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Strain Name:
C57BL/6J-MtgxR7743Btlr/Mmmh
Stock Number:
045799-MU
Citation ID:
RRID:MMRRC_045799-MU
Other Names:
R7743 (G1)
Major Collection:

Strain Information

Npr3
Name: natriuretic peptide receptor 3
Synonyms: Nppc receptor, lgj, longjohn, NPR-C, B430320C24Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 18162
VEGA: 15
HGNC: HGNC:7945
Homologene: 699
Erbb4
Name: erb-b2 receptor tyrosine kinase 4
Synonyms: ErbB4, Her4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13869
HGNC: HGNC:3432
Homologene: 21084
Tead3
Name: TEA domain family member 3
Synonyms: ETFR-1, TEAD-3, DTEF-1, Tcf13r2, TEF-5
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 21678
Homologene: 81821
Abtb3
Name: ankyrin repeat and BTB domain containing 3
Synonyms: 6330404E16Rik, Btbd11
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 74007
Homologene: 72536
Slc37a1
Name: solute carrier family 37 (glycerol-3-phosphate transporter), member 1
Synonyms: G3PP
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224674
VEGA: 17
Homologene: 70486
Syt3
Name: synaptotagmin III
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20981
Homologene: 9617
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 68,328,119 bp
  • T to A, chromosome 1 at 88,166,395 bp
  • C to T, chromosome 1 at 107,079,358 bp
  • C to T, chromosome 1 at 163,024,553 bp
  • T to A, chromosome 1 at 188,810,179 bp
  • A to G, chromosome 2 at 69,944,449 bp
  • T to C, chromosome 2 at 76,951,483 bp
  • T to C, chromosome 2 at 130,393,422 bp
  • T to G, chromosome 3 at 93,773,258 bp
  • A to G, chromosome 3 at 138,068,755 bp
  • C to A, chromosome 4 at 14,818,389 bp
  • T to A, chromosome 4 at 76,086,089 bp
  • A to G, chromosome 5 at 53,135,885 bp
  • A to G, chromosome 5 at 65,808,459 bp
  • C to G, chromosome 5 at 93,273,343 bp
  • G to A, chromosome 5 at 110,102,503 bp
  • T to G, chromosome 5 at 110,840,050 bp
  • A to G, chromosome 5 at 122,461,571 bp
  • C to T, chromosome 6 at 34,846,830 bp
  • A to T, chromosome 6 at 140,555,986 bp
  • A to T, chromosome 7 at 3,694,602 bp
  • G to A, chromosome 7 at 4,521,892 bp
  • A to C, chromosome 7 at 34,192,831 bp
  • A to T, chromosome 7 at 44,392,667 bp
  • A to T, chromosome 7 at 45,181,309 bp
  • A to G, chromosome 7 at 45,308,338 bp
  • A to T, chromosome 7 at 58,803,709 bp
  • CGGC to CGGCGGCGGAGGC, chromosome 7 at 97,579,932 bp
  • A to T, chromosome 7 at 102,588,431 bp
  • A to G, chromosome 7 at 103,717,353 bp
  • T to A, chromosome 7 at 109,711,828 bp
  • A to G, chromosome 7 at 109,716,059 bp
  • T to C, chromosome 8 at 3,536,594 bp
  • T to C, chromosome 8 at 36,249,052 bp
  • G to A, chromosome 8 at 120,086,728 bp
  • T to C, chromosome 8 at 125,464,233 bp
  • T to C, chromosome 9 at 7,962,378 bp
  • T to C, chromosome 9 at 18,657,477 bp
  • A to G, chromosome 9 at 38,516,328 bp
  • A to T, chromosome 9 at 60,876,395 bp
  • A to C, chromosome 9 at 64,152,935 bp
  • A to T, chromosome 9 at 80,276,329 bp
  • A to T, chromosome 9 at 88,398,349 bp
  • A to G, chromosome 9 at 122,785,136 bp
  • G to T, chromosome 10 at 33,257,062 bp
  • G to A, chromosome 10 at 57,511,335 bp
  • G to A, chromosome 10 at 80,304,915 bp
  • A to T, chromosome 10 at 85,624,949 bp
  • A to G, chromosome 10 at 93,980,424 bp
  • T to A, chromosome 11 at 29,733,790 bp
  • C to T, chromosome 11 at 59,099,777 bp
  • A to T, chromosome 11 at 72,778,876 bp
  • A to T, chromosome 11 at 82,922,900 bp
  • T to C, chromosome 11 at 96,961,109 bp
  • G to A, chromosome 11 at 116,049,436 bp
  • T to C, chromosome 11 at 116,601,601 bp
  • A to T, chromosome 11 at 116,603,949 bp
  • G to A, chromosome 12 at 16,976,047 bp
  • A to C, chromosome 12 at 54,656,416 bp
  • G to T, chromosome 12 at 84,940,269 bp
  • A to G, chromosome 12 at 112,784,763 bp
  • A to G, chromosome 12 at 113,544,532 bp
  • A to G, chromosome 14 at 47,670,293 bp
  • G to A, chromosome 14 at 54,957,150 bp
  • A to T, chromosome 14 at 60,756,249 bp
  • A to G, chromosome 15 at 11,037,130 bp
  • A to C, chromosome 15 at 11,399,372 bp
  • A to G, chromosome 15 at 11,905,638 bp
  • A to G, chromosome 15 at 81,949,198 bp
  • G to T, chromosome 15 at 89,421,404 bp
  • A to G, chromosome 16 at 25,882,625 bp
  • A to G, chromosome 16 at 93,919,727 bp
  • T to C, chromosome 16 at 96,437,408 bp
  • G to A, chromosome 17 at 3,518,156 bp
  • G to A, chromosome 17 at 7,765,137 bp
  • C to T, chromosome 17 at 23,345,798 bp
  • T to C, chromosome 17 at 26,198,868 bp
  • T to C, chromosome 17 at 26,924,202 bp
  • T to A, chromosome 17 at 28,332,827 bp
  • T to A, chromosome 17 at 31,316,185 bp
  • A to T, chromosome 17 at 42,672,562 bp
  • C to T, chromosome 19 at 7,683,836 bp
  • T to C, chromosome 19 at 18,827,408 bp
  • T to C, chromosome 19 at 43,739,941 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7743 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045799-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.