Strain Name:
C57BL/6J-MtgxR7739Btlr/Mmmh
Stock Number:
045795-MU
Citation ID:
RRID:MMRRC_045795-MU
Other Names:
R7739 (G1)
Major Collection:

Strain Information

Pik3r1
Name: phosphoinositide-3-kinase regulatory subunit 1
Synonyms: PI3K, p85alpha, p50alpha, p55alpha
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 18708
HGNC: HGNC:8979
Homologene: 7889
Dspp
Name: dentin sialophosphoprotein
Synonyms: Dmp3, Dpp, Dsp
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 666279
HGNC: HGNC:3054
Macf1
Name: microtubule-actin crosslinking factor 1
Synonyms: Aclp7, Acf7, trabeculin alpha
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11426
Homologene: 136191
Drd5
Name: dopamine receptor D5
Synonyms: DRD1b, Drd-5, D5R, Drd1b, Gpcr1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 13492
HGNC: HGNC:3026
Homologene: 20216
Pik3c2a
Name: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha
Synonyms: PI3KC2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18704
HGNC: HGNC:8971
Homologene: 20581
Atp2a2
Name: ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
Synonyms: sarco/endoplasmic reticulum Ca2+-ATPase 2, SERCA2B, Serca2a, 9530097L16Rik, SERCA2, D5Wsu150e
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 11938
HGNC: HGNC:812
Homologene: 80167
Cabin1
Name: calcineurin binding protein 1
Synonyms: Ppp3in, A330070M20Rik, Cain
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 104248
VEGA: 10
Homologene: 49307
Chd9
Name: chromodomain helicase DNA binding protein 9
Synonyms: 1810014J18Rik, AD013, A330063D19Rik, 9030205D12Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 109151
Homologene: 11844
Mtf1
Name: metal response element binding transcription factor 1
Synonyms: Thyls, metal response element-binding transcription factor 1, MTF-1, metalloregulatory transcription factor
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 17764
HGNC: HGNC:7428
Homologene: 4347
Dmtf1
Name: cyclin D binding myb like transcription factor 1
Synonyms: Dmp1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 23857
Homologene: 8017
Polr1a
Name: polymerase (RNA) I polypeptide A
Synonyms: 3010014K16Rik, 194kDa, RPA194, Rpo1-4, mRPA1, 2900087K15Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20019
Homologene: 7033
Tenm2
Name: teneurin transmembrane protein 2
Synonyms: 9330187F13Rik, Odz2, Ten-m2, D3Bwg1534e, 2610040L17Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 23964
Homologene: 22672
Sh3d19
Name: SH3 domain protein D19
Synonyms: Kryn
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 27059
Homologene: 19064
Gtf3c3
Name: general transcription factor IIIC, polypeptide 3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98488
HGNC: HGNC:4666
Homologene: 40805
Cdc42bpg
Name: CDC42 binding protein kinase gamma
Synonyms: MRCKgamma
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 240505
Homologene: 28384
Ccdc80
Name: coiled-coil domain containing 80
Synonyms: DRO1, Urb, Ssg1, 2610001E17Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 67896
Homologene: 12206
Trim39
Name: tripartite motif-containing 39
Synonyms: RING-B box-coiled-coil-B30.2, Rnf23, E130103K13Rik, RBCC-B30.2, tfp, 1100001D15Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 79263
Homologene: 10940
Lrrk2
Name: leucine-rich repeat kinase 2
Synonyms: cI-46, D630001M17Rik, LOC381026, 9330188B09Rik, 4921513O20Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 66725
Homologene: 18982
Atp2b1
Name: ATPase, Ca++ transporting, plasma membrane 1
Synonyms: PMCA1, E130111D10Rik, 2810442I22Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 67972
VEGA: 10
HGNC: HGNC:814
Homologene: 55597
Rnf103
Name: ring finger protein 103
Synonyms: Zfp103, kf-1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 22644
Homologene: 4146
Acvr1
Name: activin A receptor, type 1
Synonyms: ALK2, D330013D15Rik, ActR-I, Acvr1a, Alk-2, SKR1, Tsk7L, Acvr, Acvrlk2, ActRIA, Alk8
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11477
HGNC: HGNC:171
Homologene: 7
Naa35
Name: N(alpha)-acetyltransferase 35, NatC auxiliary subunit
Synonyms: A330027C19Rik, Mak10, A330021G12Rik, C030004C14Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 78689
Homologene: 5781
Tcerg1
Name: transcription elongation regulator 1 (CA150)
Synonyms: Fbp28, 2900090C16Rik, 2410022J09Rik, ca150, p144, Taf2s
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 56070
Homologene: 4879
Tubgcp3
