185 bp
  • T to A, chromosome 1 at 177,743,262 bp
  • T to C, chromosome 2 at 31,458,026 bp
  • T to C, chromosome 2 at 58,462,971 bp
  • T to C, chromosome 3 at 86,123,731 bp
  • T to C, chromosome 3 at 100,883,895 bp
  • T to C, chromosome 3 at 101,435,531 bp
  • T to C, chromosome 4 at 123,385,598 bp
  • T to A, chromosome 4 at 124,824,288 bp
  • A to G, chromosome 5 at 9,140,453 bp
  • G to T, chromosome 5 at 38,320,078 bp
  • G to A, chromosome 5 at 104,178,146 bp
  • A to T, chromosome 5 at 108,802,177 bp
  • G to A, chromosome 5 at 122,469,705 bp
  • T to G, chromosome 6 at 40,477,980 bp
  • C to T, chromosome 6 at 66,612,373 bp
  • T to A, chromosome 6 at 71,509,479 bp
  • T to C, chromosome 6 at 71,954,835 bp
  • A to T, chromosome 7 at 29,894,274 bp
  • T to C, chromosome 7 at 88,130,058 bp
  • T to C, chromosome 7 at 104,430,179 bp
  • T to C, chromosome 7 at 116,394,294 bp
  • A to G, chromosome 8 at 12,657,561 bp
  • A to G, chromosome 8 at 40,279,896 bp
  • A to G, chromosome 8 at 69,742,883 bp
  • T to C, chromosome 8 at 91,035,025 bp
  • T to C, chromosome 9 at 60,593,692 bp
  • A to G, chromosome 10 at 75,658,658 bp
  • T to A, chromosome 10 at 99,001,365 bp
  • T to C, chromosome 11 at 36,069,561 bp
  • T to G, chromosome 11 at 46,456,557 bp
  • C to A, chromosome 11 at 55,281,131 bp
  • A to G, chromosome 11 at 68,490,498 bp
  • G to T, chromosome 11 at 69,048,232 bp
  • G to T, chromosome 11 at 75,441,985 bp
  • A to T, chromosome 11 at 95,726,160 bp
  • A to G, chromosome 11 at 109,579,709 bp
  • A to G, chromosome 11 at 109,974,591 bp
  • G to A, chromosome 11 at 119,410,861 bp
  • A to T, chromosome 12 at 54,068,718 bp
  • A to T, chromosome 12 at 56,700,099 bp
  • A to T, chromosome 13 at 56,773,766 bp
  • A to G, chromosome 13 at 59,599,784 bp
  • A to G, chromosome 13 at 101,709,697 bp
  • T to C, chromosome 14 at 52,266,260 bp
  • C to T, chromosome 15 at 57,936,098 bp
  • C to A, chromosome 15 at 58,022,479 bp
  • T to A, chromosome 15 at 76,600,311 bp
  • T to A, chromosome 15 at 91,700,613 bp
  • A to G, chromosome 16 at 29,456,601 bp
  • A to C, chromosome 16 at 45,095,823 bp
  • A to C, chromosome 17 at 18,135,818 bp
  • A to G, chromosome 17 at 36,014,591 bp
  • T to C, chromosome 17 at 36,260,504 bp
  • T to C, chromosome 17 at 56,626,620 bp
  • A to G, chromosome 18 at 41,912,368 bp
  • A to G, chromosome 18 at 42,523,974 bp
  • T to A, chromosome 19 at 6,310,815 bp
  • A to G, chromosome 19 at 12,120,545 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7739 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045795-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.