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Strain Name:
C57BL/6J-MtgxR7760Btlr/Mmmh
Stock Number:
045816-MU
Citation ID:
RRID:MMRRC_045816-MU
Other Names:
R7760 (G1)
Major Collection:

Strain Information

Wnt3
Name: wingless-type MMTV integration site family, member 3
Synonyms: Wnt-3, Int-4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 22415
Homologene: 22527
Ppp5c
Name: protein phosphatase 5, catalytic subunit
Synonyms: ANP receptor, PP5
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 19060
HGNC: HGNC:9322
Homologene: 4550
Slc6a5
Name: solute carrier family 6 (neurotransmitter transporter, glycine), member 5
Synonyms: Glyt2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 104245
Homologene: 37901
Tlk2
Name: tousled-like kinase 2 (Arabidopsis)
Synonyms: protein kinase U-alpha, PKUalpha, 4933403M19Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 24086
Homologene: 4993
Gatad2b
Name: GATA zinc finger domain containing 2B
Synonyms: C430014D17Rik, p66beta
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229542
Homologene: 32484
Wac
Name: WW domain containing adaptor with coiled-coil
Synonyms: Wwp4, 1110067P07Rik, A230035H12Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225131
Homologene: 41148
Senp7
Name: SUMO1/sentrin specific peptidase 7
Synonyms: 6030449K19Rik, 2900036C23Rik, 2410152H17Rik, 2810413I22Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 66315
Homologene: 10778
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 46,201,253 bp
  • T to C, chromosome 1 at 87,540,773 bp
  • A to T, chromosome 1 at 130,846,631 bp
  • C to T, chromosome 1 at 151,442,674 bp
  • T to C, chromosome 2 at 118,711,388 bp
  • C to T, chromosome 3 at 90,354,469 bp
  • A to G, chromosome 4 at 56,790,892 bp
  • G to T, chromosome 5 at 36,470,642 bp
  • A to G, chromosome 5 at 100,392,628 bp
  • A to G, chromosome 5 at 110,205,850 bp
  • A to G, chromosome 6 at 72,557,786 bp
  • A to G, chromosome 6 at 123,270,341 bp
  • A to G, chromosome 7 at 17,006,349 bp
  • C to T, chromosome 7 at 19,080,735 bp
  • T to A, chromosome 7 at 21,427,484 bp
  • T to A, chromosome 7 at 25,472,025 bp
  • T to C, chromosome 7 at 35,457,075 bp
  • T to C, chromosome 7 at 49,946,617 bp
  • T to G, chromosome 7 at 111,046,601 bp
  • T to C, chromosome 7 at 127,489,400 bp
  • T to A, chromosome 7 at 141,651,057 bp
  • T to A, chromosome 8 at 35,802,337 bp
  • C to A, chromosome 8 at 69,832,795 bp
  • A to G, chromosome 8 at 106,108,341 bp
  • T to A, chromosome 8 at 106,133,470 bp
  • C to T, chromosome 8 at 126,452,807 bp
  • T to C, chromosome 9 at 57,139,363 bp
  • T to G, chromosome 10 at 24,927,463 bp
  • T to C, chromosome 10 at 63,421,537 bp
  • T to G, chromosome 10 at 68,005,609 bp
  • T to C, chromosome 11 at 60,274,965 bp
  • T to A, chromosome 11 at 77,151,926 bp
  • T to A, chromosome 11 at 80,864,563 bp
  • T to A, chromosome 11 at 103,811,440 bp
  • T to C, chromosome 11 at 105,279,167 bp
  • T to A, chromosome 11 at 106,073,112 bp
  • T to C, chromosome 12 at 16,723,416 bp
  • T to A, chromosome 12 at 113,702,175 bp
  • T to C, chromosome 13 at 56,526,934 bp
  • C to T, chromosome 13 at 56,537,003 bp
  • G to T, chromosome 13 at 81,711,877 bp
  • T to C, chromosome 14 at 14,175,905 bp
  • C to T, chromosome 14 at 25,872,827 bp
  • T to A, chromosome 14 at 34,542,503 bp
  • T to A, chromosome 14 at 53,454,646 bp
  • A to T, chromosome 14 at 54,172,356 bp
  • T to G, chromosome 14 at 54,172,357 bp
  • T to C, chromosome 15 at 8,358,702 bp
  • C to T, chromosome 15 at 78,673,841 bp
  • A to T, chromosome 16 at 56,139,079 bp
  • T to C, chromosome 16 at 59,618,806 bp
  • T to C, chromosome 17 at 21,588,366 bp
  • A to T, chromosome 17 at 34,712,937 bp
  • T to A, chromosome 18 at 7,921,913 bp
  • A to G, chromosome 18 at 37,731,637 bp
  • A to C, chromosome 19 at 23,235,890 bp
  • G to A, chromosome 19 at 47,113,198 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7760 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045816-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.