Name: tubulin, gamma complex component 3
Synonyms: GCP3, Spc98p
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 259279
Homologene: 4609
Vtcn1
Name: V-set domain containing T cell activation inhibitor 1
Synonyms: B7x, B7-H4
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242122
Homologene: 11627
Trpc7
Name: transient receptor potential cation channel, subfamily C, member 7
Synonyms: TRP7, Trrp8
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 26946
Homologene: 22689
Hmcn2
Name: hemicentin 2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 665700
Homologene: 90772
Fat2
Name: FAT atypical cadherin 2
Synonyms: LOC245827, mKIAA0811, EMI2, Fath2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 245827
HGNC: HGNC:3596
Homologene: 1110
Cpsf1
Name: cleavage and polyadenylation specific factor 1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 94230
VEGA: 15
HGNC: HGNC:2324
Homologene: 40865
Vmn1r33
Name: vomeronasal 1 receptor 33
Synonyms: V1rc14
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 171187
Homologene: 110800
Rnf213
Name: ring finger protein 213
Synonyms: D11Ertd759e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 672511
Homologene: 45439
Pax9
Name: paired box 9
Synonyms: Pax-9
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 18511
HGNC: HGNC:8623
Homologene: 31360
Lonp1
Name: lon peptidase 1, mitochondrial
Synonyms: LON, Prss15, 1200017E13Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 74142
VEGA: 17
HGNC: HGNC:9479
Homologene: 3521
Npas3
Name: neuronal PAS domain protein 3
Synonyms: bHLHe12, 4930423H22Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 27386
VEGA: 12
Homologene: 8461
Ccdc168
Name: coiled-coil domain containing 168
Synonyms: Gm8251
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 102636082
VEGA: 1
Homologene: 141149
Trim30a
Name: tripartite motif-containing 30A
Synonyms: Rpt-1, Rpt1, Trim30
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20128
Homologene: 114426
Abca8b
Name: ATP-binding cassette, sub-family A member 8b
Synonyms: Abca8
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 27404
HGNC: HGNC:38
Homologene: 56029
Pik3r5
Name: phosphoinositide-3-kinase regulatory subunit 5
Synonyms: p101, Foap2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 320207
Homologene: 8627
Grm5
Name: glutamate receptor, metabotropic 5
Synonyms: mGluR5, Gprc1e, 6430542K11Rik, Glu5R
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 108071
HGNC: HGNC:4597
Homologene: 37354
Wipi1
Name: WD repeat domain, phosphoinositide interacting 1
Synonyms: D11Ertd498e, 4930533H01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 52639
Homologene: 117983
Igsf3
Name: immunoglobulin superfamily, member 3
Synonyms: 2810035F16Rik, 4833439O17Rik, 1700016K10Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 78908
HGNC: HGNC:5950
Homologene: 1182
Atp13a4
Name: ATPase type 13A4
Synonyms: 9330174J19Rik, 4631413J11Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224079
Homologene: 75330
H2-T24
Name: histocompatibility 2, T region locus 24
Synonyms: H-2T24
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 15042
Homologene: 69019
B130006D01Rik
Name: RIKEN cDNA B130006D01 gene
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 320616
VEGA: 11
Lrrc49
Name: leucine rich repeat containing 49
Synonyms: D430025H09Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 102747
Homologene: 9782
Vmn2r91
Name: vomeronasal 2, receptor 91
Synonyms: EG665210
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 665210
Homologene: 115024
Zfp27
Name: zinc finger protein 27
Synonyms: Zfp-27, mkr-4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22689
Homologene: 81823
Aurkb
Name: aurora kinase B
Synonyms: AIRK2, IPL1, STK-1, aurora B, Stk12, Stk5, Aik2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20877
Homologene: 55807
Prelid2
Name: PRELI domain containing 2
Synonyms: 1700003A01Rik, C330008K14Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 77619
VEGA: 18
Homologene: 45749
Zfp963
Name: zinc finger protein 963
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 620419
Homologene: 49795
Tbc1d31
Name: TBC1 domain family, member 31
Synonyms: LOC210544, Wdr67, D330013L20Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 210544
Homologene: 17089
Spata31e5
Name: spermatogenesis associated 31 subfamily E member 5
Synonyms: Gm597, LOC210962
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 210962
