Loading Mouse GIF
Loading...

Strain Name:
C57BL/6J-MtgxR7761Btlr/Mmmh
Stock Number:
045817-MU
Citation ID:
RRID:MMRRC_045817-MU
Other Names:
R7761 (G1)
Major Collection:

Strain Information

Pln
Name: phospholamban
Synonyms: PLB
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 18821
VEGA: 10
HGNC: HGNC:9080
Homologene: 2002
Casq2
Name: calsequestrin 2
Synonyms: cardiac calsequestrin, ESTM52, cCSQ, Csq2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12373
HGNC: HGNC:1513
Homologene: 20330
Pax6
Name: paired box 6
Synonyms: Pax-6, Dey, Dickie's small eye, 1500038E17Rik, AEY11, Gsfaey11
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18508
HGNC: HGNC:8620
Homologene: 1212
Abca12
Name: ATP-binding cassette, sub-family A member 12
Synonyms: 4832428G11Rik, 4833417A11Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74591
Homologene: 45441
Scn3a
Name: sodium channel, voltage-gated, type III, alpha
Synonyms: LOC381367, Nav1.3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20269
Homologene: 56005
Ggnbp2
Name: gametogenetin binding protein 2
Synonyms: DIF-3, Zfp403, D330017P12Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217039
Homologene: 11750
U2surp
Name: U2 snRNP-associated SURP domain containing
Synonyms: 2610101N10Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 67958
Homologene: 13964
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 60,319,341 bp
  • C to T, chromosome 1 at 71,330,288 bp
  • A to T, chromosome 1 at 125,677,512 bp
  • A to G, chromosome 1 at 150,722,445 bp
  • A to T, chromosome 1 at 156,525,137 bp
  • T to A, chromosome 2 at 14,434,330 bp
  • T to A, chromosome 2 at 65,529,454 bp
  • T to G, chromosome 2 at 69,161,122 bp
  • T to C, chromosome 2 at 76,719,930 bp
  • T to C, chromosome 2 at 90,703,112 bp
  • T to G, chromosome 2 at 105,691,691 bp
  • T to C, chromosome 2 at 111,257,174 bp
  • C to T, chromosome 2 at 111,368,793 bp
  • T to A, chromosome 2 at 111,912,877 bp
  • T to C, chromosome 2 at 120,699,379 bp
  • T to C, chromosome 2 at 177,193,734 bp
  • T to C, chromosome 2 at 177,265,517 bp
  • G to T, chromosome 3 at 88,762,471 bp
  • T to C, chromosome 3 at 89,242,258 bp
  • G to T, chromosome 3 at 102,145,264 bp
  • T to C, chromosome 4 at 12,146,460 bp
  • T to C, chromosome 4 at 118,435,989 bp
  • T to C, chromosome 4 at 156,247,825 bp
  • C to T, chromosome 5 at 34,323,430 bp
  • T to A, chromosome 5 at 137,639,763 bp
  • T to C, chromosome 6 at 15,728,056 bp
  • G to A, chromosome 6 at 38,555,064 bp
  • G to A, chromosome 6 at 43,304,191 bp
  • C to T, chromosome 6 at 132,600,343 bp
  • A to T, chromosome 7 at 66,714,105 bp
  • T to C, chromosome 7 at 80,380,867 bp
  • CGGCGGCGG to CGGCGGCGGGGGCGGCGG, chromosome 7 at 97,579,920 bp
  • A to G, chromosome 7 at 105,126,719 bp
  • A to T, chromosome 7 at 126,581,714 bp
  • A to T, chromosome 7 at 140,112,465 bp
  • A to G, chromosome 7 at 142,968,103 bp
  • A to T, chromosome 8 at 60,501,202 bp
  • T to C, chromosome 8 at 63,926,912 bp
  • A to T, chromosome 8 at 65,001,312 bp
  • T to C, chromosome 8 at 85,284,078 bp
  • G to T, chromosome 9 at 18,580,574 bp
  • T to C, chromosome 9 at 27,029,530 bp
  • A to G, chromosome 9 at 56,852,538 bp
  • A to G, chromosome 9 at 95,488,761 bp
  • T to C, chromosome 10 at 53,343,909 bp
  • T to C, chromosome 10 at 81,084,999 bp
  • A to G, chromosome 10 at 117,683,435 bp
  • A to G, chromosome 11 at 5,788,597 bp
  • T to C, chromosome 11 at 23,891,884 bp
  • C to A, chromosome 11 at 61,684,758 bp
  • C to T, chromosome 11 at 75,167,374 bp
  • A to T, chromosome 11 at 84,839,977 bp
  • A to T, chromosome 11 at 98,837,659 bp
  • T to C, chromosome 12 at 80,475,772 bp
  • C to T, chromosome 12 at 101,055,821 bp
  • T to A, chromosome 12 at 111,109,863 bp
  • T to A, chromosome 12 at 118,023,913 bp
  • G to C, chromosome 13 at 40,725,180 bp
  • A to T, chromosome 13 at 46,798,479 bp
  • A to G, chromosome 13 at 95,513,874 bp
  • T to A, chromosome 14 at 31,001,650 bp
  • T to A, chromosome 14 at 33,622,552 bp
  • T to A, chromosome 14 at 34,598,852 bp
  • C to A, chromosome 14 at 123,294,379 bp
  • C to G, chromosome 14 at 123,294,380 bp
  • A to G, chromosome 15 at 44,529,884 bp
  • T to C, chromosome 15 at 95,432,669 bp
  • A to C, chromosome 15 at 98,600,014 bp
  • G to A, chromosome 16 at 65,546,859 bp
  • T to C, chromosome 16 at 87,411,793 bp
  • G to A, chromosome 17 at 80,217,312 bp
  • T to C, chromosome 18 at 36,946,294 bp
  • A to G, chromosome 19 at 5,426,291 bp
  • A to T, chromosome 19 at 27,427,092 bp
  • T to A, chromosome 19 at 55,926,036 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7761 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045817-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.