9130401M01Rik
Name: RIKEN cDNA 9130401M01 gene
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 75758
Homologene: 12622
Vmn2r8
Name: vomeronasal 2, receptor 8
Synonyms: EG627479
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 627479
Homologene: 129606
Or5a1
Name: olfactory receptor family 5 subfamily A member 1
Synonyms: MOR215-3, GA_x6K02T2RE5P-2479601-2478648, Olfr76, V5
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258677
HGNC: HGNC:8319
Homologene: 17342
Spmip3
Name: sperm microtubule inner protein 3
Synonyms: 1700016C15Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 69428
Homologene: 19111
Wdr81
Name: WD repeat domain 81
Synonyms: MGC32441, shakey 5, nur5
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 192652
Homologene: 13983
Havcr2
Name: hepatitis A virus cellular receptor 2
Synonyms: Tim3, Timd3, TIM-3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 171285
Homologene: 129541
Rab29
Name: RAB29, member RAS oncogene family
Synonyms: Rab7l1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226422
HGNC: HGNC:9789
Homologene: 20842
Fgf20
Name: fibroblast growth factor 20
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 80857
HGNC: HGNC:3677
Homologene: 10527
Ssbp1
Name: single-stranded DNA binding protein 1
Synonyms: G630031O20Rik, mtDBP, 2810480P10Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 381760
Homologene: 74462
Rab2b
Name: RAB2B, member RAS oncogene family
Synonyms: D530043M21Rik, 4930528G15Rik, 1500012D09Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 76338
Homologene: 23789
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 28,777,608 bp
  • G to A, chromosome 1 at 44,056,418 bp
  • G to T, chromosome 1 at 54,405,039 bp
  • T to A, chromosome 1 at 131,872,185 bp
  • T to A, chromosome 1 at 177,743,262 bp
  • T to C, chromosome 2 at 31,458,026 bp
  • T to C, chromosome 2 at 58,462,971 bp
  • T to C, chromosome 3 at 86,123,731 bp
  • T to C, chromosome 3 at 100,883,895 bp
  • T to C, chromosome 3 at 101,435,531 bp
  • T to C, chromosome 4 at 123,385,598 bp
  • T to A, chromosome 4 at 124,824,288 bp
  • A to G, chromosome 5 at 9,140,453 bp
  • G to T, chromosome 5 at 38,320,078 bp
  • G to A, chromosome 5 at 104,178,146 bp
  • A to T, chromosome 5 at 108,802,177 bp
  • G to A, chromosome 5 at 122,469,705 bp
  • T to G, chromosome 6 at 40,477,980 bp
  • C to T, chromosome 6 at 66,612,373 bp
  • T to A, chromosome 6 at 71,509,479 bp
  • T to C, chromosome 6 at 71,954,835 bp
  • A to T, chromosome 7 at 29,894,274 bp
  • T to C, chromosome 7 at 88,130,058 bp
  • T to C, chromosome 7 at 104,430,179 bp
  • T to C, chromosome 7 at 116,394,294 bp
  • A to G, chromosome 8 at 12,657,561 bp
  • A to G, chromosome 8 at 40,279,896 bp
  • A to G, chromosome 8 at 69,742,883 bp
  • T to C, chromosome 8 at 91,035,025 bp
  • T to C, chromosome 9 at 60,593,692 bp
  • A to G, chromosome 10 at 75,658,658 bp
  • T to A, chromosome 10 at 99,001,365 bp
  • T to C, chromosome 11 at 36,069,561 bp
  • T to G, chromosome 11 at 46,456,557 bp
  • C to A, chromosome 11 at 55,281,131 bp
  • A to G, chromosome 11 at 68,490,498 bp
  • G to T, chromosome 11 at 69,048,232 bp
  • G to T, chromosome 11 at 75,441,985 bp
  • A to T, chromosome 11 at 95,726,160 bp
  • A to G, chromosome 11 at 109,579,709 bp
  • A to G, chromosome 11 at 109,974,591 bp
  • G to A, chromosome 11 at 119,410,861 bp
  • A to T, chromosome 12 at 54,068,718 bp
  • A to T, chromosome 12 at 56,700,099 bp
  • A to T, chromosome 13 at 56,773,766 bp
  • A to G, chromosome 13 at 59,599,784 bp
  • A to G, chromosome 13 at 101,709,697 bp
  • T to C, chromosome 14 at 52,266,260 bp
  • C to T, chromosome 15 at 57,936,098 bp
  • C to A, chromosome 15 at 58,022,479 bp
  • T to A, chromosome 15 at 76,600,311 bp
  • T to A, chromosome 15 at 91,700,613 bp
  • A to G, chromosome 16 at 29,456,601 bp
  • A to C, chromosome 16 at 45,095,823 bp
  • A to C, chromosome 17 at 18,135,818 bp
  • A to G, chromosome 17 at 36,014,591 bp
  • T to C, chromosome 17 at 36,260,504 bp
  • T to C, chromosome 17 at 56,626,620 bp
  • A to G, chromosome 18 at 41,912,368 bp
  • A to G, chromosome 18 at 42,523,974 bp
  • T to A, chromosome 19 at 6,310,815 bp
  • A to G, chromosome 19 at 12,120,545 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7739 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045795-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.